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Article ; Online: Understanding the pathophysiological changes via untargeted metabolomics in COVID-19 patients.

Doğan, Halef O / Şenol, Onur / Bolat, Serkan / Yıldız, Şeyma N / Büyüktuna, Seyit A / Sarıismailoğlu, Rağıp / Doğan, Kübra / Hasbek, Mürşit / Hekim, Süleyman N

Journal of medical virology

2020 Volume 93, Issue 4, Page(s) 2340–2349

Abstract: Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular responses of COVID-19. In this study, we aimed to determine the variation of ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular responses of COVID-19. In this study, we aimed to determine the variation of metabolites between healthy control and COVID-19 via the untargeted metabolomics method. Serum samples were obtained from 44 COVID-19 patients and 41 healthy controls. Untargeted metabolomics analyses were performed by the LC/Q-TOF/MS (liquid chromatography quadrupole time-of-flight mass spectrometry) method. Data acquisition, classification, and identification were achieved by the METLIN database and XCMS. Significant differences were determined between patients and healthy controls in terms of purine, glutamine, leukotriene D4 (LTD4), and glutathione metabolisms. Downregulations were determined in R-S lactoglutathione and glutamine. Upregulations were detected in hypoxanthine, inosine, and LTD4. Identified metabolites indicate roles for purine, glutamine, LTD4, and glutathione metabolisms in the pathogenesis of the COVID-19. The use of selective leukotriene D4 receptor antagonists, targeting purinergic signaling as a therapeutic approach and glutamine supplementation may decrease the severity and mortality of COVID-19.
MeSH term(s)	Adult ; Aged ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Chromatography, Liquid/methods ; Databases, Factual ; Female ; Humans ; Male ; Metabolome ; Metabolomics/methods ; Middle Aged ; Prospective Studies ; ROC Curve ; SARS-CoV-2/isolation & purification ; Tandem Mass Spectrometry/methods
Language	English
Publishing date	2020-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26716
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Zs.A 1320: Show issues

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Article ; Online: Metabolomic profiling in ankylosing spondylitis using time-of-flight mass spectrometry.

Doğan, Halef Okan / Şenol, Onur / Karadağ, Ahmet / Yıldız, Seyma Nur

Clinical nutrition ESPEN

2022 Volume 50, Page(s) 124–132

Abstract: Background & aims: Ankylosing spondylitis (AS) is an inflammatory disease associated with destructive changes in the skeleton and joints. The exact molecular mechanism of the disease has not been fully elucidated. This study aimed to determine metabolic ...

Abstract	Background & aims: Ankylosing spondylitis (AS) is an inflammatory disease associated with destructive changes in the skeleton and joints. The exact molecular mechanism of the disease has not been fully elucidated. This study aimed to determine metabolic differences between active AS patients and healthy controls to understand the molecular mechanism of AS. Patients and methods: The study included 38 subjects, comprising 18 patients with active AS and 20 healthy controls. Metabolic profiling of the plasma was performed using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS). Data acquisition, classification, and identification were achieved with the METLIN (https://metlin.scripps.edu/) database and XCMS (https://xcmsonline.scripps.edu). Results: Significant alterations were identified in the unsaturated fatty acids (FA), linoleic acid, alpha-linolenic acid, FA degradation, and FA biosynthesis pathways. Down -regulations were observed in phosphatidylcholine (PC) (16:0/0:0), beta-d-Fructose, stearic acid, trimipramine N-Oxide and muconic acid, and up-regulation were detected in PC (18:2/0:0), 3-Methylindole, palmitic acid (PA), alpha-Tocotrienol, and beta-d-glucopyranoside in active AS patients compared to the healthy control subjects. Conclusion: Pathway analysis revealed that dysregulation in FA metabolism is associated with AS, and therefore, modulation of diet according to PA and PC may be potential therapeutic targets.
MeSH term(s)	Biomarkers ; Humans ; Lipid Metabolism ; Mass Spectrometry ; Metabolomics/methods ; Spondylitis, Ankylosing
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2022.06.011
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Article ; Online: DYSREGULATED LEUKOTRIENE METABOLISM IN COVID-19 PATIENTS.

