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  1. AU=Tian Henghe
  2. AU=Rahal Elias A.
  3. AU=Denholt Charlotte
  4. AU=Neale Benjamin M
  5. AU="Simon, Krzysztof"
  6. AU="Srivastava, Abhay Krishna"
  7. AU=Serrano Luis A
  8. AU="D'Orio, Vincent"
  9. AU="Davies, Neville"
  10. AU="Wise, J.C."
  11. AU="Mazer, Benjamin L"
  12. AU="Vellore J. Karthikeyan"

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  1. Artikel: Is Traditional Chinese Medicine Use Associated with Worse Patient-reported Outcomes among Chinese American Rheumatology Patients?

    Sun, Kai / Szymonifka, Jackie / Tian, Henghe / Chang, Yaju / Leng, Jennifer C / Mandl, Lisa A

    The Journal of rheumatology

    2019  Band 46, Heft 12, Seite(n) 1634–1639

    Abstract: Objective: Chinese Americans are a fast-growing immigrant group with more severe rheumatic disease manifestations than whites and often a strong cultural preference for traditional Chinese medicine (TCM). We aimed to examine TCM use patterns and ... ...

    Abstract Objective: Chinese Americans are a fast-growing immigrant group with more severe rheumatic disease manifestations than whites and often a strong cultural preference for traditional Chinese medicine (TCM). We aimed to examine TCM use patterns and association with patient-reported outcomes (PRO) among Chinese American rheumatology patients.
    Methods: Chinese Americans actively treated for systemic rheumatic diseases were recruited from urban Chinatown rheumatology clinics. Data on sociodemographics, acculturation, clinical factors, and TCM use (11 modalities) were gathered. Self-reported health status was assessed using Patient Reported Outcomes Measurement Information System (PROMIS) short forms. TCM users and nonusers were compared. Factors independently associated with TCM use were identified using multivariable logistic regression.
    Results: Among 230 participants, median age was 57 years (range 20-97), 65% were women, 71% had ≤ high school education, 70% were on Medicaid insurance, 47% lived in the United States for ≥ 20 years, and 22% spoke English fluently. Half used TCM in the past year; these participants had worse self-reported anxiety, depression, fatigue, and ability to participate in social roles and activities compared with nonusers. In multivariable analysis, TCM use was associated with belief in TCM, female sex, ≥ 20 years of US residency, reporting Western medicine as ineffective, and shorter rheumatic disease duration.
    Conclusion: Among these Chinese American rheumatology patients, TCM users had worse PRO in many physical and mental health domains. TCM use may be a proxy for unmet therapeutic needs. Asking about TCM use could help providers identify patients with suboptimal health-related quality of life who may benefit from targeted interventions.
    Mesh-Begriff(e) Acculturation ; Adult ; Aged ; Aged, 80 and over ; Anxiety/complications ; Asian Americans ; Depression/complications ; Fatigue/complications ; Female ; Health Status ; Humans ; Male ; Medicine, Chinese Traditional/psychology ; Middle Aged ; Patient Reported Outcome Measures ; Rheumatic Diseases/complications ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/psychology ; Sex Factors ; Social Participation ; Treatment Outcome ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2019-05-01
    Erscheinungsland Canada
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.181148
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Association of Traditional Chinese Medicine Use With Adherence to Prescribed Western Rheumatic Medications Among Chinese American Patients: A Cross-Sectional Survey.

    Sun, Kai / Szymonifka, Jackie / Tian, Henghe / Chang, Yaju / Leng, Jennifer C / Mandl, Lisa A

    Arthritis care & research

    2019  Band 72, Heft 10, Seite(n) 1474–1480

    Abstract: Objective: Chinese Americans are a fast-growing immigrant group with worse rheumatic disease outcomes compared to white populations and frequently use traditional Chinese medicine (TCM). Whether TCM use is associated with lower adherence to Western ... ...

    Abstract Objective: Chinese Americans are a fast-growing immigrant group with worse rheumatic disease outcomes compared to white populations and frequently use traditional Chinese medicine (TCM). Whether TCM use is associated with lower adherence to Western rheumatic medications is unknown. The present study was undertaken to examine adherence to Western medications for systemic rheumatic diseases in the Chinese American immigrant population and its association with TCM use.
    Methods: Chinese Americans actively treated for a systemic rheumatic disease were recruited from 2 Chinatown clinics. Sociodemographic, TCM use, and clinical data were gathered. Self-reported health status was assessed using Patient-Reported Outcome Measurement Information System short forms. Adherence was stratified using the 8-item Morisky Medication Adherence Scale. Factors independently associated with high adherence were identified using multivariable logistic regression.
    Results: Of 230 subjects, the median age was 55 years (range 20-97 years), 65% were female, 71% had a high school education or less, 70% were enrolled in Medicaid, and 22% reported fluency in English. The most common rheumatic diagnoses were rheumatoid arthritis (41%), systemic lupus erythematosus (17%), and seronegative spondyloarthropathies (15%). One-half reported TCM use in the past year, and 28% reported high adherence to Western rheumatic medications. In multivariable analysis, high adherence was associated with TCM use (odds ratio [OR] 3.96, P < 0.001), being married (OR 3.69, P = 0.004), medication regimen complexity (OR 1.13, P = 0.004), and older age (OR 1.06, P < 0.001), and was negatively associated with anxiety (OR 0.94, P = 0.001).
    Conclusion: While adherence to Western rheumatic medications was low in this cohort, interestingly, it was higher among TCM users compared to nonusers. TCM use appears to represent a complementary rather than an alternate approach to disease management for these patients. Future studies should evaluate whether TCM use is associated with better disease outcomes.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Antirheumatic Agents/therapeutic use ; Asian Americans/statistics & numerical data ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Medicine, Chinese Traditional ; Middle Aged ; Rheumatic Diseases/drug therapy ; Young Adult
    Chemische Substanzen Antirheumatic Agents
    Sprache Englisch
    Erscheinungsdatum 2019-07-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.24031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis.

