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  1. Article ; Online: SARS, MERS and COVID-19, the story continues

    Mahmoodpoor, Ata

    Journal of Cellular & Molecular Anesthesia; Vol. 5 No.; 57-58 ; 2476-5120 ; 2538-2462

    2020  Volume 2, Issue : April 2020

    Abstract: Although the three viruses corona viruses (SARS-CoV: 2003, MERS-CoV: 2012 and SARS-CoV-2: 2019) have similarities especially regarding clinical features, there are key differences between them that limit the relevance of experiences from previous crises. ...

    Abstract Although the three viruses corona viruses (SARS-CoV: 2003, MERS-CoV: 2012 and SARS-CoV-2: 2019) have similarities especially regarding clinical features, there are key differences between them that limit the relevance of experiences from previous crises. Regarding treatment in the absence of vaccine, it is recommended an the first stage to use pharmaceuticals and their combinations (protease inhibitors, interferon compounds, antiviral antibodies) aiming to suppress diverse targets during virus propagation and during the second disease stage, it seems crucial and reasonable to rely on administration of pathogenetic drugs to restrict life threatening events resulting in marked inflammation, intoxication, hypoxia and infection. The most important method to prevent viral zoonosis is to maintain the barriers between natural reservoirs and human society.
    Keywords SARS ; MERS ; COVID-19 ; covid19
    Language English
    Publishing date 2020-07-02
    Publisher Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences
    Publishing country ir
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: SORT as any easy technique to do; but needs more trials to be as a routine practice.

    Sanaie, Sarvin / Mahmoodpoor, Ata

    Annals of intensive care

    2020  Volume 10, Issue 1, Page(s) 162

    Language English
    Publishing date 2020-12-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-00779-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management Of Patients With Stroke In Critical Care Units, Considering Osmotic Therapy And Hypothermia

    Ata Mahmoodpoor

    Advances in Bioscience and Clinical Medicine, Vol 0, Iss

    2017  

    Abstract: Cytotoxic brain edema is an early complication of stroke which increases the possibility of secondary ischemia. Hypertonic solutions, mannitol and recently hypertonic saline (HS) has been considered for treatment of increased ICP. HS could decrease ICP ... ...

    Abstract Cytotoxic brain edema is an early complication of stroke which increases the possibility of secondary ischemia. Hypertonic solutions, mannitol and recently hypertonic saline (HS) has been considered for treatment of increased ICP. HS could decrease ICP especially in hypotensive patients with different mechanisms, direct effect on edema, decreasing inflammation which is mediated by attenuation of TNFa and IL-1b stimulation on Na-K-Cl cotransporter 1 and improvement of microcirculation. Improvement of microcirculation is so important for hypertonic solutions to be effective in ischemia especially focal ischemia. Based on the literature, hypertonic saline is more effective in decreasing cerebral edema than the equal volume of mannitol. The optimal dose and duration of therapy needs more trials. Caution should be performed with patients with moderate size hemispheric infarcts on presentation, race and genetic factors regarding osmotic therapy. Hypothermia has been rated as one of the most active modes of neuroprotection based on the results of different trials. Hypothermia in both ways, surface and intravascular, decreases cerebral metabolic rate of O2 and glucose and reduces brain oxygen consumption, inflammation and oxidative stress. Recent data continue to support consideration of therapeutic hypothermia for cerebral ischemia in larger clinical trials of acute ischemic stroke. By increasing the time window to therapy initiation and decreasing the treatment duration, selective intracarotid cold saline administration brings increased feasibility, potentially better outcomes and perhaps fewer complications compared with the whole body cooling. Hypothermia is now recommended as a targeted temperature management with defined protocol which should be started early; it may be performed pharmacologically in combination with other therapies. Applying hypothermia should be considered regarding its cost, using in awaked patients, re-warming protocol, incorporation of thrombolysis and its complications.
    Keywords osmotic therapy ; hypothermia ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2017-02-01T00:00:00Z
    Publisher Australian International Academic Centre PTY.LTD.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Early application of prone position for management of Covid-19 patients.

    Golestani-Eraghi, Majid / Mahmoodpoor, Ata

    Journal of clinical anesthesia

    2020  Volume 66, Page(s) 109917

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Prone Position ; Respiratory Distress Syndrome ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2020.109917
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  5. Article: An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach.

    Mokhtari, Behnaz / Yavari, Rana / Badalzadeh, Reza / Mahmoodpoor, Ata

    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

    2022  Volume 2022, Page(s) 3277274

    Abstract: Sepsis is defined as a life-threatening organ failure due to dysregulated host response to infection. Despite current advances in our knowledge about sepsis, it is still considered as a major global health challenge. Myocardial dysfunction is a well- ... ...

    Abstract Sepsis is defined as a life-threatening organ failure due to dysregulated host response to infection. Despite current advances in our knowledge about sepsis, it is still considered as a major global health challenge. Myocardial dysfunction is a well-defined manifestation of sepsis which is related to worse outcomes in septic patients. Given that the heart is a mitochondria-rich organ and the normal function of mitochondria is essential for successful modulation of septic response, the contribution of mitochondrial damage in sepsis-related myocardial dysfunction has attracted the attention of many scientists. It is widely accepted that mitochondrial damage is involved in sepsis-related myocardial dysfunction; however, effective and potential treatment modalities in clinical setting are still lacking. Mitochondrial-based therapies are potential approaches in sepsis treatment. Although various therapeutic strategies have been used for mitochondrial function improvement, their effects are limited when mitochondria undergo irreversible alterations under septic challenge. Therefore, application of more effective approaches such as mitochondrial transplantation has been suggested. This review highlights the crucial role of mitochondrial damage in sepsis-related myocardial dysfunction, then provides an overview on mitochondrial-based therapies and current approaches to mitochondrial transplantation as a novel strategy, and proposes future directions for more researches in this field.
    Language English
    Publishing date 2022-06-06
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 1057056-1
    ISSN 1712-9532 ; 1180-2332
    ISSN 1712-9532 ; 1180-2332
    DOI 10.1155/2022/3277274
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  6. Article ; Online: Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response.

