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  1. Article ; Online: Optimizing blood utilization: Experience of blood redistribution policy from a tertiary care hospital based blood centre.

    Patidar, Gopal K / Gupta, Vidushi / Hazarika, Anjali

    Transfusion medicine (Oxford, England)

    2024  

    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Letter
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.13037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Consumables Quality: Is It Critical for Transfusion Services?

    Dhiman, Yashaswi / Patidar, Gopal K

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2020  Volume 36, Issue 4, Page(s) 758–759

    Language English
    Publishing date 2020-02-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-020-01268-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Association of ABO Blood Group Antigen and Neurological Tumors

    Patidar, Gopal K. / Dhiman, Yashaswi / Hazarika, Anjali

    Journal of Neuroanaesthesiology and Critical Care

    2022  Volume 09, Issue 02, Page(s) 93–98

    Abstract: Background: Various risk factors for tumors such as smoking, alcohol consumption, diet, and radiation, etc., were already identified. ABO blood group antigens are also present on epithelia, endothelia, and neurons. Recent evidence suggested the role of ... ...

    Abstract Background: Various risk factors for tumors such as smoking, alcohol consumption, diet, and radiation, etc., were already identified. ABO blood group antigens are also present on epithelia, endothelia, and neurons. Recent evidence suggested the role of ABO antigens in the pathogenesis of certain malignancies.
    Materials: and Methods: A retrospective observational study was conducted in a tertiary care neurosurgical center in North India from January 2016 to December 2018. The hospital information system was used to obtain patient information while the blood center information system was used to collect blood group information. Brain tumors were majorly divided into cavernoma, glioma, meningioma, neuroma, pituitary adenoma, schwannoma, and others.
    Results: We found a total of 1,970 patients with brain tumors admitted during our study period. Most patients had glioma (33.55%), followed by pituitary adenoma (20.05%) and neuroma (2.23%). B blood group individuals had more prevalence of cavernoma, glioma, meningioma, pituitary adenoma, schwannoma, and others followed by O, A, and AB. Only association of O blood group with neuroma tumor was found statistically significant.
    Conclusions: Our patient population had blood group distribution similar to our general population and no significant association was observed by blood group antigens and brain tumors. Although neuroma was significantly associated with blood group O but the prevalence of neuroma in our patient population is very low hence large sample study is required to draw a firm conclusion regarding this association.
    Keywords blood groups ; neurological tumors ; association ; neuroma
    Language English
    Publishing date 2022-06-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2937287-2
    ISSN 2348-926X ; 2348-0548
    ISSN (online) 2348-926X
    ISSN 2348-0548
    DOI 10.1055/s-0042-1749656
    Database Thieme publisher's database

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  4. Article ; Online: Association of blood donor's biological characteristics on outcomes of cardiac surgery patients receiving red blood cells transfusion.

    Gupta, Vidushi / Patidar, Gopal K / Hote, Milind / Mehar, Radheshyam / Dhiman, Yashaswi / Hazarika, Anjali

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2022  Volume 30, Issue 1, Page(s) 130–136

    Abstract: Objectives: This study aimed to assess the association of blood donor variables on the outcome of patients undergoing cardiac surgery.: Study design and methods: A retrospective observational study was conducted on patients who had cardiac surgery ... ...

    Abstract Objectives: This study aimed to assess the association of blood donor variables on the outcome of patients undergoing cardiac surgery.
    Study design and methods: A retrospective observational study was conducted on patients who had cardiac surgery between January 2018 and December 2020. Blood donor characteristics such as age (≤ or >30 years), sex, and body mass index (BMI) (≤ or >25 kg/m
    Results: During the study period, 5788 patients had cardiac surgery; receiving a total of 20,348 red cell units. Of which, 522 (9%) died, 531 (9.2%) re-admitted and median LOS was 11 days (IQR 7-18). BMI >25 kg/m
    Discussion: Blood donor sex, and BMI can influence mortality and LOS in cardiac surgery patients. The use of computer tools to match the patient's and donor's characteristics can assist to eliminate these types of adverse consequences.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Blood Donors ; Erythrocyte Transfusion ; Cardiac Surgical Procedures ; Blood Transfusion ; Retrospective Studies ; Erythrocytes
    Language English
    Publishing date 2022-09-30
    Publishing country France
    Document type Observational Study ; Journal Article
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/j.tracli.2022.09.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Consecutive reactive results in screening of transfusion transmitted infections: Family history of blood donors is also important.

    Dhiman, Yashaswi / Patidar, Gopal K / Hazarika, Anjali

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2019  Volume 58, Issue 4, Page(s) 464–467

    Abstract: Background: Enzyme linked immunosorbent assay (ELISA) test is used for screening of transfusion transmitted infections (TTI) in blood donors. Consecutive reactive results in ELISA is due to sample/reagent carryover or donor related. In this study we ... ...

