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Article ; Online: Dural arteriovenous fistula causing reversible cognitive impairment.

Alexandratou, Anna / Mah, Yee / Ramsey, Deborah / Kandasamy, Naga / Tolias, Christos M / Gadapa, Naveen / Ankolekar, Sandeep

Practical neurology

2022 Volume 23, Issue 1, Page(s) 82–84

Abstract: A previously independent 82-year-old woman presented with 5 months of worsening confusion, mobility and cognitive decline, with deficits in orientation, language and executive function. A cerebral dural arteriovenous fistula was identified and ... ...

Abstract	A previously independent 82-year-old woman presented with 5 months of worsening confusion, mobility and cognitive decline, with deficits in orientation, language and executive function. A cerebral dural arteriovenous fistula was identified and successfully embolised, after which her cognitive ability and independence dramatically improved. Although rare, a dural arteriovenous fistula may mimic a rapidly progressive dementia, but its early recognition and treatment can completely reverse the dementia.
MeSH term(s)	Female ; Humans ; Aged, 80 and over ; Embolization, Therapeutic ; Dementia/etiology ; Central Nervous System Vascular Malformations/complications ; Central Nervous System Vascular Malformations/diagnostic imaging ; Central Nervous System Vascular Malformations/therapy ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Confusion
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2170881-2
ISSN	1474-7766 ; 1474-7758
ISSN (online)	1474-7766
ISSN	1474-7758
DOI	10.1136/pn-2021-003332
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Article: A Mixed-Methods Protocol to Identify Best Practices for Implementing Pharmacogenetic Testing in Clinical Settings.

Sperber, Nina R / Cragun, Deborah / Roberts, Megan C / Bendz, Lisa M / Ince, Parker / Gonzales, Sarah / Haga, Susanne B / Wu, R Ryanne / Petry, Natasha J / Ramsey, Laura / Uber, Ryley

Journal of personalized medicine

2022 Volume 12, Issue 8

Abstract: Using a patient's genetic information to inform medication prescriptions can be clinically effective; however, the practice has not been widely implemented. Health systems need guidance on how to engage with providers to improve pharmacogenetic test ... ...

Abstract	Using a patient's genetic information to inform medication prescriptions can be clinically effective; however, the practice has not been widely implemented. Health systems need guidance on how to engage with providers to improve pharmacogenetic test utilization. Approaches from the field of implementation science may shed light on the complex factors affecting pharmacogenetic test use in real-world settings and areas to target to improve utilization. This paper presents an approach to studying the application of precision medicine that utilizes mixed qualitative and quantitative methods and implementation science frameworks to understand which factors or combinations consistently account for high versus low utilization of pharmocogenetic testing. This approach involves two phases: (1) collection of qualitative and quantitative data from providers-the cases-at four clinical institutions about their experiences with, and utilization of, pharmacogenetic testing to identify salient factors; and (2) analysis using a Configurational Comparative Method (CCM), using a mathematical algorithm to identify the minimally necessary and sufficient factors that distinguish providers who have higher utilization from those with low utilization. Advantages of this approach are that it can be used for small to moderate sample sizes, and it accounts for conditions found in real-world settings by demonstrating how they coincide to affect utilization.
Language	English
Publishing date	2022-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12081313
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Article ; Online: Integrating metabolic expenditure information from wearable fitness sensors into an AI-augmented automated insulin delivery system: a randomised clinical trial.

Jacobs, Peter G / Resalat, Navid / Hilts, Wade / Young, Gavin M / Leitschuh, Joseph / Pinsonault, Joseph / El Youssef, Joseph / Branigan, Deborah / Gabo, Virginia / Eom, Jae / Ramsey, Katrina / Dodier, Robert / Mosquera-Lopez, Clara / Wilson, Leah M / Castle, Jessica R

The Lancet. Digital health

2023 Volume 5, Issue 9, Page(s) e607–e617

Abstract: ... by limiting hypoglycaemia.: Funding: JDRF Foundation and the Leona M and Harry B Helmsley Charitable Trust ...