Doğan, Halef Okan / Budak, Mahir / Doğan, Kübra / Zararsız, Gözde Ertürk / Yerlitaş, Serra İlayda / Bolat, Serkan / Şenol, Onur / Büyüktuna, Seyit Ali / Pınarbaşı, Ergun / Sarıismailoğlu, Rağıp / Yavuz, Hayrettin

Japanese journal of infectious diseases

2023

Abstract: The aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need ... ...

Abstract	The aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and mRNA expressions of 5-LO, ALOX5AP and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. As compared to the control group, both non-ICU and ICU groups had lower levels of 5-LO and mRNA expression. ICU patients had lower levels of 5-LO and mRNA expression compared with non-ICU patients. The expression of CYSLTR1 mRNA was higher in patients compared to healthy controls. CYSLTR1 mRNA expression was found to be higher in ICU group than in non-ICU group. CYSLT levels were higher in the control group compared to both non-ICU and ICU patients. Due to the higher expressions of CYSLTR1 in patients than control group, selective leukotriene receptor blockers can be used as a treatment option. CYSLTR1 expressions were also higher in ICU group than non-ICU group. Thus, CYSLTR1 mRNA expression could be a promising biomarker of COVID-19 severity.
Language	English
Publishing date	2023-12-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2023.211
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Article ; Online: Mitochondrial Homeostasis and Mast Cells in Experimental Hepatic Ischemia-Reperfusion Injury of Rats.

Koc, Suleyman / Dogan, Halef Okan / Karatas, Ozhan / Erdogan, Mehmet Mustafa / Polat, Vural

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2022 Volume 33, Issue 9, Page(s) 777–784

Abstract: Background: Ischemia-reperfusion injury is a histopathological event and is an important cause of morbidity and mortality after hepatobiliary surgery. We aimed to investigate the protective effect of uridine on hepatic ischemia-reperfusion injury in ... ...

Abstract	Background: Ischemia-reperfusion injury is a histopathological event and is an important cause of morbidity and mortality after hepatobiliary surgery. We aimed to investigate the protective effect of uridine on hepatic ischemia-reperfusion injury in rats. Methods: The animals were divided into 4 groups (n = 8): group I (control), group II: ischemia-reperfusion (30 minutes ischemia and 120 minutes reperfusion), group III: ischemia-reperfusion+uridine (at the beginning of reperfusion), and group IV: ischemia-reperfusion+uridine (5 minutes before ischemia-reperfusion). Uridine was administered a single dose of 30 mg/kg IV. The 3 elements of the hepatoduodenal ligament (hepatic artery, portal vein, and biliary tract) were obliterated for 30 minutes. Then hepatic reperfusion was achieved for 120 minutes. Results: In the ischemia-reperfusion group, both liver tissues and serum chymase activity and high-temperature requirement A2 levels were higher. Severe central vein dilatation and congestion, widening sinusoidal range, diffuse necrotic hepatocytes and dense erythrocyte accumulation in sinusoids, and strongly inducible nitric oxide synthase expression were seen in the ischemia-reperfusion group. A clear improvement was seen in both uridine co-administration and pretreatment groups. Conclusion: Our results revealed that uridine limits the development of liver damage under conditions of ischemia-reperfusion, thus contributing to an increase in hepatocyte viability.
MeSH term(s)	Animals ; Chymases/metabolism ; Chymases/pharmacology ; Homeostasis ; Ischemia/complications ; Ischemia/metabolism ; Ischemia/pathology ; Liver/pathology ; Mast Cells ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type II/pharmacology ; Nitric Oxide Synthase Type II/therapeutic use ; Rats ; Reperfusion Injury ; Uridine/metabolism ; Uridine/pharmacology ; Uridine/therapeutic use
Chemical Substances	Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Chymases (EC 3.4.21.39) ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2022-08-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2022.21911
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Zs.A 4524: Show issues

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Article ; Online: [No title information]

Pazarci, Özhan / Doğan, Halef Okan / Kilinç, Seyran / Çamurcu, Ismet Yalkin

Turkish journal of medical sciences

2019 Volume 49, Issue 6, Page(s) 1774–1778

Abstract: Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and ...

