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Article: Molecular Characterization of

Reslan, Lina / Araj, George F / Finianos, Marc / El Asmar, Rima / Hrabak, Jaroslav / Dbaibo, Ghassan / Bitar, Ibrahim

2022 Volume 12, Page(s) 770635

Abstract: Background: The globally emerging : Methods: A total of 28 : Results: Candida auris: Conclusion: This characterization ... ...

Abstract	Background: The globally emerging Methods: A total of 28 Results: Candida auris Conclusion: This characterization of
Language	English
Publishing date	2022-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.770635
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Article ; Online: Erratum: Rotavirus Genotypes and Vaccine Effectiveness from a Sentinel, Hospital-Based, Surveillance Study for Three Consecutive Rotavirus Seasons in Lebanon.

Ali, Zainab / Harastani, Houda / Hammadi, Moza / Reslan, Lina / Ghanem, Soha / Hajar, Farah / Sabra, Ahmad / Haidar, Amjad / Inati, Adlette / Rajab, Mariam / Fakhouri, Hassan / Ghanem, Bassam / Baasiri, Ghassan / Gerbaka, Bernard / Zaraket, Hassan / Matar, Ghassan M / Dbaibo, Ghassan

PloS one

2023 Volume 18, Issue 6, Page(s) e0286701

Abstract: This corrects the article DOI: 10.1371/journal.pone.0161345.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0161345.].
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0286701
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Article ; Online: Erratum

Zainab Ali / Houda Harastani / Moza Hammadi / Lina Reslan / Soha Ghanem / Farah Hajar / Ahmad Sabra / Amjad Haidar / Adlette Inati / Mariam Rajab / Hassan Fakhouri / Bassam Ghanem / Ghassan Baasiri / Bernard Gerbaka / Hassan Zaraket / Ghassan M Matar / Ghassan Dbaibo

PLoS ONE, Vol 18, Iss 6, p e

Rotavirus Genotypes and Vaccine Effectiveness from a Sentinel, Hospital-Based, Surveillance Study for Three Consecutive Rotavirus Seasons in Lebanon.

2023 Volume 0286701

Abstract: This corrects the article DOI:10.1371/journal.pone.0161345.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pone.0161345.].
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Does intervention improve the outcomes of patients after total knee replacement surgery?

Abbass Reslan, Hassan / Moustafa, Sawsan M / Saghieh, Said / Sharara, Eman S / Badr, Lina Kurdahi

International journal of orthopaedic and trauma nursing

2018 Volume 31, Page(s) 26–31

Abstract: Objective: To assess the effect of a one to one intervention by a nurse on the outcomes of patients undergoing Total Knee Replacement (TNR) surgery.: Methods: A quasi-experimental design was used with 60 participants, half of which received a one to ... ...

Abstract	Objective: To assess the effect of a one to one intervention by a nurse on the outcomes of patients undergoing Total Knee Replacement (TNR) surgery. Methods: A quasi-experimental design was used with 60 participants, half of which received a one to one intervention including education and exercise training by a nurse prior to surgery. Follow up was at two and four weeks post-surgery to assess pain, knee function using the Hospital for Special Surgery (HSS) Knee Rating Sheet and activities of daily living measured on the Lower Extremity Functional Scale (LEFS). ANOVA tests were used to compare significant differences between groups. Results: The intervention group had less pain at two and four weeks, p = 0.00, and better knee function at four weeks, p = 0.026. Activities of daily living were better for the intervention group at both two and four weeks, p = 0.002 and 0.048. Conclusion: The one to one intervention provided by a nurse before TKR surgery was instrumental in decreasing pain, improving knee function and enhancing activities of daily living.
MeSH term(s)	Activities of Daily Living/psychology ; Adult ; Aftercare/methods ; Aged ; Arthroplasty, Replacement, Knee/nursing ; Arthroplasty, Replacement, Knee/rehabilitation ; Exercise/physiology ; Exercise/psychology ; Female ; Humans ; Male ; Middle Aged ; Pain/rehabilitation ; Patient Education as Topic ; Preoperative Care/education ; Range of Motion, Articular/physiology
Language	English
Publishing date	2018-08-14
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2537649-4
ISSN	1878-1292 ; 1878-1241
ISSN (online)	1878-1292
ISSN	1878-1241
DOI	10.1016/j.ijotn.2018.08.001
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Article ; Online: Spoligotyping of Mycobacterium tuberculosis isolates using Luminex®-based method in Lebanon.