    Mokhtari, Behnaz / Hamidi, Masoud / Badalzadeh, Reza / Mahmoodpoor, Ata

    Molecular biology reports

    2022  Volume 50, Issue 3, Page(s) 2147–2158

    Abstract: Background: Sepsis-induced myocardial dysfunction is associated with worse clinical outcomes and high mortality, but no effective therapeutic intervention has been explored, reinforcing the urgent need to develop innovative strategies. Mitochondrial ... ...

    Abstract Background: Sepsis-induced myocardial dysfunction is associated with worse clinical outcomes and high mortality, but no effective therapeutic intervention has been explored, reinforcing the urgent need to develop innovative strategies. Mitochondrial dysfunction underlies the pathogenesis of sepsis-induced myocardial dysfunction. Herein, we assessed the effect of mitochondrial transplantation on sepsis-induced myocardial dysfunction in a rat model of cecal ligation and puncture (CLP)-induced sepsis.
    Methods: Male Wistar rats (n = 80, 12 weeks old, 250-300 g) were divided into groups with/without CLP-induced sepsis receiving mitochondrial transplantation in single or two repetitive injections (1 h or 1 and 7 h post-CLP, respectively). Mitochondria were isolated from donor rats and injected intravenously (400 µl of mitochondrial suspension containing 7.5 × 10
    Results: Mitotherapy significantly improved 72-hours survival (P < .05) and decreased LDH and cTn-I levels (P < .01). It also restored mitochondrial function and expression of mitochondrial biogenesis and fusion genes, and decreased the expression of mitochondrial fission gene and the levels of inflammatory cytokines (P < .05 to P < .01). Mitotherapy with repetitive injections at 1 and 7 h post-CLP provided noticeable mitoprotection in comparison with the group receiving mitotherapy at single injection.
    Conclusion: Mitotherapy improved mitochondrial function, biogenesis, and dynamic associated with SIRT-1/PGC-1α network and suppressed inflammatory response in CLP-induced sepsis model, therefore, offers a promising strategy to overcome life-threatening sepsis challenge.
    MeSH term(s) Rats ; Male ; Animals ; Rats, Wistar ; Organelle Biogenesis ; Mitochondria/metabolism ; Cardiomyopathies/metabolism ; Cytokines/metabolism ; Sepsis/complications ; Sepsis/therapy
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-12-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-08115-4
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    Zs.A 1140: Show issues Location:
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  7. Article ; Online: Immune Responses to the Novel Coronavirus-2: Friend or Foe?

    Mahmoodpoor, Ata / Nader, Nader D

    Immunological investigations

    2020  Volume 50, Issue 8, Page(s) 949–951

    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Cytokine Release Syndrome/epidemiology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/virology ; Humans ; Immunity ; Lung/immunology ; Lung/pathology ; Lung/virology ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/immunology ; Respiratory Distress Syndrome/virology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; Respiratory Mucosa/virology ; SARS-CoV-2/immunology ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Letter
    ZDB-ID 632565-8
    ISSN 1532-4311 ; 0882-0139
    ISSN (online) 1532-4311
    ISSN 0882-0139
    DOI 10.1080/08820139.2020.1795191
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    Zs.A 988: Show issues Location:
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  8. Article: Historical perspective of aspirin: A journey from discovery to clinical practice Ancient and modern history.

    Rezabakhsh, Aysa / Mahmoodpoor, Ata / Soleimanpour, Hassan

    Journal of cardiovascular and thoracic research

    2021  Volume 13, Issue 2, Page(s) 179–180

    Language English
    Publishing date 2021-04-17
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2654729-6
    ISSN 2008-6830 ; 2008-5117
    ISSN (online) 2008-6830
    ISSN 2008-5117
    DOI 10.34172/jcvtr.2021.28
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  9. Article: COVID-19 Is Not Over and Needs Prediction Scores: An Endless Road!

    Mahmoodpoor, Ata / Imani, Farnad / Soleimanpour, Hassan

    Anesthesiology and pain medicine

    2021  Volume 11, Issue 6, Page(s) e121654

    Language English
    Publishing date 2021-12-26
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 3018888-X
    ISSN 2228-7531 ; 2228-7523
    ISSN (online) 2228-7531
    ISSN 2228-7523
    DOI 10.5812/aapm.121654
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  10. Article ; Online: Individualized masks and respirators for COVID-19 patients and involved medical staff.

    Sanaie, Sarvin / Mahmoodpoor, Ata / Hosseini, Mohammad-Salar

    Revista da Associacao Medica Brasileira (1992)

    2021  Volume 67, Issue 4, Page(s) 488–489

    MeSH term(s) COVID-19 ; Humans ; Masks ; Medical Staff ; SARS-CoV-2 ; Ventilators, Mechanical
    Language English
    Publishing date 2021-09-07
    Publishing country Brazil
    Document type Letter
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20210100
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