Abstract	Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. The aim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guide for further research on the roles of these proteins in fracture healing. Materials and methods: A total of 34 patients (10 females, 24 males) with bone fractures and 32 controls (10 females, 22 males) participated in this study. After collecting serum venous blood samples, the quantitative sandwich ELISA technique was used for the determination of serum mTOR and SESN 1 levels. Results: The mean serum mTOR level was significantly higher in the fracture group compared to the control group (P = 0.001). However, SESN 1 levels did not significantly differ between groups (P = 0.913). Conclusion: We found that serum mTOR levels increased on the first day after fracture compared to the control group. However, we obtained no significant difference between groups in terms of SESN 1 levels. This study may guide further clinical studies investigating the potential role of mTOR signaling in the bone healing process.
MeSH term(s)	Adolescent ; Adult ; Case-Control Studies ; Female ; Fracture Healing/physiology ; Fractures, Bone/blood ; Heat-Shock Proteins/blood ; Heat-Shock Proteins/physiology ; Humans ; Male ; Middle Aged ; TOR Serine-Threonine Kinases/blood ; TOR Serine-Threonine Kinases/physiology ; Young Adult
Chemical Substances	Heat-Shock Proteins ; SESN1 protein, human ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2019-12-16
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-1809-117
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Zs.A 3242: Show issues

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Article ; Online: Evaluation of Serum Glucagon-Like Peptide 1 and Vitamin D Levels in Elderly Patients with Bone Fractures.

Pazarci, Özhan / Dogan, Halef Okan / Kilinc, Seyran / Çamurcu, Yalkin

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

2019 Volume 29, Issue 3, Page(s) 219–224

Abstract: Objectives: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures.: Materials and methods: This study included 56 patients and 31 control subjects. The patients ... ...

Abstract	Objectives: To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. Materials and methods: This study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups. Results: Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1. Conclusion: Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Fractures, Bone/epidemiology ; Glucagon-Like Peptide 1/blood ; Humans ; Ketone Bodies ; Male ; Vitamin D/blood
Chemical Substances	Ketone Bodies ; Vitamin D (1406-16-2) ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2019-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	645108-1
ISSN	1423-0151 ; 1011-7571
ISSN (online)	1423-0151
ISSN	1011-7571
DOI	10.1159/000502132
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Article: A novel therapeutic approach to NASH: Both polyethylene glycol 3350 and lactulose reduce hepatic inflammation in C57BL/6J mice.

Gokcen, Pinar / Ozturk, Oguzhan / Adali, Gupse / Tosun, Ilkay / Dogan, Halef Okan / Kara, Haki / Yalman, Yucel / Doganay, Hamdi Levent / Ozdil, Kamil

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2021 Volume 30, Issue 11, Page(s) 1167–1174

Abstract: Background: The gut-liver axis is one of the most emphasized topics in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Intestinal microbiota dysbiosis has been shown to be a predictor of disease severity and progression to fatty liver ... ...

