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Article: [Besprechung von:] American economic growth. An economist's history of the United States. By Lance E. Davis, Richard A. Easterlin, William N. Parker [u.a.] London, New York 1972. Davis, Lance E. and Douglas C. North: Intitutional change and American economic growth. London, New York 1971

Robertson, Ross M / Davis, Lance E / North, Douglass C

Journal of economic literature Vol. 10, No. 4 , p. 1210-1212

1972 Volume 10, Issue 4, Page(s) 1210–1212

Author's details	Ross M. Robertson
Publisher	Assoc.
Publishing place	Nashville, Tenn.
Document type	Article
ZDB-ID	3076-4
Database	ECONomics Information System

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Article ; Online: Spatial and temporal aspects of neuronal calcium and sodium signals measured with low-affinity fluorescent indicators.

Canepari, Marco / Ross, William N

Pflugers Archiv : European journal of physiology

2023 Volume 476, Issue 1, Page(s) 39–48

Abstract: Low-affinity fluorescent indicators for ... ...

Abstract	Low-affinity fluorescent indicators for Ca
MeSH term(s)	Calcium ; Sodium ; Neurons ; Coloring Agents
Chemical Substances	Calcium (SY7Q814VUP) ; Sodium (9NEZ333N27) ; Coloring Agents
Language	English
Publishing date	2023-10-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	6380-0
ISSN	1432-2013 ; 0031-6768
ISSN (online)	1432-2013
ISSN	0031-6768
DOI	10.1007/s00424-023-02865-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uc I Zs.35: Show issues

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Article ; Online: Fast Synaptically Activated Calcium and Sodium Kinetics in Hippocampal Pyramidal Neuron Dendritic Spines.

Miyazaki, Kenichi / Ross, William N

eNeuro

2022 Volume 9, Issue 6

Abstract: An accurate assessment of the time course, components, and magnitude of postsynaptic currents is important for a quantitative understanding of synaptic integration and signaling in dendritic spines. These parameters have been studied in some detail in ... ...

Abstract	An accurate assessment of the time course, components, and magnitude of postsynaptic currents is important for a quantitative understanding of synaptic integration and signaling in dendritic spines. These parameters have been studied in some detail in previous experiments, primarily using two-photon imaging of [Ca
MeSH term(s)	Mice ; Animals ; Calcium/metabolism ; Dendritic Spines/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sodium ; Kinetics ; Pyramidal Cells/physiology ; Hippocampus/metabolism ; Glutamic Acid ; Dendrites/metabolism ; Synapses/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Receptors, N-Methyl-D-Aspartate ; Sodium (9NEZ333N27) ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2022-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0396-22.2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Impact of Prior Fragility Fractures on Complications After Total Hip Arthroplasty: A Propensity Score-Matched Cohort Study.

Ross, Austin J / Ross, Bailey J / Lee, Olivia C / Guild, George N / Sherman, William F

Arthroplasty today

2021 Volume 11, Page(s) 41–48

Abstract: Background: The impact of prior fragility fractures and osteoporosis treatment before total hip arthroplasty (THA) on postoperative complications is unclear. The purpose of this study was to characterize the effect of prior fragility fractures and ... ...

Abstract	Background: The impact of prior fragility fractures and osteoporosis treatment before total hip arthroplasty (THA) on postoperative complications is unclear. The purpose of this study was to characterize the effect of prior fragility fractures and preoperative osteoporosis treatment on short-term complications and secondary fragility fractures after THA. Methods: A propensity score-matched retrospective cohort study was conducted using a commercially available database to (1) characterize the impact of prior fragility fractures on rates of short-term complications after THA and (2) evaluate if osteoporosis treatment before arthroplasty reduces risk of postoperative complications. Rates of periprosthetic fracture, revision THA, and fragility fractures were compared via multivariable logistic regression. Results: After 1:1 propensity score matching, 2188 patients were assigned to each cohort. Patients with a fragility fracture in the 3 years preceding THA were more likely to sustain a periprosthetic fracture (1 year: 1.7% vs 1.0%, odds ratio [OR] 1.89; 2 years: 2.1% vs 1.1%, OR 1.82), fragility fracture (1 year: 4.7% vs 1.1%, OR 3.59; 2 years: 6.7% vs 1.7%, OR 3.21), and revision THA (1 year: 2.7% vs 1.7%, OR 1.65; 2 years: 3.1% vs 1.9%, OR 1.58). Among patients with a prior fragility fracture, only 13.8% received osteoporosis pharmacotherapy before THA. Rates of all complications were statistically comparable postoperatively for patients with and without pre-THA osteoporosis treatment. Conclusions: Fragility fractures within 3 years before THA are associated with significantly increased risk of periprosthetic fracture, all-cause revision, and secondary fragility fractures postoperatively. Preoperative osteoporosis treatment may not decrease risk of postoperative complications.
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ISSN	2352-3441
ISSN	2352-3441
DOI	10.1016/j.artd.2021.07.008
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Article ; Online: Impact of Clinical Characteristics and Biomarkers on AIRQ Exacerbation Prediction Ability.

