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  1. Article ; Online: A Need for Understanding Clinically Meaningful Differences in Endotypes Derived From Polysomnography.

    Keenan, Brendan T / Magalang, Ulysses J / Schwab, Richard J

    Chest

    2023  Volume 164, Issue 5, Page(s) e160–e161

    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.05.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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  2. Article ; Online: Night-to-night reliability and agreement of physiological endotypes: two steps forward, one step back.

    Keenan, Brendan T / Magalang, Ulysses J / Schwab, Richard J

    Sleep

    2023  Volume 46, Issue 8

    MeSH term(s) Humans ; Aged ; Polysomnography ; Reproducibility of Results ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad116
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    Zs.A 1475: Show issues Location:
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  3. Article: In vivo

    van Hal, Vera H J / de Hoop, Hein / van Sambeek, Marc R H M / Schwab, Hans-Martin / Lopata, Richard G P

    Frontiers in physiology

    2024  Volume 15, Page(s) 1320456

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1320456
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  4. Article ; Online: State-Dependent Biomechanical Behavior of Oropharyngeal Structures in Apneics and Controls: A Proof-of-Concept Study.

    Schwab, Richard J / Lin, Theodore C / Wiemken, Andrew / Dedhia, Raj C / Wehrli, Felix W / Keenan, Brendan T

    Annals of the American Thoracic Society

    2024  

    Abstract: Rationale: ...

    Abstract Rationale:
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202309-847OC
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    Zs.A 5828: Show issues Location:
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  5. Article ; Online: Using the Remote Monitoring Framework to Promote Adherence to Continuous Positive Airway Pressure.

    Keenan, Brendan T / Schwab, Richard J

    Sleep medicine clinics

    2020  Volume 16, Issue 1, Page(s) 85–99

    Abstract: The ability to remotely monitor positive airway pressure therapy adherence and efficacy provides a unique opportunity for the field of sleep medicine to quickly and efficiently improve patient adherence. Smaller randomized studies and larger-scale ... ...

    Abstract The ability to remotely monitor positive airway pressure therapy adherence and efficacy provides a unique opportunity for the field of sleep medicine to quickly and efficiently improve patient adherence. Smaller randomized studies and larger-scale retrospective evaluations show that telemedicine interventions leveraging these data can increase average usage and efficiency of care. However, more evidence on the impact of these programs on longer-term adherence and improving patient-reported outcomes is needed. Combining data from remote monitoring with clinical information in electronic health records may prove to be invaluable to the future of clinical sleep medicine practice and research.
    MeSH term(s) Continuous Positive Airway Pressure ; Humans ; Patient Compliance/statistics & numerical data ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Sleep Apnea, Obstructive/therapy ; Telemedicine
    Language English
    Publishing date 2020-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1556-4088
    ISSN (online) 1556-4088
    DOI 10.1016/j.jsmc.2020.11.001
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  6. Article ; Online: Sleep-stage-dependent alterations in cerebral oxygen metabolism quantified by magnetic resonance.

    Xu, Jing / Wiemken, Andrew / Langham, Michael C / Rao, Hengyi / Nabbout, Marianne / Caporale, Alessandra S / Schwab, Richard J / Detre, John A / Wehrli, Felix W

    Journal of neuroscience research

    2024  Volume 102, Issue 3, Page(s) e25313

    Abstract: A key function of sleep is to provide a regular period of reduced brain metabolism, which is critical for maintenance of healthy brain function. The purpose of this work was to quantify the sleep-stage-dependent changes in brain energetics in terms of ... ...

    Abstract A key function of sleep is to provide a regular period of reduced brain metabolism, which is critical for maintenance of healthy brain function. The purpose of this work was to quantify the sleep-stage-dependent changes in brain energetics in terms of cerebral metabolic rate of oxygen (CMRO
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Sleep Stages ; Sleep ; Oxygen ; Magnetic Resonance Spectroscopy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25313
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    Zs.A 1232: Show issues Location:
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  7. Article ; Online: Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial.

    Malhotra, Atul / Bednarik, Josef / Chakladar, Sujatro / Dunn, Julia P / Weaver, Terri / Grunstein, Ron / Fietze, Ingo / Redline, Susan / Azarbarzin, Ali / Sands, Scott A / Schwab, Richard J / Bunck, Mathijs C

    Contemporary clinical trials

    2024  Volume 141, Page(s) 107516

    Abstract: Background: Weight reduction is a standard recommendation for obstructive sleep apnea (OSA) treatment in people with obesity or overweight; however, weight loss can be challenging to achieve and maintain without bariatric surgery. Currently, no approved ...