    Abstract Background: Enzyme linked immunosorbent assay (ELISA) test is used for screening of transfusion transmitted infections (TTI) in blood donors. Consecutive reactive results in ELISA is due to sample/reagent carryover or donor related. In this study we tried to find out the possibilities of family history/close contacts with patients of hepatitis among these consecutive reactive donors.
    Aim: To analyze the consecutive reactive results in ELISA tests for TTI testing on samples of healthy blood donors.
    Material and methods: A retrospective observational study was conducted from January 2016 to July 2018 in a tertiary care hospital, North India. Consecutive reactive results by fourth generation ELISA for TTIs screening were evaluated for possible reasons. Confirmation tests were not done. Reactive donors were contacted telephonically for relevant history of close contact with infected personnel.
    Results: Out of 53,740 donations 1,061 were reactive for TTIs during our study period. Prevalence of Hepatitis B (HBV), Human Immunodeficiency (HIV) and Hepatitis C (HCV) virus infection in blood donors were 1.27%, 0.20% and 0.50% respectively. Consecutive reactive results for HBV were 9.20% (63/685), for HCV 6.0% (16/266) and nil for HIV. There was no sample carryover in this. Out of 79 consecutive reactive donors 69 donated for same patients and 32 were related with infected patient which are statistically significant (p < 0.0001).
    Discussion: This study recommends that in analysis of consecutive positive results in ELISA along with looking for procedure/sample error, there is also a need to take retrospective history of donors for close contact with infected patients.
    MeSH term(s) Adult ; Blood Donors ; Donor Selection ; Family ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Transfusion Reaction/epidemiology ; Virus Diseases/epidemiology ; Virus Diseases/transmission
    Language English
    Publishing date 2019-07-10
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Observational Study
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2019.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Covid‐19 pandemic‐ response to challenges by blood transfusion services in India

    Dhiman, Yashaswi / Patidar, Gopal K. / Arora, Satyam

    ISBT Science Series ; ISSN 1751-2816 1751-2824

    a review report

    2020  

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/voxs.12563
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: National blood donor vigilance programme of India: Analysis of donor adverse reactions reported during initial 2 years of implementation (2016 and 2017).

    Bisht, Akanksha / Marwaha, Neelam / Arora, Satyam / Patidar, Gopal K / Chhabra, Reba

    Asian journal of transfusion science

    2021  Volume 15, Issue 1, Page(s) 1–11

    Abstract: Introduction: The donor vigilance program is intended to collect and assess information on unexpected or undesirable effects or reactions resulting from blood donation. In this report, we discuss the analysis of the blood donor adverse reactions (DARs) ... ...

    Abstract Introduction: The donor vigilance program is intended to collect and assess information on unexpected or undesirable effects or reactions resulting from blood donation. In this report, we discuss the analysis of the blood donor adverse reactions (DARs) reported in the National Blood Donor Vigilance Programme of India during the first 2 years of implementation.
    Materials and methods: DAR reporting form prepared and approved by the National Executive Committee of the Haemovigilance Programme of India was used to capture the data by the blood centers and submitted to Donor-Vigil software prepared and hosted by the official website of the National Institute of Biologicals. Data reported for the years 2016 and 2017 were reviewed, analyzed, and validated by independent transfusion medicine experts.
    Results: During this period, a total of 19,98,101 donations denominator data were reported, in which 1,622,600 (80.9%) were valid. A total of 6091 DARs were reported, out of which 3980 (65.35%) were found valid. Only validated numerator and denominator data were included in the analysis. Generalized DARs were the most common type of DARs reported (83.7%), followed by "others" type (7.7%), localized (7.6%), allergic (0.4%), and complications related to apheresis (0.4%). The overall DAR rate was 2.45/1000 blood donations, which was higher in apheresis donations (3.07/1000) as compared to whole blood donations (2.39/1000). The DARs rates were higher in females (3.5/1000) compared to male donors (2.3/1000) and in the first time (2.5/1000) compared to repeat donors (2.15/1000).
    Conclusion: In this report, we concluded that younger age, first time, and female donors are more prone to DARs as compared to older age, repeat, and male donors. During the analysis of the data, we found some limitations, which can be improved by upgrading the reporting form and conducting regular continuing medical education (CMEs) of participant blood centers.
    Language English
    Publishing date 2021-06-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2267310-6
    ISSN 1998-3565 ; 0973-6247
    ISSN (online) 1998-3565
    ISSN 0973-6247
    DOI 10.4103/ajts.ajts_195_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Covid-19 pandemic- response to challenges by blood transfusion services in india: A review report

    Dhiman, Yashaswi / Patidar, Gopal K. / Arora, Satyam

    ISBT Science Series

    Abstract: Abstract The role of blood transfusion services in a pandemic depends on the type, potential of community spread and risk of transfusion transmissibility The Covid-19 pandemic is the biggest pandemic of the 21st century, affecting over 3 million people ... ...

