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  1. Book: Current challenges in personalized cancer medicine

    Smalley, Keiran S. M.

    (Advances in pharmacology ; 65)

    2012  

    Author's details ed. by Keiran S. M. Smalley
    Series title Advances in pharmacology ; 65
    Collection
    Language English
    Size XVIII, 558 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017483573
    ISBN 978-0-12-397927-8 ; 0-12-397927-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uf I Zs 171 -65- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Too Much Fuel on the Fire? Linking Obesity, Metabolism, and Melanoma Outcomes.

    Smalley, Keiran S M

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 29, Issue 1, Page(s) 5–7

    Abstract: Patients with metastatic melanoma who are overweight or obese have improved outcomes when treated with immunotherapies or targeted therapies. A recent study provides the first evidence that the host metabolic state influences the tumor metabolic ... ...

    Abstract Patients with metastatic melanoma who are overweight or obese have improved outcomes when treated with immunotherapies or targeted therapies. A recent study provides the first evidence that the host metabolic state influences the tumor metabolic phenotype, with implications for tumor progression and therapeutic response. See related article by Hahn et al., p. 154.
    MeSH term(s) Humans ; Melanoma/therapy ; Melanoma/drug therapy ; Obesity/complications ; Overweight ; Neoplasms, Second Primary
    Language English
    Publishing date 2022-10-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-3028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Space Is the Place: Mapping the Cell-Cell Interactions That Predict Immunotherapy Responses in Melanoma.

    Smalley, Inna / Smalley, Keiran S M

    Cancer research

    2022  Volume 82, Issue 18, Page(s) 3198–3200

    Abstract: Although immune checkpoint inhibition (ICI) has revolutionized the treatment of advanced melanoma, reliable predictive biomarkers are still lacking. In this issue of Cancer Research, Antoranz and colleagues used RNA sequencing and multiplexed IHC to ... ...

    Abstract Although immune checkpoint inhibition (ICI) has revolutionized the treatment of advanced melanoma, reliable predictive biomarkers are still lacking. In this issue of Cancer Research, Antoranz and colleagues used RNA sequencing and multiplexed IHC to study the spatial immune landscape of pretreatment melanoma specimens from patients who either responded or did not respond to antiprogrammed death protein 1 (PD-1) therapy. The authors identified the spatial interaction between cytotoxic T cells and M1-like macrophages expressing PD-L1 at the tumor boundary as predictive of responses to immune checkpoint inhibition. These studies pave the way for the development of new spatial biomarkers to identify patients most likely to benefit from ICI therapy. See related article by Antoranz et al., p. 3275.
    MeSH term(s) B7-H1 Antigen ; Cell Communication ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunologic Factors ; Immunotherapy ; Melanoma/drug therapy ; Melanoma/genetics ; Neoplasms, Second Primary ; Programmed Cell Death 1 Receptor
    Chemical Substances B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Immunologic Factors ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-2192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Targeting

    Phadke, Manali S / Smalley, Keiran S M

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 14, Page(s) 2661–2664

    MeSH term(s) Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Mutation ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Membrane Proteins/genetics ; GTP Phosphohydrolases/genetics
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; NRAS protein, human (EC 3.6.1.-) ; Membrane Proteins ; GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  5. Article ; Online: Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease.

    Law, Vincent / Smalley, Inna / Evernden, Brittany R / Baldwin, Margaret / Smalley, Keiran S M / Forsyth, Peter A

    Journal of visualized experiments : JoVE

    2024  , Issue 205

    Abstract: Melanoma-associated leptomeningeal disease (M-LMD) occurs when circulating tumor cells (CTCs) enter ... Once established, the prognosis for M-LMD patients is dismal, with overall survival ranging from weeks to months ... the availability of effective treatment options. Defining the underlying biology of M-LMD will significantly ...

    Abstract Melanoma-associated leptomeningeal disease (M-LMD) occurs when circulating tumor cells (CTCs) enter into the cerebral spinal fluid (CSF) and colonize the meninges, the membrane layers that protect the brain and the spinal cord. Once established, the prognosis for M-LMD patients is dismal, with overall survival ranging from weeks to months. This is primarily due to a paucity in our understanding of the disease and, as a consequence, the availability of effective treatment options. Defining the underlying biology of M-LMD will significantly improve the ability to adapt available therapies for M-LMD treatment or design novel inhibitors for this universally fatal disease. A major barrier, however, lies in obtaining sufficient quantities of CTCs from the patient-derived CSF (CSF-CTCs) to conduct preclinical experiments, such as molecular characterization, functional analysis, and in vivo efficacy studies. Culturing CSF-CTCs ex vivo has also proven to be challenging. To address this, a novel protocol for the culture of patient-derived M-LMD CSF-CTCs ex vivo and in vivo is developed. The incorporation of conditioned media produced by human meningeal cells (HMCs) is found to be critical to the procedure. Cytokine array analysis reveals that factors produced by HMCs, such as insulin-like growth factor-binding proteins (IGFBPs) and vascular endothelial growth factor-A (VEGF-A), are important in supporting CSF-CTC survival ex vivo. Here, the usefulness of the isolated patient-derived CSF-CTC lines is demonstrated in determining the efficacy of inhibitors that target the insulin-like growth factor (IGF) and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, the ability to intrathecally inoculate these cells in vivo to establish murine models of M-LMD that can be employed for preclinical testing of approved or novel therapies is shown. These tools can help unravel the underlying biology driving CSF-CTC establishment in the meninges and identify novel therapies to reduce the morbidity and mortality associated with M-LMD.
    MeSH term(s) Humans ; Animals ; Mice ; Neoplastic Cells, Circulating ; Vascular Endothelial Growth Factor A ; Melanoma ; Brain ; Cell Membrane
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/66071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Two Worlds Collide: Unraveling the Role of the Immune System in BRAF-MEK Inhibitor Responses.

