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Article ; Online: DAN: Deep-Attention Network for 3D Shape Recognition.

Nie, Weizhi / Zhao, Yue / Song, Dan / Gao, Yue

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2021 Volume 30, Page(s) 4371–4383

Abstract: ... attention network (DAN) for 3D shape representation based on multiview information. More specifically ... aspects: 1) information selection, in which DAN utilizes the self-attention mechanism to update ... in which DAN applies attention mechanism that can save more effective information by considering ...

Abstract	Due to the wide applications in a rapidly increasing number of different fields, 3D shape recognition has become a hot topic in the computer vision field. Many approaches have been proposed in recent years. However, there remain huge challenges in two aspects: exploring the effective representation of 3D shapes and reducing the redundant complexity of 3D shapes. In this paper, we propose a novel deep-attention network (DAN) for 3D shape representation based on multiview information. More specifically, we introduce the attention mechanism to construct a deep multiattention network that has advantages in two aspects: 1) information selection, in which DAN utilizes the self-attention mechanism to update the feature vector of each view, effectively reducing the redundant information, and 2) information fusion, in which DAN applies attention mechanism that can save more effective information by considering the correlations among views. Meanwhile, deep network structure can fully consider the correlations to continuously fuse effective information. To validate the effectiveness of our proposed method, we conduct experiments on the public 3D shape datasets: ModelNet40, ModelNet10, and ShapeNetCore55. Experimental results and comparison with state-of-the-art methods demonstrate the superiority of our proposed method. Code is released on https://github.com/RiDang/DANN.
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2021.3071687
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Article ; Online: Qi-dan-dihuang decoction ameliorates renal fibrosis in diabetic rats via p38MAPK/AKT/mTOR signaling pathway.

Kuang, Liuyan / You, Yanting / Qi, Jieying / Chen, Jieyu / Zhou, Xinghong / Ji, Shuai / Cheng, Jingru / Kwan, Hiu Yee / Jiang, Pingping / Sun, Xiaomin / Su, Mengting / Wang, Ming / Chen, Wenxiao / Luo, Ren / Zhao, Xiaoshan / Zhou, Lin

Environmental toxicology

2024

Abstract: Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD ...

Abstract	Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. Objective: This study reveals the mechanism by which QDD ameliorates DKD. Materials and methods: The compounds in QDD were identified by high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Key targets and signaling pathways were screened through bioinformatics. Nondiabetic Lepr db/m mice were used as control group, while Lepr db/db mice were divided into model group, dapagliflozin group, 1% QDD-low (QDD-L), and 2% QDD-high (QDD-H) group. After 12 weeks of administration, 24 h urinary protein, serum creatinine, and blood urea nitrogen levels were detected. Kidney tissues damage and fibrosis were evaluated by pathological staining. In addition, 30 mmol/L glucose-treated HK-2 and NRK-52E cells to induce DKD model. Cell activity and migration capacity as well as protein expression levels were evaluated. Results: A total of 46 key target genes were identified. Functional enrichment analyses showed that key target genes were significantly enriched in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, in vivo and in vitro experiments confirmed that QDD ameliorated renal fibrosis in diabetic mice by resolving inflammation and inhibiting the epithelial-mesenchymal transition (EMT) via the p38MAPK and AKT-mammalian target of rapamycin (mTOR) pathways. Discussion and conclusion: QDD inhibits EMT and the inflammatory response through the p38MAPK and AKT/mTOR signaling pathways, thereby playing a protective role in renal fibrosis in DKD.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24179
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Article: Babao Dan decreases hepatocarcinogenesis by inhibiting hepatic progenitor cells malignant transformation via down-regulating toll-like receptor 4.

Liang, Lei / Zhang, Lu-Yao / Liu, Wen-Ting / Zong, Chen / Gao, Lu / Li, Rong / Zhao, Qiu-Dong / Zhao, Na-Ping / Wei, Li-Xin / Zhang, Li / Han, Zhi-Peng

Frontiers in oncology

2023 Volume 13, Page(s) 1073859

Abstract: Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used ...

