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  1. Article ; Online: Interaction between sleep duration and trouble sleeping on depressive symptoms among U.S. adults, NHANES 2015-2018.

    Wang, Shanshan / Rossheim, Matthew E / Nandy, Rajesh R / Nguyen, Uyen-Sa

    Journal of affective disorders

    2024  Volume 351, Page(s) 285–292

    Abstract: ... and trouble sleeping on depressive symptoms among U.S. adults.: Methods: National Health and ...

    Abstract Background: This study aims to examine the associations and interaction effects of sleep duration and trouble sleeping on depressive symptoms among U.S. adults.
    Methods: National Health and Nutrition Examination Survey (NHANES) data from 2015 to 2018 were analyzed (N = 10,044). Trouble sleeping and sleep duration were self-reported. Sleep duration was defined as short (≤6 h) or long (≥9 h), compared with normal (>6 and < 9 h). Depressive symptoms were determined by the Patient Health Questionnaire-9 score ≥ 10. Both multiplicative interaction and additive interaction were reported.
    Results: There was a significant positive additive interaction between short sleep duration and trouble sleeping on depressive symptoms in the fully adjusted model (Relative excess risk due to interaction, RERI
    Limitations: The cross-sectional design limits the ability to draw causal inferences.
    Conclusions: Findings suggest that different aspects of sleep health interact synergistically, accounting for a substantial portion of the association with depressive symptoms. This underscores the importance of simultaneously considering multiple dimensions of sleep health in relation to depressive symptoms.
    MeSH term(s) Adult ; Humans ; Nutrition Surveys ; Sleep Duration ; Cross-Sectional Studies ; Depression/epidemiology ; Sleep ; Sleep Wake Disorders/epidemiology
    Language English
    Publishing date 2024-01-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Environmental tobacco smoke and children’s health

    Sneha S. Patil / Naveen Puttaswamy / Sachin C. Sarode / Gargi S. Sarode / Smita S. Patil / Andres Cardenas / Rajesh Kumar Gandhirajan / Kalpana Balakrishnan

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    a bibliometric and altmetric analysis of 100 most cited articles

    2023  Volume 10

    Abstract: ... to describe the state of research and future trends on ETS exposure and Children’s Health (CH) topics ... shifted towards emerging fields such as children’s oral health and DNA methylation. Twitter, policy ...

    Abstract Abstract Background Exposure to environmental tobacco smoke (ETS) is arguably the most ubiquitous and hazardous, even at very low levels, starting in early life. The objective of this study was to describe the state of research and future trends on ETS exposure and Children’s Health (CH) topics with bibliometrics and altmetrics. Methods An electronic search was performed in Scopus database on January 31, 2023. Consensus was arrived on 100 most-cited articles by two reviewers. These papers were then cross matched with citations harvested from Web of Science (WoS) and Google Scholar. Altmetric Attention Score (AAS) and Dimension counts were also collected. Analysis and network visualization of authors, countries, and keywords were generated using VOSviewer software. Results Among a total of 1107 articles published on ETS and CH, the 100 top-cited articles appeared in 54 journals, with Pediatrics (n = 12) contributing a maximum number of articles. The time period between 2000 and 2009 accounted for 44% of all publications. With respect to the research design employed across these studies, cross-sectional design took precedence over others accounting for approximately 40%. Predominantly, articles focused on childhood asthma; however, current research trends have shifted towards emerging fields such as children’s oral health and DNA methylation. Twitter, policy documents, and news outlets were the main platforms where outputs were discussed. The AAS was not associated with journal impact factor or access type. Weak correlations were observed between AAS and citation count in Scopus, WoS, and Google Scholar (r = 0.17 to 0.27) while a positive association existed between dimension count and the number of citations across all three databases (r = 0.84 to 0.98). Conclusion This study demonstrates the evolution, digital dissemination and research hotspots in the field of ETS and CH, predicting the possible future research directions. High-quality studies with more specific exposure classification are warranted to better ...
    Keywords Altmetric ; Bibliometric analysis ; Dimensions ; Environmental tobacco smoke ; Child health ; Most cited ; Public aspects of medicine ; RA1-1270
    Subject code 001
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Mechanistic insights into excited-state palladium catalysis for C-S bond formations and dehydrogenative sulfonylation of amines.

    Muralirajan, Krishnamoorthy / Kancherla, Rajesh / Maity, Bholanath / Karuthedath, Safakath / Laquai, Frédéric / Cavallo, Luigi / Rueping, Magnus

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6622

    Abstract: Photocatalytic selective C( ... ...

    Abstract Photocatalytic selective C(sp
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42392-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Glutathione S-transferase: a versatile protein family.