    Smalley, Keiran S M

    Cancer discovery

    2020  Volume 10, Issue 2, Page(s) 176–178

    Abstract: Although BRAF-MEK inhibition can enhance the immune recognition of melanoma cells, the mechanisms that underlie this remain poorly defined. In this issue ... ...

    Abstract Although BRAF-MEK inhibition can enhance the immune recognition of melanoma cells, the mechanisms that underlie this remain poorly defined. In this issue of
    MeSH term(s) Humans ; Melanoma ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins B-raf ; Pyroptosis ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances Protein Kinase Inhibitors ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-19-1441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Pharmacological research and cancer: A call to arms.

    Smalley, Keiran S M

    Pharmacological research

    2019  Volume 146, Page(s) 104291

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Humans ; Immunotherapy/methods ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/therapy ; Pharmacology/methods ; Research
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-05-31
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2019.104291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Increased immunity and BRAF inhibition: Yet another argument for combination therapy?

    Smalley, Keiran S M

    Pharmacological research

    2016  Volume 113, Issue Pt A, Page(s) 719–720

    Language English
    Publishing date 2016-11
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2016.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: In Vivo Acute Toxicity Studies of Novel Anti-Melanoma Compounds Downregulators of hnRNPH1/H2.

    Velayutham, Sadeeshkumar / Seal, Trisha / Danthurthy, Samaya / Zaias, Julia / Smalley, Keiran S M / Minond, Dmitriy

    Biomolecules

    2023  Volume 13, Issue 2

    Abstract: Despite the recent advances in melanoma therapy, the need for new targets and novel approaches to therapy is urgent. We previously reported melanoma actives that work via binding and downregulating spliceosomal proteins hnRNPH1 and H2. Given the lack of ... ...

    Abstract Despite the recent advances in melanoma therapy, the need for new targets and novel approaches to therapy is urgent. We previously reported melanoma actives that work via binding and downregulating spliceosomal proteins hnRNPH1 and H2. Given the lack of knowledge about the side effects of using spliceosomal binders in humans, an acute toxicity study was conducted to evaluate these compounds in mice. Male and female mice were treated with compounds 2155-14 and 2155-18 at 50 mg/kg/day via subcutaneous injections, and the clinical signs of distress were monitored for 21 days and compared with control mice. Additionally, the effect of the leads on blood chemistry, blood cell counts, and organs was evaluated. No significant changes were observed in the body weight, blood cell count, blood chemistry, or organs of the mice following the compound treatment. The results show that our compounds, 2155-14 and 2155-18, are not toxic for the study period of three weeks.
    MeSH term(s) Humans ; Mice ; Male ; Female ; Animals ; Melanoma
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13020349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acral melanoma: new insights into the immune and genomic landscape.

    Carvalho, Larissa Anastacio DaCosta / Aguiar, Flavia C / Smalley, Keiran S M / Possik, Patricia A

    Neoplasia (New York, N.Y.)

    2023  Volume 46, Page(s) 100947

    Abstract: Acral melanoma is a rare subtype of melanoma that arises on the non-hair bearing skin of the nail bed, palms of the hand and soles of the feet. It is unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from the sun, and, as ...

    Abstract Acral melanoma is a rare subtype of melanoma that arises on the non-hair bearing skin of the nail bed, palms of the hand and soles of the feet. It is unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from the sun, and, as such, its incidence is similar across populations who are of Asian, Hispanic, African and European origin. Although research into acral melanoma has lagged behind that of sun-exposed cutaneous melanoma, recent studies have begun to address the unique genetics and immune features of acral melanoma. In this review we will discuss the latest progress in understanding the biology of acral melanoma across different ethnic populations and will outline how these new discoveries can help to guide the therapeutic management of this rare tumor.
    MeSH term(s) Humans ; Melanoma/genetics ; Melanoma/drug therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/drug therapy ; Ultraviolet Rays/adverse effects ; Genomics ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483840-0
    ISSN 1476-5586 ; 1522-8002
    ISSN (online) 1476-5586
    ISSN 1522-8002
    DOI 10.1016/j.neo.2023.100947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5203: Show issues Location:
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