Abstract	Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the effect of BBD on the incidence of diethylnitrosamine (DEN)-initiated hepatocellular carcinoma formation in rats and explored its possible mechanism. Methods: To verify this hypothesis, BBD was administrated to rats at a dose of 0.5g/kg body weight per two days from the 9th to 12th week in HCC-induced by DEN. Liver injury biomarkers and hepatic inflammatory parameters were evaluated by histopathology as well as serum and hepatic content analysis. We applied immunohistochemical analysis to investigate the expression of CK-19 and SOX-9 in liver tissues. The expression of TLR4 was determined by immunohistochemical, RT-PCR, and western blot analysis. Furthermore, we also detected the efficacy of BBD against primary HPCs neoplastic transformation induced by LPS. Results: We observed that DEN could induce hepatocarcinogenesis, and BBD could obviously decrease the incidence. The biochemical and histopathological examination results confirmed that BBD could protect against liver injury and decrease inflammatory infiltration. Immunohistochemistry staining results showed that BBD could effectively inhibit the ductal reaction and the expression of TLR4. The results showed that BBD-serumcould obviously inhibit primary HPCs neoplastic transformation induced by regulating the TLR4/Ras/ERK signaling pathway. Conclusion: In summary, our results indicate that BBD has potential applications in the prevention and treatment of HCC, which may be related to its effect on hepatic progenitor cells malignant transformation via inhibiting the TLR4/Ras/ERK signaling pathway.
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1073859
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Article: Safety evaluation of Balanced Health Care Dan-A medicinal formulation containing traditional edible ingredients in lung tumor-loaded mice.

Dong, Feng / Zhao, Changhui / He, Xiaoyun / Dong, Yueyang / Liu, Haiyan / Yao, Peng / Xu, Wentao

Food science & nutrition

2022 Volume 11, Issue 3, Page(s) 1544–1552

Abstract: ... not well studied. In this research, the edible safety assessment of Balanced Health Care Dan ... Health Care Dan (200 mg/kg or 400 mg/kg b.w. in gavage feeding) for 4 weeks. The body weight, blood parameters ... intestinal microbiota that are associated with many diseases. Balanced Health Care Dan modified the gut ...

Abstract	Chinese formulation-based medicinal food has been widely used in clinical trials, but its safety is not well studied. In this research, the edible safety assessment of Balanced Health Care Dan-a formulation containing traditional edible ingredients that were initially formulated to reduce side effects for lung cancer patients-was studied in mice based on biochemical and gut microbial analyses. The experimental mice were subcutaneously loaded with lung tumor A549 cells and then administrated with Balanced Health Care Dan (200 mg/kg or 400 mg/kg b.w. in gavage feeding) for 4 weeks. The body weight, blood parameters, and pathogenic phenotype in tissues were examined. No toxicological symptom was found in experimental mice compared with the normal control. Comprehensive analyses were also conducted to evaluate intestinal microbiota that are associated with many diseases. Balanced Health Care Dan modified the gut microbiota structure in a positive way. In conclusion, the Chinese formulation-based medicinal food has shown no toxicological effect in mice within 4 weeks of feeding experiment and has the potential to be used in clinical trials.
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3195
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Article ; Online: DAN-SuperPoint: Self-Supervised Feature Point Detection Algorithm with Dual Attention Network.

Li, Zhaoyang / Cao, Jie / Hao, Qun / Zhao, Xue / Ning, Yaqian / Li, Dongxing

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 5

Abstract: In view of the poor performance of traditional feature point detection methods in low-texture situations, we design a new self-supervised feature extraction network that can be applied to the visual odometer (VO) front-end feature extraction module based ...