Abstract	Background: Exercise can rapidly drop glucose in people with type 1 diabetes. Ubiquitous wearable fitness sensors are not integrated into automated insulin delivery (AID) systems. We hypothesised that an AID can automate insulin adjustments using real-time wearable fitness data to reduce hypoglycaemia during exercise and free-living conditions compared with an AID not automating use of fitness data. Methods: Our study population comprised of individuals (aged 21-50 years) with type 1 diabetes from from the Harold Schnitzer Diabetes Health Center clinic at Oregon Health and Science University, OR, USA, who were enrolled into a 76 h single-centre, two-arm randomised (4-block randomisation), non-blinded crossover study to use (1) an AID that detects exercise, prompts the user, and shuts off insulin during exercise using an exercise-aware adaptive proportional derivative (exAPD) algorithm or (2) an AID that automates insulin adjustments using fitness data in real-time through an exercise-aware model predictive control (exMPC) algorithm. Both algorithms ran on iPancreas comprising commercial glucose sensors, insulin pumps, and smartwatches. Participants executed 1 week run-in on usual therapy followed by exAPD or exMPC for one 12 h primary in-clinic session involving meals, exercise, and activities of daily living, and 2 free-living out-patient days. Primary outcome was time below range (<3·9 mmol/L) during the primary in-clinic session. Secondary outcome measures included mean glucose and time in range (3·9-10 mmol/L). This trial is registered with ClinicalTrials.gov, NCT04771403. Findings: Between April 13, 2021, and Oct 3, 2022, 27 participants (18 females) were enrolled into the study. There was no significant difference between exMPC (n=24) versus exAPD (n=22) in time below range (mean [SD] 1·3% [2·9] vs 2·5% [7·0]) or time in range (63·2% [23·9] vs 59·4% [23·1]) during the primary in-clinic session. In the 2 h period after start of in-clinic exercise, exMPC had significantly lower mean glucose (7·3 [1·6] vs 8·0 [1·7] mmol/L, p=0·023) and comparable time below range (1·4% [4·2] vs 4·9% [14·4]). Across the 76 h study, both algorithms achieved clinical time in range targets (71·2% [16] and 75·5% [11]) and time below range (1·0% [1·2] and 1·3% [2·2]), significantly lower than run-in period (2·4% [2·4], p=0·0004 vs exMPC; p=0·012 vs exAPD). No adverse events occurred. Interpretation: AIDs can integrate exercise data from smartwatches to inform insulin dosing and limit hypoglycaemia while improving glucose outcomes. Future AID systems that integrate exercise metrics from wearable fitness sensors may help people living with type 1 diabetes exercise safely by limiting hypoglycaemia. Funding: JDRF Foundation and the Leona M and Harry B Helmsley Charitable Trust, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.
MeSH term(s)	Female ; Humans ; Activities of Daily Living ; Artificial Intelligence ; Cross-Over Studies ; Diabetes Mellitus, Type 1/drug therapy ; Glucose/therapeutic use ; Health Expenditures ; Hypoglycemia ; Hypoglycemic Agents/therapeutic use ; Insulin ; United States ; Wearable Electronic Devices ; Male
Chemical Substances	Glucose (IY9XDZ35W2) ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2589-7500
ISSN (online)	2589-7500
DOI	10.1016/S2589-7500(23)00112-7
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Article ; Online: Assessment of a Decision Support System for Adults with Type 1 Diabetes on Multiple Daily Insulin Injections.