Murphy, Kevin R / Beuther, David A / Chipps, Bradley / Wise, Robert A / McCann, William / Reibman, Joan / George, Maureen / Gilbert, Ileen / Eudicone, James M / Gandhi, Hitesh N / Ross, Melissa / Coyne, Karin S / Zeiger, Robert S

The journal of allergy and clinical immunology. In practice

2024

Abstract: Background: Complex models combining impairment-based control assessments with clinical characteristics and biomarkers have been developed to predict asthma exacerbations. The composite Asthma Impairment and Risk Questionnaire (AIRQ) with adjustments ... ...

Abstract	Background: Complex models combining impairment-based control assessments with clinical characteristics and biomarkers have been developed to predict asthma exacerbations. The composite Asthma Impairment and Risk Questionnaire (AIRQ) with adjustments for demographics (age, sex, race, body mass index [BMI]) predicts 12-month exacerbation occurrence similarly to these more complex models. Objective: To examine whether AIRQ exacerbation prediction is enhanced when models are adjusted for a wider range of clinical characteristics and biomarkers. Methods: Patients aged ≥12 years completed monthly online surveys regarding exacerbation-related oral corticosteroid use, emergency-department/urgent-care visits, and hospitalizations. Univariate logistic regressions to predict exacerbations were performed with sociodemographics, comorbidities, exacerbation history, lung function, blood eosinophils, immunoglobulin E, and fractional exhaled nitric oxide. Significant (P≤0.05) variables were included in multivariable logistic regressions with and without AIRQ control categories to predict 12-month exacerbations (log odds ratio [OR], 95% Wald confidence interval [CI]). Model performances were compared. Results: Over 12 months, 1070 patients (70% female; mean[SD] age 43.9[19.4] years; 22% non-White; BMI[SD] 30.6[8.7]) completed ≥1 survey (mean[SD] 10.5[2.8]). In the multivariable analysis, AIRQ control category adjusted for significant clinical characteristics and biomarkers was predictive of ≥1 exacerbation: OR(95%CI) not well-controlled vs well-controlled: 1.93(1.41-2.62), very poorly controlled vs well-controlled: 3.81(2.65-5.47). Receiver operating characteristic area under the curve for this more complex model of exacerbation prediction (AUC=0.72) did not differ from AIRQ (AUC=0.70). Models with AIRQ performed better than those without AIRQ (AUC=0.67, P<0.05). Conclusion: Costly and time-consuming complex modeling with clinical characteristics and biomarkers does not enhance the strong exacerbation prediction ability of AIRQ.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2024.04.050
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Zs.A 7086: Show issues

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Article ; Online: Hepatitis C Is Associated With Higher Short-Term Complication Rates After Initial Aseptic and Septic Revision Total Hip Arthroplasty: A Matched Cohort Study.

Ross, Bailey J / Cole, Matthew W / Ross, Austin J / Guild, George N / Lee, Olivia C / Sherman, William F

The Journal of arthroplasty

2022 Volume 38, Issue 3, Page(s) 548–554

Abstract: ... All patients who underwent rTHA were retrospectively identified in a national database. Patients who had HCV (n ... 1,746) were matched 1:3 with a matching group (n = 5,238) for age, gender, and several comorbidities ...