    Vaish, Swati / Gupta, Divya / Mehrotra, Rajesh / Mehrotra, Sandhya / Basantani, Mahesh Kumar

    3 Biotech

    2020  Volume 10, Issue 7, Page(s) 321

    Abstract: Glutathione-S transferase (GST) is a most ancient protein superfamily of multipurpose roles and ...

    Abstract Glutathione-S transferase (GST) is a most ancient protein superfamily of multipurpose roles and evolved principally from gene duplication of an ancestral GSH binding protein. They have implemented in diverse plant functions such as detoxification of xenobiotic, secondary metabolism, growth and development, and majorly against biotic and abiotic stresses. The vital structural features of GSTs like highly divergent functional topographies, conserved integrated architecture with separate binding pockets for substrates and ligand, the stringent structural fidelity with high Tm values (50º-60º), and stress-responsive cis-regulatory elements in the promoter region offer this protein as most flexible plant protein for plant breeding approaches, biotechnological applications, etc. This review article summarizes the recent information of GST evolution, and their distribution and structural features with emphasis on the assorted roles of Ser and Cys GSTs with the signature motifs in their active sites, alongside their recent biotechnological application in the area of agriculture, environment, and nanotechnology have been highlighted.
    Language English
    Publishing date 2020-06-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-020-02312-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Adherence to quality indicators and best practices in surveillance endoscopy of Barrett’s esophagus: A video-based assessment

    Enke, Thomas / Keswani, Rajesh / Triggs, Joseph / Gannavarapu, Bhargava / Mittal, Chetan / Sinha, Jasmine / Kwasny, Mary J / Komanduri, Srinadh

    Endoscopy International Open

    2024  Volume 12, Issue 01, Page(s) E90–E96

    Abstract: ... for endoscopic surveillance of Barrett’s esophagus (BE) is low based on clinical documentation which is ...

    Abstract Background and study aims: Adherence to quality indicators (QIs) and best practices (BPs) for endoscopic surveillance of Barrett’s esophagus (BE) is low based on clinical documentation which is an inaccurate representation of events occurring during procedures. This study aimed to assess adherence to measurable QI and BP using video evaluation.
    Methods: We performed a single center video-based retrospective review of surveillance endoscopies performed for BE ≥1 cm between March 1, 2018 and October 1, 2020. Adherence to QIs and BPs was assessed through video review and documentation. Videos were evaluated by five gastroenterologists. Interrater variability was determined using 10 videos before reviewing the remaining 128 videos. A generalized linear regression model was used to determine predictors of adherence to QIs and BPs.
    Results: There were 138 endoscopies reviewed. Inspection with virtual chromoendoscopy (VC) occurred in 75 cases (54%) on video review with documentation in 50 of these cases (67%). Adherence to the Seattle protocol (SP) occurred in 74 cases (54%) on video review with documentation in 28 of these cases (38%). Use of VC or the SP was documented but not observed on video review in 16 (12%) and 30 (22%) cases, respectively. Length of BE was associated with increased use of the Prague classification (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.07–1.37) while years in practice was associated with a decreased likelihood of VC use (OR 0.93, 95% CI 0.88–0.99).
    Conclusions: This study validates prior data demonstrating poor adherence to QIs and BPs and highlights discrepancies between clinical documentation and events occurring during procedures.
    Keywords Barrett's and adenocarcinoma ; Quality and logistical aspects
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722 ; 2196-9736
    ISSN (online) 2196-9736
    ISSN 2364-3722 ; 2196-9736
    DOI 10.1055/a-2226-3689
    Database Thieme publisher's database

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  6. Article: Determination of standard molar enthalpies of formation of Bi2Mo3O12 (s), Bi2MoO6 (s), Bi6Mo2O15 (s) and Bi6MoO12 (s) by solution calorimetry

    Aiswarya, P.M / Kumar, S. Shyam / Ganesan, Rajesh / Gnanasekaran, T

    Thermochimica acta. 2019 Dec., v. 682

    2019  

    Abstract: The standard molar enthalpies of formation of Bi2Mo3O12 (s), orthorhombic phase of Bi2MoO6 (s ... monoclinic phase of Bi2MoO6 (s), Bi6Mo2O15 (s) and Bi6MoO12 (s) were determined by solution calorimetry and ...

    Abstract The standard molar enthalpies of formation of Bi2Mo3O12 (s), orthorhombic phase of Bi2MoO6 (s), monoclinic phase of Bi2MoO6 (s), Bi6Mo2O15 (s) and Bi6MoO12 (s) were determined by solution calorimetry and the values obtained are (−2915.8 ± 8.2), (−1407.2 ± 7.1), (−1385.7 ± 7.3), (−3346.5 ± 21.7) and (−2605.2 ± 20.3) kJ mol−1, respectively. The given uncertainties were calculated as 2σ of the mean with 0.95 level of confidence.
    Keywords calorimetry ; enthalpy ; uncertainty
    Language English
    Dates of publication 2019-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500974-9
    ISSN 0040-6031
    ISSN 0040-6031
    DOI 10.1016/j.tca.2019.178401
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Plasmodium Iron-Sulfur [Fe-S] cluster assembly protein Dre2 as a plausible target of Artemisinin: Mechanistic insights derived in a prokaryotic heterologous system.

