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  1. Article: Durability, household usage and washing pattern of DuraNet

    Sharma, S K / Yadav, R S / Srivastava, H C / Bhatt, R M / Pant, C S / Haque, M A / Sreehari, U / Raghavendra, K

    Journal of vector borne diseases

    2022  Volume 58, Issue 3, Page(s) 219–227

    Abstract: Background & objectives: Universal coverage of population with long-lasting insecticidal nets (LLINs) living in endemic areas inhabited by ethnic tribal communities or in difficult to reach areas was found effective for disease control where other ... ...

    Abstract Background & objectives: Universal coverage of population with long-lasting insecticidal nets (LLINs) living in endemic areas inhabited by ethnic tribal communities or in difficult to reach areas was found effective for disease control where other interventions such as indoor residual spraying have limited success because of operational issues. Evaluation of different LLINs with varied insecticides and fabrics are being evaluated to meet the demand of new products. This study was undertaken on two brands of LLINs, DuraNet© and Interceptor® that varied in fabric and manufacturing technologies to assess the usability in field conditions for atleast three years.
    Methods: In large-scale field trials DuraNet©, alpha cypermethrin incorporated polyethylene net, was evaluated in Odisha state while, Interceptor® net, alpha cypermethrin coated polyester net was evaluated in Chhattisgarh and Gujarat states for a period of three years following WHO guidelines. Durability, usage pattern and washing behavior were monitored through periodic surveys and physical examination of nets.
    Results: Survivorship of both the nets was 84-100% and every night usage rate was >62% in all seasons. Washing frequency was largely within the prescribed limits. The proportion of DuraNet© with holes was 26.7% in year one 74% in year three. In Gujarat, proportion of Interceptor® nets with holes at six months was 33.3% increased to 87% in year three and in Chhattisgarh, 6.7% after six months to 93.3% after three years of use respectively.
    Interpretation & conclusion: Both the nets revealed a useful life of three years under the field condition.
    MeSH term(s) Humans ; India ; Insecticide-Treated Bednets ; Insecticides/pharmacology ; Macrolides ; Malaria/prevention & control ; Mosquito Control
    Chemical Substances Insecticides ; Macrolides ; milbemycin oxime (0502PUN0GT)
    Language English
    Publishing date 2022-02-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2161218-3
    ISSN 0972-9062
    ISSN 0972-9062
    DOI 10.4103/0972-9062.328974
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  2. Article ; Online: Adipokine Visfatin's Role in Pathogenesis of Diabesity and Related Metabolic Derangements.

    Kumari, B / Yadav, U C S

    Current molecular medicine

    2018  Volume 18, Issue 2, Page(s) 116–125

    Abstract: Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo ...

    Abstract Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokines including visfatin. Visfatin, which also acts as an enzyme nicotinamide phosphoribosyl transferase, is one of the prominent adipokines that influence metabolic homeostasis in the body. Visfatin exists in two forms, extracellular and intracellular, and enacts a multitude of actions. The direct and indirect evidence gathered from in-vitro, in-vivo and clinical studies indicate that visfatin modulates obesity and metabolic syndrome-related pathophysiological activities including enhanced inflammation, angiogenesis, synthesis of NAD mononucleotide, and upregulation of antiapoptotic proteins in a number of cell types. It has been implicated in a number of obesity-related alterations and metabolic derangement such as diabetes, cardiovascular complications and some forms of cancers. In this review, the novel hypothesis about the role of visfatin in diabesity has been proposed which implies recent advances in studies about the pathophysiological roles of visfatin during obesity and chronic high glucose in the circulation. Visfatin at high concentration attracts immune cells and produces chronic inflammation in adipocytes. Additionally, it induces insulin resistance in many tissues and causes pancreatic beta cells dysfunction at later stages. Further, its potential as an important target to develop molecular medicine in diabesity and related metabolic syndrome has been highlighted.
    MeSH term(s) Adipocytes/metabolism ; Adipokines/genetics ; Adipokines/metabolism ; Adipose Tissue/metabolism ; Animals ; Apoptosis/genetics ; Apoptosis/immunology ; Biomarkers ; Cytokines/genetics ; Cytokines/metabolism ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/etiology ; Diabetes Mellitus/metabolism ; Disease Susceptibility ; Glucose ; Humans ; Immunity/genetics ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Molecular Targeted Therapy ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/genetics ; Nicotinamide Phosphoribosyltransferase/metabolism ; Signal Transduction/drug effects
    Chemical Substances Adipokines ; Biomarkers ; Cytokines ; NAD (0U46U6E8UK) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; nicotinamide phosphoribosyltransferase, human (EC 2.4.2.12) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2064873-X
    ISSN 1875-5666 ; 1566-5240
    ISSN (online) 1875-5666
    ISSN 1566-5240
    DOI 10.2174/1566524018666180705114131
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  3. Article ; Online: Thermal screening.

