LIVIVO - Search results -

Search results

Result 1 - 10 of total 38

Search options

Article ; Online: Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography-Mass Spectrometry (LC-MS).

Whiley, Luke / Lawler, Nathan G / Zeng, Annie Xu / Lee, Alex / Chin, Sung-Tong / Bizkarguenaga, Maider / Bruzzone, Chiara / Embade, Nieves / Wist, Julien / Holmes, Elaine / Millet, Oscar / Nicholson, Jeremy K / Gray, Nicola

Journal of proteome research

2024 Volume 23, Issue 4, Page(s) 1313–1327

Abstract: To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. We evaluated ... ...

Abstract	To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. We evaluated the capability of liquid chromatography-mass spectrometry (LC-MS) assays targeting organic acids and bile acids to validate metabolic phenotypes of SARS-CoV-2 infection. Two independent sample sets were collected: (1) Australia: plasma, SARS-CoV-2 positive (
MeSH term(s)	Humans ; SARS-CoV-2 ; Liquid Chromatography-Mass Spectrometry ; Chromatography, Liquid/methods ; COVID-19 ; Tandem Mass Spectrometry/methods ; Phenotype ; Bile Acids and Salts
Chemical Substances	Bile Acids and Salts
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00797
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6189: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc

Bizkarguenaga, Maider / Gomez-Santos, Laura / Madrid, Juan Francisco / Sáez, Francisco José / Alonso, Edurne

Microscopy research and technique

2021 Volume 85, Issue 4, Page(s) 1454–1464

Abstract: Globozoospermia is a type of teratozoospermia characterized by round morphology of the sperm head. ... ...

Abstract	Globozoospermia is a type of teratozoospermia characterized by round morphology of the sperm head. Gopc
MeSH term(s)	Acrosome/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Golgi Matrix Proteins/metabolism ; Male ; Mice ; Receptors, Cell Surface/metabolism ; Seminal Plasma Proteins ; Spermatids ; Spermatogenesis ; Spermatozoa/physiology ; Zona Pellucida
Chemical Substances	Adaptor Proteins, Signal Transducing ; Golgi Matrix Proteins ; Gopc protein, mouse ; Receptors, Cell Surface ; Seminal Plasma Proteins ; sp56 protein, mouse ; spermadhesin
Language	English
Publishing date	2021-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099714-3
ISSN	1097-0029 ; 1059-910X
ISSN (online)	1097-0029
ISSN	1059-910X
DOI	10.1002/jemt.24009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2251: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Characterization of preovulatory follicular fluid secretome and its effects on equine oocytes during in vitro maturation.

Luis-Calero, Marcos / Marinaro, Federica / Fernández-Hernández, Pablo / Ortiz-Rodríguez, José M / G Casado, Javier / Pericuesta, Eva / Gutiérrez-Adán, Alfonso / González, Esperanza / Azkargorta, Mikel / Conde, Ricardo / Bizkarguenaga, Maider / Embade, Nieves / Elortza, Félix / Falcón-Pérez, Juan M / Millet, Óscar / González-Fernández, Lauro / Macías-García, Beatriz

Research in veterinary science

2024 Volume 171, Page(s) 105222

Abstract: In vitro maturation (IVM) of oocytes is clinically used in horses to produce blastocysts but current conditions used for horses are suboptimal. We analyzed the composition of equine preovulatory follicular fluid (FF) secretome and tested its effects on ... ...

Abstract	In vitro maturation (IVM) of oocytes is clinically used in horses to produce blastocysts but current conditions used for horses are suboptimal. We analyzed the composition of equine preovulatory follicular fluid (FF) secretome and tested its effects on meiotic competence and gene expression in oocytes subjected to IVM. Preovulatory FF was obtained, concentrated using ultrafiltration with cut-off of 10 kDa, and stored at -80 °C. The metabolic and proteomic composition was analyzed, and its ultrastructural composition was assessed by cryo-transmission microscopy. Oocytes obtained post-mortem or by ovum pick up (OPU) were subjected to IVM in the absence (control) or presence of 20 or 40 μg/ml (S20 or S40) of secretome. Oocytes were then analyzed for chromatin configuration or snap frozen for gene expression analysis. Proteomic analysis detected 255 proteins in the Equus caballus database, mostly related to the complement cascade and cholesterol metabolism. Metabolomic analysis yielded 14 metabolites and cryo-transmission electron microscopy analysis revealed the presence of extracellular vesicles (EVs). No significant differences were detected in maturation rates among treatments. However, the expression of GDF9 and BMP15 significantly increased in OPU-derived oocytes compared to post-mortem oocytes (fold increase ± SEM: 9.4 ± 0.1 vs. 1 ± 0.5 for BMP15 and 9.9 ± 0.3 vs. 1 ± 0.5 for GDF9, respectively; p < 0.05). Secretome addition increased the expression of TNFAIP6 in S40 regardless of the oocyte source. Further research is necessary to fully understand whether secretome addition influences the developmental competence of equine oocytes.
MeSH term(s)	Female ; Horses ; Animals ; Follicular Fluid/chemistry ; Follicular Fluid/metabolism ; Proteomics ; Secretome ; Meiosis ; Oocytes/metabolism ; In Vitro Oocyte Maturation Techniques/veterinary
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2024.105222
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 673: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy.