    Kirtikumar Bub, Nidhi / Anand, Sakshi / Garg, Swati / Saxena, Vishal / Khanna, Dhanabala Subhiksha Rajesh / Agarwal, Deeptanshu / Kochar, Sanjay Kumar / Singh, Shailja / Garg, Shilpi

    Gene

    2023  Volume 869, Page(s) 147396

    Abstract: Iron-sulfur (Fe-S) cluster containing proteins have been assigned roles in various essential ... of Dre2, a protein involved in redox mechanism for the cytoplasmic Fe-S cluster assembly in different ...

    Abstract Iron-sulfur (Fe-S) cluster containing proteins have been assigned roles in various essential cellular processes, such as regulation of gene expression, electron transfer, sensing of oxygen and balancing free radical chemistry. However, their role as the drug target remains sparse. Recently the screening of protein alkylation targets for artemisinin in Plasmodium falciparum led to identification of Dre2, a protein involved in redox mechanism for the cytoplasmic Fe-S cluster assembly in different organisms. In the present study, to further explore the interaction between artemisinin and Dre2, we have expressed the Dre2 protein of both P. falciparum and P. vivax in E. coli. The opaque brown colour of the IPTG induced recombinant Plasmodium Dre2 bacterial pellet, suggested iron accumulation as confirmed by the ICP-OES analysis. In addition, overexpression of rPvDre2 in E. coli reduced its viability, growth and increased the ROS levels of bacterial cells, which in turn led to an increase in expression of stress response genes of E. coli such as recA, soxS, mazF. Moreover, the overexpression of rDre2 induced cell death could be rescued by treatment with Artemisinin derivatives suggesting their interaction. The interaction between DHA and PfDre2 was later demonstrated by CETSA and microscale thermophoresis. Overall, this study suggests that Dre2 is the probable target of Artemisinin and the antimalarial activity of DHA/Artemether could also be due to yet unidentified molecular mechanism altering the Dre2 activity in addition to inducing DNA and protein damage.
    MeSH term(s) Artemisinins/pharmacology ; DNA-Binding Proteins/metabolism ; Endoribonucleases ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Iron/metabolism ; Iron-Sulfur Proteins/genetics ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/metabolism ; Plasmodium/metabolism ; Sulfur/metabolism
    Chemical Substances artemisinin (9RMU91N5K2) ; Artemisinins ; DNA-Binding Proteins ; Endoribonucleases (EC 3.1.-) ; Escherichia coli Proteins ; Iron (E1UOL152H7) ; Iron-Sulfur Proteins ; MazF protein, E coli ; Sulfur (70FD1KFU70) ; Dre2 protein, Plasmodium vivax ; Dre2 protein, Plasmodium falciparum
    Language English
    Publishing date 2023-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2023.147396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of U.S. Preventive Services Task Force lung cancer screening update on drivers of disparities in screening eligibility.

    Maki, Kristin G / Talluri, Rajesh / Toumazis, Iakovos / Shete, Sanjay / Volk, Robert J

    Cancer medicine

    2022  Volume 12, Issue 4, Page(s) 4647–4654

    Abstract: Background: In 2021, the U.S. Preventive Services Task Force (USPSTF) updated its recommendation ... the number of non-White individuals who are eligible for LCS, the update's impact on drivers of disparities ...

    Abstract Background: In 2021, the U.S. Preventive Services Task Force (USPSTF) updated its recommendation to expand lung cancer screening (LCS) eligibility and mitigate disparities. Although this increased the number of non-White individuals who are eligible for LCS, the update's impact on drivers of disparities is less clear. This analysis focuses on racial disparities among Black individuals because members of this group disproportionately share late-stage lung cancer diagnoses, despite typically having a lower intensity smoking history compared to non-Hispanic White individuals.
    Methods: We used data from the National Health Interview Survey to examine the impact of the 2021 eligibility criteria on racial disparities by factors such as education, poverty, employment history, and insurance status. We also examined preventive care use and reasons for delaying medical care.
    Results: When comparing Black individuals and non-Hispanic White individuals, our analyses show significant differences in who would be eligible for LCS: Those who do not have a high school diploma (28.7% vs. 17.0%, p = 0.002), are in poverty (26.2% vs. 14.9%, p < 0.001), and have not worked in the past 12 months (66.5% vs. 53.9%, p = 0.009). Further, our analyses also show that more Black individuals delayed medical care due to not having transportation (11.1% vs. 3.6%, p < 0.001) compared to non-Hispanic White individuals.
    Conclusions: Our results suggest that despite increasing the number of Black individuals who are eligible for LCS, the 2021 USPSTF recommendation highlights ongoing socioeconomic disparities that need to be addressed to ensure equitable access.
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Early Detection of Cancer/methods ; Racial Groups ; Surveys and Questionnaires ; Preventive Health Services ; Mass Screening
    Language English
    Publishing date 2022-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Lipidic Poly (2-oxazoline)s as PEG Replacement Steric Stabilisers for Cubosomes