    Tian, Henghe / Cronstein, Bruce N

    Bulletin of the NYU hospital for joint diseases

    2007  Band 65, Heft 3, Seite(n) 168–173

    Abstract: Methotrexate has been widely used for the treatment of rheumatoid arthritis (RA). The mechanisms of action of methotrexate are complex. Developed as a folic acid analogue, methotrexate inhibits purine and pyrimidine synthesis, which accounts for its ... ...

    Abstract Methotrexate has been widely used for the treatment of rheumatoid arthritis (RA). The mechanisms of action of methotrexate are complex. Developed as a folic acid analogue, methotrexate inhibits purine and pyrimidine synthesis, which accounts for its efficacy in the therapy of cancer as well as for some of its toxicities. Recently, many studies have focused on the adenosine-mediated antiinflammatory effects of methotrexate. Certain aspects of methotrexate toxicities are also attributed to adenosine release. A better understanding of the mechanisms of action and toxicities of methotrexate will direct clinicians in their treatment approach and toxicity monitoring. Toward that objective, the latest developments in the pharmacokinetics, mechanism of action, pharmacogenetics, and toxicity of methotrexate are herein discussed.
    Mesh-Begriff(e) Adenosine/metabolism ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/pharmacokinetics ; Antirheumatic Agents/pharmacology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Drug Interactions ; Humans ; Methotrexate/adverse effects ; Methotrexate/pharmacokinetics ; Methotrexate/pharmacology ; Pharmacogenetics
    Chemische Substanzen Antirheumatic Agents ; Adenosine (K72T3FS567) ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2007
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 390411-8
    ISSN 2328-5273 ; 1936-9727 ; 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    ISSN (online) 2328-5273 ; 1936-9727
    ISSN 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.

    Tian, Henghe / Mahajan, Muktar A / Wong, Chun Tung / Habeos, Ioanis / Samuels, Herbert H

    Molecular endocrinology (Baltimore, Md.)

    2006  Band 20, Heft 9, Seite(n) 2036–2051

    Abstract: Thyroid hormone receptors (TRs), expressed as TRalpha1, TRbeta1, and TRbeta2 isoforms, are members of the steroid hormone nuclear receptor gene superfamily, which comprises ligand-dependent transcription factors. The TR isoforms differ primarily in their ...

    Abstract Thyroid hormone receptors (TRs), expressed as TRalpha1, TRbeta1, and TRbeta2 isoforms, are members of the steroid hormone nuclear receptor gene superfamily, which comprises ligand-dependent transcription factors. The TR isoforms differ primarily in their N-terminal (A/B) domains, suggesting that the A/B regions mediate distinct transcriptional activation functions in a cell type-dependent or promoter-specific fashion. The nuclear receptor ligand-binding domain (LBD) undergoes a conformational change upon ligand binding that results in the recruitment of coactivators to the LBD. For glucocorticoid receptor and estrogen receptor-alpha, the same coactivator can contact both the LBD and A/B domains, thus leading to enhanced transcriptional activation. Very little is known regarding the role of the A/B domains of the TR isoforms. The A/B domain of TRbeta2 exhibits higher ligand-independent transcriptional activity than the A/B regions of TRalpha1 or TRbeta1. Thus, we examined the role of the A/B domain and the LBD of rat TRbeta2 in integrating the transcriptional activation function of the A/B and LBD domains by different coactivators. Both domains are essential for a productive functional interaction with cAMP response element-binding protein (CREB)-binding protein (CBP), and we found that CBP binds to the A/B domain of TRbeta2 in vitro. In contrast, steroid receptor coactivator-1a (SRC-1a) interacts strongly with the LBD but not the A/B domain. The coactivator NRC (nuclear receptor coactivator) interacts primarily with the LBD, although a weak interaction with the A/B domain further enhances ligand-dependent binding with TRbeta2. Our studies document the interplay between the A/B domain and the LBD of TRbeta2 in recruiting different coactivators to the receptor. Because NRC and SRC-1a bind CBP, and CBP enhances ligand-dependent activity, our studies suggest a model in which coactivator recruitment of NRC (or SRC-1a) occurs primarily through the LBD whereas the complex is further stabilized through an interaction of CBP with the N terminus of TRbeta2.
    Mesh-Begriff(e) Animals ; Binding Sites ; CREB-Binding Protein/genetics ; CREB-Binding Protein/metabolism ; Gene Deletion ; HeLa Cells ; Histone Acetyltransferases ; Humans ; Ligands ; Mutation/genetics ; Nuclear Receptor Coactivator 1 ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Rats ; Thyroid Hormone Receptors beta/genetics ; Thyroid Hormone Receptors beta/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemische Substanzen Ligands ; Protein Isoforms ; Thyroid Hormone Receptors beta ; Transcription Factors ; CREB-Binding Protein (EC 2.3.1.48) ; Histone Acetyltransferases (EC 2.3.1.48) ; NCOA1 protein, human (EC 2.3.1.48) ; Nuclear Receptor Coactivator 1 (EC 2.3.1.48)
    Sprache Englisch
    Erscheinungsdatum 2006-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639167-9
    ISSN 1944-9917 ; 0888-8809
    ISSN (online) 1944-9917
    ISSN 0888-8809
    DOI 10.1210/me.2005-0437
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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