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  1. Article ; Online: The Noble Addendum of a Phosphenium Ligand to a Base Metal: Coordination, Activation, and Hydrogenation of Alkenes and Alkynes on a Chromium Complex.

    Birchall, Nicholas / Nieger, Martin / Gudat, Dietrich

    ChemPlusChem

    2024  , Page(s) e202400144

    Abstract: The synthesis of a new bis-NHP complex (NHP=N-heterocyclic phosphenium) of chromium via salt metathesis and studies of its reactivity are reported. Photochemical reactions with ... ...

    Abstract The synthesis of a new bis-NHP complex (NHP=N-heterocyclic phosphenium) of chromium via salt metathesis and studies of its reactivity are reported. Photochemical reactions with H
    Language English
    Publishing date 2024-03-22
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202400144
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  2. Article: Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?

    Kuemper, Sandra / Cairns, Andrew G / Birchall, Kristian / Yao, Zhi / Large, Jonathan M

    Frontiers in molecular neuroscience

    2024  Volume 17, Page(s) 1370509

    Abstract: Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of ... ...

    Abstract Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of certain blood cancers. Many current approaches are focused on oncology targets, leaving numerous potential applications underexplored. Targeting proteins for degradation offers a novel therapeutic route for targets whose inhibition remains challenging, such as protein aggregates in neurodegenerative diseases. This mini review focuses on the prospect of utilizing TPD for neurodegenerative disease targets, particularly PROTAC and molecular glue formats and opportunities for novel CNS E3 ligases. Some key challenges of utilizing such modalities including molecular design of degrader molecules, drug delivery and blood brain barrier penetrance will be discussed.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2024.1370509
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  3. Article ; Online: Laryngological presentations and patient-reported outcome measures in Ehlers-Danlos syndrome.

    Lam, C M / Wood, G / Birchall, M A

    The Journal of laryngology and otology

    2021  Volume 136, Issue 10, Page(s) 947–951

    Abstract: Objective: This study aimed to characterise the laryngological presentations of Ehlers-Danlos syndrome and conduct a preliminary exploration of patient-reported outcome measures.: Methods: This paper describes a retrospective case series of patients ... ...

    Abstract Objective: This study aimed to characterise the laryngological presentations of Ehlers-Danlos syndrome and conduct a preliminary exploration of patient-reported outcome measures.
    Methods: This paper describes a retrospective case series of patients with Ehlers-Danlos syndrome seen by the senior author between 2005 and 2019. A literature review was conducted to summarise the existing findings.
    Results: Twenty-one patients met the inclusion criteria. All reported symptoms were grouped; this showed that swallowing, voice and hyolaryngeal skeletal complex problems were commonest. Patient-reported outcome measures were available for eight patients, which showed large variations in: the Reflux Severity Index (median = 25.5; range = 0-33), Eating Assessment Tool score (median = 21.5; range = 0-35) and Voice Handicap Index (median = 21.5; range = 0-104). Twelve studies met our literature review inclusion criteria, involving at least 91 patients with laryngological presentations of Ehlers-Danlos syndrome.
    Conclusion: Ehlers-Danlos syndrome patients experience musculoskeletal issues, which in the throat manifest as hyolaryngeal skeletal complex problems. Future studies with larger patient numbers are required to validate laryngological patient-reported outcome measure tools in Ehlers-Danlos syndrome.
    MeSH term(s) Ehlers-Danlos Syndrome/complications ; Ehlers-Danlos Syndrome/diagnosis ; Humans ; Patient Reported Outcome Measures ; Retrospective Studies
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215121004072
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  4. Article: Ear, nose and throat (ENT) manifestations and complications of reflux.

    Brar, Sabrina / Watters, Carolina / Watson, Natalie / Birchall, Martin / Karagama, Yakubu

    Frontline gastroenterology

    2022  Volume 13, Issue e1, Page(s) e57–e64

    Abstract: Laryngopharyngeal reflux disease describes the backflow of acidic stomach content towards the larynx and is associated with symptoms such as cough, throat clearing and globus. It is a common presentation in primary care and the sequelae of symptoms that ... ...

    Abstract Laryngopharyngeal reflux disease describes the backflow of acidic stomach content towards the larynx and is associated with symptoms such as cough, throat clearing and globus. It is a common presentation in primary care and the sequelae of symptoms that arise from the disease often present in ear, nose and throat clinics. Assessment and examination of patients presenting with reflux symptoms includes questionnaires, as well as direct visualisation of the pharynx and larynx, and takes a multidisciplinary team approach. Treatment options include lifestyle modification, medical therapy and in some specialist centres, surgical management to address the multitude of symptoms associated with the disease.
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2022-102184
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    Zs.A 6880: Show issues Location:
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  5. Article ; Online: Recent advances in human respiratory epithelium models for drug discovery.

    Yaqub, Naheem / Wayne, Gareth / Birchall, Martin / Song, Wenhui

    Biotechnology advances

    2021  Volume 54, Page(s) 107832

    Abstract: The respiratory epithelium is intimately associated with the pathophysiologies of highly infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary disorder, presently the third leading cause of death worldwide with a ... ...

    Abstract The respiratory epithelium is intimately associated with the pathophysiologies of highly infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary disorder, presently the third leading cause of death worldwide with a projected economic burden of £1.7 trillion by 2030. Preclinical studies of respiratory physiology have almost exclusively utilised non-humanised animal models, alongside reductionistic cell line-based models, and primary epithelial cell models cultured at an air-liquid interface (ALI). Despite their utility, these model systems have been limited by their poor correlation to the human condition. This has undermined the ability to identify novel therapeutics, evidenced by a 15% chance of success for medicinal respiratory compounds entering clinical trials in 2018. Consequently, preclinical studies require new translational efficacy models to address the problem of respiratory drug attrition. This review describes the utility of the current in vivo (rodent), ex vivo (isolated perfused lungs and precision cut lung slices), two-dimensional in vitro cell-line (A549, BEAS-2B, Calu-3) and three-dimensional in vitro ALI (gold-standard and co-culture) and organoid respiratory epithelium models. The limitations to the application of these model systems in drug discovery research are discussed, in addition to perspectives of the future innovations required to facilitate the next generation of human-relevant respiratory models.
    MeSH term(s) Animals ; Cell Line ; Drug Discovery ; Epithelial Cells ; Humans ; Lung ; Respiratory Mucosa
    Language English
    Publishing date 2021-09-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 47165-3
    ISSN 1873-1899 ; 0734-9750
    ISSN (online) 1873-1899
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2021.107832
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    Zs.A 3730: Show issues Location:
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  6. Article: Self-reported throat symptoms in Ehlers-Danlos syndromes and hypermobility spectrum disorders: A cross-sectional survey study.

    Williams, Hannah R / Wood, Gary / Hakim, Alan J / Birchall, Martin / Hirani, Shashivadan P

    Laryngoscope investigative otolaryngology

    2023  Volume 8, Issue 5, Page(s) 1259–1264

    Abstract: Objectives: This study identified the frequency and severity of dysphagia, dysphonia, and laryngopharyngeal reflux symptoms in people with Ehlers-Danlos syndromes (EDS) or hypermobility spectrum disorders (HSD) and explored differences between ... ...

    Abstract Objectives: This study identified the frequency and severity of dysphagia, dysphonia, and laryngopharyngeal reflux symptoms in people with Ehlers-Danlos syndromes (EDS) or hypermobility spectrum disorders (HSD) and explored differences between diagnostic groups.
    Methods: Participants were recruited via non-probability convenience sampling. Information was gathered via online survey, including the Reflux Symptom Index (RSI; Belafsky et al.,
    Results: There were 1620 participants (96.6% female, 2.8% male) that met the inclusion criteria. The mean age was 38.09 (SD 12.22). 75.51% had hypermobile EDS (hEDS), 17.83% had HSD and 3.33% had classic EDS (cED). The cohort's mean scores were RSI = 22.95 (SD 9.01), EAT-10 = 11.91 (SD 9.66), and VHI score = 31.99 (SD 24.36). The hEDS group had significantly higher mean scores than the HSD group on RSI score and on some RSI items, on EAT-10 score and on all EAT-10 items, and on one VHI item.
    Conclusion: People with EDS/HSD experience symptoms of acid reflux, dysphagia, and dysphonia to varying degrees with significant differences between hEDS than HSD. Awareness of the impact of EDS/HSD on throat symptoms will enable health care professionals to anticipate throat symptoms more readily in this population, providing individualized and effective management plans.
    Level of evidence: IV.
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.1120
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  7. Article ; Online: Barriers to research progress for perioperative care practitioners working in cardiothoracic surgery.

    Britton, Carolina Relvas / Rathinam, Sridhar / Birchall, Martin / Iles-Smith, Heather / Krishnamoorthy, Bhuvaneswari

    Journal of perioperative practice

    2023  Volume 34, Issue 5, Page(s) 146–153

    Abstract: Policy and research literature worldwide support the need to build research capacity and capability among non-medical practitioners within healthcare systems. However, there exists a paucity of evidence on whether practitioners in cardiothoracic surgery ... ...

    Abstract Policy and research literature worldwide support the need to build research capacity and capability among non-medical practitioners within healthcare systems. However, there exists a paucity of evidence on whether practitioners in cardiothoracic surgery are attuned to this and on what barriers or enablers exist. A survey was carried out with non-medical practitioners working in cardiothoracic surgery in the United Kingdom to explore attitudes towards health research and audit, and to identify current challenges and barriers to surgical research and audit as perceived by cardiothoracic nurses and allied health professionals. A total of 160 completed questionnaires were returned. 99% of respondents supported the need for research and believed that evidence-based surgical care improves outcomes for patients. Seventy-two percent reported that their employer motivates them to take part in national research or audit but, only 22% were allocated time to do so within their role; 96% reported their interest in being involved in research and audit, yet only 30% believed they had the skills to undertake research, and 96% reported needing additional training. More work is needed to increase awareness, capacity and capability among cardiothoracic surgery care practitioners, and indeed other specialities to achieve research progress.
    MeSH term(s) Humans ; United Kingdom ; Surveys and Questionnaires ; Perioperative Care ; Female ; Attitude of Health Personnel ; Male ; Thoracic Surgical Procedures ; Adult ; Thoracic Surgery ; Middle Aged ; Cardiac Surgical Procedures
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2226186-2
    ISSN 2515-7949 ; 1750-4589
    ISSN (online) 2515-7949
    ISSN 1750-4589
    DOI 10.1177/17504589231176388
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    Zs.A 4006: Show issues Location:
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    Zs.MG 83: Show issues

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  8. Article ; Online: A PH-functionalized dicationic bis(imidazolio)diphosphine.

    Cicač-Hudi, Mario / Feil, Christoph M / Birchall, Nicholas / Nieger, Martin / Gudat, Dietrich

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 3, Page(s) 998–1007

    Abstract: Reaction of the iodide salt of a secondary imidazolio-iodophosphine [(L)PHI]I ( ... ...

    Abstract Reaction of the iodide salt of a secondary imidazolio-iodophosphine [(L)PHI]I (L
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d1dt03978d
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  9. Article ; Online: Annellated 1,3,4,2-Triazaphospholenes-Simple Modular Synthesis and a First Exploration of Ligand Properties.

    Richter, Ferdinand / Birchall, Nicholas / Feil, Christoph M / Nieger, Martin / Gudat, Dietrich

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 15

    Abstract: The successful use of 1,3,4,2-triazaphospholenes (TAPs) as organo-catalysts stresses the need for efficient synthetic routes to these molecules. In this study, we establish the [1 + 4]-cycloaddition of ... ...

    Abstract The successful use of 1,3,4,2-triazaphospholenes (TAPs) as organo-catalysts stresses the need for efficient synthetic routes to these molecules. In this study, we establish the [1 + 4]-cycloaddition of PBr
    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27154747
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  10. Article ; Online: Instrumental swallowing assessment in adults in residential aged care homes: Practice patterns and opportunities.

    Birchall, Olga / Bennett, Michelle / Lawson, Nadine / Cotton, Susan M / Vogel, Adam P

    Australasian journal on ageing

    2022  Volume 42, Issue 1, Page(s) 108–117

    Abstract: Objective: To describe practice patterns in the use of instrumental swallowing assessment (ISA) for older adults in residential aged care homes (RACHs).: Methods: A retrospective audit of medical records of residents living in RACHs in Melbourne, ... ...

    Abstract Objective: To describe practice patterns in the use of instrumental swallowing assessment (ISA) for older adults in residential aged care homes (RACHs).
    Methods: A retrospective audit of medical records of residents living in RACHs in Melbourne, Australia to extract data on speech-language pathologist (SLP) involvement, indications for ISA and ISA practice patterns.
    Results: Medical files of 323 residents across four Melbourne facilities were reviewed. 36% (n = 115) of residents were referred to SLP for swallowing assessment. Referral to SLP was related to length of stay (U = 7393.00, p < 0.001), dementia status (χ
    Conclusions: Instrumental swallowing assessment is not being used for the management of swallowing in RACHs in Australia despite a clinical need for ISA and a potential role for ISA to improve swallowing care quality. Lack of timely ISA may fail to meet the complex health-care needs of older adults living with dysphagia in RACHs, increasing their vulnerability to complications of dysphagia and its management.
    MeSH term(s) Humans ; Aged ; Deglutition Disorders/diagnosis ; Deglutition Disorders/therapy ; Deglutition ; Retrospective Studies ; Nursing Homes ; Referral and Consultation
    Language English
    Publishing date 2022-08-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1457406-8
    ISSN 1741-6612 ; 0726-4240 ; 1440-6381
    ISSN (online) 1741-6612
    ISSN 0726-4240 ; 1440-6381
    DOI 10.1111/ajag.13122
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