    Rajesh .:, Sarigama / Leiske, Meike N. / Leitch, Victoria / Zhai, Jiali / Drummond, Calum J. / Kempe, Kristian / Tran, Nhiem

    Journal of colloid and interface science. 2022 Apr. 26,

    2022  

    Abstract: ... we hypothesise that lipidic poly(2-oxazoline)s have the potential to stabilise cubosomes, which can be used ...

    Abstract Hypothesis Cubosomes are promising delivery vehicles for a wide range of drugs and biomolecules. Polymers such as the polyethylene glycol (PEG)-based Pluronic F-127 have been widely used for dispersing and stabilising lipid cubosomes. However, due to the PEG-immunogenicity, and pre-existing anti-PEG antibodies in some individuals, the efficacy of PEG-stabilised nanomedicines has been reduced. In this study, we hypothesise that lipidic poly(2-oxazoline)s have the potential to stabilise cubosomes, which can be used to encapsulate a hydrophobic drug similar to cubosomes stabilised with F-127. Experiments Two lipidic polymers consisting of an oleyl (OA) chain connected to a poly(2-methyl-2-oxazoline) backbone were synthesised using cationic ring-opening polymerisation (PMeOx₄₀-OA and PMeOx₈₀-OA). The PMeOxₙ-OA stabilised monoolein cubosomes were compared to F-127 cubosomes in particle size, stability, mesophase structure, and biocompatibility. Findings The obtained PMeOxₙ-OA were well-defined (low dispersity) and had a high degree of OA functionalisation (≥ 95%). These polymers were as good as F-127 in producing well dispersed monoolein cubosomes and maintained the internal cubic structure. The cubosomes stabilised with PMeOxₙ-OA showed lower cytotoxic effect compared to F-127 stabilised cubosomes against OVCAR-3 cells. Furthermore, the PMeOxₙ-OA cubosomes significantly improved the solubility of SN-38, a poorly water-soluble cancer drug.
    Keywords antineoplastic agents ; biocompatibility ; cytotoxicity ; hydrophobicity ; lipids ; nanomedicine ; particle size ; polyethylene glycol ; polymerization ; water solubility
    Language English
    Dates of publication 2022-0426
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.04.158
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Heavy metal (loid)s phytotoxicity in crops and its mitigation through seed priming technology.

    Singhal, Rajesh Kumar / Kumar, Mahesh / Bose, Bandana / Mondal, Sananda / Srivastava, Sudhakar / Dhankher, Om Parkash / Tripathi, Rudra Deo

    International journal of phytoremediation

    2022  , Page(s) 1–20

    Abstract: Unexpected bioaccumulation and biomagnification of heavy metal(loid)s (HMs) in the environment have ... and transport, and phytotoxic effects of HMs with special attention to different mechanism/s ... defense system, generation of low molecular weight metallothionein's (MTs), and phytochelatins (PCs), and ...

    Abstract Unexpected bioaccumulation and biomagnification of heavy metal(loid)s (HMs) in the environment have become a predicament for all living organisms, including plants. The presence of these HMs in the plant system raised the level of reactive oxygen species (ROS) and remodeled several vital cellular biomolecules. These lead to several morphological, physiological, metabolic, and molecular aberrations in plants ranging from chlorosis of leaves to the lipid peroxidation of membranes, and degradation of proteins and nucleic acid including the modulation of the enzymatic system, which ultimately affects the plant growth and productivity. Plants are equipped with several mechanisms to counteract the HMs toxicity. Among them, seed priming (SP) technology has been widely tested with the use of several inorganic chemicals, plant growth regulators (PGRs), gasotransmitters, nanoparticles, living organisms, and plant leaf extracts. The use of these compounds has the potential to alleviate the HMs toxicity through the strengthening of the antioxidant defense system, generation of low molecular weight metallothionein's (MTs), and phytochelatins (PCs), and improving seedling vigor during early growth stages. This review presents an account of the sources, uptake and transport, and phytotoxic effects of HMs with special attention to different mechanism/s, occurring to mitigate the HMs toxicity in plants employing SP technology.
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055357-2
    ISSN 1549-7879 ; 1522-6514
    ISSN (online) 1549-7879
    ISSN 1522-6514
    DOI 10.1080/15226514.2022.2068502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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