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Article ; Online: The biotherapeutic

Paz Del Socorro, Thomas / Oka, Kentaro / Boulard, Olivier / Takahashi, Motomichi / Poulin, Lionel Franz / Hayashi, Atsushi / Chamaillard, Mathias

Gut microbes

2024 Volume 16, Issue 1, Page(s) 2315631

Abstract: Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic association between supplementation ... ...

Abstract	Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic association between supplementation with
MeSH term(s)	Animals ; Mice ; Carcinoma, Non-Small-Cell Lung ; CD8-Positive T-Lymphocytes ; Clostridium butyricum/physiology ; Gastrointestinal Microbiome ; Interleukin-10/genetics ; Lung Neoplasms ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Programmed Cell Death 1 Receptor ; T-Lymphocytes, Regulatory
Chemical Substances	Interleukin-10 (130068-27-8) ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2024.2315631
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.

Muharram, Ghaffar / Thépaut, Marion / Lobert, Pierre-Emmanuel / Grandjean, Teddy / Boulard, Olivier / Delacre, Myriam / Wakeford, Emmrich / Wheeler, Richard / Poulin, Lionel Franz / Boneca, Ivo Gomperts / Lafont, Frank / Michallet, Marie-Cécile / Hober, Didier / Cadwell, Ken / Chamaillard, Mathias

Gut microbes

2023 Volume 15, Issue 2, Page(s) 2249960

Abstract: Over 90% of epidemic non-bacterial gastroenteritis are caused by human noroviruses (NoVs), which persist in a substantial subset of people allowing their spread worldwide. This has led to a significant number of endemic cases and up to 70,000 children ... ...

Abstract	Over 90% of epidemic non-bacterial gastroenteritis are caused by human noroviruses (NoVs), which persist in a substantial subset of people allowing their spread worldwide. This has led to a significant number of endemic cases and up to 70,000 children deaths in developing countries. NoVs are primarily transmitted through the fecal-oral route. To date, studies have focused on the influence of the gut microbiota on enteric viral clearance by mucosal immunity. In this study, the use of mouse norovirus S99 (MNoV_S99) and CR6 (MNoV_CR6), two persistent strains, allowed us to provide evidence that the norovirus-induced exacerbation of colitis severity relied on bacterial sensing by nucleotide-binding oligomerization domain 2 (Nod2). Consequently,
MeSH term(s)	Animals ; Mice ; Caliciviridae Infections/immunology ; Colitis/chemically induced ; Colitis/virology ; Gastroenteritis/immunology ; Gastroenteritis/virology ; Gastrointestinal Microbiome ; Nod2 Signaling Adaptor Protein/metabolism
Chemical Substances	Nod2 protein, mouse ; Nod2 Signaling Adaptor Protein
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2023.2249960
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Article ; Online: Keeping the (S)toolbox Alive Outside of the Body for Drugs Discovery.

Poulin, Lionel Franz / Peyrin-Biroulet, Laurent / Collard, Dominique / Chamaillard, Mathias

Gastroenterology

2017

Language	English
Publishing date	2017-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2017.10.022
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Article: Understanding the Cellular Origin of the Mononuclear Phagocyte System Sheds Light on the Myeloid Postulate of Immune Paralysis in Sepsis.

Poulin, Lionel Franz / Lasseaux, Corentin / Chamaillard, Mathias

Frontiers in immunology

2018 Volume 9, Page(s) 823

Abstract: Sepsis, in essence, is a serious clinical condition that can subsequently result in death as a consequence of a systemic inflammatory response syndrome including febrile leukopenia, hypotension, and multiple organ failures. To date, such life-threatening ...

