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  1. Article ; Online: Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study.

    Ali, Ahmed Y / Medhat, Basma M / Ashour, Sara S / Badr, Amul M / Dorgham, Dalia / Ramadan, Hala / Behiry, Mervat E

    Current rheumatology reviews

    2023  Volume 19, Issue 4, Page(s) 463–469

    Abstract: ... is autophagy. Immunity-related GTPase family M protein (IRGM) has been shown to be linked to immune ...

    Abstract Objective: One of the potential factors that cause systemic lupus erythematosus (SLE) development is autophagy. Immunity-related GTPase family M protein (IRGM) has been shown to be linked to immune-mediated diseases. The aim of the current study was to assess the role of the IRGM-autophagy gene in SLE susceptibility in an Egyptian population and its relation to lupus nephritis.
    Methods: A case-control study was conducted in which a total of 200 subjects (100SLE and 100 healthy controls) were enrolled. Two single-nucleotide polymorphisms (SNPs) (rs10065172 and rs4958847) were genotyped. Genotypes and alleles analysis was conducted to compare between cases and controls, as well as a stratification analysis was conducted on the presence or absence of lupus nephritis.
    Results: Among selected SNPs of IRGM, no association was found between both SNPs and SLE susceptibility. For rs10065172, the major expressed genotype was CC (61% and 71%) (Adj OR= 2.9, 95%= 0.545-15.5), followed by TC (34% and 27%) (Adj OR= 1.985, 95% = 0.357-11.041) in cases and controls, respectively. For rs4958847, AA and AG were comparably expressed in case [(43% and 39%) (Adj OR= 1.073, 95% = 0.483-2.382)] and control [(41% and 43%) (Adj OR= 1.24, 95% = 0.557- 2.763)], respectively. Additionally, no relationship among both SNPs and gender, lupus nephritis, disease activity, or disease duration, was observed.
    Conclusion: IRGM SNPs (rs10065172 and rs4958847) expression was comparable among SLE patients and controls of the Egyptian cohort. Genotype and allele frequency of IRGM SNPs did not differ in lupus nephritis and non-lupus nephritis patients.
    MeSH term(s) Humans ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Crohn Disease/epidemiology ; Crohn Disease/genetics ; Case-Control Studies ; Egypt ; GTP-Binding Proteins/genetics ; Lupus Erythematosus, Systemic/genetics ; Lupus Nephritis/genetics
    Chemical Substances GTP-Binding Proteins (EC 3.6.1.-) ; IRGM protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2023-03-31
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6360
    ISSN (online) 1875-6360
    DOI 10.2174/1573397119666230330081708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of Au Plasmonic Material on Poly M-Toluidine for Photoelectrochemical Hydrogen Generation from Sewage Water.

    Abdelazeez, Ahmed Adel A / Hadia, N M A / Mourad, Abdel-Hamid I / El-Fatah, Gehad Abd / Shaban, Mohamed / Ahmed, Ashour M / Alzaid, Meshal / Cherupurakal, Nizamudeen / Rabia, Mohamed

    Polymers

    2022  Volume 14, Issue 4

    Abstract: This study provides ... ...

    Abstract This study provides H
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14040768
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  3. Article ; Online: Effect of Au Plasmonic Material on Poly M-Toluidine for Photoelectrochemical Hydrogen Generation from Sewage Water

    Ahmed Adel A. Abdelazeez / N.M.A. Hadia / Abdel-Hamid I. Mourad / Gehad Abd El-Fatah / Mohamed Shaban / Ashour M. Ahmed / Meshal Alzaid / Nizamudeen Cherupurakal / Mohamed Rabia

    Polymers, Vol 14, Iss 768, p

    2022  Volume 768

    Abstract: This study provides H 2 gas as a renewable energy source from sewage water splitting reaction using a PMT/Au photocathode. So, this study has a dual benefit for hydrogen generation; at the same time, it removes the contaminations of sewage water. The ... ...