    Kumar, U / Parmar, P / Kaur, C K / Yadav, S / Rajpu, A

    British dental journal

    2020  Volume 229, Issue 3, Page(s) 148

    MeSH term(s) Body Temperature ; Dentistry ; Humans ; Mass Screening
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-020-2005-9
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  4. Article: Elucidation of the population structure and genetic diversity of

    Keerthana, U / Phalguni, M / Prabhukarthikeyan, S R / Naveenkumar, R / Yadav, Manoj K / Parameswaran, C / Baite, Mathew S / Raghu, S / Reddy, Madem Gurivi / Harish, S / Panneerselvam, P / Rath, P C

    3 Biotech

    2022  Volume 12, Issue 10, Page(s) 281

    Abstract: Brown spot disease, caused by : Supplementary information: The online version contains supplementary material available at 10.1007/s13205-022-03347-4. ...

    Abstract Brown spot disease, caused by
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-022-03347-4.
    Language English
    Publishing date 2022-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-022-03347-4
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  5. Article ; Online: In vitro and in silico investigation of glycyrrhizic acid encapsulated zein nanoparticles: A synergistic targeted drug delivery approach for breast cancer.

    Srivastav, Amit Kumar / Rajput, Pradeep Kumar / Jaiswal, Jyoti / Yadav, Umesh C S / Kumar, Umesh

    International journal of biological macromolecules

    2024  Volume 266, Issue Pt 2, Page(s) 131368

    Abstract: This study presents an innovative approach for targeted drug delivery through the development of Glycyrrhizic acid-loaded zein nanoparticles (GA-LNPs) as a proficient carrier system. The juxtaposition of zein, a hydrophobic biological macromolecule as a ... ...

    Abstract This study presents an innovative approach for targeted drug delivery through the development of Glycyrrhizic acid-loaded zein nanoparticles (GA-LNPs) as a proficient carrier system. The juxtaposition of zein, a hydrophobic biological macromolecule as a protein carrier, and Glycyrrhizic acid (GA), a hydrophilic therapeutic compound, exemplifies the adaptability of hydrocolloids within cutting-edge drug delivery systems. The characterization and functional traits of research encompass multifaceted analyses of natural macromolecules, which elucidate the homogeneous and spherical morphology of GA-LNPs with an average size of 170.49 nm. The controlled drug release profile of GA, orchestrated under simulated gastrointestinal conditions, adheres to diffusion-based Higuchi kinetics, reflecting the controlled release of the natural macromolecules. The intermolecular interactions among Zein, GA, and cross-linker EDC, facilitated through molecular dynamics simulations, fortify the structural integrity of the encapsulation matrix. In Vitro studies revealed enhanced cellular uptake of GA-LNPs in MCF-7 breast cancer cells. This cellular internalization was further confirmed through cytotoxicity assessments using MTT and apoptosis assays (fluorescence microscopy), which demonstrated the prominent anticancer effects of GA-LNPs on MCF-7 in time/dose-dependent manner. The successful formulation of GA-LNPs, coupled with their sustained release and potent anticancer properties, makes them a potential platform for advanced targeted therapeutic strategies in biomedical applications.
    Language English
    Publishing date 2024-04-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131368
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  6. Article ; Online: Lipoate protein ligase B primarily recognizes the C

    Dhembla, Chetna / Yadav, Usha / Kundu, Suman / Sundd, Monica

    The Journal of biological chemistry

    2022  Volume 298, Issue 8, Page(s) 102203

    Abstract: ... of lipoate protein ligase B (LipB) and lipoyl synthase (LipA). LipB takes up the octanoyl chain from C ...