Abstract	Background: The gut-liver axis is one of the most emphasized topics in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Intestinal microbiota dysbiosis has been shown to be a predictor of disease severity and progression to fatty liver disease. Therefore, research addressing gut-based therapies has become popular. Objectives: To investigate the effect of lactulose and polyethylene glycol 3350 (PEG 3350) in mice with induced obesity and NAFLD at a non-diarrheal dose. Material and methods: Thirty-six C57BL/6J male mice were divided into 6 groups. The first 2 groups (n = 6 each) were used as an induced obesity model (group A) and NAFLD model (group B) for 8 weeks. The remaining 24 animals were categorized into control diet group, high-fat diet (HFD) group, HFD + lactulose group, and HFD + PEG 3350 group. Serum and liver tissue samples were obtained for biochemical and histopathological analyses, respectively. Results: The HFD + lactulose treatment group displayed a significant decrease in liver weight (1.3 (1.3-1.4) kg compared to 1.8 (1.6-1.9) kg) and NAFLD activity score (NAS) (1.5 (1.0-3.0) compared to 5.0 (4.0-5.0), respectively; p = 0.0043, p = 0.0021) when compared with the HFD group. However, a decrease in body weight (35.0 (34.6-36.0) kg compared to 40.9 (34.7-41.9) kg) and hepatosteatosis (HS) rate (33.3% compared to 100.0%) were not statistically significant (p = 0.1796, p = 0.0606, respectively). The HFD + PEG 3350 treatment group showed a statistically significant decrease in body weight (32.4 (30.2-33.9) kg compared to 40.9 (34.7-41.9) kg), liver weight (1.5 (1.3-1.5) kg compared to 1.8 (1.6-1.9) kg), HS rate (16.7% compared to 100.0%) and NAS (0.5 (0.0-1.0) compared to 5.0 (4.0-5.0); p = 0.0086, p = 0.0086, p = 0.0151, and p = 0.0021, respectively) when compared with the HFD group. Conclusions: We demonstrated that non-diarrheal dose of lactulose and PEG 3350 reduced hepatic inflammation in mice with induced NAFLD. It was also observed that PEG 3350 decreased HS and body weight. We believe these mechanisms can be utilized as novel therapeutic approaches in NAFLD in prospective human studies.
MeSH term(s)	Animals ; Inflammation ; Lactulose ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/drug therapy ; Polyethylene Glycols ; Prospective Studies
Chemical Substances	Polyethylene Glycols (3WJQ0SDW1A) ; Lactulose (4618-18-2) ; polyethylene glycol 3350 (G2M7P15E5P)
Language	English
Publishing date	2021-10-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/140506
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Article ; Online: Presepsin Levels of Patients with Crimean-Congo Hemorrhagic Fever.

Demirpençe, Özlem / Doğan, Halef Okan / Erşan, Serpil / Şahin, Mehtap / Şahin, Hasan / Bakır, Mehmet

Japanese journal of infectious diseases

2016 Volume 69, Issue 6, Page(s) 505–509

Abstract: Levels of presepsin (a soluble cluster of differentiation subtype 14 [CD14]) are thought to increase in cases of bacterial infection. CD14 has also been found to play a role in the pathogenesis of various viral diseases. Crimean-Congo hemorrhagic fever ( ... ...

Abstract	Levels of presepsin (a soluble cluster of differentiation subtype 14 [CD14]) are thought to increase in cases of bacterial infection. CD14 has also been found to play a role in the pathogenesis of various viral diseases. Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arboviral infection. Our study focuses on presepsin levels as a biomarker for CCHF. Serum presepsin levels in a CCHF group (n = 59) and control group (n = 28) were compared. Patients with CCHF were classified according to severity grading score as having mild, moderate, or severe infection and were allocated to corresponding subgroups (groups 1, 2, and 3, respectively). Presepsin levels were measured in serum samples by using a commercial enzyme-linked immunosorbent assay kit. The mean presepsin levels in the CCHF group as a whole and the healthy group were found to be significantly different (1,499.46 ± 411.96 pg/ml and 430.68 ± 61.21 pg/ml, respectively). The mean presepsin levels of the CCHF subgroups (1, 2 and 3) and the healthy group were also found to be significantly different (1,204.53 ± 371.18, 1,464.21 ± 338.37, 2,007.36 ± 82.18, and 430.68 ± 61.21 pg/ml, respectively) (p < 0.05). We also found that as the severity of the disease increased, the presepsin level also increased. We postulate that the presepsin levels could be used as a supportive biomarker for diagnosis and follow-up of the disease.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Diagnostic Tests, Routine/methods ; Enzyme-Linked Immunosorbent Assay ; Female ; Hemorrhagic Fever, Crimean/diagnosis ; Hemorrhagic Fever, Crimean/pathology ; Humans ; Lipopolysaccharide Receptors/blood ; Male ; Middle Aged ; Peptide Fragments/blood ; Prospective Studies ; Serum/chemistry ; Severity of Illness Index ; Young Adult
Chemical Substances	Biomarkers ; Lipopolysaccharide Receptors ; Peptide Fragments ; presepsin protein, human
Language	English
Publishing date	2016-11-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2015.392
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Article ; Online: Decreased Chitotriosidase Activity and Levels in Familial Mediterranean Fever.