Abstract	In view of the poor performance of traditional feature point detection methods in low-texture situations, we design a new self-supervised feature extraction network that can be applied to the visual odometer (VO) front-end feature extraction module based on the deep learning method. First, the network uses the feature pyramid structure to perform multi-scale feature fusion to obtain a feature map containing multi-scale information. Then, the feature map is passed through the position attention module and the channel attention module to obtain the feature dependency relationship of the spatial dimension and the channel dimension, respectively, and the weighted spatial feature map and the channel feature map are added element by element to enhance the feature representation. Finally, the weighted feature maps are trained for detectors and descriptors respectively. In addition, in order to improve the prediction accuracy of feature point locations and speed up the network convergence, we add a confidence loss term and a tolerance loss term to the loss functions of the detector and descriptor, respectively. The experiments show that our network achieves satisfactory performance under the Hpatches dataset and KITTI dataset, indicating the reliability of the network.
MeSH term(s)	Algorithms ; Reproducibility of Results
Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22051940
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Article: Dan Bai Xiao Formula combined with glucocorticoids and cyclophosphamide for pediatric lupus nephritis: A pilot prospective study.

Cao, Tong-Tong / Chen, Li / Zhen, Xiao-Fang / Zhao, Gao-Jie / Zhang, Hui-Fang / Hu, Yan

World journal of clinical cases

2021 Volume 10, Issue 31, Page(s) 11391–11402

Abstract: ... Aim: To evaluate whether Dan Bai Xiao Formula (DBXF) can reduce the exposure to GCs and ...

Abstract	Background: Patients with lupus nephritis (LN) typically undergo long-term treatment with glucocorticoids (GCs) and immunosuppressants. There is a growing demand for optimal therapy with better remission results and fewer side effects. Sustained traditional Chinese medicine (TCM) might be quite valuable for multitarget therapy, reducing the total dosage of GCs and minimizing the side effects of immunosuppressants. Aim: To evaluate whether Dan Bai Xiao Formula (DBXF) can reduce the exposure to GCs and cyclophosphamide (CYC) and to assess the efficacy and safety of DBXF for the resolution of proteinuria and hematuria in children with LN. Methods: A 24-wk pilot study was conducted at Beijing Children's Hospital. Children with active LN were divided into either a TCM group or a control group. Children in the TCM group received DBXF combined with GCs and CYC, and the ones in the control group received GCs and CYC every 4 wk for 24 wk. The primary endpoints of this trial were urinary protein excretion of < 150 mg/d and normal serum albumin concentration and renal function. Results: The trial included 78 children, of whom 38 received GCs and CYC treatment (control group) and the remaining 40 received DBXF combined with GCs and CYC treatment (TCM group). At week 24, the TCM group showed a better rate of complete remission (42.5%); however, there was no significant difference compared with the control group (31.5%, Conclusion: The findings suggest that DBXF treatment is effective and safe as a supplementary therapy for LN and is superior to routine GC and CYC therapy. DBXF containing combination treatment possibly results in a faster resolution of proteinuria and hematuria, smoother GC reduction, fewer methylprednisolone pulses, and fewer adverse events.
Language	English
Publishing date	2021-05-28
Publishing country	United States
Document type	Clinical Trial
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i31.11391
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Article ; Online: Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through Regulating the Gut Microbiota and Serum Metabolism.

Xie, Xuehua / Liao, Jiabao / Ai, Yuanliang / Gao, Jinmei / Zhao, Jie / Qu, Fei / Xu, Chao / Zhang, Zhaiyi / Wen, Weibo / Cui, Huantian / Wang, Hongwu

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 748872

Abstract: Pi-Dan-Jian-Qing decoction (PDJQ) can been used in the treatment of type 2 diabetes mellitus (T2DM ...

Abstract	Pi-Dan-Jian-Qing decoction (PDJQ) can been used in the treatment of type 2 diabetes mellitus (T2DM) in clinic. However, the protective mechanisms of PDJQ on T2DM remain unknown. Recent studies have shown that the changes in gut microbiota could affect the host metabolism and contribute to progression of T2DM. In this study, we first investigated the therapeutic effects of PDJQ on T2DM rats. 16S rRNA sequencing and untargeted metabolomics analyses were used to investigate the mechanisms of action of PDJQ in the treatment of T2DM. Our results showed that PDJQ treatment could improve the hyperglycemia, hyperlipidemia, insulin resistance (IR) and pathological changes of liver, pancreas, kidney, and colon in T2DM rats. PDJQ could also decrease the levels of pro-inflammatory cytokines and inhibit the oxidative stress. 16S rRNA sequencing showed that PDJQ could decrease the
MeSH term(s)	Animals ; Diabetes Mellitus, Type 2/drug therapy ; Dysbiosis ; Gastrointestinal Microbiome ; Hyperglycemia ; RNA, Ribosomal, 16S/genetics ; Rats
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-12-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.748872
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Article ; Online: The effect and mechanism of Qingre Huashi formula in the treatment of chronic hepatitis B with Gan-dan-shi-Re syndrome: An integrated transcriptomic and targeted metabolomic analysis.