    Abstract Lipoic acid is a sulfur-containing cofactor indispensable for the function of several metabolic enzymes. In microorganisms, lipoic acid can be salvaged from the surroundings by lipoate protein ligase A (LplA), an ATP-dependent enzyme. Alternatively, it can be synthesized by the sequential actions of lipoate protein ligase B (LipB) and lipoyl synthase (LipA). LipB takes up the octanoyl chain from C
    MeSH term(s) Acyl Carrier Protein/metabolism ; Acyltransferases/chemistry ; Acyltransferases/metabolism ; Coenzyme A/metabolism ; Escherichia coli/chemistry ; Escherichia coli/enzymology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Ligases/metabolism ; Pantetheine/analogs & derivatives ; Thioctic Acid/metabolism
    Chemical Substances Acyl Carrier Protein ; Escherichia coli Proteins ; Pantetheine (496-65-1) ; Thioctic Acid (73Y7P0K73Y) ; Acyltransferases (EC 2.3.-) ; LipB protein, E coli (EC 2.3.1.-) ; Ligases (EC 6.-) ; 4'-phosphopantetheine (NM39WU8OFM) ; Coenzyme A (SAA04E81UX)
    Language English
    Publishing date 2022-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102203
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  7. Article: Thermo-hydraulic and exergetic performance of a cost-effective solar air heater: CFD and experimental study

    Nidhul, Kottayat / Yadav, Ajay Kumar / Anish, S. / Arunachala, U.C.

    Renewable energy. 2022 Jan., v. 184

    2022  

    Abstract: An experimental and computational fluid dynamics (CFD) study is carried out to investigate the impact of secondary flow strengthening the thermo-hydraulic performance of discrete multiple inclined baffles in a flat plate solar air heater (SAH) with semi- ... ...

    Abstract An experimental and computational fluid dynamics (CFD) study is carried out to investigate the impact of secondary flow strengthening the thermo-hydraulic performance of discrete multiple inclined baffles in a flat plate solar air heater (SAH) with semi-cylindrical sidewalls. Initially, for a fixed relative baffle height (Rₕ = 0.1), the relative baffle pitch (Rₚ) for continuous baffles is varied in the range of 0.6–1 to obtain the optimum baffle pitch for 6000 <Re < 14000. The impact of gaps at leading, trailing, and both leading and trailing apices are studied as three different configurations with the optimum Rₚ. A maximum thermo-hydraulic performance of 2.69 is obtained for the gap at the trailing apex. The proposed design has a higher collector efficiency, 55–70%, compared to the ribbed rectangular SAH design exhibiting 30–55%. With lower exergy losses, the present SAH design has higher exergetic efficiency (1.5%–2.2%)than ribbed rectangular SAH (0.9%–1.7%) for the range of Re studied. Further, at low Re, the present SAH design has a higher coefficient of performance, indicating that it is cost-effective than ribbed rectangular SAH designs.<br />
    Keywords cost effectiveness ; exergy ; fluid mechanics ; solar heaters
    Language English
    Dates of publication 2022-01
    Size p. 627-641.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 1879-0682 ; 0960-1481
    ISSN (online) 1879-0682
    ISSN 0960-1481
    DOI 10.1016/j.renene.2021.11.111
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Boron carbide thin film surface characterization after graphitic carbon removal using low-pressure oxygen gas RF plasma.

    Yadav, Praveen K / Gupta, Raj Kumar / Gupta, Shruti / Mukherjee, C / Goutam, U K / Modi, Mohammed H

    Applied optics

    2023  Volume 62, Issue 5, Page(s) 1399–1405

    Abstract: ... ...

    Abstract B
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.482981
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  9. Article ; Online: Synthesis, physiochemical characterization, molecular docking study, and anti-breast cancer activity of silymarin loaded zein nanoparticles.

    Jaiswal, Jyoti / Rajput, Pradeep Kumar / Srivastav, Amit Kumar / Rao, Maddila Jagapathi / Yadav, Umesh C S / Kumar, Umesh

    International journal of biological macromolecules

    2024  Volume 264, Issue Pt 2, Page(s) 130679

    Abstract: Breast cancer is a major cause of death in women worldwide leading to requirement of new therapeutic strategies. Silymarin demonstrated the anti-cancer activity however, due to low bioavailability its use is restricted. This study aimed to improve the ... ...

