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Article: A Complex Case of Pulmonary Silico-Tuberculosis and Review of Literature.

D'Sa, Lauren / Pezzuto, Federica / Lunardi, Francesca / Scalvenzi, Francesca / Tinè, Mariaenrica / Comacchio, Giovanni / Giraudo, Chiara / Calabrese, Fiorella

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 17

Abstract: Silicosis caused by the inhalation/deposition of free silica particles is characterized by pulmonary inflammation/fibrosis. Among the clinical disorders associated with silicosis, tuberculosis is by far the most prominent. A 66-year-old male non-smoker, ... ...

Abstract	Silicosis caused by the inhalation/deposition of free silica particles is characterized by pulmonary inflammation/fibrosis. Among the clinical disorders associated with silicosis, tuberculosis is by far the most prominent. A 66-year-old male non-smoker, originally from North Africa, reported a dry cough and significant weight loss. He was a foundry worker. He had a medical history of bladder carcinoma associated with schistosomiasis. Computed tomography (CT) and positron emission tomography (PET)/CT showed bilateral multiple hypermetabolic lung nodules, some with cavitation. The patient underwent surgical resection of the largest nodule, which was highly suspicious of lung metastasis. The histological examination revealed multiple nodular formations. Several lesions showed the characteristic features of silicotic nodules. There were also adjacent well-formed granulomas, some with central caseous necrosis. A real-time polymerase chain reaction, performed for the identification and quantification of the DNA of the
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13172728
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Article ; Online: Exploring the pathologist's role in understanding COVID-19: from pneumonia to long-COVID lung sequelae.

Olteanu, Gheorghe-Emilian / Pezzuto, Federica / Lunardi, Francesca / Fortarezza, Francesco / Dubini, Alessandra / Calabrese, Fiorella

Pathologica

2023 Volume 115, Issue 5, Page(s) 275–283

Abstract: The crucial role of pathologists in enhancing our understanding of SARS-CoV-2-related disease, from initial pneumonia manifestations to persistent long COVID lung symptoms, is the focus of this review. Pathological explorations have offered unprecedented ...

Abstract	The crucial role of pathologists in enhancing our understanding of SARS-CoV-2-related disease, from initial pneumonia manifestations to persistent long COVID lung symptoms, is the focus of this review. Pathological explorations have offered unprecedented insights into the early stages of severe COVID-19, shedding light on the interplay between the virus and subsequent complications, thereby shaping clinical approaches. Growing interest is directed to residual lung abnormalities of COVID-19 survivors. Although various radiological studies reported long-lasting pulmonary changes (e.g., ground glass opacities, reticulations, and bronchiectasis), the true incidence of pulmonary fibrosis and corresponding pathological findings in these patients remains largely unknown. There are a few high-impact and knowledgeable works on late complications in COVID-19 survivors, several coming from explant or autopsy cases, and rare cases from in vivo sampling. The study of biopsy samples has further deepened our knowledge of the aftermath of COVID-19 on lung tissue, uncovering alterations at the cellular level and shifts in vascular and epithelial dynamics. Despite the substantial progress made, future research is needed to devise a uniform strategy for interpreting lung biopsies, with a focus on leveraging advanced tools such as molecular and digital pathology techniques, along with artificial intelligence.
MeSH term(s)	Humans ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Artificial Intelligence ; Pathologists ; SARS-CoV-2 ; Pneumonia ; Lung/diagnostic imaging
Language	English
Publishing date	2023-04-08
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
DOI	10.32074/1591-951X-906
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Article ; Online: The significance of co-mutations in EGFR-mutated non-small cell lung cancer: Optimizing the efficacy of targeted therapies?

Pezzuto, Federica / Hofman, Véronique / Bontoux, Christophe / Fortarezza, Francesco / Lunardi, Francesca / Calabrese, Fiorella / Hofman, Paul

Lung cancer (Amsterdam, Netherlands)

2023 Volume 181, Page(s) 107249

Abstract: Non-small cell lung cancer (NSCLC) is the most common cause of cancer death worldwide. In non-squamous NSCLC, the identification of oncogenic drivers and the development of target-specific molecules led to remarkable progress in therapeutic strategies ... ...

