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Article ; Online: Trial Forge Guidance 4: a guideline for reporting the results of randomised Studies Within A Trial (SWATs).

Arundel, C E / Clark, L K / Parker, A / Beard, D / Coleman, E / Cooper, C / Devane, D / Eldridge, S / Galvin, S / Gillies, K / Hewitt, C E / Sutton, C / Torgerson, D J / Treweek, S

Trials

2024 Volume 25, Issue 1, Page(s) 183

Abstract: Background: Evidence to support decisions on trial processes is minimal. One way to generate this evidence is to use a Study Within A Trial (SWAT) to test trial processes or explore methodological uncertainties. SWAT evidence relies on replication to ... ...

Abstract	Background: Evidence to support decisions on trial processes is minimal. One way to generate this evidence is to use a Study Within A Trial (SWAT) to test trial processes or explore methodological uncertainties. SWAT evidence relies on replication to ensure sufficient power and broad applicability of findings. Prompt reporting is therefore essential; however, SWAT publications are often the first to be abandoned in the face of other time pressures. Reporting guidance for embedded methodology trials does exist but is not widely used. We sought therefore to build on these guidelines to develop a straightforward, concise reporting standard, which remains adherent to the CONSORT guideline. Methods: An iterative process was used to develop the guideline. This included initial meetings with key stakeholders, development of an initial guideline, pilot testing of draft guidelines, further iteration and pilot testing, and finalisation of the guideline. Results: We developed a reporting guideline applicable to randomised SWATs, including replications of previous evaluations. The guideline follows the Consolidated Standards for Reporting Trials (CONSORT) statement and provides example text to ensure ease and clarity of reporting across all domains. Conclusions: The SWAT reporting guideline will aid authors, reviewers, and journal editors to produce and review clear, structured reports of randomised SWATs, whilst also adhering to the CONSORT guideline. Trial registration: EQUATOR Network - Guidelines Under Development ( https://www.equator-network.org/library/reporting-guidelines-under-development/reporting-guidelines-under-development-for-clinical-trials/#SWAT ). Registered on 25 March 2021.
MeSH term(s)	Humans ; Randomized Controlled Trials as Topic ; Guidelines as Topic
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-024-08004-0
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Article ; Online: Somatic Genetic Reversion of a Duplication Event in IL2RG in Siblings.

Cruz, Patricia Dela / Rylaarsdam, Stacey / Torgerson, Troy R / Hagin, David / Allenspach, Eric J

Journal of clinical immunology

2023 Volume 43, Issue 8, Page(s) 1747–1750

MeSH term(s)	Humans ; Siblings ; Interleukin Receptor Common gamma Subunit
Chemical Substances	IL2RG protein, human ; Interleukin Receptor Common gamma Subunit
Language	English
Publishing date	2023-07-22
Publishing country	Netherlands
Document type	Letter
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-023-01557-w
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Article ; Online: Electronic cigarettes and public health awareness: a cross-sectional analysis of Google search inquiries.

Lester, Drew / Torgerson, Trevor / Eyabi, Jorgen / Wayant, Cole / Vassar, Matt

Health education research

2021 Volume 36, Issue 4, Page(s) 446–455

Abstract: The number of American adults who use electronic nicotine delivery systems (ENDS) increased by 3 million people in 2018, up 38.3% from 8.1 to 11.2 million. Search data for ENDS were analyzed against relevant traits including state longitude, tobacco tax ... ...

Abstract	The number of American adults who use electronic nicotine delivery systems (ENDS) increased by 3 million people in 2018, up 38.3% from 8.1 to 11.2 million. Search data for ENDS were analyzed against relevant traits including state longitude, tobacco tax rate and national tobacco program funding. Searches increased 88% (95% CI, 70-100) over the last 5 years and peaked on 8 September 2019, after the CDC issued a warning about the link between ENDS and high-profile lung damage cases. Searches aimed at buying ENDS subsequently dropped 25% (95% CI, 20.1-29.6), while health-related ENDS searches spiked to their all-time high, increasing 22% (95% CI, -6 to 55) compared with the first half of 2019. ENDS searches are now more concentrated than 5 years ago, reversing the trend of the early 2010s, likely because certain states have passed laws to curb the use of ENDS. The public prefers searching for 'vaping' over 'e-cigarette' in a phenomenon similar to 'high fructose corn syrup' versus 'sugar'. Consequently, public policy discussions and public education campaigns need to use 'vaping' terms, and more states should enact policies that are strongly associated with lower ENDS usage, many of which we identify.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems ; Humans ; Public Health ; Search Engine ; Tobacco Products ; United States ; Vaping
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632781-3
ISSN	1465-3648 ; 0268-1153
ISSN (online)	1465-3648
ISSN	0268-1153
DOI	10.1093/her/cyab015
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Zs.B 2896: Show issues

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Article ; Online: Ex vivo comparison of 3 Tesla magnetic resonance imaging and multidetector computed tomography arthrography to identify artificial soft tissue lesions in equine stifles.

