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  1. Book ; Conference proceedings: Optimizing the treatment of hemophilia B

    Aledort, Louis M.

    laboratory and clinical perspectives ; [symposium held at the XXII congress of the International Society on Thrombosis and Haemostasis in Boston, Massachusetts in July 2009]

    (Haemophilia ; 16, Suppl. 6)

    2010  

    Author's details guest ed.: Louis M. Aledort
    Series title Haemophilia ; 16, Suppl. 6
    Collection
    Language English
    Size 18 S. : graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT016442510
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4249 -16,Suppl.6- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: New directions to develop therapies for people with hemophilia.

    Gogia, Pooja / Tarantino, Michael / Schramm, Wolfgang / Aledort, Louis

    Expert review of hematology

    2023  Volume 16, Issue 6, Page(s) 417–433

    Abstract: Introduction: The past few decades have seen a tremendous advancement in the management of hemophilia. Whether it is improved methods to attenuate critical viruses, recombinant bioengineering with decreased immunogenicity, extended half-life replacement ...

    Abstract Introduction: The past few decades have seen a tremendous advancement in the management of hemophilia. Whether it is improved methods to attenuate critical viruses, recombinant bioengineering with decreased immunogenicity, extended half-life replacement therapies to mitigate the burden of repeated infusion treatments, novel nonreplacement products to avoid the drawback of inhibitor development with its attractive subcutaneous administration and then the introduction of gene therapy, the management has trodden a long way.
    Areas covered: This expert review describes the progress in the treatment of hemophilia over the years. We discuss, in detail, the past and current therapies, their benefits, drawbacks, along with relevant studies leading to approval, efficacy and safety profile, ongoing trials, and future prospects.
    Expert opinion: The technological advances in the treatment of hemophilia with convenient modes of administration and innovative modalities offer a chance for a normal existence of the patients living with this disease. However, it is imperative for clinicians to be aware of the potential adverse effects and the need for further studies to establish causality or chance association of these events with novel agents. Thus, it is crucial for clinicians to engage patients and their families in informed decision-making and tailor individual concerns and necessities.
    MeSH term(s) Humans ; Hemophilia A/therapy ; Factor VIII/adverse effects ; Half-Life ; Hemophilia B/therapy ; Factor IX/adverse effects
    Chemical Substances Factor VIII (9001-27-8) ; Factor IX (9001-28-9)
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2023.2184341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6943: Show issues Location:
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  3. Book: The evolution of recombinant factors for hemophilia: making therapeutic choices

    Aledort, Louis M.

    (Haematologica ; 89, Suppl. 1)

    2004  

    Author's details guest ed.: Louis M. Aledort
    Series title Haematologica ; 89, Suppl. 1
    Collection
    Language English
    Size 35 S. : Ill., graph. Darst.
    Publisher Ferrata Storti Found
    Publishing place Pavia
    Publishing country Italy
    Document type Book
    HBZ-ID HT015052958
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 76 -89,Suppl.1- verfügbar in Königswinter Königswinter

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  4. Article ; Online: The evolution of comprehensive haemophilia care in the United States: perspectives from the frontline.

    Aledort, L M

    Haemophilia : the official journal of the World Federation of Hemophilia

    2016  Volume 22, Issue 5, Page(s) 676–683

    Abstract: The establishment of dedicated comprehensive treatment centres more than a half century ago transformed the management of haemophilia in the United States. Formerly, a disease associated with crippling disability and premature death, today, persons with ... ...

    Abstract The establishment of dedicated comprehensive treatment centres more than a half century ago transformed the management of haemophilia in the United States. Formerly, a disease associated with crippling disability and premature death, today, persons with haemophilia who are treated appropriately from infancy and do not develop inhibitors can expect a normal life expectancy and relatively few bleeding episodes. The evolution of the comprehensive haemophilia care, while chastened by the viral epidemics of the 1980s, has been marked by ongoing advances, including prophylaxis, immune tolerance induction, new drugs and gene therapy research. Current challenges include sustaining the comprehensive care model despite decreased funding and expanding the delivery and affordability of comprehensive haemophilia care.
    MeSH term(s) Blood Coagulation Factors/genetics ; Blood Coagulation Factors/metabolism ; Blood Coagulation Factors/therapeutic use ; Comprehensive Health Care/standards ; Delivery of Health Care/organization & administration ; Genetic Therapy ; Hemophilia A/diagnosis ; Hemophilia A/therapy ; Hemophilia B/diagnosis ; Hemophilia B/therapy ; Humans ; Protein Engineering ; Recombinant Proteins/therapeutic use ; United States
    Chemical Substances Blood Coagulation Factors ; Recombinant Proteins
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.12970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4249: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 450: Show issues

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  5. Book ; Conference proceedings: Coagulation therapy in the new millennium

    Aledort, Louis M.

    proceedings ... based on a Satellite Symposium Entitled Coagulation Therapy in the New Millennium ... held in New Orleans, USA, on 3 December 1999