Abstract	Non-small cell lung cancer (NSCLC) is the most common cause of cancer death worldwide. In non-squamous NSCLC, the identification of oncogenic drivers and the development of target-specific molecules led to remarkable progress in therapeutic strategies and overall survival over the last decade. Nevertheless, responses are limited by systematically acquired mechanisms of resistance early on after starting a targeted therapy. Moreover, mounting evidence has demonstrated that each oncogenic-driven cluster is actually heterogeneous in terms of molecular features, clinical behaviour, and sensitivity to targeted therapy. In this review, we aimed to examine the prognostic and predictive significance of oncogene-driven co-mutations, focusing mainly on EGFR and TP53. A narrative review was performed by searching MEDLINE databases for English articles published over the last decade (from January 2012 until November 2022). The bibliographies of key references were manually reviewed to select those eligible for the topic. The genetic landscape of EGFR-mutated NSCLC is more complicated than what is known so far. In particular, the occurrence of TP53 co-mutations stratify patients carrying EGFR mutations in terms of treatment response. The study provides a deeper understanding of the mechanisms underlying the variability of the genetic landscape of EGFR-mutated NSCLC and summarizes notably the clinical importance of TP53 co-mutations for an open avenue to more properly addressing the clinical decision-making in the near future.
MeSH term(s)	Humans ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; ErbB Receptors/genetics ; Lung Neoplasms/drug therapy ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Antineoplastic Agents ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2023-05-18
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2023.107249
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 423: Show issues

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Article ; Online: An unexpected guest: Pulmonary echinococcosis diagnosed by intraoperative frozen section examination. A case report and literature review.

Maggioni, Giuseppe / Bonis, Alessandro / Schiavon, Marco / Giraudo, Chiara / Lunardi, Francesca / Pezzuto, Federica / Calabrese, Fiorella

Pathology, research and practice

2023 Volume 248, Page(s) 154615

Abstract: Echinococcosis is caused by tapeworms belonging to the Echinococcus genus. The most common site of infection is the liver although it may involve almost any organ. Symptoms of pulmonary echinococcosis vary depending on the location and structure of the ... ...

Abstract	Echinococcosis is caused by tapeworms belonging to the Echinococcus genus. The most common site of infection is the liver although it may involve almost any organ. Symptoms of pulmonary echinococcosis vary depending on the location and structure of the cyst. While uncomplicated cysts usually appear at imaging as well-defined homogeneous lesions with fluid content and smooth walls of variable thickness, complicated lesions may have a more heterogeneous content with higher density making more difficult the distinction from malignancies or other infections. Hereby we describe the case of a 61-year-old Northern African male admitted to our tertiary center for left upper chest pain who then underwent a chest computed tomography (CT) scan which demonstrated a large hypodense lesion, with smooth and thick walls, in the upper left lobe. The following magnetic resonance confirmed the homogeneous fluid content, and the 18 F- fluorodeoxyglucose-positron emission tomography/CT demonstrated a mild uptake of the walls. According to these findings, the main differential diagnoses at imaging included bronchogenic cyst, synovial sarcoma, and pulmonary hematoma although the patient denied any recent trauma. Given the large size and clinical symptoms he underwent surgery. Intra-operative frozen section, supported by imprint cytology, excluded the presence of malignancy while suggested an echinococcal laminar exocyst. The final pathological examination confirmed the diagnosis of echinococcosis (i.e., Echinococcus Granulosus protoscolex). After surgery he was treated with albendazole and at the six-month follow-up he was in good clinical conditions. Our case highlights the importance of considering rare infections, particularly in individuals from endemic areas. Frozen tissue analyses can be a diagnostic challenge and often require ancillary tools such as imprint cytology and serial sections for more sensitive and accurate diagnosis.
MeSH term(s)	Animals ; Humans ; Male ; Middle Aged ; Echinococcosis, Pulmonary/diagnosis ; Echinococcosis, Pulmonary/surgery ; Echinococcosis, Pulmonary/drug therapy ; Frozen Sections ; Echinococcus granulosus ; Tomography, X-Ray Computed ; Albendazole/therapeutic use ; Cysts
Chemical Substances	Albendazole (F4216019LN)
Language	English
Publishing date	2023-06-12
Publishing country	Germany
Document type	Review ; Case Reports
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154615
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Article ; Online: Reliability of a special device for measuring the cross-sectional area of the patellar tendon by ultrasonography.