Aßmann, Anton D / Ohlerth, Stefanie / Suárez Sánchez-Andráde, José / Torgerson, Paul R / Bischofberger, Andrea S

Veterinary surgery : VS

2022 Volume 51, Issue 4, Page(s) 648–657

Abstract: Objective: To determine the diagnostic performance of computed tomographic arthrography (CTA) and 3 Tesla magnetic resonance imaging (MRI) for detecting artificial meniscal, meniscotibial ligament (MTL) lesions and cruciate ligament (CL) lesions in ... ...

Abstract	Objective: To determine the diagnostic performance of computed tomographic arthrography (CTA) and 3 Tesla magnetic resonance imaging (MRI) for detecting artificial meniscal, meniscotibial ligament (MTL) lesions and cruciate ligament (CL) lesions in horses. Study design: Ex vivo controlled laboratory study. Animals: Nineteen stifles from adult horses. Methods: Stablike defects (n = 84) (16 mm long, 10 mm deep) were created in the menisci (n = 35), CLs (n = 24), and MTLs (n = 25) via arthroscopy prior to MRI and CTA (80 mL contrast at 85 mg/mL per joint). Two radiologists, unaware of the lesions, reached a consensus regarding the presence of lesions, based on 2 reviews of each study. Sensitivity and specificity of MRI and CTA were determined using arthroscopy as a reference and compared with McNemar's tests. Results: The sensitivity and specificity of MRI (41% and 86% respectively) and CTA (32% and 90% respectively) did not differ (P = .65). The sensitivity (MRI: 24%-50%; CTA:19%-40%) and specificity (MRI: 75%-92%; CTA 75%-100%) of imaging modalities did not differ when detecting lesions of the menisci, MTLs, and CLs (P = .1-1.0). The highest sensitivities were achieved when MTLs were evaluated with MRI (50%) and CLs with both modalities (40%). Conclusions: The diagnostic performance of CTA was comparable with that of MRI, with a low to moderate sensitivity and high specificity. Clinical significance: Computed tomographic arthrography should be considered as an adjunct to diagnose CL injuries. This is important for equine clinicians, as the CL cannot be visualized adequately using basic imaging techniques preoperatively.
MeSH term(s)	Animals ; Arthrography/methods ; Arthrography/veterinary ; Arthroscopy/veterinary ; Horse Diseases/diagnostic imaging ; Horses ; Joint Diseases/veterinary ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/veterinary ; Multidetector Computed Tomography ; Sensitivity and Specificity ; Stifle/diagnostic imaging
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491071-8
ISSN	1532-950X ; 0161-3499
ISSN (online)	1532-950X
ISSN	0161-3499
DOI	10.1111/vsu.13798
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Article ; Online: A rare presentation of a bilateral intracranial parameningeal embryonal rhabdomyosarcoma mimicking vestibular schwannoma in a two-year-old child: a case report.

Salloum, Nadia Liber / Sokol, Drahoslav / Kandasamy, Jothy / Torgerson, Antonia / Wallace, Hamish B / Kaliaperumal, Chandrasekaran

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2022 Volume 39, Issue 3, Page(s) 815–819

Abstract: Intracranial parameningeal rhabdomyosarcomas are rare, aggressive, rapidly progressive paediatric malignancies that carry a poor prognosis. The authors report a case of a 2-year-old boy who initially presented with a left facial palsy, ataxia and, ... ...