Castle, Jessica R / Wilson, Leah M / Tyler, Nichole S / Espinoza, Alejandro Z / Mosquera-Lopez, Clara M / Kushner, Taisa / Young, Gavin M / Pinsonault, Joseph / Dodier, Robert H / Hilts, Wade W / Oganessian, Sos M / Branigan, Deborah L / Gabo, Virginia B / Eom, Jae H / Ramsey, Katrina / Youssef, Joseph El / Cafazzo, Joseph A / Winters-Stone, Kerri / Jacobs, Peter G

Diabetes technology & therapeutics

2022 Volume 24, Issue 12, Page(s) 892–897

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Adult ; Humans ; Insulin/therapeutic use ; Diabetes Mellitus, Type 1/drug therapy ; Blood Glucose Self-Monitoring ; Blood Glucose ; Hypoglycemic Agents/therapeutic use ; Glycated Hemoglobin/analysis
Chemical Substances	Insulin ; Blood Glucose ; Hypoglycemic Agents ; Glycated Hemoglobin A
Language	English
Publishing date	2022-09-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2022.0252
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Article ; Online: Characterizing opioid consumption in the 30-day post-operative period following shoulder surgery: are we over prescribing?

Patel, Manan Sunil / Updegrove, Gary F / Singh, Arjun M / Jamgochian, Grant C / LoBiondo, Deborah / Abboud, Joseph A / Ramsey, Matthew L / Lazarus, Mark D

The Physician and sportsmedicine

2020 Volume 49, Issue 2, Page(s) 158–164

Abstract: ... ...

Abstract	Objectives
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Humans ; Inappropriate Prescribing ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Practice Patterns, Physicians' ; Shoulder
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article
ZDB-ID	753046-8
ISSN	2326-3660 ; 0091-3847
ISSN (online)	2326-3660
ISSN	0091-3847
DOI	10.1080/00913847.2020.1789439
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Article ; Online: Patient-specific abutments for anterior maxillary implants.

Ramsey, Christopher D / Leal, Karina F / Lyle, Deborah M

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)

2014 Volume 35, Issue 6, Page(s) 404–411;quiz 412

Abstract: Many factors influence the long-term functional and esthetic success of implant-supported restorations. This article reviews recent findings related to several of these factors, including the implant-abutment junction, bacterial adhesion to implant ... ...

Abstract	Many factors influence the long-term functional and esthetic success of implant-supported restorations. This article reviews recent findings related to several of these factors, including the implant-abutment junction, bacterial adhesion to implant surfaces, and the esthetic and functional consequences of implant and abutment material choices, particularly titanium-nitride-coated abutments. Restoration of a failed maxillary central incisor using a platformswitched implant and titanium-nitride-coated abutment is presented.
MeSH term(s)	Dental Abutments ; Dental Implants ; Esthetics, Dental ; Humans ; Maxilla/surgery
Chemical Substances	Dental Implants
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	632569-5
ISSN	2158-1797 ; 0734-0338
ISSN (online)	2158-1797
ISSN	0734-0338
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Article ; Online: Mechanistic studies of sanguinamide B derivatives: a unique inhibitor of eukaryotic ribosomes.

Tantisantisom, Worawan / Ramsey, Deborah M / McAlpine, Shelli R

Organic letters

2013 Volume 15, Issue 18, Page(s) 4638–4641

Abstract: Described are mechanistic studies of two Sanguinamide B (San B) derivatives. These compounds were identified as eukaryotic ribosomal inhibitors. Two biotinylated San B derivatives were synthesized and used to capture protein targets in a pull-down assay. ...

Abstract	Described are mechanistic studies of two Sanguinamide B (San B) derivatives. These compounds were identified as eukaryotic ribosomal inhibitors. Two biotinylated San B derivatives were synthesized and used to capture protein targets in a pull-down assay. LC/MS/MS analysis of the San B-captured targets identified several proteins that comprise eukaryotic ribosomal subunits. The translation inhibitory effect of San B was confirmed using an in vitro translation assay. Moreover, an evaluation of cell death mechanisms is reported.
MeSH term(s)	Apoptosis/drug effects ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Oxazoles/chemical synthesis ; Oxazoles/chemistry ; Oxazoles/pharmacology ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/pharmacology ; Proteins/metabolism ; Ribosomes/drug effects ; Ribosomes/metabolism ; Thiazoles/chemical synthesis ; Thiazoles/chemistry ; Thiazoles/pharmacology
Chemical Substances	Oxazoles ; Peptides, Cyclic ; Proteins ; Thiazoles ; sanguinamide B
Language	English
Publishing date	2013-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/ol401749p
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Article: Halting metastasis through CXCR4 inhibition

Ramsey, Deborah M / McAlpine, Shelli R

Bioorganic & medicinal chemistry letters. 2013 Jan. 1, v. 23, no. 1

2013

Abstract: Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4–SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches ... ...