Lu, Yiyu / Zhao, Chaoqun / Wang, Chengbao / Cai, Hong / Hu, Yuting / Chen, Long / Yu, Shanghai / Zhu, Huiming / Liu, Ping / Wan'e, Wang / Zhang, Hua

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 1, Page(s) 117092

Abstract: ... for the treatment of Gan-Dan-Shi-Re syndrome (GDSR) syndrome in traditional Chinese medicine (TCM). GDSR is one ...

Abstract	Ethnopharmacological relevance: Qingre Huashi (QRHS) formula is an empirical prescription for the treatment of Gan-Dan-Shi-Re syndrome (GDSR) syndrome in traditional Chinese medicine (TCM). GDSR is one of the typical TCM syndromes in chronic hepatitis B (CHB). However, little is known about the mechanism of the QRHS formula in treating CHB patients with GDSR. The biological basis of GDSR also remains largely unknown. Aim of the study: GDSR mostly occurs in the acute and early stages of chronic liver disease. Effectively alleviating GDSR stalls disease development and benefits patients. The purpose of this study was to explore the molecular basis of GDSR in CHB and then study the mechanism of the QRHS formula treating GDSR using transcriptomics and metabolomics. Materials and methods: The transcriptome and metabolome of CHB patients with GDSR syndrome were detected using RNA microarray combined with ultra-high performance liquid chromatography/mass spectrometry and information mining. The potential biomarkers were identified from differentially expressed genes and metabolites, and the metabolic pathway was analyzed. We also investigated the callback of metabolic biomarkers after treatment with the QRHS formula, an empirical prescription for the treatment of GDSR syndrome. RT-PCR analysis was carried out in an independent patient cohort of CHB for validation. Results: Four candidate genes-GPT2, HK2, DDIT3, and HIF1A-and 14 candidate metabolic biomarkers, including L-alpha-aminobutyric acid, selenomethionine, and fructose 1,6-bisphosphate, were identified and validated. All four transcripts of GPT2, HK2, DDIT3, and HIF1A were significantly differentially expressed between the GDSR and non-GDSR groups through independent microarray data and RT-PCR. After treatment with the QRHS formula, the clinical indexes and TCM syndrome were significantly improved, and the 14 disturbed biomarkers were obviously corrected. Three metabolic pathways were confirmed to be perturbed in CHB GDSR patients: alanine, aspartate, and glutamate metabolism, arginine biosynthesis, and aminoacyl-tRNA biosynthesis. Conclusion: Using integrated transcriptomic and targeted metabolomic methods, we identified the potential biomarkers and dysregulated metabolic pathways in CHB patients with GDSR syndrome, which was alleviated by the QRHS formula treatment. These results may provide the mechanism of metabolic dysregulation in GDSR syndrome as well as that underlying the curative effect of the QRHS formula.
MeSH term(s)	Humans ; Transcriptome ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/genetics ; Metabolomics/methods ; Medicine, Chinese Traditional/methods ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/metabolism ; Biomarkers
Chemical Substances	Drugs, Chinese Herbal ; Biomarkers
Language	English
Publishing date	2023-08-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117092
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Zs.A 1494: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A multiomics and network pharmacological study reveals the neuroprotective efficacy of Fu-Fang-Dan-Zhi tablets against glutamate-induced oxidative cell death.

