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  1. Book: Environmental CNS Stimulation in Aging, Health and Disease

    Lei Cao

    2022  

    Keywords Environmental Enrichment ; Brain ; cancer
    Language English
    Size 436 p.
    Publisher WSPC
    Document type Book
    Note PDA Manuell_15
    Format 157 x 235 x 28
    ISBN 9789811250330 ; 9811250332
    Database PDA

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  2. Article ; Online: The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.

    Mukhopadhyay, Partha / Baggelaar, Marc / Erdelyi, Katalin / Cao, Zongxian / Cinar, Resat / Fezza, Filomena / Ignatowska-Janlowska, Bogna / Wilkerson, Jenny / van Gils, Noortje / Hansen, Thomas / Ruben, Marc / Soethoudt, Marjolein / Heitman, Laura / Kunos, George / Maccarrone, Mauro / Lichtman, Aron / Pacher, Pál / Van der Stelt, Mario

    British journal of pharmacology

    2016  Volume 173, Issue 3, Page(s) 446–458

    Abstract: ... dioxidothiomorpholino)methyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione hydrochloride (LEI-101) as a novel ... models.: Experimental approach: We investigated the effects of LEI-101 on binding and functional activity. We assessed ... its in vitro and in vivo selectivity. Efficacy of LEI-101 was determined in a mouse model of cisplatin-induced ...

    Abstract Background and purpose: Here, we have characterized 3-cyclopropyl-1-(4-(6-((1,1-dioxidothiomorpholino)methyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione hydrochloride (LEI-101) as a novel, peripherally restricted cannabinoid CB2 receptor agonist, using both in vitro and in vivo models.
    Experimental approach: We investigated the effects of LEI-101 on binding and functional activity. We assessed its in vitro and in vivo selectivity. Efficacy of LEI-101 was determined in a mouse model of cisplatin-induced nephrotoxicity.
    Key results: LEI-101 behaved as a partial agonist at CB2 receptors using β-arrestin and GTPγS assays and was ~100-fold selective in CB2 /CB1 receptor-binding assays. It did not display any activity on endocannabinoid hydrolases and nor did it react with serine hydrolases in an activity-based protein profiling assay. In mice, LEI-101 had excellent oral bioavailability reaching high concentrations in the kidney and liver with minimal penetration into the brain. LEI-101 up to a dose of 60 mg·kg(-1) (p.o.) did not exert any CNS-mediated effects in the tetrad assay, in mice. LEI-101 (p.o. or i.p.) at 3 or 10 mg·kg(-1) dose-dependently prevented kidney dysfunction and/or morphological damage induced by cisplatin in mice. These protective effects were associated with improved renal histopathology, attenuated oxidative stress and inflammation in the kidney. These effects were absent in CB2 receptor knockout mice.
    Conclusion and implications: These results indicate that LEI-101 is a selective, largely peripherally restricted, orally available CB2 receptor agonist with therapeutic potential in diseases that are associated with inflammation and/or oxidative stress, including kidney disease.
    MeSH term(s) Administration, Oral ; Animals ; Apoptosis/drug effects ; CHO Cells ; Cisplatin/adverse effects ; Cricetulus ; DNA Fragmentation ; Imidazolidines/chemistry ; Imidazolidines/pharmacology ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/chemically induced ; Kidney Diseases/drug therapy ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Lipid Peroxidation/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Morpholines/chemistry ; Morpholines/pharmacology ; Protective Agents/pharmacokinetics ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Reactive Oxygen Species/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/genetics
    Chemical Substances 3-cyclopropyl-1-(4-(6-((1,1-dioxidothiomorpholino)methyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione hydrochloride ; Imidazolidines ; Morpholines ; Protective Agents ; Reactive Oxygen Species ; Receptor, Cannabinoid, CB2 ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2016-01-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.13338
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  3. Article: A mechanism study on the synergistic effects of rifapentine and fluconazole against fluconazole-resistant

    Wang, Yulian / He, Yufei / Cai, Tongkai / Lei, Zhongwei / Lei, Wenzhi / Cao, Yongbing / Wu, Jianhua

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27346

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27346
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  4. Article: Research on evaluation of university education informatization level based on clustering technique.

    Shen, Yue / Lei, Cao

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e25215

    Abstract: Today, the utilization of Information Technology tools is considered an inevitable path in the education system. In this regard, assessing the effective integration of Information Technology tools in the educational system holds significant importance. ... ...

    Abstract Today, the utilization of Information Technology tools is considered an inevitable path in the education system. In this regard, assessing the effective integration of Information Technology tools in the educational system holds significant importance. This process can be automated using artificial intelligence techniques, which are the subject of the current study. In this research, initially, a set of 14 indicators related to levels of Education Informatization (EI) in higher education is introduced. Subsequently, a clustering-based strategy is proposed to rank the indicators and determine an optimal subset of these features. Based on this framework, it is demonstrated that using 11 indicators related to educational behaviors can achieve the highest accuracy in evaluating EI levels. The proposed approach employs a group of Support Vector Machines (SVMs) for EI level assessment, where classifier hyperparameters are tuned using reinforcement learning strategy. The performance of the proposed method is evaluated on real-world data and compared with previous works. The results indicate that the proposed method can assess EI levels in universities with an average accuracy of 93.64 %, outperforming compared methods by at least 4.09 %.
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25215
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  5. Article ; Online: One-Step Hydrothermal/Solvothermal Preparation of Pt/TiO

    Lei, Lijun / Cao, Qianyue / Ma, Jiachen / Hou, Fengxiao

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: The selective oxidation of biobutanol to prepare butyric acid is an important conversion process, but the preparation of low-temperature and efficient catalysts for butanol oxidation is currently a bottleneck problem. In this work, we prepared Pt- ... ...

    Abstract The selective oxidation of biobutanol to prepare butyric acid is an important conversion process, but the preparation of low-temperature and efficient catalysts for butanol oxidation is currently a bottleneck problem. In this work, we prepared Pt-TiO
    Language English
    Publishing date 2024-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071450
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    Zs.MO 81: Show issues

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  6. Article: Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases.

    Cao, Lei / Ji, Bin / Ni, Ruiqing

    Neural regeneration research

    2024  Volume 19, Issue 10, Page(s) 2115–2116

    Language English
    Publishing date 2024-01-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.392886
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  7. Article ; Online: Correction: Bioactive VS4-based sonosensitizer for robust chemodynamic, sonodynamic and osteogenic therapy of infected bone defects.

    He, Yaqi / Liu, Xin / Lei, Jie / Ma, Liang / Zhang, Xiaoguang / Wang, Hongchuan / Lei, Chunchi / Feng, Xiaobo / Yang, Cao / Gao, Yong

    Journal of nanobiotechnology

    2024  Volume 22, Issue 1, Page(s) 46

    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-024-02303-z
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  8. Article: Editorial: Therapeutic potential of smart hydrogel and nanomaterial carriers in neurogenic disease.

    Lei, Kun / Jiang, Yanyan / Cao, Yi / Wei, Xin

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1285763

    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1285763
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  9. Article: Editorial: Exploration of the non-invasive brain-computer interface and neurorehabilitation.

    Chen, Shugeng / Yao, Lin / Cao, Lei / Caimmi, Marco / Jia, Jie

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1377665

    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1377665
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  10. Article ; Online: Correction: Variation in intensive care unit beds capacity in China from 2007 to 2021.

    Yuan, Lei / Xu, Siyu / Xu, Jingmin / Cao, Jing / Qian, Zhaoxin

    Intensive care medicine

    2024  Volume 50, Issue 4, Page(s) 616

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07376-w
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