Doğan, Halef Okan / Omma, Ahmet / Turhan, Turan / Boğdaycıoğlu, Nihal / Karaaslan, Yaşar / Yavuz, Hayrettin / Demirpençe, Özlem / Aydın, Hüseyin / Bakır, Sevtap

Journal of Korean medical science

2016 Volume 31, Issue 12, Page(s) 1902–1906

Abstract: Different studies have demonstrated changes in chitotriosidase (ChT) activity and concentrations in multiple diseases. However, changes in ChT activity and concentrations have not been concurrently evaluated in patients with Familial Mediterranean Fever ( ...

Abstract	Different studies have demonstrated changes in chitotriosidase (ChT) activity and concentrations in multiple diseases. However, changes in ChT activity and concentrations have not been concurrently evaluated in patients with Familial Mediterranean Fever (FMF). In this study, we analyzed the changes in serum ChT activity and concentrations in patients with FMF. The study included a total of 80 patients with FMF and 80 healthy controls. ChT enzyme activity and concentrations were measured and then compared between the groups. ChT activity was measured by using fluorometric ELISA and ChT concentrations were measured by using colorimetric ELISA methods. The median ChT activity was 10.00 (6.00-15.00) nmol/mL/hr in the patients and 14.00 (6.25-20.75) nmol/mL/hr in the controls. There was a statistically significant difference in the ChT activity between the controls and patients (P = 0.027). The median ChT concentrations were 65.40 (46.20-84.92) pg/mL and 125.00 (75.72-143.95) pg/mL in the patients and controls, respectively (P < 0.001), which were expressed as median percentiles (25th-75th). Additionally, we found no correlation between C-reactive protein and ChT activity (P = 0.978, r = 0.003) and concentrations (P = 0.446, r = -0.87). Serum ChT enzyme activity and concentrations may not be considered as a biomarker in FMF patients taking colchicine. New studies are needed to evaluate the changes of enzyme activity and concentration in colchicine-negative patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; C-Reactive Protein/analysis ; Case-Control Studies ; Colchicine/therapeutic use ; Enzyme-Linked Immunosorbent Assay ; Familial Mediterranean Fever/blood ; Familial Mediterranean Fever/drug therapy ; Familial Mediterranean Fever/pathology ; Female ; Genotype ; Hexosaminidases/blood ; Hexosaminidases/genetics ; Hexosaminidases/metabolism ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Young Adult
Chemical Substances	C-Reactive Protein (9007-41-4) ; Hexosaminidases (EC 3.2.1.-) ; chitotriosidase (EC 3.2.1.-) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2016-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2016.31.12.1902
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Zs.B 3163: Show issues

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Article: Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs.

Dogan, Halef Okan / Ersan, Etem Erdal / Aydin, Hüseyin / Erdoğan, Serpil / Erşan, Serpil / Alişik, Murat / Bakir, Sevtap / Erel, Özcan / Koç, Derya

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

2017 Volume 16, Issue 1, Page(s) 39–45

Abstract: Objective: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in ... ...

Abstract	Objective: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs. Methods: Thirteen schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population. Results: The TAS ( Conclusion: These results may suggest that atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress via the inhibition of the formation of disulfide bonds. The study population number was one of the limitations of this study. Therefore, further studies are needed to establish the association between thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.
Language	English
Publishing date	2017-11-27
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2211550-X
ISSN	1738-1088
ISSN	1738-1088
DOI	10.9758/cpn.2018.16.1.39
Database	MEDical Literature Analysis and Retrieval System OnLINE

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