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  1. Article: Comment on the paper by Kapsala et al.

    Alarcón, Graciela S / Pons-Estel, Bernardo A / Pons-Estel, Guillermo J / Zavala, Ernesto / Nieto, Romina / Quintana, Rosana

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 11, Page(s) 2341

    Language English
    Publishing date 2023-06-15
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/tz7trd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Rise and Rise of Lupus.

    González, Luis A / Ugarte-Gil, Manuel F / Pons-Estel, Guillermo J / Alarcón, Graciela S

    Lupus

    2023  Volume 32, Issue 6, Page(s) 713–726

    Abstract: Despite how difficult the early diagnosis of systemic lupus erythematosus (SLE) is, which is mainly due to the heterogeneity and non-specificity of its clinical manifestations, SLE is currently being diagnosed more frequently than in past decades. In ... ...

    Abstract Despite how difficult the early diagnosis of systemic lupus erythematosus (SLE) is, which is mainly due to the heterogeneity and non-specificity of its clinical manifestations, SLE is currently being diagnosed more frequently than in past decades. In fact, there has been an increase in the incidence and prevalence of SLE over the last four decades; this can be explained by a number of reasons including a better knowledge of the pathogenesis of the disease which allows its earlier diagnosis, the rising ethnic and racial diversity of the world population, the use of the 2019 EULAR/ACR criteria that allows classifying patients earlier, and improvements in survival over the last decades, which results in an increase in the prevalent cases of SLE. In this article, we will also review the genetic, environmental, and lifestyle factors, that are reported to increase the risk of developing SLE and how preventive strategies through a clinical care pathway may prevent or delay the development of SLE and improve these patients' outcomes.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/epidemiology ; Racial Groups
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033231169896
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  3. Article ; Online: How well do the new classification criteria for SLE perform?

    Pons-Estel, Guillermo J / Alarcón, Graciela S

    Nature reviews. Rheumatology

    2020  Volume 17, Issue 1, Page(s) 7–8

    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/diagnosis ; Rheumatology
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-00545-3
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  4. Article: Global excellence in rheumatology in Latin America: The case of systemic lupus erythematosus.

    Ugarte-Gil, Manuel F / Fuentes-Silva, Yurilis / Pimentel-Quiroz, Victor R / Pons-Estel, Guillermo J / Quintana, Rosana / Pons-Estel, Bernardo A / Alarcón, Graciela S

    Frontiers in medicine

    2023  Volume 9, Page(s) 988191

    Abstract: Systemic lupus erythematosus (SLE) affects more severely non-White populations, due to their genetic background and sociodemographic characteristics. Several studies have evaluated Latin American SLE patients to determine their genetic and clinical ... ...

    Abstract Systemic lupus erythematosus (SLE) affects more severely non-White populations, due to their genetic background and sociodemographic characteristics. Several studies have evaluated Latin American SLE patients to determine their genetic and clinical characteristics as well as prognostic factors; these studies have not only allowed the development of treatment guidelines aimed at the region but also to support regional and global projects. Additionally, educational activities in Spanish and Portuguese have been started to reduce our patients' health illiteracy. Despite the relatively low research output from Latin American countries, we consider that studies from our region coupled with the networks developed to increase our capabilities, could be a model for other rare autoimmune diseases.
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.988191
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  5. Article ; Online: Whole-hand and regional bone mineral density involvement in rheumatoid arthritis.

    Brance, María Lorena / Razzini, Agustín / Pons-Estel, Bernardo A / Quagliato, Norberto J / Jorfen, Marisa / Berbotto, Guillermo / Brun, Lucas R

    Reumatologia clinica

    2023  Volume 19, Issue 10, Page(s) 555–559

    Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by symmetric polyarthritis that can lead to joint deformity, disability, and osteoporosis. We aimed to evaluate whole hand and regional BMD in RA patients compared to controls. In ... ...

    Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by symmetric polyarthritis that can lead to joint deformity, disability, and osteoporosis. We aimed to evaluate whole hand and regional BMD in RA patients compared to controls. In addition, we evaluated the BMD of dominant versus non-dominant hands in healthy subjects. We included adult female and male RA patients and control subjects matched by age, sex, and BMI. BMD (g/cm
    MeSH term(s) Adult ; Humans ; Male ; Female ; Bone Density ; Hand/diagnostic imaging ; Osteoporosis/diagnostic imaging ; Osteoporosis/etiology ; Metacarpal Bones/diagnostic imaging ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnostic imaging
    Language English
    Publishing date 2023-12-06
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5743
    ISSN (online) 2173-5743
    DOI 10.1016/j.reumae.2023.04.005
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  6. Article ; Online: Correspondence on "New EULAR/ACR 2019 SLE classification criteria: defining ominosity in SLE".

    Pons-Estel, Guillermo J / Ugarte-Gil, Manuel F / Harvey, Guillermina B / Pons-Estel, Bernardo A / Alarcón, Graciela S

    Annals of the rheumatic diseases

    2021  Volume 82, Issue 8, Page(s) e189

    MeSH term(s) Humans ; Rheumatology ; Severity of Illness Index ; Lupus Erythematosus, Systemic/diagnosis
    Language English
    Publishing date 2021-08-03
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-220994
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  7. Article ; Online: Controversies in Systemic Lupus Erythematosus 2021: Changing the Paradigm in the Management of Lupus Nephritis.

    Porta, Sabrina Valeria / Enfrein, Antoine / Houssiau, Frédéric / García, Mercedes / Furie, Richard / Rovin, Brad H / Alarcón, Graciela S / Pons-Estel, Bernardo A / Pons-Estel, Guillermo J

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2022  Volume 28, Issue 4, Page(s) 229–233

    Abstract: Abstract: Lupus nephritis (LN) affects about a third of patients with systemic lupus erythematosus. Although the use of conventional therapy has significantly improved the prognosis of LN, the response to treatment remains suboptimal, with high rates of ...

    Abstract Abstract: Lupus nephritis (LN) affects about a third of patients with systemic lupus erythematosus. Although the use of conventional therapy has significantly improved the prognosis of LN, the response to treatment remains suboptimal, with high rates of relapse and the occurrence of end-stage kidney disease. The implementation of new diagnostic and treatment strategies aimed at improving these outcomes represents a necessary paradigm shift in the management of LN.Herein, we discuss different points of view regarding these still unresolved issues; these comments represent a debate that took place during the virtual congress of the Pan American League of Associations for Rheumatology (PANLAR) and which was organized by the PANLAR Lupus Study Group, GLADEL (Grupo Latino Americano De Estudio del Lupus) on August 15, 2021.
    MeSH term(s) Humans ; Kidney Failure, Chronic ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/therapy ; Lupus Nephritis/diagnosis ; Lupus Nephritis/epidemiology ; Lupus Nephritis/therapy ; Prognosis
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001859
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    Zs.A 4815: Show issues Location:
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  8. Article: A glimpse into the future of systemic lupus erythematosus.

    Aringer, Martin / Alarcón-Riquelme, Marta E / Clowse, Megan / Pons-Estel, Guillermo J / Vital, Edward M / Dall'Era, Maria

    Therapeutic advances in musculoskeletal disease

    2022  Volume 14, Page(s) 1759720X221086719

    Abstract: This viewpoint article on a forecast of clinically meaningful changes in the management of systemic lupus erythematosus (SLE) in the next 10 years is based on a review of the current state of the art. The groundwork has been laid by a robust series of ... ...