Lunardi, Morgana / Furtado, Franklin Everaldo / Sakugawa, Raphael Luiz / Sonda, Francesca Chaida / Sampaio, Lucas Tavares / Diefenthaeler, Fernando

Journal of ultrasound

2023 Volume 26, Issue 4, Page(s) 897–903

Abstract: The objective of this study was to evaluate the intra- and inter-rater reliability and agreement between conditions with and without a special device (SD) in the evaluation of the patellar tendon (PT) cross-sectional area (CSA). Forty trained adult ... ...

Abstract	The objective of this study was to evaluate the intra- and inter-rater reliability and agreement between conditions with and without a special device (SD) in the evaluation of the patellar tendon (PT) cross-sectional area (CSA). Forty trained adult volunteers participated in the study. With the knee positioned at 90°, the ultrasound probe was placed in the transverse plane at 25, 50, and 75% of the PT length. Two raters and one analyzer obtained the images. We use a two-way ANOVA with a significance level of α = 0.05. No significant differences were found between raters or conditions. Intra-rater reliability ranged from moderate to good. Inter-rater reliability without the SD ranged from low to good, improving from moderate to good when the SD was used. Evaluation of the PT ends showed a lower coefficient of variation with the SD. We observed a moderate correlation at the ends and a strong correlation in the middle between conditions. The mean difference in the three positions is small (~ 0.013 cm
MeSH term(s)	Adult ; Humans ; Patellar Ligament/diagnostic imaging ; Reproducibility of Results ; Observer Variation ; Knee Joint ; Ultrasonography/methods
Language	English
Publishing date	2023-09-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-023-00829-w
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Article ; Online: Correction: Repotrectinib's Clinical Benefit and Its Brain Penetration in a Patient with Meningeal Carcinomatosis from G2032R-Mutated ROS-1 Positive Non-Small Cell Lung Cancer.

Metro, Giulio / Gariazzo, Eleonora / Costabile, Silvia / Baglivo, Sara / Roila, Fausto / Colamartini, Francesca / Palumbo, Barbara / Chiarini, Pietro / Gori, Stefania / Conti, Antonio / Marcomigni, Luca / Bellezza, Guido / Lunardi, Gianluigi

Oncology and therapy

2024 Volume 12, Issue 1, Page(s) 173–174

Language	English
Publishing date	2024-01-01
Publishing country	New Zealand
Document type	Published Erratum
ZDB-ID	2848647-X
ISSN	2366-1089 ; 2366-1070
ISSN (online)	2366-1089
ISSN	2366-1070
DOI	10.1007/s40487-023-00258-z
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Article ; Online: Comment on: Onset of eosinophilic granulomatosis with polyangiitis in a patient treated with an IL-5 pathway inhibitor for severe asthma: reply.

Caminati, Marco / Maule, Matteo / Nalin, Francesca / Senna, Gianenrico / Lunardi, Claudio

Rheumatology (Oxford, England)

2020 Volume 60, Issue 2, Page(s) e79–e80

MeSH term(s)	Asthma/drug therapy ; Churg-Strauss Syndrome/chemically induced ; Churg-Strauss Syndrome/drug therapy ; Eosinophils ; Granulomatosis with Polyangiitis ; Humans ; Interleukin-5
Chemical Substances	Interleukin-5
Language	English
Publishing date	2020-12-02
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keaa799
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: Isolated intracranial myeloid sarcoma: report of a case and review of the literature.

