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  1. Article ; Online: The Role of Exosomes in Health and Disease.

    Lionetti, Vincenzo

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: Who would have thought that the discovery made by researchers at Washington University [ ... ]. ...

    Abstract Who would have thought that the discovery made by researchers at Washington University [...].
    MeSH term(s) Exosomes ; Humans
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Plant cell wall in pathogenesis, parasitism and symbiosis, Volume II.

    Vicré, Maïté / Lionetti, Vincenzo

    Frontiers in plant science

    2023  Volume 14, Page(s) 1230438

    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1230438
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  3. Book ; Online: Plant cell wall in pathogenesis, parasitism and symbiosis

    Metraux, Jean-Pierre / Lionetti, Vincenzo

    2015  

    Abstract: The cell wall is a complex structure mainly composed of cellulose microfibrils embedded in a cohesive hemicellulose and pectin matrix. Cell wall structural proteins, enzymes and their inhibitors are also essential components of plant cell walls. They are ...

    Abstract The cell wall is a complex structure mainly composed of cellulose microfibrils embedded in a cohesive hemicellulose and pectin matrix. Cell wall structural proteins, enzymes and their inhibitors are also essential components of plant cell walls. They are involved in the cross-link of cell wall polysaccharides, wall structure, and the perception and signaling of defense-related elicitors at the cell surface. In the outer part of the epidermal cells, the polysaccharides are coated by the cuticle, consisting of hydrophobic cutin, suberin and wax layers. Lignin, a macromolecule composed of highly cross-linked phenolic molecules, is a major component of the secondary cell wall. The cell wall is the first cell structure on which interactions between plants and a wide range of other organisms, including insects, nematodes, pathogenic or symbiotic micro-organisms take place. It not only represents a barrier that limits access to the cellular contents that provide a rich nutrient source for pathogens but serves as a source of elicitors of plant defense responses released upon partial enzymatic degradation of wall polysaccharides during infection. Modification of the plant cell wall can also occur at the level of plasmodesmata during virus infection as well as during abiotic stresses. The fine structure and composition of the plant cell wall as well as the regulation of its biosynthesis can thus strongly influence resistance and susceptibility to pathogens. This Research Topic provides novel insights and detailed overviews on the dynamics of the plant cell wall in plant defence, parasitism and symbiosis and describes experimental approaches to study plant cell wall modifications occurring during interaction of plants with different organisms
    Keywords Botany ; Science (General)
    Size 1 electronic resource (150 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090908
    ISBN 9782889194421 ; 2889194426
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology.

    Angelone, Tommaso / Rocca, Carmine / Lionetti, Vincenzo / Penna, Claudia / Pagliaro, Pasquale

    Antioxidants & redox signaling

    2024  Volume 40, Issue 7-9, Page(s) 369–432

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Selenoproteins/metabolism ; Selenium/metabolism ; Cardiovascular Diseases ; Inflammation
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Selenoproteins ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0285
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  5. Article ; Online: Fndc5/irisin-enriched extracellular vesicles: a new hormonal relay in the regular race against vascular ageing.

    Lionetti, Vincenzo / Barile, Lucio

    European heart journal

    2022  Volume 43, Issue 43, Page(s) 4596–4598

    MeSH term(s) Humans ; Fibronectins/metabolism ; Transcription Factors/metabolism ; Muscle, Skeletal/metabolism ; Aging ; Extracellular Vesicles ; Sirtuins
    Chemical Substances Fibronectins ; Transcription Factors ; Sirtuins (EC 3.5.1.-) ; SIRT6 protein, human (EC 3.5.1.-) ; FNDC5 protein, human
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac517
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    Zs.A 1563: Show issues Location:
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  6. Article ; Online: Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System.

    Micera, Silvestro / Menciassi, Arianna / Cianferotti, Luisella / Gruppioni, Emanuele / Lionetti, Vincenzo

    Advanced healthcare materials

    2024  , Page(s) e2302896

    Abstract: Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities ... ...

    Abstract Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to treat diseases such as diabetes or hypertension. Here, this study proposes to extend the use of these technologies to (re-)establish the connection between new (transplanted or artificial) organs and the nervous system in order to increase the long-term efficacy and the effective biointegration of these solutions. In this perspective paper, some clinically relevant applications of this approach are briefly described. Then, the choices that neural engineers must implement about the type, implantation location, and closed-loop control algorithms to successfully realize this approach are highlighted. It is believed that these new "organ neuroprostheses" are going to become more and more valuable and very effective solutions in the years to come.
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202302896
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    Zs.A 6966: Show issues Location:
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  7. Article: The Plant Invertase/Pectin Methylesterase Inhibitor Superfamily.