Abstract	Sepsis, in essence, is a serious clinical condition that can subsequently result in death as a consequence of a systemic inflammatory response syndrome including febrile leukopenia, hypotension, and multiple organ failures. To date, such life-threatening organ dysfunction remains one of the leading causes of death in intensive care units, with an increasing incidence rate worldwide and particularly within the rapidly growing senior population. While most of the clinical trials are aimed at dampening the overwhelming immune response to infection that spreads through the bloodstream, based on several human immunological investigations, it is now widely accepted that susceptibility to nosocomial infections and long-term sepsis mortality involves an immunosuppressive phase that is characterized by a decrease in some subsets of dendritic cells (DCs). Only recently substantial advances have been made in terms of the origin of the mononuclear phagocyte system that is now likely to allow for a better understanding of how the paralysis of DCs leads to sepsis-related death. Indeed, the unifying view of each subset of DCs has already improved our understanding of the pivotal pathways that contribute to the shift in commitment of their progenitors that originate from the bone marrow. It is quite plausible that this anomaly in sepsis may occur at the single level of DC-committed precursors, and elucidating the immunological basis for such a derangement during the ontogeny of each subset of DCs is now of particular importance for restoring an adequate cell fate decision to their vulnerable progenitors. Last but not least, it provides a direct perspective on the development of sophisticated myelopoiesis-based strategies that are currently being considered for the treatment of immunosenescence within different tissue microenvironments, such as the kidney and the spleen.
MeSH term(s)	Animals ; Cell Differentiation/immunology ; Cellular Microenvironment ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Disease Models, Animal ; Humans ; Mice ; Mononuclear Phagocyte System/cytology ; Mononuclear Phagocyte System/immunology ; Myelopoiesis ; Sepsis/immunology ; Sepsis/pathology
Language	English
Publishing date	2018-04-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.00823
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Article ; Online: Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia.

Lasseaux, Corentin / Fourmaux, Marie-Pierre / Chamaillard, Mathias / Poulin, Lionel Franz

Scientific reports

2017 Volume 7, Issue 1, Page(s) 16935

Abstract: Emergency monocytopoiesis is an inflammation-driven hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Yet, the regulatory mechanisms by which early bone marrow myeloid ...

Abstract	Emergency monocytopoiesis is an inflammation-driven hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Yet, the regulatory mechanisms by which early bone marrow myeloid progenitors commit to monocyte-derived phagocytes during endotoxemia remains elusive. Herein, we show that type I interferons signaling promotes the differentiation of monocyte-derived phagocytes at the level of their progenitors during a mouse model of endotoxemia. In this model, we characterized early changes in the numbers of conventional dendritic cells, monocyte-derived antigen-presenting cells and their respective precursors. While loss of caspase-1/11 failed to impair a shift toward monocytopoiesis, we observed sustained type-I-IFN-dependent monocyte progenitors differentiation in the bone marrow correlated to an accumulation of Mo-APCs in the spleen. Importantly, IFN-alpha and -beta were found to efficiently generate the development of monocyte-derived antigen-presenting cells while having no impact on the precursor activity of conventional dendritic cells. Consistently, the LPS-driven decrease of conventional dendritic cells and their direct precursor occurred independently of type-I-IFN signaling in vivo. Our characterization of early changes in mononuclear phagocytes and their dependency on type I IFN signaling during sepsis opens the way to the development of treatments for limiting the immunosuppressive state associated with sepsis.
MeSH term(s)	Animals ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Endotoxemia/chemically induced ; Endotoxemia/metabolism ; Endotoxemia/pathology ; Hematopoiesis ; Inflammasomes/metabolism ; Interferon Type I/metabolism ; Lipopolysaccharides/toxicity ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/metabolism ; Monocytes/pathology ; Receptor, Interferon alpha-beta/genetics ; Receptors, IgG/metabolism ; Spleen/pathology
Chemical Substances	Ifnar1 protein, mouse ; Inflammasomes ; Interferon Type I ; Lipopolysaccharides ; Receptors, IgG ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2017-12-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-16869-2
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Article ; Online: Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia

Corentin Lasseaux / Marie-Pierre Fourmaux / Mathias Chamaillard / Lionel Franz Poulin

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 13

Abstract: Abstract Emergency monocytopoiesis is an inflammation-driven hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Yet, the regulatory mechanisms by which early bone ... ...