    Abstract Background: Weight reduction is a standard recommendation for obstructive sleep apnea (OSA) treatment in people with obesity or overweight; however, weight loss can be challenging to achieve and maintain without bariatric surgery. Currently, no approved anti-obesity medication has demonstrated effectiveness in OSA management. This study is evaluating the efficacy and safety of tirzepatide for treatment of moderate to severe OSA in people with obesity.
    Methods: SURMOUNT-OSA, a randomized, placebo -controlled, 52-week phase 3 trial, is investigating the efficacy and safety of tirzepatide for treatment of moderate to severe OSA (apnea hypopnea- index ≥15 events/h) in participants with obesity (body mass index ≥30 kg/m
    Results: The primary endpoint for the individual ISAs is the difference in apnea hypopnea- index response, as measured by polysomnography, between tirzepatide and placebo arms at week 52. Secondary endpoints include sleep apnea-specific hypoxic burden, functional outcomes, and cardiometabolic biomarkers. The trial employs digital wearables, including home sleep testing to capture time to improvement and accelerometry for daily physical activity assessment, to evaluate exploratory outcomes.
    Conclusion: SURMOUNT-OSA brings a novel design to investigate if tirzepatide provides clinically meaningful improvement in obesity-related OSA by targeting the underlying etiology.
    Trial registration: ClinicalTrials.gov, NCT05412004.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2024.107516
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    Zs.A 1581: Show issues Location:
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  8. Article ; Online: An aberration correction approach for single and dual aperture ultrasound imaging of the abdomen.

    van Hal, Vera H J / Muller, Jan-Willem / van Sambeek, Marc R H M / Lopata, Richard G P / Schwab, Hans-Martin

    Ultrasonics

    2023  Volume 131, Page(s) 106936

    Abstract: Abdominal ultrasound image quality is hampered by phase aberration, that is mainly caused by the large speed-of-sound (SoS) differences between fat and muscle tissue in the abdominal wall. The mismatch between the assumed and actual SoS distribution ... ...

    Abstract Abdominal ultrasound image quality is hampered by phase aberration, that is mainly caused by the large speed-of-sound (SoS) differences between fat and muscle tissue in the abdominal wall. The mismatch between the assumed and actual SoS distribution introduces general blurring of the ultrasound images, and acoustic refraction can lead to geometric distortion of the imaged features. Large aperture imaging or dual-transducer imaging can improve abdominal imaging at deep locations by providing increased contrast and resolution. However, aberration effects for large aperture imaging can be even more severe, which limits its full potential. In this study, a model-based aberration correction method for arbitrary acquisition schemes is introduced for delay-and-sum (DAS) beamforming and its performance was analyzed for both single- and dual-transducer ultrasound imaging. The method employs aberration corrected wavefront arrival times, using manually assigned local SoS values. Two wavefront models were compared. The first model is based on a straight ray approximation, and the second model on the Eikonal equation, which is solved by a multi-stencils fast marching method. Their accuracy for abdominal imaging was evaluated in acoustic simulations and phantom experiments involving tissue-mimicking and porcine material with large SoS contrast (∼100 m/s). The lateral resolution was improved by up to 90% in simulations and up to 65% in experiments compared to standard DAS, in which the use of Eikonal beamforming generally outperformed straight ray beamforming. Moreover, geometric distortions were mitigated in multi-aperture imaging, leading to a reduction in position error of around 80%. A study on the sensitivity of the aberration correction to shape and SoS of aberrating layers was performed, showing that even with imperfect segmentations or SoS values, aberration correction still outperforms standard DAS.
    MeSH term(s) Animals ; Swine ; Algorithms ; Ultrasonography/methods ; Abdomen/diagnostic imaging ; Phantoms, Imaging ; Sound
    Language English
    Publishing date 2023-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 200839-7
    ISSN 1874-9968 ; 0041-624X
    ISSN (online) 1874-9968
    ISSN 0041-624X
    DOI 10.1016/j.ultras.2023.106936
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  9. Article ; Online: Reply to Kawada: Weight Loss and Upper Airway Anatomy in Patients with Obstructive Sleep Apnea.

    Schwab, Richard J / Keenan, Brendan T / Sarwer, David B / Pack, Allan I

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 2, Page(s) 270–271

    MeSH term(s) Humans ; Polysomnography ; Sleep Apnea, Obstructive ; Tongue ; Weight Loss
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202009-3632LE
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  10. Article ; Online: Correction: a phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer.

    Shatsky, Rebecca A / Batra-Sharma, Hemali / Helsten, Teresa / Schwab, Richard B / Pittman, Emily I / Pu, Minya / Weihe, Elizabeth / Ghia, Emanuela M / Rassenti, Laura Z / Molinolo, Alfredo / Cabrera, Betty / Breitmeyer, James B / Widhopf Ii, George F / Messer, Karen / Jamieson, Catriona / Kipps, Thomas J / Parker, Barbara A

    Breast cancer research : BCR

    2024  Volume 26, Issue 1, Page(s) 46

    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-024-01805-w
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