Abstract	Intracranial parameningeal rhabdomyosarcomas are rare, aggressive, rapidly progressive paediatric malignancies that carry a poor prognosis. The authors report a case of a 2-year-old boy who initially presented with a left facial palsy, ataxia and, shortly after, bloody otorrhoea. MRI imaging was initially suggestive of a vestibular schwannoma. However, there was rapid progression of symptoms and further MRI imaging showed very rapid increase in tumour size with mass effect and development of a similar tumour on the contralateral side. A histological diagnosis of bilateral parameningeal embryonal rhabdomyosarcoma was made. Despite treatment, progression led to hydrocephalus and diffuse leptomeningeal disease, from which the patient did not survive. Few intracranial parameningeal rhabdomyosarcomas have previously been reported and these report similar presenting symptoms and rapid disease progression. However, this is the first reported case of a bilateral intracranial parameningeal embryonal rhabdomyosarcoma which, on initial presentation and imaging, appeared to mimic a vestibular schwannoma.
MeSH term(s)	Male ; Humans ; Child ; Child, Preschool ; Rhabdomyosarcoma, Embryonal/diagnostic imaging ; Rhabdomyosarcoma, Embryonal/therapy ; Neuroma, Acoustic/diagnostic imaging ; Rhabdomyosarcoma/therapy ; Combined Modality Therapy ; Facial Paralysis
Language	English
Publishing date	2022-11-10
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-022-05735-w
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Zs.A 2036: Show issues

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Article ; Online: Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome.

Largent, Andrea D / Lambert, Katharina / Chiang, Kristy / Shumlak, Natali / Liggitt, Denny / Oukka, Mohammed / Torgerson, Troy R / Buckner, Jane H / Allenspach, Eric J / Rawlings, David J / Jackson, Shaun W

Science translational medicine

2023 Volume 15, Issue 703, Page(s) eade7028

Abstract: Heterozygous signal transducer and activator of transcription 1 ( ...

Abstract	Heterozygous signal transducer and activator of transcription 1 (
MeSH term(s)	Humans ; Child ; Mice ; Animals ; Autoimmunity/genetics ; Gain of Function Mutation ; Interferon-gamma/metabolism ; Syndrome ; Inflammation ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism
Chemical Substances	Interferon-gamma (82115-62-6) ; STAT1 Transcription Factor ; STAT1 protein, human
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.ade7028
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Zs.A 6941: Show issues

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Article ; Online: Surgical versus non-surgical management of lateral compression type-1 pelvic fracture in adults 60 years and older: the L1FE RCT.

Cook, Elizabeth / Laycock, Joanne / Sivapathasuntharam, Dhanupriya / Maturana, Camila / Hilton, Catherine / Doherty, Laura / Hewitt, Catherine / McDaid, Catriona / Torgerson, David / Bates, Peter

Health technology assessment (Winchester, England)

2024 Volume 28, Issue 15, Page(s) 1–67

Abstract: Background: Lateral compression type-1 pelvic fractures are a common fragility fracture in older adults. Patients who do not mobilise due to ongoing pain are at greater risk of immobility-related complications. Standard treatment in the United Kingdom ... ...

Abstract	Background: Lateral compression type-1 pelvic fractures are a common fragility fracture in older adults. Patients who do not mobilise due to ongoing pain are at greater risk of immobility-related complications. Standard treatment in the United Kingdom is provision of pain relief and early mobilisation, unlike fragility hip fractures, which are usually treated surgically based on evidence that early surgery is associated with better outcomes. Currently there is no evidence on whether patients with lateral compression type-1 fragility fractures would have a better recovery with surgery than non-surgical management. Objectives: To assess the clinical and cost effectiveness of surgical fixation with internal fixation device compared to non-surgical management of lateral compression type-1 fragility fractures in older adults. Design: Pragmatic, randomised controlled superiority trial, with 12-month internal pilot; target sample size was 600 participants. Participants were randomised between surgical and non-surgical management (1 : 1 allocation ratio). An economic evaluation was planned. Setting: UK Major Trauma Centres. Participants: Patients aged 60 years or older with a lateral compression type-1 pelvic fracture, arising from a low-energy fall and unable to mobilise independently to a distance of 3 m and back due to pelvic pain 72 hours after injury. Interventions: Internal fixation device surgical fixation and non-surgical management. Participants, surgeons and outcome assessors were not blinded to treatment allocation. Main outcome measures: Primary outcome - average patient health-related quality of life, over 6 months, assessed by the EuroQol-5 Dimensions, five-level version utility score. Secondary outcomes (over the 6 months following injury) - self-rated health, physical function, mental health, pain, delirium, displacement of pelvis, mortality, complications and adverse events, and resource use data for the economic evaluation. Results: The trial closed early, at the end of the internal pilot, due to low recruitment. The internal pilot was undertaken in two separate phases because of a pause in recruitment due to the coronavirus disease 2019 pandemic. The planned statistical and health economic analyses were not conducted. Outcome data were summarised descriptively. Eleven sites opened for recruitment for a combined total of 92 months. Three-hundred and sixteen patients were assessed for eligibility, of whom 43 were eligible (13.6%). The main reason for ineligibility was that the patient was able to mobilise independently to 3 m and back ( Conclusions: It was not feasible to recruit to this trial in the current context. Further research to understand the treatment and recovery pathways of this group of patients, along with their outcomes, would be needed prior to undertaking a future trial. Future work: Exploration of equipoise across different healthcare professional groups. Investigate longer-term patient outcomes. Trial registration: This trial is registered as ISRCTN16478561. Funding: This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 16/167/57) and is published in full in
MeSH term(s)	Humans ; Aged ; Quality of Life ; Pelvis ; Hip Fractures ; Pelvic Pain ; Pain Management
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2006765-3
ISSN	2046-4924 ; 1366-5278
ISSN (online)	2046-4924
ISSN	1366-5278
DOI	10.3310/LAPW3412
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Article ; Online: Efficacy and feasibility of the BREATHE asthma intervention with American Indian children: a randomized controlled trial.