Abstract	Abstract Emergency monocytopoiesis is an inflammation-driven hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Yet, the regulatory mechanisms by which early bone marrow myeloid progenitors commit to monocyte-derived phagocytes during endotoxemia remains elusive. Herein, we show that type I interferons signaling promotes the differentiation of monocyte-derived phagocytes at the level of their progenitors during a mouse model of endotoxemia. In this model, we characterized early changes in the numbers of conventional dendritic cells, monocyte-derived antigen-presenting cells and their respective precursors. While loss of caspase-1/11 failed to impair a shift toward monocytopoiesis, we observed sustained type-I-IFN-dependent monocyte progenitors differentiation in the bone marrow correlated to an accumulation of Mo-APCs in the spleen. Importantly, IFN-alpha and -beta were found to efficiently generate the development of monocyte-derived antigen-presenting cells while having no impact on the precursor activity of conventional dendritic cells. Consistently, the LPS-driven decrease of conventional dendritic cells and their direct precursor occurred independently of type-I-IFN signaling in vivo. Our characterization of early changes in mononuclear phagocytes and their dependency on type I IFN signaling during sepsis opens the way to the development of treatments for limiting the immunosuppressive state associated with sepsis.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Le derme de la peau s'enrichit d'une nouvelle population de cellules dendritiques.

Henri, Sandrine / Franz Poulin, Lionel / Malissen, Bernard

Medecine sciences : M/S

2008 Volume 24, Issue 4, Page(s) 346–347

Title translation	The skin dermis host a new population of dendritic cells.
MeSH term(s)	Dendritic Cells/cytology ; Dendritic Cells/physiology ; Dermis/cytology ; Dermis/physiology ; Epidermis/cytology ; Epidermis/physiology ; Humans ; Monocytes/cytology ; Stem Cells/cytology ; Stem Cells/physiology
Language	French
Publishing date	2008-04
Publishing country	France
Document type	Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2008244346
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Article ; Online: Disentangling the complexity of the skin dendritic cell network.

Henri, Sandrine / Guilliams, Martin / Poulin, Lionel Franz / Tamoutounour, Samira / Ardouin, Laurence / Dalod, Marc / Malissen, Bernard

Immunology and cell biology

2010 Volume 88, Issue 4, Page(s) 366–375

Abstract: Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present ... ...

Abstract	Using 'knockin' mice to track and ablate dendritic cells (DCs) expressing notably the langerin (Cd207) gene, it has been possible to identify five DC subsets within the skin and to assess whether functional specialization exists among them. The present review summarizes recent information concerning the phenotype and the function of these five DC subsets before and after their migration to cutaneous draining lymph nodes. Moreover, it integrates this information into a unifying model that emphasizes the similarities that exist among the mouse DC subsets that are found in both lymphoid and nonlymphoid tissues.
MeSH term(s)	Animals ; Cell Movement ; Immune Tolerance ; Langerhans Cells/immunology ; Mice ; Models, Immunological
Language	English
Publishing date	2010-03-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1038/icb.2010.34
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Article ; Online: The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells.

Poulin, Lionel Franz / Henri, Sandrine / de Bovis, Béatrice / Devilard, Elisabeth / Kissenpfennig, Adrien / Malissen, Bernard

The Journal of experimental medicine

2007 Volume 204, Issue 13, Page(s) 3119–3131

Abstract: Langerhans cells (LCs) constitute a subset of dendritic cells (DCs) that express the lectin langerin and that reside in their immature state in epidermis. Paradoxically, in mice permitting diphtheria toxin (DT)-mediated ablation of LCs, epidermal LCs ... ...