Masoud, Khaldoun / Araj, George F / Reslan, Lina / Fadlallah, Sukayna / Wehbe, Michel / Itani, Lina / Avedissian, Aline / Dbaibo, Ghassan / Saade, Antoine / Refrégier, Guislaine / Sola, Christophe / Matar, Ghassan M

Journal of infection in developing countries

2020 Volume 14, Issue 8, Page(s) 878–885

Abstract: Introduction: Data about the genotypes of circulating Mycobacterium tuberculosis isolates (MTB) in Lebanon are scarce. This study was undertaken to reveal the spoligotypes of MTB isolates recovered from patients in Lebanon.: Methodology: MTB isolates ...

Abstract	Introduction: Data about the genotypes of circulating Mycobacterium tuberculosis isolates (MTB) in Lebanon are scarce. This study was undertaken to reveal the spoligotypes of MTB isolates recovered from patients in Lebanon. Methodology: MTB isolates from 49 patients living in Lebanon were recovered and identified. The samples were heat killed and subjected to DNA extraction. Spoligotyping was performed using microbeads from TB-SPOL Kit and the fluorescence intensity was measured using Luminex 200®. Generated patterns were assigned to families using the SITVIT2 international database of the Pasteur Institute of Guadeloupe and compared. Results: The spoligotyping of the 49 MTB isolates revealed that 31 isolates belonged to Lineage 4 (Euro-American, 63.3%), 12 to Lineage 3 (East- African Indian, 24.5%), 3 to Lineage 2 (East Asian, 6%) and 2 were unknown. Over half of the genotypes (16 of 30) harbored SIT127 supposed to belong to the L4.5 sublineage. One isolate belonging to the rare Manu-Ancestor SIT523 was recovered for the first time in Lebanon, being associated with highly virulent extensively drug-resistant (XDR) MTB phenotype. Conclusion: The application of the Spoligotyping Multiplex Luminex® method is an efficient, discriminatory and rapid method to use for first-lane genotyping of MTB isolates. Though humble numbers were tested, this study is one of the first to describe the genomic diversity and epidemiology of MTB isolates of Lebanon, and suggests an increasing prevalence of SIT127 in the country.
MeSH term(s)	Bacterial Typing Techniques/instrumentation ; Genotype ; Humans ; Lebanon ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Polymerase Chain Reaction/methods ; Tuberculosis/microbiology
Language	English
Publishing date	2020-08-31
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.12072
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Article ; Online: Genotyping of Mycobacterium tuberculosis in Lebanon using a novel rapid spoligotyping multiplex luminex method.

Massoud, Khaldoun / Araj, George Farah / Fadlallah, Sukayna / Reslan, Lina / Itani, Lina / Avedissian, Aline / Dbaibo, Ghassan / Saade, Antoine / Matar, Ghassan Matar

Journal of infection in developing countries

2018 Volume 12, Issue 2.1, Page(s) 18S

Abstract: Introduction: Incidence of Tuberculosis (TB) in Lebanon, according to the WHO, is estimated to be 35 cases per 100,000 people. However, data about the genotypes of circulating Mycobacterium tuberculosis isolates (MTB) in this country is lacking. This ... ...