Raines, Nathan H / Leone, Dominick A / O'Callaghan-Gordo, Cristina / Ramirez-Rubio, Oriana / Amador, Juan José / Lopez Pilarte, Damaris / Delgado, Iris S / Leibler, Jessica H / Embade, Nieves / Gil-Redondo, Rubén / Bruzzone, Chiara / Bizkarguenaga, Maider / Scammell, Madeleine K / Parikh, Samir M / Millet, Oscar / Brooks, Daniel R / Friedman, David J

Metabolites

2023 Volume 13, Issue 3

Abstract: Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men in Mesoamerica. Strenuous agricultural labor is a consistent risk factor for MeN, but the pathophysiologic mechanism leading to disease is poorly ... ...

Abstract	Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men in Mesoamerica. Strenuous agricultural labor is a consistent risk factor for MeN, but the pathophysiologic mechanism leading to disease is poorly understood. We compared the urine metabolome among men in Nicaragua engaged in sugarcane harvest and seed cutting (
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13030325
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Prospective Metabolomic Studies in Precision Medicine: The AKRIBEA Project.

Bizkarguenaga, Maider / Gil-Redondo, Rubén / Bruzzone, Chiara / Bernardo-Seisdedos, Ganeko / Laín, Ana / González-Valle, Beatriz / Embade, Nieves / Mato, José M / Millet, Oscar

Handbook of experimental pharmacology

2022 Volume 277, Page(s) 275–297

Abstract: For a long time, conventional medicine has analysed biomolecules to diagnose diseases. Yet, this approach has proven valid only for a limited number of metabolites and often through a bijective relationship with the disease (i.e. glucose relationship ... ...

Abstract	For a long time, conventional medicine has analysed biomolecules to diagnose diseases. Yet, this approach has proven valid only for a limited number of metabolites and often through a bijective relationship with the disease (i.e. glucose relationship with diabetes), ultimately offering incomplete diagnostic value. Nowadays, precision medicine emerges as an option to improve the prevention and/or treatment of numerous pathologies, focusing on the molecular mechanisms, acting in a patient-specific dimension, and leveraging multiple contributing factors such as genetic, environmental, or lifestyle. Metabolomics grasps the required subcellular complexity while being sensitive to all these factors, which results in a most suitable technique for precision medicine. The aim of this chapter is to describe how NMR-based metabolomics can be integrated in the design of a precision medicine strategy, using the Precision Medicine Initiative of the Basque Country (the AKRIBEA project) as a case study. To that end, we will illustrate the procedures to be followed when conducting an NMR-based metabolomics study with a large cohort of individuals, emphasizing the critical points. The chapter will conclude with the discussion of some relevant biomedical applications.
MeSH term(s)	Humans ; Precision Medicine ; Prospective Studies ; Metabolomics/methods ; Diabetes Mellitus/metabolism ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-10-18
Publishing country	Germany
Document type	Journal Article
ISSN	0171-2004
ISSN	0171-2004
DOI	10.1007/164_2022_610
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
danach: Sign. bei den Einzelbänden: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 Infection.

Gray, Nicola / Lawler, Nathan G / Zeng, Annie Xu / Ryan, Monique / Bong, Sze How / Boughton, Berin A / Bizkarguenaga, Maider / Bruzzone, Chiara / Embade, Nieves / Wist, Julien / Holmes, Elaine / Millet, Oscar / Nicholson, Jeremy K / Whiley, Luke

Metabolites

2021 Volume 11, Issue 7

Abstract: Improved methods are required for investigating the systemic metabolic effects of SARS-CoV-2 infection and patient stratification for precision treatment. We aimed to develop an effective method using lipid profiles for discriminating between SARS-CoV-2 ... ...