Abstract	Langerhans cells (LCs) constitute a subset of dendritic cells (DCs) that express the lectin langerin and that reside in their immature state in epidermis. Paradoxically, in mice permitting diphtheria toxin (DT)-mediated ablation of LCs, epidermal LCs reappeared with kinetics that lagged behind that of their putative progeny found in lymph nodes (LNs). Using bone marrow (BM) chimeras, we showed that a major fraction of the langerin(+), skin-derived DCs found in LNs originates from a developmental pathway that is independent from that of epidermal LCs. This pathway, the existence of which was unexpected, originates in the dermis and gives rise to langerin(+) dermal DCs (DDCs) that should not be confused with epidermal LCs en route to LNs. It explains that after DT treatment, some langerin(+), skin-derived DCs reappear in LNs long before LC-derived DCs. Using CD45 expression and BrdU-labeling kinetics, both LCs and langerin(+) DDCs were found to coexist in wild-type mice. Moreover, DT-mediated ablation of epidermal LCs opened otherwise filled niches and permitted repopulation of adult noninflammatory epidermis with BM-derived LCs. Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models.
MeSH term(s)	Animals ; Antigens, Surface/metabolism ; Antigens, Surface/physiology ; Bone Marrow Cells/metabolism ; Dendritic Cells/cytology ; Dendritic Cells/metabolism ; Dermis/cytology ; Dermis/metabolism ; Dermis/pathology ; Epidermis/metabolism ; Kidney/metabolism ; Kinetics ; Langerhans Cells/metabolism ; Lectins, C-Type/metabolism ; Lectins, C-Type/physiology ; Leukocyte Common Antigens/biosynthesis ; Lymph Nodes/pathology ; Mannose-Binding Lectins/metabolism ; Mannose-Binding Lectins/physiology ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Spleen/metabolism
Chemical Substances	Antigens, Surface ; Cd207 protein, mouse ; Lectins, C-Type ; Mannose-Binding Lectins ; Leukocyte Common Antigens (EC 3.1.3.48)
Language	English
Publishing date	2007-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20071724
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Article ; Online: ZAP-70 restoration in mice by in vivo thymic electroporation.

Irla, Magali / Saade, Murielle / Kissenpfennig, Adrien / Poulin, Lionel Franz / Leserman, Lee / Marche, Patrice N / Jouvin-Marche, Evelyne / Berger, François / Nguyen, Catherine

PloS one

2008 Volume 3, Issue 4, Page(s) e2059

Abstract: Viral and non-viral vectors have been developed for gene therapy, but their use is associated with unresolved problems of efficacy and safety. Efficient and safe methods of DNA delivery need to be found for medical application. Here we report a new ... ...

Abstract	Viral and non-viral vectors have been developed for gene therapy, but their use is associated with unresolved problems of efficacy and safety. Efficient and safe methods of DNA delivery need to be found for medical application. Here we report a new monopolar system of non-viral electro-gene transfer into the thymus in vivo that consists of the local application of electrical pulses after the introduction of the DNA. We assessed the proof of concept of this approach by correcting ZAP-70 deficient severe combined immunodeficiency (SCID) in mice. The thymic electro-gene transfer of the pCMV-ZAP-70-IRES-EGFP vector in these mice resulted in rapid T cell differentiation in the thymus with mature lymphocytes detected by three weeks in secondary lymphoid organs. Moreover, this system resulted in the generation of long-term functional T lymphocytes. Peripheral reconstituted T cells displayed a diversified T cell receptor (TCR) repertoire, and were responsive to alloantigens in vivo. This process applied to the thymus could represent a simplified and effective alternative for gene therapy of T cell immunodeficiencies.
MeSH term(s)	Anesthesia ; Animals ; Cell Differentiation ; Electric Conductivity ; Electroporation/methods ; Green Fluorescent Proteins/metabolism ; Immunophenotyping ; Lymphoid Tissue/cytology ; Mice ; Receptors, Antigen, T-Cell/metabolism ; Spleen/cytology ; T-Lymphocytes/cytology ; Thymus Gland/cytology ; Time Factors ; Transfection ; ZAP-70 Protein-Tyrosine Kinase/deficiency ; ZAP-70 Protein-Tyrosine Kinase/metabolism
Chemical Substances	Receptors, Antigen, T-Cell ; enhanced green fluorescent protein ; Green Fluorescent Proteins (147336-22-9) ; ZAP-70 Protein-Tyrosine Kinase (EC 2.7.10.2) ; Zap70 protein, mouse (EC 2.7.10.2)
Language	English
Publishing date	2008-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0002059
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