Abstract	Introduction: Incidence of Tuberculosis (TB) in Lebanon, according to the WHO, is estimated to be 35 cases per 100,000 people. However, data about the genotypes of circulating Mycobacterium tuberculosis isolates (MTB) in this country is lacking. This study aims to reveal the genotypes of TB isolates recovered from patients in Lebanon. Methodology: Fifty M. tuberculosis isolates from patients in Lebanon were recovered and identified at the reference TB center of the Ministry of Public Health. All isolates were heat killed and subjected to DNA extraction. Spoligotyping method (TB-Spol, Beamedex, France) was used to identify the presence of 43 spacers via a multi-analyte profiling system (Luminex, Bio-Rad). Generated patterns were assigned to families using the SITVIT2 international database of the Pasteur Institute of Guadeloupe. Results: The spoligotyping of the 50 MTB isolates revealed 13 lineages, one being novel. The most frequent shared-types (SIT) identified lineage was the Ural (34%), followed by the Central Asian lineage (10%) and a single isolate (2%) belonging to the rare Manu-Ancestor SIT523 lineage, associated with a highly virulent XDR MTB phenotype. The rest of the SIT isolates (18%) were equally distributed along 9 different lineages. The 13th non-SIT lineage is a novel one constituting 36% of the total isolates. Conclusion: The application of Spoligotyping Multiplex Luminex method is a novel, discriminatory and rapid method to use for genotyping of MTB isolates employing the multi-spacer analysis system. Our study showed genomic diversification of MTB isolates from Lebanon.
Language	English
Publishing date	2018-02-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.10094
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Article: The Emergence of Invasive

Reslan, Lina / Finianos, Marc / Bitar, Ibrahim / Moumneh, Mohamad Bahij / Araj, George F / Zaghlout, Alissar / Boutros, Celina / Jisr, Tamima / Nabulsi, Malak / Kara Yaccoub, Gilbert / Hamze, Monzer / Osman, Marwan / Bou Raad, Elie / Hrabak, Jaroslav / Matar, Ghassan M / Dbaibo, Ghassan

Frontiers in microbiology

2021 Volume 12, Page(s) 637813

Abstract: Background: Invasive pneumococcal disease (IPD) remains a global health problem. IPD incidence has significantly decreased by the use of pneumococcal conjugate vaccines (PCV). Nevertheless, non-PCV serotypes remain a matter of concern. Eight : Methods! ...

Abstract	Background: Invasive pneumococcal disease (IPD) remains a global health problem. IPD incidence has significantly decreased by the use of pneumococcal conjugate vaccines (PCV). Nevertheless, non-PCV serotypes remain a matter of concern. Eight Methods: WGS using long reads sequencing (PacBio) was performed to produce complete circular genomes and to determine clonality, antimicrobial resistance and virulence determinants. Results: The sequencing results yielded eight closed circular genomes. Three multilocus sequence typing (MLST) types were identified (ST11618, ST14184, ST15253). Both MLST and WGS analyses revealed that these isolates from Lebanon were genetically homogenous belonging to clonal complex CC230 and clustered closely with isolates originating from Canada, United States of America, United Kingdom and Iceland. Their penicillin binding protein profiles correlated with both β-lactam susceptibility patterns and MLST types. Moreover, the isolates harbored the macrolide and tetracycline resistance genes and showed a similar virulence gene profile. To our knowledge, this study represents the first report of complete phenotypic and genomic characterization of the emerging
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.637813
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Article ; Online: Genetic Diversity of Human Rotavirus A Among Hospitalized Children Under-5 Years in Lebanon.

Harastani, Houda H / Reslan, Lina / Sabra, Ahmad / Ali, Zainab / Hammadi, Moza / Ghanem, Soha / Hajar, Farah / Matar, Ghassan M / Dbaibo, Ghassan S / Zaraket, Hassan

Frontiers in immunology

2020 Volume 11, Page(s) 317

Abstract: Human rotavirus remains a major cause of gastroenteritis worldwide despite the availability of effective vaccines. In this study, we investigated the genetic diversity of rotaviruses circulating in Lebanon. We genetically characterized the VP4 and VP7 ... ...