Abstract	Background: It is unclear if hepatitis C virus (HCV) negatively impacts outcomes of revision total hip arthroplasty (rTHA). The purpose of this study is to trend recent rTHA utilization in patients who have HCV and compare postoperative complication rates versus a matched cohort. Methods: All patients who underwent rTHA were retrospectively identified in a national database. Patients who had HCV (n = 1,746) were matched 1:3 with a matching group (n = 5,238) for age, gender, and several comorbidities. Cochran-Armitage tests were used to analyze trends in the annual proportion of rTHA performed in patients who had HCV from 2010 to 2019. Rates of 90-day medical and prosthesis-related complications within 2 years postoperatively were compared with multivariable logistic regressions. Results: The annual proportion of rTHA performed in patients who had HCV significantly increased from 2010 to 2019 (P < .001). Patients who had HCV exhibited significantly higher rates of acute kidney injuries (7.6% versus 4.4%; odds ratio [OR] 1.50), transfusions (20.6% versus 14.6%; OR 1.38), and re-revisions for prosthetic joint infection (10.9% versus 6.5%; OR 1.73). In subgroup analyses, rates of re-revision for prosthetic joint infection after initial aseptic rTHA (7.1% versus 3.8%; OR 1.82) and periprosthetic fracture after initial septic rTHA (4.5% versus 1.6%; OR 2.77) were significantly higher in the HCV cohort. Conclusion: Similar to primary THA, patients who have HCV exhibit significantly increased complication rates after rTHA. With growing utilization in recent years, these data suggest that this population will comprise an increasingly larger proportion of rTHA procedures performed in the coming years.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Cohort Studies ; Retrospective Studies ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/epidemiology ; Reoperation
Language	English
Publishing date	2022-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2022.09.018
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Article ; Online: Sodium Dynamics in Pyramidal Neuron Dendritic Spines: Synaptically Evoked Entry Predominantly through AMPA Receptors and Removal by Diffusion.

Miyazaki, Kenichi / Ross, William N

The Journal of neuroscience : the official journal of the Society for Neuroscience

2017 Volume 37, Issue 41, Page(s) 9964–9976

Abstract: Dendritic spines are key elements underlying synaptic integration and cellular plasticity, but many features of these important structures are not known or are controversial. We examined these properties using newly developed simultaneous sodium and ... ...

Abstract	Dendritic spines are key elements underlying synaptic integration and cellular plasticity, but many features of these important structures are not known or are controversial. We examined these properties using newly developed simultaneous sodium and calcium imaging with single-spine resolution in pyramidal neurons in rat hippocampal slices from either sex. Indicators for both ions were loaded through the somatic patch pipette, which also recorded electrical responses. Fluorescence changes were detected with a high-speed, low-noise CCD camera. Following subthreshold electrical stimulation, postsynaptic sodium entry is almost entirely through AMPA receptors with little contribution from entry through NMDA receptors or voltage-gated sodium channels. Sodium removal from the spine head is through rapid diffusion out to the dendrite through the spine neck with a half-removal time of ∼16 ms, which suggests the neck has low resistance. Peak [Na
MeSH term(s)	Animals ; Calcium/metabolism ; Dendritic Spines/metabolism ; Diffusion ; Electric Stimulation ; Excitatory Postsynaptic Potentials/physiology ; Female ; In Vitro Techniques ; Male ; Pyramidal Cells/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sodium/metabolism ; Synapses/physiology ; Voltage-Gated Sodium Channels/metabolism
Chemical Substances	Receptors, AMPA ; Receptors, N-Methyl-D-Aspartate ; Voltage-Gated Sodium Channels ; Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017-09-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1758-17.2017
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Article: Improvements in Simultaneous Sodium and Calcium Imaging.

Miyazaki, Kenichi / Lisman, John E / Ross, William N

Frontiers in cellular neuroscience

2019 Volume 12, Page(s) 514

Abstract: ... signal to noise ratio (S/N), less background fluorescence, and less photodynamic damage. In addition ... compartments in neurons (Miyazaki and Ross, 2015). We used this technique to analyze the dynamics of these ions ... in individual pyramidal neuron dendritic spines (Miyazaki and Ross, 2017). This system is based on high speed ...