    Coculo, Daniele / Lionetti, Vincenzo

    Frontiers in plant science

    2022  Volume 13, Page(s) 863892

    Abstract: Invertases (INVs) and pectin methylesterases (PMEs) are essential enzymes coordinating carbohydrate metabolism, stress responses, and sugar signaling. INVs catalyzes the cleavage of sucrose into glucose and fructose, exerting a pivotal role in sucrose ... ...

    Abstract Invertases (INVs) and pectin methylesterases (PMEs) are essential enzymes coordinating carbohydrate metabolism, stress responses, and sugar signaling. INVs catalyzes the cleavage of sucrose into glucose and fructose, exerting a pivotal role in sucrose metabolism, cellulose biosynthesis, nitrogen uptake, reactive oxygen species scavenging as well as osmotic stress adaptation. PMEs exert a dynamic control of pectin methylesterification to manage cell adhesion, cell wall porosity, and elasticity, as well as perception and signaling of stresses. INV and PME activities can be regulated by specific proteinaceous inhibitors, named INV inhibitors (INVIs) and PME Inhibitors (PMEIs). Despite targeting different enzymes, INVIs and PMEIs belong to the same large protein family named "Plant Invertase/Pectin Methylesterase Inhibitor Superfamily." INVIs and PMEIs, while showing a low aa sequence identity, they share several structural properties. The two inhibitors showed mainly alpha-helices in their secondary structure and both form a non-covalent 1:1 complex with their enzymatic counterpart. Some PMEI members are organized in a gene cluster with specific PMEs. Although the most important physiological information was obtained in
    Language English
    Publishing date 2022-03-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.863892
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  8. Article: Editorial: The Analysis of Nanovesicles, Biomaterials and Chemical Compounds: Assisting the Promotion of Angiogenesis and Enhancing Tissue Engineering Strategies.

    Lionetti, Vincenzo / Sareen, Niketa / Dhingra, Sanjiv

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 904738

    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.904738
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  9. Article ; Online: Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity.

    Del Corpo, Daniele / Coculo, Daniele / Greco, Marco / De Lorenzo, Giulia / Lionetti, Vincenzo

    Plant communications

    2024  , Page(s) 100931

    Abstract: The apoplast is one of the first cellular compartments outside the plasma membrane that phytopathogenic microbes encounter in the early stages of plant tissue invasion. Plants have developed sophisticated surveillance mechanisms to sense the danger ... ...

    Abstract The apoplast is one of the first cellular compartments outside the plasma membrane that phytopathogenic microbes encounter in the early stages of plant tissue invasion. Plants have developed sophisticated surveillance mechanisms to sense the danger events at the cell surface and promptly activate immunity. However, a fine tuning of the activation of immune pathways is necessary to mount a robust and effective defense response. Several endogenous proteins and enzymes are synthesized as inactive precursors, and their post-translational processing emerges as a critical mechanism to trigger alarms in the apoplast. In this review, we focus on the precursors of the phytocytokines, cell wall remodeling enzymes and proteases. The physiological events that convert the inactive precursors into immunomodulatory active peptides or enzymes are described. This review also explores the functional synergies between phytocytokines, cell wall damage associated molecular patterns and remodeling, highlighting their role in boosting extracellular immunity and reinforcing defenses against pests.
    Language English
    Publishing date 2024-04-30
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2590-3462
    ISSN (online) 2590-3462
    DOI 10.1016/j.xplc.2024.100931
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  10. Article ; Online: Simultaneous exposure to nitric oxide inhibition and angiotensin II overload: is it a murine model of mitochondrial dysfunction in nonischemic heart failure?

    Lionetti, Vincenzo

    American journal of physiology. Heart and circulatory physiology

    2016  Volume 310, Issue 11, Page(s) H1385–7

    MeSH term(s) Angiotensin II ; Animals ; Disease Models, Animal ; Heart Failure ; Mice ; Mitochondria ; NG-Nitroarginine Methyl Ester ; Nitric Oxide ; Oxidative Stress
    Chemical Substances Angiotensin II (11128-99-7) ; Nitric Oxide (31C4KY9ESH) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2016-05-03
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00127.2016
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