Abstract	Improved methods are required for investigating the systemic metabolic effects of SARS-CoV-2 infection and patient stratification for precision treatment. We aimed to develop an effective method using lipid profiles for discriminating between SARS-CoV-2 infection, healthy controls, and non-SARS-CoV-2 respiratory infections. Targeted liquid chromatography-mass spectrometry lipid profiling was performed on discovery (20 SARS-CoV-2-positive; 37 healthy controls; 22 COVID-19 symptoms but SARS-CoV-2negative) and validation (312 SARS-CoV-2-positive; 100 healthy controls) cohorts. Orthogonal projection to latent structure-discriminant analysis (OPLS-DA) and Kruskal-Wallis tests were applied to establish discriminant lipids, significance, and effect size, followed by logistic regression to evaluate classification performance. OPLS-DA reported separation of SARS-CoV-2 infection from healthy controls in the discovery cohort, with an area under the curve (AUC) of 1.000. A refined panel of discriminant features consisted of six lipids from different subclasses (PE, PC, LPC, HCER, CER, and DCER). Logistic regression in the discovery cohort returned a training ROC AUC of 1.000 (sensitivity = 1.000, specificity = 1.000) and a test ROC AUC of 1.000. The validation cohort produced a training ROC AUC of 0.977 (sensitivity = 0.855, specificity = 0.948) and a test ROC AUC of 0.978 (sensitivity = 0.948, specificity = 0.922). The lipid panel was also able to differentiate SARS-CoV-2-positive individuals from SARS-CoV-2-negative individuals with COVID-19-like symptoms (specificity = 0.818). Lipid profiling and multivariate modelling revealed a signature offering mechanistic insights into SARS-CoV-2, with strong predictive power, and the potential to facilitate effective diagnosis and clinical management.
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11070467
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts.

Masuda, Reika / Lodge, Samantha / Nitschke, Philipp / Spraul, Manfred / Schaefer, Hartmut / Bong, Sze-How / Kimhofer, Torben / Hall, Drew / Loo, Ruey Leng / Bizkarguenaga, Maider / Bruzzone, Chiara / Gil-Redondo, Rubén / Embade, Nieves / Mato, José M / Holmes, Elaine / Wist, Julien / Millet, Oscar / Nicholson, Jeremy K

Journal of proteome research

2021 Volume 20, Issue 8, Page(s) 4139–4152

Abstract: Quantitative plasma lipoprotein and metabolite profiles were measured on an autonomous community of the Basque Country (Spain) cohort consisting of hospitalized COVID-19 patients ( ...

Abstract	Quantitative plasma lipoprotein and metabolite profiles were measured on an autonomous community of the Basque Country (Spain) cohort consisting of hospitalized COVID-19 patients (
MeSH term(s)	Australia ; Biomarkers ; COVID-19 ; Humans ; Lipoproteins ; SARS-CoV-2
Chemical Substances	Biomarkers ; Lipoproteins
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.1c00458
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6189: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Abnormal concentration of porphyrins in serum from COVID-19 patients.

San Juan, Itxaso / Bruzzone, Chiara / Bizkarguenaga, Maider / Bernardo-Seisdedos, Ganeko / Laín, Ana / Gil-Redondo, Rubén / Diercks, Tammo / Gil-Martínez, Jon / Urquiza, Pedro / Arana, Eunate / Seco, Marisa / García de Vicuña, Aitor / Embade, Nieves / Mato, José M / Millet, Oscar

British journal of haematology

2020 Volume 190, Issue 5, Page(s) e265–e267

MeSH term(s)	Aged ; Aged, 80 and over ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/blood ; Female ; Heme/metabolism ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Porphyrins/blood ; SARS-CoV-2
Chemical Substances	Porphyrins ; Heme (42VZT0U6YR)
Keywords	covid19
Language	English
Publishing date	2020-08-29
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17060
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.182: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Uneven metabolic and lipidomic profiles in recovered COVID-19 patients as investigated by plasma NMR metabolomics.