Gu, Yu / Huang, Pengli / Cheng, Taofang / Yang, Jian / Wu, Gaosong / Sun, Yuting / Liu, Aijun / Li, Houkai / Zhao, Jing / Ye, Ji

Computers in biology and medicine

2022 Volume 148, Page(s) 105873

Abstract: ... still insufficient. The Fu-Fang-Dan-Zhi tablet (FFDZT) is a proprietary Chinese medicine clinically ...

Abstract	Neuroprotective therapy after ischemic stroke remains a significant need, but current measures are still insufficient. The Fu-Fang-Dan-Zhi tablet (FFDZT) is a proprietary Chinese medicine clinically employed to treat ischemic stroke in the recovery period. This work aims to systematically investigate the neuroprotective mechanism of FFDZT. A systems strategy that integrated metabolomics, transcriptomics, network pharmacology, and in vivo and in vitro experiments was used. First, middle cerebral artery occlusion (MCAO) model rats were treated with FFDZT. FFDZT treatment significantly reduced the infarct volume in the brains of middle cerebral artery occlusion (MCAO) model rats. Then, samples of serum and brain tissue were taken for metabolomics and transcriptomics studies, respectively; gene expression profiles of MCF7 cells treated with FFDZT and its 4 active compounds (senkyunolide I, formononetin, drilodefensin, and tanshinone IIA) were produced for CMAP analysis. Computational analysis of metabolomics and transcriptomics results suggested that FFDZT regulated glutamate and oxidative stress-related metabolites (2-hydroxybutanoic acid and 2-hydroxyglutaric acid), glutamate receptors (NMDAR, KA, and AMPA), glutamate involved pathways (glutamatergic synapse pathway; d-glutamine and d-glutamate metabolism; alanine, aspartate and glutamate metabolism), as well as the reactive oxygen species metabolic process. CMAP analysis indicated that two active ingredients of FFDZT (tanshinone ⅡA and senkyunolide I) could act as glutamate receptor antagonists. Next, putative therapeutic targets of FFDZT's active ingredients identified in the brain were collected from multiple resources and filtered by statistical criteria and tissue expression information. Network pharmacological analysis revealed extensive interactions between FFDZT's putative targets, anti-IS drug targets, and glutamate-related enzymes, while the resulting PPI network exhibited modular topology. The targets in two of the modules were significantly enriched in the glutamatergic synapse pathway. The interactions between FFDZT's ingredients and important targets were verified by molecular docking. Finally, in vitro experiments validated the effects of FFDZT and its ingredients in suppressing glutamate-induced PC12 cell injury and reducing the generation of reactive oxygen species. All of our findings indicated that FFDZT's efficacy for treating ischemic stroke could be due to its neuroprotection against glutamate-induced oxidative cell death.
MeSH term(s)	Animals ; Cell Death ; Drugs, Chinese Herbal ; Glutamic Acid ; Infarction, Middle Cerebral Artery ; Ischemic Stroke ; Molecular Docking Simulation ; Neuroprotection ; Oxidative Stress ; Rats ; Reactive Oxygen Species ; Tablets
Chemical Substances	Drugs, Chinese Herbal ; Reactive Oxygen Species ; Tablets ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2022-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2022.105873
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Zs.A 653: Show issues

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Article: Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.

Zhao, Jinyan / Lan, Weilan / Peng, Jun / Guan, Bin / Liu, Jie / Zhang, Min / Zhan, Zhixue / Lin, Jiumao

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 5631942

Abstract: Multidrug resistance (MDR) is a critical reason for cancer chemotherapy failure. Babaodan (BBD) is a famous traditional Chinese patent medicine reported to have antigastric cancer activity. However, the roles and molecular mechanisms of the reversal of ... ...

Abstract	Multidrug resistance (MDR) is a critical reason for cancer chemotherapy failure. Babaodan (BBD) is a famous traditional Chinese patent medicine reported to have antigastric cancer activity. However, the roles and molecular mechanisms of the reversal of MDR of gastric cancer by BBD have not been well described until now. Therefore, the purpose of this study was to elucidate further the role of BBD in reversing the MDR of gastric cancer cells and its specific regulatory mechanism via
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/5631942
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Zs.A 5995: Show issues

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