    Abstract Breast cancer is a major cause of death in women worldwide leading to requirement of new therapeutic strategies. Silymarin demonstrated the anti-cancer activity however, due to low bioavailability its use is restricted. This study aimed to improve the solubility of silymarin by developing a silymarin loaded zein nanoparticles (SLNPs) which was stabilized by beta cyclodextrin. Comprehensive physiochemical characterization studies based on DLS, FTIR, UV-Vis Spectroscopy, FE-SEM, TEM, XRD, DSC, NMR and TGA confirmed the successful synthesis of SLNPs via an anti-solvent precipitation method. FE-SEM and TEM images demonstrated the uniform size and spherical shape of nanoparticles with encapsulation and loading efficiencies of 84.32 ± 1.9 % and 15.25 ± 2.4 % respectively. The zein protein interaction with silymarin, and β-cyclodextrin was shown to be beneficial via the use of molecular simulations and binding energy calculations. Cellular studies demonstrated dose and time dependent cytotoxicity of SLNPs on MCF-7 breast cancer cell. FACS, qRT-PCR and Western blotting showed Bax (pro-apoptotic) upregulation while Bcl-2 (anti-apoptotic) downregulation. Our findings suggest that these loaded nanoparticles are more efficient than pure drug, enhancing its bioavailability and paving the path for developing it as a promising nutraceutical to treat breast cancer.
    MeSH term(s) Female ; Humans ; Silymarin/pharmacology ; Silymarin/chemistry ; Zein/chemistry ; Molecular Docking Simulation ; Breast Neoplasms/drug therapy ; Nanoparticles/chemistry ; Particle Size
    Chemical Substances Silymarin ; Zein (9010-66-6)
    Language English
    Publishing date 2024-03-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130679
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  10. Article ; Online: Integrating Synthesis, Physicochemical Characterization, and In Silico Studies of Cordycepin-Loaded Bovine Serum Albumin Nanoparticles.

    Jaiswal, Jyoti / Srivastav, Amit Kumar / Rajput, Pradeep Kumar / Yadav, Umesh C S / Kumar, Umesh

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 32, Page(s) 12225–12236

    Abstract: Cordycepin gets rapidly metabolized in the body into inactive form due to its structural similarity to adenosine, thus inhibiting its development as a medicinal agent. This study was aimed to improve the solubility and stability of cordycepin, a ... ...

    Abstract Cordycepin gets rapidly metabolized in the body into inactive form due to its structural similarity to adenosine, thus inhibiting its development as a medicinal agent. This study was aimed to improve the solubility and stability of cordycepin, a potential drug with known antiproliferative activity, by encapsulating it in bovine serum albumin: β-cyclodextrin nanoparticles. Cordycepin-loaded nanoparticles (CLNPs) were synthesized using the antisolvent method and characterized thoroughly using various techniques. Our dynamic light scattering measurement showed a particle size and zeta potential of 160 ± 2.75 nm and -20.21 ± 2.1 mV, respectively, for CLNPs. Transmission electron microscopy studies revealed that particles were spherical in morphology. These CLNPs showed sustained release of cordycepin with encapsulation and loading efficiency of 81.62 ± 1.5 and 27.02 ± 2.0%, respectively, based on high-performance liquid chromatography and UV-vis studies. Based on differential scanning calorimetry and zeta potential studies, CLNPs improve cordycepin stability and solubility. Our molecular simulations and binding energy calculation also showed favorable protein interaction between cordycepin, bovine serum albumin, and β-cyclodextrin, further supporting the notion of improved stability. In vitro cytotoxicity, apoptosis, and cellular uptake studies on breast cancer cells showed that the synthesized nanoparticles had greater cytotoxicity as compared to free cordycepin.
    MeSH term(s) Serum Albumin, Bovine/chemistry ; Drug Carriers/chemistry ; Deoxyadenosines/pharmacology ; Nanoparticles/chemistry ; Particle Size
    Chemical Substances Serum Albumin, Bovine (27432CM55Q) ; cordycepin (GZ8VF4M2J8) ; Drug Carriers ; Deoxyadenosines
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c03608
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