O'Leary, Rae A / O'Leary, Marcia A / Torgerson, Dara G / Mettler, Raeann D / Enright, Kendra J / Best, Lyle G

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21220

Abstract: American Indian (AI) children experience significant disparities in asthma prevalence, severity, and burden of disease, yet few asthma education interventions are tested in this population. This study aimed to evaluate the efficacy and feasibility of the ...

Abstract	American Indian (AI) children experience significant disparities in asthma prevalence, severity, and burden of disease, yet few asthma education interventions are tested in this population. This study aimed to evaluate the efficacy and feasibility of the BREATHE intervention with parents and AI children, during a 3-year follow-up period (n = 108), using a randomized controlled design. Children with asthma identified by electronic medical records (EMR) were screened and matched with 2 controls. The intervention included an initial educational and 24 months of follow-up. The control group continued their usual care. The primary outcome was the frequency of EMR documented, emergency department (ED) visits or hospitalization for respiratory complaints. There was no statistical difference in mean primary outcomes (1.34 (1.98) vs 1.22 (1.95), - 0.88 to 0.63, 95% CI of the difference, p = 0.75), nor percent with any ED visit or hospitalization (29/53, 55% vs 30/55, 54%, p = 0.99) between the intervention or control groups respectively. After 365 days, there was a borderline significant difference in time to primary outcome. Although limited in power, the present study did not demonstrate a persistent effect of this intervention. We recommend that AI pediatric asthma interventions are culturally-designed, use feasible procedures, and repeat education at least every 12 months.
MeSH term(s)	Child ; Humans ; American Indian or Alaska Native ; Parents
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25447-0
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Article ; Online: Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial.

Kearney, Rebecca S / Ellard, David R / Parsons, Helen / Haque, Aminul / Mason, James / Nwankwo, Henry / Bradley, Helen / Drew, Stephen / Modi, Chetan / Bush, Howard / Torgerson, David / Underwood, Martin

BMJ (Clinical research ed.)

2024 Volume 384, Page(s) e076925

Abstract: Objective: To assess the effects of an additional programme of physiotherapy in adults with a first-time traumatic shoulder dislocation compared with single session of advice, supporting materials, and option to self-refer to physiotherapy.: Design: ... ...

Abstract	Objective: To assess the effects of an additional programme of physiotherapy in adults with a first-time traumatic shoulder dislocation compared with single session of advice, supporting materials, and option to self-refer to physiotherapy. Design: Pragmatic, multicentre, randomised controlled trial (ARTISAN). Setting and participants: Trauma research teams at 41 UK NHS Trust sites screened adults with a first time traumatic anterior shoulder dislocation confirmed radiologically, being managed non-operatively. People were excluded if they presented with both shoulders dislocated, had a neurovascular complication, or were considered for surgical management. Interventions: One session of advice, supporting materials, and option to self-refer to physiotherapy (n=240) was assessed against the same advice and supporting materials and an additional programme of physiotherapy (n=242). Analyses were on an intention-to-treat basis with secondary per protocol analyses. Main outcome measures: The primary outcome was the Oxford shoulder instability score (a single composite measure of shoulder function), measured six months after treatment allocation. Secondary outcomes included the QuickDASH, EQ-5D-5L, and complications. Results: 482 participants were recruited from 40 sites in the UK. 354 (73%) participants completed the primary outcome score (n=180 allocated to advice only, n=174 allocated to advice and physiotherapy). Participants were mostly male (66%), with a mean age of 45 years. No significant difference was noted between advice compared with advice and a programme of physiotherapy at six months for the primary intention-to-treat adjusted analysis (between group difference favouring physiotherapy 1.5 (95% confidence interval -0.3 to 3.5)) or at earlier three month and six week timepoints. Complication profiles were similar across the two groups (P>0.05). Conclusions: An additional programme of current physiotherapy is not superior to advice, supporting materials, and the option to self-refer to physiotherapy. Trial registration: Current Controlled Trials ISRCTN63184243.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Cost-Benefit Analysis ; Joint Instability ; Physical Therapy Modalities ; Quality of Life ; Shoulder Dislocation/etiology ; Shoulder Dislocation/therapy ; Shoulder Joint
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Pragmatic Clinical Trial ; Randomized Controlled Trial
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2023-076925
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Article ; Online: Public interest in Cannabis during election season: a Google Trends analysis.