Abstract	Human rotavirus remains a major cause of gastroenteritis worldwide despite the availability of effective vaccines. In this study, we investigated the genetic diversity of rotaviruses circulating in Lebanon. We genetically characterized the VP4 and VP7 genes encoding the outer capsid proteins of 132 rotavirus-associated gastroenteritis specimens, previously identified in hospitalized children (<5 years) from 2011 to 2013 in Lebanon. These included 43 vaccine-breakthrough specimens and the remainder were from non-vaccinated subjects. Phylogenetic analysis of VP4 and VP7 genes revealed distinct clustering compared to the vaccine strains, and several substitutions were identified in the antigenic epitopes of Lebanese specimens. No unique changes were identified in the breakthrough specimens compared to non-breakthroughs that could explain the occurrence of infection in vaccinated children. Further, we report the emergence of a rare P[8] OP354-like strain with a G9 VP7 in Lebanon, possessing high genetic variability in their VP4 compared to vaccine strains. Therefore, human rotavirus strains circulating in Lebanon and globally have accumulated numerous substitutions in their antigenic sites compared to those currently used in the licensed vaccines. The successful spread and continued genetic drift of these strains over time might undermine the effectiveness of the vaccines. The effect of such changes in the antigenic sites on vaccine efficacy remains to be assessed.
MeSH term(s)	Amino Acid Sequence ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Capsid Proteins/genetics ; Capsid Proteins/immunology ; Child, Hospitalized ; Child, Preschool ; Epitopes/genetics ; Female ; Gastroenteritis/epidemiology ; Gastroenteritis/virology ; Genetic Variation ; Glycosylation ; Humans ; Infant ; Lebanon/epidemiology ; Male ; Models, Molecular ; Phylogeny ; Protein Conformation ; Protein Processing, Post-Translational ; RNA, Viral/genetics ; Rotavirus/genetics ; Rotavirus/immunology ; Rotavirus/isolation & purification ; Rotavirus Infections/epidemiology ; Rotavirus Infections/prevention & control ; Rotavirus Infections/virology ; Sequence Alignment ; Sequence Homology, Amino Acid ; Vaccines, Attenuated ; Viral Vaccines
Chemical Substances	Antigens, Viral ; Capsid Proteins ; Epitopes ; RNA, Viral ; VP4 protein, Rotavirus ; VP7 protein, Rotavirus ; Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2020-02-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.00317
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Article ; Online: The origins of G12P[6] rotavirus strains detected in Lebanon.

Reslan, Lina / Mishra, Nischay / Finianos, Marc / Zakka, Kimberley / Azakir, Amanda / Guo, Cheng / Thakka, Riddhi / Dbaibo, Ghassan / Lipkin, W Ian / Zaraket, Hassan

The Journal of general virology

2020 Volume 102, Issue 3

Abstract: The G12 rotaviruses are an increasingly important cause of severe diarrhoea in infants and young children worldwide. Seven human G12P[6] rotavirus strains were detected in stool samples from children hospitalized with gastroenteritis in Lebanon during a ... ...

Abstract	The G12 rotaviruses are an increasingly important cause of severe diarrhoea in infants and young children worldwide. Seven human G12P[6] rotavirus strains were detected in stool samples from children hospitalized with gastroenteritis in Lebanon during a 2011-2013 surveillance study. Complete genomes of these strains were sequenced using VirCapSeq-VERT, a capture-based high-throughput viral-sequencing method, and further characterized based on phylogenetic analyses with global RVA and vaccine strains. Based on the complete genomic analysis, all Lebanese G12 strains were found to have Wa-like genetic backbone G12-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Phylogenetically, these strains fell into two clusters where one of them might have emerged from Southeast Asian strains and the second one seems to have a mixed backbone between North American and Southeast Asian strains. Further analysis of these strains revealed high antigenic variability compared to available vaccine strains. To our knowledge, this is the first report on the complete genome-based characterization of G12P[6] emerging in Lebanon. Additional studies will provide important insights into the evolutionary dynamics of G12 rotaviruses spreading in Asia.
MeSH term(s)	Antigens, Viral/chemistry ; Antigens, Viral/immunology ; Asia, Southeastern ; Capsid Proteins/chemistry ; Capsid Proteins/immunology ; Capsid Proteins/metabolism ; Child, Preschool ; Epitopes ; Evolution, Molecular ; Female ; Gastroenteritis/virology ; Genome, Viral ; Glycosylation ; Humans ; Infant ; Infant, Newborn ; Lebanon ; Male ; North America ; Phylogeny ; Rotavirus/chemistry ; Rotavirus/genetics ; Rotavirus/immunology ; Rotavirus/isolation & purification ; Rotavirus Infections/virology ; Rotavirus Vaccines/immunology ; Vaccines, Attenuated/immunology ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/immunology
Chemical Substances	Antigens, Viral ; Capsid Proteins ; Epitopes ; RIX4414 vaccine ; RotaTeq ; Rotavirus Vaccines ; VP4 protein, Rotavirus ; VP7 protein, Rotavirus ; Vaccines, Attenuated ; Viral Proteins
Language	English
Publishing date	2020-12-17
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001535
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Article ; Online: Wide Variability in the Sensitivity and Specificity of Rotavirus Immunoassay Diagnostic Kits in Practice.