Abstract	High speed imaging of ion concentration changes in neurons is an important and growing tool for neuroscientists. We previously developed a system for simultaneously measuring sodium and calcium changes in small compartments in neurons (Miyazaki and Ross, 2015). We used this technique to analyze the dynamics of these ions in individual pyramidal neuron dendritic spines (Miyazaki and Ross, 2017). This system is based on high speed multiplexing of light emitting diodes (LEDs) and classic organic indicators. To improve this system we made additional changes, primarily incorporating lasers in addition to the LEDs, more sophisticated imaging protocols, and the use of newer sodium and calcium indicators. This new system generates signals with higher signal to noise ratio (S/N), less background fluorescence, and less photodynamic damage. In addition, by using longer wavelength indicators instead of indicators sensitive in the UV range, it allows for the incorporation of focal uncaging along with simultaneous imaging, which should extend the range of experiments.
Language	English
Publishing date	2019-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2018.00514
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Article ; Online: Ratio-independent prey preferences by an estuarine mysid

Froneman, P. William / Cuthbert, Ross N.

2020

Abstract: The present study quantified prey preferences by adult males and females of the mysid Mesopodopsis wooldridgei fed the calanoid copepods Pseudodiaptomus hessei and Paracartia longipatella at varying proportions. Both sexes of M. wooldridgei showed a lack ...

Abstract	The present study quantified prey preferences by adult males and females of the mysid Mesopodopsis wooldridgei fed the calanoid copepods Pseudodiaptomus hessei and Paracartia longipatella at varying proportions. Both sexes of M. wooldridgei showed a lack of prey switching and a strong preference for the smaller, less active P. longipatella irrespective of density. Given a lack of low-density prey refuge, this finding may have important implications for the distribution of P. longipatella in estuaries along the eastern seaboard of South Africa. Results of the present study contribute to a growing body of literature that suggests that selective predation may play an important role in structuring plankton prey populations in shallow water ecosystems.
Language	English
Publishing date	2020-05-15
Publisher	Oxford University Press
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: miRNA family miR-29 inhibits PINK1-PRKN dependent mitophagy via ATG9A.

Markham, Briana N / Ramnarine, Chloe / Kim, Songeun / Grever, William E / Soto-Beasley, Alexandra I / Heckman, Michael / Ren, Yingxue / Osborne, Andrew C / Bhagwate, Aditya V / Liu, Yuanhang / Wang, Chen / Kim, Jungsu / Wszolek, Zbigniew K / Ross, Owen A / Springer, Wolfdieter / Fiesel, Fabienne C

bioRxiv : the preprint server for biology

2024

Abstract: Loss-of-function mutations in the genes encoding PINK1 and PRKN result in early-onset Parkinson disease (EOPD). Together the encoded enzymes direct a neuroprotective pathway that ensures the elimination of damaged mitochondria via autophagy. We performed ...

Abstract	Loss-of-function mutations in the genes encoding PINK1 and PRKN result in early-onset Parkinson disease (EOPD). Together the encoded enzymes direct a neuroprotective pathway that ensures the elimination of damaged mitochondria via autophagy. We performed a genome-wide high content imaging miRNA screen for inhibitors of the PINK1-PRKN pathway and identified all three members of the miRNA family 29 (miR-29). Using RNAseq we identified target genes and found that siRNA against ATG9A phenocopied the effects of miR-29 and inhibited the initiation of PINK1-PRKN mitophagy. Furthermore, we discovered two rare, potentially deleterious, missense variants (p.R631W and p.S828L) in our EOPD cohort and tested them experimentally in cells. While expression of wild-type ATG9A was able to rescue the effects of miR-29a, the EOPD-associated variants behaved like loss-of-function mutations. Together, our study validates miR-29 and its target gene ATG9A as novel regulators of mitophagy initiation. It further serves as proof-of-concept of finding novel, potentially disease-causing EOPD-linked variants specifically in mitophagy regulating genes. The nomination of genetic variants and biological pathways is important for the stratification and treatment of patients that suffer from devastating diseases, such as EOPD.
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.17.576122
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