Abstract	Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4–SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical trials. Continued exploration of CXCR4 inhibitors will generate compounds that have improved activity over current candidates.
Keywords	chemistry ; clinical trials ; metastasis ; neoplasms
Language	English
Dates of publication	2013-0101
Size	p. 20-25.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2012.10.138
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Accuracy of the Dexcom G6 Glucose Sensor during Aerobic, Resistance, and Interval Exercise in Adults with Type 1 Diabetes.

Guillot, Florian H / Jacobs, Peter G / Wilson, Leah M / Youssef, Joseph El / Gabo, Virginia B / Branigan, Deborah L / Tyler, Nichole S / Ramsey, Katrina / Riddell, Michael C / Castle, Jessica R

Biosensors

2020 Volume 10, Issue 10

Abstract: The accuracy of continuous glucose monitoring (CGM) sensors may be significantly impacted by exercise. We evaluated the impact of three different types of exercise on the accuracy of the Dexcom G6 sensor. Twenty-four adults with type 1 diabetes on ... ...

Abstract	The accuracy of continuous glucose monitoring (CGM) sensors may be significantly impacted by exercise. We evaluated the impact of three different types of exercise on the accuracy of the Dexcom G6 sensor. Twenty-four adults with type 1 diabetes on multiple daily injections wore a G6 sensor. Participants were randomized to aerobic, resistance, or high intensity interval training (HIIT) exercise. Each participant completed two in-clinic 30-min exercise sessions. The sensors were applied on average 5.3 days prior to the in-clinic visits (range 0.6-9.9). Capillary blood glucose (CBG) measurements with a Contour Next meter were performed before and after exercise as well as every 10 min during exercise. No CGM calibrations were performed. The median absolute relative difference (MARD) and median relative difference (MRD) of the CGM as compared with the reference CBG did not differ significantly from the start of exercise to the end exercise across all exercise types (ranges for aerobic MARD: 8.9 to 13.9% and MRD: -6.4 to 0.5%, resistance MARD: 7.7 to 14.5% and MRD: -8.3 to -2.9%, HIIT MARD: 12.1 to 16.8% and MRD: -14.3 to -9.1%). The accuracy of the no-calibration Dexcom G6 CGM was not significantly impacted by aerobic, resistance, or HIIT exercise.
MeSH term(s)	Blood Glucose ; Blood Glucose Self-Monitoring ; Calibration ; Diabetes Mellitus, Type 1 ; Exercise ; Humans
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios10100138
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Article ; Online: Halting metastasis through CXCR4 inhibition.

Ramsey, Deborah M / McAlpine, Shelli R

Bioorganic & medicinal chemistry letters

2012 Volume 23, Issue 1, Page(s) 20–25

Abstract: Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches ... ...

Abstract	Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical trials. Continued exploration of CXCR4 inhibitors will generate compounds that have improved activity over current candidates.
MeSH term(s)	Antibodies, Monoclonal/immunology ; Antineoplastic Agents/therapeutic use ; Binding Sites ; Chemokine CXCL12/antagonists & inhibitors ; Chemokine CXCL12/metabolism ; Clinical Trials as Topic ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/therapeutic use ; Humans ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/pathology ; Neoplasms/drug therapy ; Neoplasms/pathology ; Peptides/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Single-Domain Antibodies/immunology
Chemical Substances	Antibodies, Monoclonal ; Antineoplastic Agents ; CXCL12 protein, human ; Chemokine CXCL12 ; Heterocyclic Compounds ; Peptides ; Receptors, CXCR4 ; Single-Domain Antibodies ; plerixafor (S915P5499N)
Language	English
Publishing date	2012-11-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2012.10.138
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