Shaker, Rouba / Abdalrahman, Ebla / Ali, Zainab / Reslan, Lina / Harastani, Houda / Haidar, Amjad / Ghanem, Soha / Hajar, Farah / Inati, Adlette / Rajab, Mariam / Baassiri, Ghassan / Ghanem, Bassam / Fakhoury, Hassan / Araj, George / Matar, Ghassan M / Dbaibo, Ghassan

Journal of infection in developing countries

2021 Volume 15, Issue 11, Page(s) 1701–1707

Abstract: Introduction: Most hospitals rely on rapid antigen-detection kits for the diagnosis of rotavirus infection. Several small studies reviewed the sensitivity and specificity of some of these kits. These studies showed discrepancy in results obtained for ... ...

Abstract	Introduction: Most hospitals rely on rapid antigen-detection kits for the diagnosis of rotavirus infection. Several small studies reviewed the sensitivity and specificity of some of these kits. These studies showed discrepancy in results obtained for sensitivity and specificity that varied according to the type of kit used, area of study, and type of test used as standard for diagnosis of rotavirus infection. The objective of the study is to determine the sensitivity and specificity of five commonly used rotavirus immunoassay kits in comparison to RT-PCR as standard. Methodology: Stool samples (N = 1,414) collected from children under 5 years of age hospitalized with gastroenteritis were tested for rotavirus by immunoassay kits and RT-PCR in a prospective hospital-based surveillance study conducted at 7 centers in Lebanon. Concordance and discrepancy between the two methods was used to calculate sensitivity and specificity, using RT-PCR as the "gold standard". Results: The sensitivity and specificity were respectively 95.08% and 86.62% for the SD Bioline® (Standard Diagnostics, Inc, South Korea) kit calculated on 645 samples, 65.86% and 45.90% for the VIROTECT® (Trinity Biotech, Ireland) kit calculated on 327 samples, 83.9% and 64.2% for the Rota-Strip (C-1001) (Coris Bioconcept, Belgium) calculated on 95 samples, 52.3% and 10.9% for the Acon® (Acon Laboratories, Inc, California, USA) kit calculated on 122 samples, 68.1% and 20% for the VIKIA® Rota-Adéno (Biomerieux, France) kit calculated on 32 samples. Conclusion: A wide discrepancy was detected between the calculated and advertised sensitivity and specificity for most of the kits.
MeSH term(s)	Child, Preschool ; Feces/virology ; Gastroenteritis/diagnosis ; Gastroenteritis/virology ; Humans ; Immunoassay/standards ; Infant ; Prospective Studies ; Reagent Kits, Diagnostic/standards ; Reagent Kits, Diagnostic/virology ; Real-Time Polymerase Chain Reaction ; Rotavirus ; Rotavirus Infections/diagnosis ; Sensitivity and Specificity
Chemical Substances	Reagent Kits, Diagnostic
Language	English
Publishing date	2021-11-30
Publishing country	Italy
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.11922
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