Bizkarguenaga, Maider / Bruzzone, Chiara / Gil-Redondo, Rubén / SanJuan, Itxaso / Martin-Ruiz, Itziar / Barriales, Diego / Palacios, Ainhoa / Pasco, Samuel T / González-Valle, Beatriz / Laín, Ana / Herrera, Lara / Azkarate, Aida / Vesga, Miguel Angel / Eguizabal, Cristina / Anguita, Juan / Embade, Nieves / Mato, José M / Millet, Oscar

NMR in biomedicine

2021 Volume 35, Issue 2, Page(s) e4637

Abstract: COVID-19 is a systemic infectious disease that may affect many organs, accompanied by a measurable metabolic dysregulation. The disease is also associated with significant mortality, particularly among the elderly, patients with comorbidities, and solid ... ...

Abstract	COVID-19 is a systemic infectious disease that may affect many organs, accompanied by a measurable metabolic dysregulation. The disease is also associated with significant mortality, particularly among the elderly, patients with comorbidities, and solid organ transplant recipients. Yet, the largest segment of the patient population is asymptomatic, and most other patients develop mild to moderate symptoms after SARS-CoV-2 infection. Here, we have used NMR metabolomics to characterize plasma samples from a cohort of the abovementioned group of COVID-19 patients (n = 69), between 3 and 10 months after diagnosis, and compared them with a set of reference samples from individuals never infected by the virus (n = 71). Our results indicate that half of the patient population show abnormal metabolism including porphyrin levels and altered lipoprotein profiles six months after the infection, while the other half show little molecular record of the disease. Remarkably, most of these patients are asymptomatic or mild COVID-19 patients, and we hypothesize that this is due to a metabolic reflection of the immune response stress.
MeSH term(s)	COVID-19/immunology ; COVID-19/metabolism ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Humans ; Lipidomics ; Magnetic Resonance Spectroscopy/methods ; Metabolomics ; SARS-CoV-2
Chemical Substances	Cholesterol, HDL ; Cholesterol, LDL
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1000976-0
ISSN	1099-1492 ; 0952-3480
ISSN (online)	1099-1492
ISSN	0952-3480
DOI	10.1002/nbm.4637
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2869: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Metabolic Landscape of the Mouse Liver by Quantitative

Bernardo-Seisdedos, Ganeko / Bilbao, Jon / Fernández-Ramos, David / Lopitz-Otsoa, Fernando / Gutierrez de Juan, Virginia / Bizkarguenaga, Maider / Mateos, Borja / Fondevila, Marcos F / Abril-Fornaguera, Jordi / Diercks, Tammo / Lu, Shelly C / Nogueiras, Rubén / Mato, José M / Millet, Oscar

Hepatology (Baltimore, Md.)

2021 Volume 74, Issue 1, Page(s) 148–163

Abstract: Background and aims: The liver plays a central role in all metabolic processes in the body. However, precise characterization of liver metabolism is often obscured by its inherent complexity. Phosphorylated metabolites occupy a prominent position in all ...

Abstract	Background and aims: The liver plays a central role in all metabolic processes in the body. However, precise characterization of liver metabolism is often obscured by its inherent complexity. Phosphorylated metabolites occupy a prominent position in all anabolic and catabolic pathways. Here, we develop a Approach and results: We applied this technique to define the metabolic landscape in livers from a mouse model of the rare disease disorder congenital erythropoietic porphyria (CEP) as well as two well-known murine models of nonalcoholic steatohepatitis: one genetic, methionine adenosyltransferase 1A knockout mice, and the other dietary, mice fed a high-fat choline-deficient diet. We report alterations in the concentrations of phosphorylated metabolites that are readouts of the balance between glycolysis, gluconeogenesis, the pentose phosphate pathway, the tricarboxylic acid cycle, and oxidative phosphorylation and of phospholipid metabolism and apoptosis. Moreover, these changes correlate with the main histological features: steatosis, apoptosis, iron deposits, and fibrosis. Strikingly, treatment with the repurposed drug ciclopirox improves the phosphoromic profile of CEP mice, an effect that was mirrored by the normalization of liver histology. Conclusions: In conclusion, these findings indicate that NMR-based phosphoromics may be used to unravel metabolic phenotypes of liver injury and to identify the mechanism of drug action.
MeSH term(s)	Animals ; Disease Models, Animal ; Feasibility Studies ; Female ; Humans ; Hydrophobic and Hydrophilic Interactions ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Magnetic Resonance Spectroscopy ; Male ; Metabolome/drug effects ; Metabolome/physiology ; Metabolomics/methods ; Mice ; Mice, Transgenic ; Models, Animal ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/pathology ; Phosphorus ; Phosphorylation/drug effects
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.31676
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1660: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito