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  1. Article ; Online: A lifetime of mental health treatments for people with schizophrenia: update and narrative review.

    DeLisi, Lynn E

    Current opinion in psychiatry

    2024  Volume 37, Issue 3, Page(s) 140–146

    Abstract: Purpose of review: To provide a summary of the most up-to-date thoughts about treatment for schizophrenia at different stages of illness.: Recent findings: The use of Coordinated Specialty Care clinics has arisen as the standard for early on in the ... ...

    Abstract Purpose of review: To provide a summary of the most up-to-date thoughts about treatment for schizophrenia at different stages of illness.
    Recent findings: The use of Coordinated Specialty Care clinics has arisen as the standard for early on in the treatment of psychosis, providing the notion that recovery is possible. New medications that do not depend on postsynaptic dopamine receptor blockade are soon becoming available.
    Summary: A focus should be made by clinicians to personalize treatment plans for each patient who has the possibility of being diagnosed with a primary psychosis and the plan should be to predict outcomes based on biological markers that include genetic vulnerability, early psychosocial combined with pharmacological treatments as needed and then a plan to determine or maintain treatments going forward into the future. It is important to individualize treatment by stage of illness, as well as characteristics of the individual patient. Research is ongoing to advance knowledge for interventions at each stage from the premorbid period through to chronicity.
    MeSH term(s) Humans ; Schizophrenia/drug therapy ; Mental Health ; Psychotic Disorders/psychology ; Psychotherapy
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645162-7
    ISSN 1473-6578 ; 0951-7367
    ISSN (online) 1473-6578
    ISSN 0951-7367
    DOI 10.1097/YCO.0000000000000926
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  2. Article ; Online: Valuing an older generation of researchers and psychiatrists.

    DeLisi, Lynn E

    Psychiatry research

    2022  Volume 317, Page(s) 114858

    MeSH term(s) Humans ; Psychiatry ; Research Personnel
    Language English
    Publishing date 2022-09-24
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2022.114858
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  3. Article ; Online: Commentary on whether progressive brain change underlies the pathology of schizophrenia: Should this even be debated?

    DeLisi, Lynn E

    Schizophrenia research

    2022  Volume 244, Page(s) 18–20

    MeSH term(s) Brain/pathology ; Head ; Humans ; Marijuana Abuse ; Schizophrenia/pathology
    Language English
    Publishing date 2022-05-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2022.05.002
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  4. Book ; Online ; E-Book: Neuroimaging of Schizophrenia and other primary psychotic disorders

    Galderisi, Silvana / Delisi, Lynn E. / Borgwardt, Stefan

    achievements and perspectives

    2019  

    Author's details Silvana Galderisi, Lynn E. DeLisi, Stefan Borgwardt editors
    Keywords Psychiatry ; Neurosciences ; Psychology, clinical ; Radiology, Medical
    Language English
    Size 1 Online-Ressource (x, 345 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019967689
    ISBN 978-3-319-97307-4 ; 9783319973067 ; 3-319-97307-X ; 3319973061
    DOI 10.1007/978-3-319-97307-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Editorial: Where have all the reviewers gone?: Is the peer review concept in crisis?

    DeLisi, Lynn E

    Psychiatry research

    2022  Volume 310, Page(s) 114454

    Abstract: Publishing science and scholarly work has long required review by colleagues before appearing in print. Peer review is one of the most important and basic tools for science worth communicating. Currently it seems to be in a crisis, and as a journal ... ...

    Abstract Publishing science and scholarly work has long required review by colleagues before appearing in print. Peer review is one of the most important and basic tools for science worth communicating. Currently it seems to be in a crisis, and as a journal editor, I question why, and call for re-allocating time for this important function in academia.
    MeSH term(s) Humans ; Peer Review ; Publishing
    Language English
    Publishing date 2022-02-17
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2022.114454
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  6. Article ; Online: Brain plasticity, language anomalies, genetic risk and the patient with schizophrenia: Trajectory of change over a lifetime. A commentary.

    DeLisi, Lynn E

    Psychiatry research

    2022  Volume 320, Page(s) 115034

    Abstract: Research on schizophrenia has been pursued for over a century. While the ability to view the brain and also the entire human genome advanced dramatically during this time and particularly in recent years, it is still unclear whether these advances helped ...

    Abstract Research on schizophrenia has been pursued for over a century. While the ability to view the brain and also the entire human genome advanced dramatically during this time and particularly in recent years, it is still unclear whether these advances helped to understand the nature of schizophrenia. What appears, however, to be the case is that early detection and treatment of people who are at high risk for developing schizophrenia due to various clinical signs, lead to better outcomes and recovery in many cases. Medications have also dramatically improved and have not been associated with the side-effects of earlier treatments, although they still are not without new sets of adverse effects. Over the years it was shown that structural brain abnormalities were present in the brains of people with chronic schizophrenia and that these observations were present early in the onset of illness. It was then shown these were not static and changed over the years of illness. At the same time it was shown that the brain centers for perceiving and speaking language appeared particularly abnormal in patients with schizophrenia and that these abnormalities could underlie the misperceptions and experiences of auditory hallucinations so characteristic of this illness. In a separate set of investigations that began with family, then twin and adoption studies, it was shown that schizophrenia is inherited, but in a complex manner. At present many genetic studies now find that genes, whose variants can lead to a high risk for schizophrenia, are ones specifically involving brain development and functioning. At present, although still speculative, it can be concluded that the progressive changes in brain structure, particularly related to language processing, take place in genetically vulnerable people and put them ultimately at high risk for developing schizophrenia in a trajectory for a lifelong illness. It is hoped that in the future these brain changes can be prevented by intervening early on the processes of brain growth and plasticity, thus arresting the illness before it begins.
    MeSH term(s) Humans ; Schizophrenia/genetics ; Schizophrenia/diagnosis ; Brain/diagnostic imaging ; Hallucinations/diagnosis ; Language ; Neuronal Plasticity
    Language English
    Publishing date 2022-12-31
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2022.115034
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  7. Article: Historical pursuits of the language pathway hypothesis of schizophrenia.

    DeLisi, Lynn E

    NPJ schizophrenia

    2021  Volume 7, Issue 1, Page(s) 53

    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2813844-2
    ISSN 2334-265X
    ISSN 2334-265X
    DOI 10.1038/s41537-021-00182-z
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  8. Article ; Online: Redefining schizophrenia through genetics: A commentary on 50 years searching for biological causes.

    DeLisi, Lynn E

    Schizophrenia research

    2021  Volume 242, Page(s) 22–24

    MeSH term(s) Humans ; Schizophrenia/genetics
    Language English
    Publishing date 2021-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2021.11.017
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  9. Article ; Online: Editorial: The association of gender dysphoria with psychosis.

    Thoman, Jason M / DeLisi, Lynn E

    Current opinion in psychiatry

    2023  Volume 36, Issue 3, Page(s) 147–149

    MeSH term(s) Humans ; Gender Dysphoria/complications ; Psychotic Disorders/complications
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645162-7
    ISSN 1473-6578 ; 0951-7367
    ISSN (online) 1473-6578
    ISSN 0951-7367
    DOI 10.1097/YCO.0000000000000863
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  10. Article ; Online: Has the glass ceiling for women in academic psychiatry been removed and replaced? A commentary from the personal experiences of a senior academic woman during the course of a 42 year career.

    DeLisi, Lynn E

    Psychiatry research

    2021  Volume 306, Page(s) 114278

    Abstract: Women have historically faced many barriers to professional achievement that have not been suffered by most men; and those women who chose psychiatry as a profession are not exceptions, despite psychiatry having a reputation for attracting more women ... ...

    Abstract Women have historically faced many barriers to professional achievement that have not been suffered by most men; and those women who chose psychiatry as a profession are not exceptions, despite psychiatry having a reputation for attracting more women members than many of the other fields of medicine. While a couple of generations ago, blatant discrimination against women was accepted, whether it was because men were thought to traditionally be the family bread winners and women in charge of household stability, or because their appearances and personalities generated a stereotype of what a leader is meant not to "look like". However, more recently, women have been raising awareness that these views can no longer be tolerated and are calling for change that requires equal opportunities for leadership roles and academic success. The ways in which change can occur include: developing mentorship programs, requiring all faculty, particularly anyone in a leadership role, to be trained in ways in which implicit bias occurs and how to remedy it, providing networking opportunities, and practicing transparent non-biased hiring practices. These will reduce not only the male/ female gap in academic success, but similarly that which exists between racial, ethnic and gender minorities and those who are not thought of as such.
    MeSH term(s) Achievement ; Faculty, Medical ; Female ; Humans ; Leadership ; Male ; Mentors ; Psychiatry
    Language English
    Publishing date 2021-11-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2021.114278
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