Torgerson, Trevor / Roberts, Will / Lester, Drew / Khojasteh, Jam / Vassar, Matt

Journal of cannabis research

2020 Volume 2, Issue 1, Page(s) 31

Abstract: Introduction: Given that 72% of internet users seek out health information using an internet search engine (Google being the most popular); we sought to investigate the public internet search interest in cannabis as a health topic when cannabis ... ...

Abstract	Introduction: Given that 72% of internet users seek out health information using an internet search engine (Google being the most popular); we sought to investigate the public internet search interest in cannabis as a health topic when cannabis legislation appeared on state ballots and during presidential elections. Materials and methods: We searched Google Trends for "cannabis" as a health topic. Google Trends data were extracted during the time period of May 1, 2008 to May 1, 2019 for the United States (US) and select states (18) within the US including: Alaska, Arizona, Arkansas, California, Colorado, Florida, Maine, Massachusetts, Michigan, Missouri, Nevada, North Dakota, Ohio, Oregon, Oklahoma, South Dakota, Utah, and Washington when cannabis was on the ballot. These state elections were referenda, not legislative votes. We then compared the internet search interest for cannabis before and after each election. To evaluate whether any associations with changes in the volume of cannabis internet searches were specific to the cannabis topic, or also occurred with other topics of general interest during an election year, the authors ran additional analyses of previously popular debated policies during Presidential Elections that may act as control topics. These policies included Education, Gun Control, Climate Change, Global Warming, and Abortion. We used the autoregressive integrated moving average (ARIMA) algorithm to forecast expected relative internet search interests for the 2012 and 2016 Presidential Elections. Individual variables were compared using a linear regression analysis for the beta coefficients performed in Stata Version 15.1 (StataCorp). Results: Public internet search interest for "cannabis" increased during the voting month above the previous mean internet search interest for all 18 bills. For the US, observed internet search interest during each Presidential Election was 26.9% [95% CI, 18.4-35.4%] greater than expected in 2012 and 29.8% [95% CI, 20.8-38.8%] greater than expected in 2016. In 2016, significant state-level findings included an increase in relative internet search rates for cannabis in states with higher usage rates of cannabis in the past month (Coeff (95% CI), 3.4 (2.8-4.0)) and past month illicit drug use except cannabis rates (Coeff (95% CI), 17.4 (9.8-25.0)). Relative internet search rates for cannabis from 2008 to 2019 were also associated with increased cannabis usage in the past month (Coeff (95% CI), 3.1 (2.5-3.7)). States with higher access to legal cannabis were associated with higher relative internet search volumes for cannabis (Coeff (95% CI), 0.31 (0.15-0.46)). Of the five additional policies that were searched as topics, only two showed an increase in internet search interest during each Presidential Election. Climate Change increased by 3.5% [95% CI, - 13-20%] in 2012 and 20.1% [95% CI, 0-40%] in 2016 while Global Warming increased by 1.1% [95% CI, - 19-21%] in 2012 and 4.6% [95% CI, - 6-15%] in 2016. Conclusion: Based on these results, we expect public interest in cannabis will spike prior to the Presidential election in 2020. Of the five selected control policies, only two showed an increase in internet search interest during both Presidential Elections and neither exceeded the internet search increase of cannabis. These results may indicate the growing awareness of cannabis in the US and mark a possible target for the timely dissemination of evidence-based information regarding cannabis and its usage/side-effects during future elections. Consequently, the results of this study may be important to physicians since they will likely receive an increased volume of questions relating to cannabis and its therapeutic uses during election season from interested patients. We recommend establishing a cannabis repository of evidence-based information, providing physician education, and a dosing guide be created to enable physicians to provide high quality care around the issue of cannabis.
Language	English
Publishing date	2020-09-22
Publishing country	England
Document type	Journal Article
ISSN	2522-5782
ISSN (online)	2522-5782
DOI	10.1186/s42238-020-00039-9
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