    (Haemophilia ; 7, Suppl. 1)

    2001  

    Event/congress Satellite Symposium Entitled Coagulation Therapy in the New Millennium (1999, NewOrleansLa.)
    Author's details guest ed.: L. M. Aledort
    Series title Haemophilia ; 7, Suppl. 1
    Collection
    Language English
    Size 35 S.
    Publisher Blackwell Science
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT012948366
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4249 -7,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  6. Book ; Conference proceedings: Unexpected bleeding disorders

    Aledort, Louis M.

    identification, diagnosis and management ; proceedings of a corporate symposium, preceding the 41st annual meeting of the American Society of Hematology, New Orleans, USA

    (Clinical and laboratory haematology ; 22, Suppl. 1)

    2000  

    Author's details guest ed.: L. M. Aledort
    Series title Clinical and laboratory haematology ; 22, Suppl. 1
    Collection
    Language English
    Size 32 S. : graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT012907681
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

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    Zs A 1499 -22,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  7. Book: Challenges in the treatment of haemophilia with inhibitors

    Aledort, Louis M.

    (Haemophilia ; 5, Suppl. 3)

    1999  

    Author's details guest ed.: L. M. Aledort
    Series title Haemophilia ; 5, Suppl. 3
    Collection
    Language English
    Size IV, 51 S. : Ill., graph. Darst.
    Publisher Blackwell Science
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT011164403
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4249 -5,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: The effect of a specialized case management programme on the cost of factor replacement use in patients with bleeding disorders.

    Aledort, L M

    Haemophilia : the official journal of the World Federation of Hemophilia

    2014  Volume 20, Issue 3, Page(s) e240–2

    MeSH term(s) Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/economics ; Case Management/economics ; Case Management/organization & administration ; Drug Costs ; Hemorrhagic Disorders/drug therapy ; Hemorrhagic Disorders/economics ; Humans ; United States
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.12422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4249: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 450: Show issues

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  9. Book ; Conference proceedings: Inhibitors to coagulation factors

    Aledort, Louis M.

    [proceedings of the Second International Symposium on Inhibitors to Coagulation Factors, held November 3 - 5, 1993, Chapel Hill, North Carolina]

    (Advances in experimental medicine and biology ; 386)

    1995  

    Event/congress International Symposium on Inhibitors to Coagulation Factors (2, 1993, ChapelHillNC)
    Author's details ed. by Louis M. Aledort
    Series title Advances in experimental medicine and biology ; 386
    Collection
    Keywords Blood Coagulation / immunology / congresses ; Blood Coagulation Disorders / therapy / congresses ; Blood Coagulation Factors / immunology / congresses ; Blood Coagulation Factors / therapeutic use / congresses ; Blood Coagulation Factors / antagonists & inhibitors / congresses ; Hämophilie ; Gerinnungsfaktor ; Antikörper ; Arzneimittelresistenz ; Gerinnungsfaktor VII ; Immunologie ; Gerinnungsfaktor VIII
    Subject Klinische Immunologie ; Antihämophiles Globulin A ; Faktor VIII ; Kogenate ; Bindegewebsfaktor VIII ; Antifibrinolytischer Faktor VIII ; Blutgerinnungsfaktor VIII ; Blutgerinnungsfaktor VII ; Faktor VII ; NovoSeven ; CAS 9001-25-6 ; Chemoresistenz ; Medikamentös therapierefraktäres Verhalten ; Pharmakoresistenz ; Blutgerinnungsfaktor ; Gerinnungsfaktoren ; Bluterkrankheit
    Language English
    Size XV, 308 S. : Ill., graph. Darst.
    Publisher Plenum Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007135466
    ISBN 0-306-45196-4 ; 978-0-306-45196-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -386- not available for loan Zeitschriften-Lesesaal

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  10. Book ; Conference proceedings: Factor VIII inhibitor treatment

    Aledort, Louis M.

    strategies for the continuing challenge ; [proceedings of a symposium held July 10, 1993, in New York, NY, in conjunction with the XIVth International Congress of Thrombosis and Hemostasis]

    (Seminars in hematology ; 31,2, Suppl. 4)

    1994  

    Event/congress International Congress on Thrombosis and Haemostasis (14, 1993, NewYorkNY)
    Author's details Louis M. Aledort, guest ed
    Series title Seminars in hematology ; 31,2, Suppl. 4
    Collection
    Keywords Factor VIII / antagonists & inhibitors / congresses ; Gerinnungsfaktor VIII
    Subject Antihämophiles Globulin A ; Faktor VIII ; Kogenate ; Bindegewebsfaktor VIII ; Antifibrinolytischer Faktor VIII ; Blutgerinnungsfaktor VIII
    Language English
    Size 66 S. : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT006324529
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 328 -31,2,Suppl.4- verfügbar in Königswinter Königswinter

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