    Abstract This viewpoint article on a forecast of clinically meaningful changes in the management of systemic lupus erythematosus (SLE) in the next 10 years is based on a review of the current state of the art. The groundwork has been laid by a robust series of classification criteria and treatment recommendations that have all been published since 2019. Building on this strong foundation, SLE management predictably will take significant steps forward. Assessment for lupus arthritis will presumably include musculoskeletal sonography. Large-scale polyomics studies are likely to unravel more of the central immune mechanisms of the disease. Biomarkers predictive of therapeutic success may enter the field; the type I interferon signature, as a companion for use of anifrolumab, an antibody against the common type I interferon receptor, is one serious candidate. Besides anifrolumab for nonrenal SLE and the new calcineurin inhibitor voclosporin in lupus nephritis, both of which are already approved in the United States and likely to become available in the European Union in 2022, several other approaches are in advanced clinical trials. These include advanced B cell depletion, inhibition of costimulation
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X221086719
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  9. Article ; Online: Controversies in the Management of Antiphospholipid Syndrome.

    Porta, Sabrina V / de Andrade, Danieli Castro Oliveira / Erkan, Doruk / Gómez-Puerta, José A / Jara, Luis J / Alba Moreyra, Paula / Pons-Estel, Guillermo J

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2023  Volume 29, Issue 5, Page(s) e107–e112

    Abstract: Abstract: Strategies to prevent thrombosis in antiphospholipid antibody (aPL)-positive patients are of the utmost importance. The risk of thrombosis in patients with aPLs varies, depending on additional venous thrombosis and cardiovascular risk factors, ...

    Abstract Abstract: Strategies to prevent thrombosis in antiphospholipid antibody (aPL)-positive patients are of the utmost importance. The risk of thrombosis in patients with aPLs varies, depending on additional venous thrombosis and cardiovascular risk factors, as well as associated comorbidities. Recurrent thrombosis despite treatment with vitamin K antagonists is relatively common in daily practice. In this context, the effectiveness of the new direct oral anticoagulants in antiphospholipid syndrome is debated, as well as that of low-dose aspirin for primary thromboprophylaxis. There is an urgent unmet need to recognize the subgroup of patients that may benefit from low-dose aspirin use. Here we also discuss different points of view on primary and secondary thrombosis preventions in aPL-positive patients, which were presented as a debate during the 2021 PANLAR Congress (Pan-American League of the Association of Rheumatology) and that was organized by GESAF (Argentine Society of Rheumatology APS Study Group). It is the intention of this article to provide a useful discussion to aid treatment decision-making in daily clinical practice.
    MeSH term(s) Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/drug therapy ; Anticoagulants/therapeutic use ; Venous Thromboembolism ; Thrombosis/etiology ; Aspirin/therapeutic use
    Chemical Substances Anticoagulants ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001961
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  10. Article ; Online: Health Disparities in Rheumatic Diseases: Understanding Global Challenges in Africa, Europe, Latin America, and Asia and Proposing Strategies for Improvement.

    Dey, Dzifa / Sciascia, Savino / Pons-Estel, Guillermo J / Ding, Huihua / Shen, Nan

    Rheumatic diseases clinics of North America

    2020  Volume 47, Issue 1, Page(s) 119–132

    Abstract: Rheumatic diseases reach across continents with some similarities as well as unique challenges. The intersection between genetic factors, environmental exposures and socioeconomic factors, as well as challenges, with delays in access to subspecialty care ...

    Abstract Rheumatic diseases reach across continents with some similarities as well as unique challenges. The intersection between genetic factors, environmental exposures and socioeconomic factors, as well as challenges, with delays in access to subspecialty care and medications, manifest in different ways. By understanding both the challenges and successes in different countries, while also recognizing the significant diversity both within and across continents, unified strategies to improve rheumatic disease outcomes and decrease disparities among the most vulnerable groups can be developed and disseminated.
    MeSH term(s) Africa/epidemiology ; Asia/epidemiology ; Europe/epidemiology ; Humans ; Latin America/epidemiology ; Rheumatic Diseases/epidemiology ; Rheumatic Diseases/therapy
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2020.09.009
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