Barbieri, Francesca Romana / De Luna, Adolfo / Moschettoni, Laura / Lunardi, Pierpaolo

British journal of neurosurgery

2020 Volume 37, Issue 3, Page(s) 350–353

Abstract: Myeloid sarcoma is a rare malignant tumor of primitive myeloid cell origin often associated with hematologic disorders. The central nervous system is rarely involved and differentiating between myeloid sarcoma and other tumors is not possible on imaging. ...

Abstract	Myeloid sarcoma is a rare malignant tumor of primitive myeloid cell origin often associated with hematologic disorders. The central nervous system is rarely involved and differentiating between myeloid sarcoma and other tumors is not possible on imaging. Here we present the rare case of an isolated intracranial myeloid sarcoma, initially misdiagnosed radiologically as a meningioma, treated with surgical total resection and subsequent chemotherapy, with no signs of any hematological disorder at follow up. Differential diagnosis and management strategies, as well as follow-up implications are discussed along with literature review, which pointed out that only five cases with no further signs of hematological disorders at follow up have been described in the literature so far and this case has the longest follow up of them at 9 years.
MeSH term(s)	Humans ; Sarcoma, Myeloid/diagnostic imaging ; Sarcoma, Myeloid/surgery ; Magnetic Resonance Imaging/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Meningioma ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/surgery
Language	English
Publishing date	2020-04-30
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2020.1759782
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Zs.A 2210: Show issues

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Article ; Online: Onset of eosinophilic granulomatosis with polyangiitis in a patient treated with an IL-5 pathway inhibitor for severe asthma.

Caminati, Marco / Maule, Matteo / Nalin, Francesca / Senna, Gianenrico / Lunardi, Claudio

Rheumatology (Oxford, England)

2020 Volume 60, Issue 2, Page(s) e59–e60

MeSH term(s)	Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Churg-Strauss Syndrome/chemically induced ; Churg-Strauss Syndrome/diagnosis ; Eosinophils/pathology ; Female ; Granulomatosis with Polyangiitis/chemically induced ; Granulomatosis with Polyangiitis/diagnosis ; Humans ; Interleukin-5/antagonists & inhibitors ; Middle Aged ; Severity of Illness Index
Chemical Substances	Antibodies, Monoclonal, Humanized ; Interleukin-5 ; mepolizumab (90Z2UF0E52)
Language	English
Publishing date	2020-09-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keaa572
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Article ; Online: Repotrectinib's Clinical Benefit and Its Brain Penetration in a Patient with Meningeal Carcinomatosis from G2032R-Mutated ROS-1 Positive Non-Small Cell Lung Cancer.

Oncology and therapy

2023 Volume 12, Issue 1, Page(s) 163–171

Abstract: In this work, we report on a clinically significant response of meningeal carcinomatosis to repotrectinib in a woman with a heavily pretreated ROS1-rearranged non-small cell lung cancer (NSCLC) that harbored the concomitant solvent front G2032R mutation. ...

Abstract	In this work, we report on a clinically significant response of meningeal carcinomatosis to repotrectinib in a woman with a heavily pretreated ROS1-rearranged non-small cell lung cancer (NSCLC) that harbored the concomitant solvent front G2032R mutation. Meningeal carcinomatosis has a higher incidence in oncogene addicted NSCLC due to increased life expectancy, yet no report has ever documented the activity of repotrectinib in this context. In line with its activity, we documented the presence of the drug at potentially active concentrations in the cerebrospinal fluid. Nevertheless, the short-lived response reported by our patient highlights the importance for novel ROS1-tyrosine kinase inhibitors (TKIs) to be specifically developed to be able to penetrate the blood-brain barrier.
Language	English
Publishing date	2023-11-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2848647-X
ISSN	2366-1089 ; 2366-1070
ISSN (online)	2366-1089
ISSN	2366-1070
DOI	10.1007/s40487-023-00251-6
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