    Abstract Abstract The role of blood transfusion services in a pandemic depends on the type, potential of community spread and risk of transfusion transmissibility The Covid-19 pandemic is the biggest pandemic of the 21st century, affecting over 3 million people across the globe as of late April 2020 In India, the count of infected persons and deaths are rising gradually, and to prevent the community spread of the SARS Cov-2 virus the Government of India announced national lockdown which affected the blood transfusion services also There are more than 3000 decentralized blood centers all over the country The major challenges to blood transfusion services are recruitment of healthy blood donors, follow-up of donors and patients, inventory management, staff safety and adequacy for emergency work and consumable management Blood transfusion services also participate in treatment of Covid-19 patients by convalescent plasma collection from recovered patients Blood transfusion services should have a strategic plan to respond to challenges generated during a pandemic which focuses on shortage, wastage and supply of blood and components in a cost-effective manner In this review article we will discuss the challenges to blood transfusion services of India due to Covid-19 pandemic and response to these challenges with experience to previous outbreaks
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #165295
    Database COVID19

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  9. Article ; Online: Allosteric Determinants in High Temperature Requirement A Enzymes Are Conserved and Regulate the Population of Active Conformations.

    Gupta, Arvind Kumar / Singh, Kushal / Patidar, Yogesh / Sharma, Ravish / Sardesai, Abhijit A / Reddy, Govardhan / Gopal, Balasubramanian

    ACS chemical biology

    2023  Volume 18, Issue 7, Page(s) 1487–1499

    Abstract: High temperature requirement A (HtrA) are allosterically regulated enzymes wherein effector binding to the PDZ domain triggers proteolytic activity. Yet, it remains unclear if the inter-residue network governing allostery is conserved across HtrA enzymes. ...

    Abstract High temperature requirement A (HtrA) are allosterically regulated enzymes wherein effector binding to the PDZ domain triggers proteolytic activity. Yet, it remains unclear if the inter-residue network governing allostery is conserved across HtrA enzymes. Here, we investigated and identified the inter-residue interaction networks by molecular dynamics simulations on representative HtrA proteases,
    MeSH term(s) Temperature ; Endopeptidases/metabolism ; Escherichia coli/metabolism ; Molecular Dynamics Simulation ; Allosteric Regulation ; Catalytic Domain
    Chemical Substances Endopeptidases (EC 3.4.-)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.2c00921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Management of blood transfusion services in low-resource countries.

    Patidar, Gopal K / Thachil, Jecko / Dhiman, Yashaswi / Oreh, Adaeze / Vrielink, Hans / van den Berg, Karin / Grubovic Rastvorceva, Rada M / So-Osman, Cynthia / Al-Riyami, Arwa Z

    Vox sanguinis

    2022  

    Abstract: Background and objectives: Enabling universal access to safe blood components should be a key component of every country's national healthcare strategy. This study aimed to assess the current status of infrastructure and resources of blood transfusion ... ...

    Abstract Background and objectives: Enabling universal access to safe blood components should be a key component of every country's national healthcare strategy. This study aimed to assess the current status of infrastructure and resources of blood transfusion services (BTS) in low- and middle-income countries.
    Materials and methods: A cross-sectional survey was designed to gather information on blood donations, components, redistribution, testing resources and quality management systems (QMSs). The survey was distributed to the International Society of Blood Transfusion members between October 2021 and November 2021.
    Results: A total of 54 respondents from 20 countries responded to the survey. This included hospital-based BTS/blood centres (46%), national blood centres (11%)and national and regional blood services (11%). Voluntary non-remunerated, replacement and paid donors accounted for 94.2%, 84.6% and 21.1% of donations, respectively. Apheresis donation was available in 59.6% of institutions. National/regional criteria for redistribution of blood components were reported by 75.9% of respondents. Blood components incurred payment charges in 81.5% of respondents' institutions, and payments were borne by patients in 50% of them. Testing methods, such as manual (83%), semi-automated (68%) or fully automated (36.2%), were used either alone or in combination. QMSs were reported in 17 institutions, while accreditation and haemovigilance were reported in 12 and 8 countries, respectively.
    Conclusion: QMS was implemented in most of the countries despite the common use of paid donations and the lack of advanced testing. Efforts to overcome persistent challenges and wider implementation of patient blood management programmes are required.
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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