    Abstract This study provides H 2 gas as a renewable energy source from sewage water splitting reaction using a PMT/Au photocathode. So, this study has a dual benefit for hydrogen generation; at the same time, it removes the contaminations of sewage water. The preparation of the PMT is carried out through the polymerization process from an acid medium. Then, the Au sputter was carried out using the sputter device under different times (1 and 2 min) for PMT/Au-1 min and PMT/Au-2min, respectively. The complete analyses confirm the chemical structure, such as XRD, FTIR, HNMR, SEM, and Vis-UV optical analyses. The prepared electrode PMT/Au is used for the hydrogen generation reaction using Na 2 S 2 O 3 or sewage water as an electrolyte. The PMT crystalline size is 15 nm. The incident photon to current efficiency ( IPCE ) efficiency increases from 2.3 to 3.6% (at 390 nm), and the number of H 2 moles increases from 8.4 to 33.1 mmol h −1 cm −2 for using Na 2 S 2 O 3 and sewage water as electrolyte, respectively. Moreover, all the thermodynamic parameters, such as activation energy ( E a ), enthalpy (Δ H *), and entropy (Δ S *), were calculated; additionally, a simple mechanism is mentioned for the water-splitting reaction.
    Keywords poly(m toluidine) ; photocatalyst ; water splitting ; photoelectrochemical H 2 generation ; plasmonic Au nanoparticles ; sewage water ; Organic chemistry ; QD241-441
    Subject code 290
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Synthesis and characterization of metals-substituted cobalt ferrite [M

    Abdel Maksoud, M I A / El-Sayyad, Gharieb S / Ashour, A H / El-Batal, Ahmed I / Abd-Elmonem, Mahmmoud S / Hendawy, Hassan A M / Abdel-Khalek, E K / Labib, Sh / Abdeltwab, E / El-Okr, M M

    Materials science & engineering. C, Materials for biological applications

    2018  Volume 92, Page(s) 644–656

    Abstract: Nanocrystalline spinel ferrite nanoparticles [M ...

    Abstract Nanocrystalline spinel ferrite nanoparticles [M
    MeSH term(s) Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Candida albicans/growth & development ; Cobalt/chemistry ; Cobalt/pharmacology ; Enterococcus faecalis/growth & development ; Ferric Compounds/chemical synthesis ; Ferric Compounds/chemistry ; Ferric Compounds/pharmacology ; Klebsiella pneumoniae/growth & development ; Nanoparticles/chemistry ; Quinazolines/analysis
    Chemical Substances Anti-Infective Agents ; Ferric Compounds ; Quinazolines ; cobalt ferrite ; Cobalt (3G0H8C9362) ; anagrelide (K9X45X0051)
    Language English
    Publishing date 2018-07-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2018.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cytotoxicity of Luffa cylindrica (L.) M.Roem. extract against circulating cancer stem cells in hepatocellular carcinoma.

    Abdel-Salam, Ibrahim M / Awadein, Nihal El-Sayed / Ashour, Mohamed

    Journal of ethnopharmacology

    2018  Volume 229, Page(s) 89–96

    Abstract: Ethnopharmacological relevance: Luffa cylindrica (L.) M.Roem. has been recognized ...

    Abstract Ethnopharmacological relevance: Luffa cylindrica (L.) M.Roem. has been recognized as traditional medicine for the treatment of various diseases like inflammatory diseases, diarrhea and viral infections. The usual parts used include fruit, seeds and leaves.
    Aim of the study: To evaluate the anticancer activity of the hot water extract of the whole plant of Luffa cylindrica using circulating tumor cells and cancer stem cells isolated from the peripheral blood of hepatocellular carcinoma patients in vitro.
    Materials and methods: Seventy five adult patients who reported as stage II and III Hepatocellular carcinoma were selected. Blood samples were withdrawn and the circulating tumor cells were isolated from the whole blood. Tumor cells and cancer stem cells were detected and isolated by flow cytometric techniques. The isolated cell types were cultured and propagated in the tissue culture facility, the extract was tested on the isolated cells.
    Results: Luffa cylindrica hot water extract has shown cytotoxic activity against circulating tumor cells of hepatocellular carcinoma especially the cells sub-population CD133
    Conclusion: Hot water extract of Luffa cylindrica whole plant could decrease the ratio of cancer stem cells in blood of HCC patients and may be used to minimize recurrence and metastasis in hepatocellular carcinoma patients.
    MeSH term(s) Antineoplastic Agents, Phytogenic/pharmacology ; Carcinoma, Hepatocellular ; Cell Survival/drug effects ; Humans ; Liver Neoplasms ; Luffa ; Neoplastic Stem Cells/drug effects ; Plant Extracts/pharmacology ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents, Phytogenic ; Plant Extracts
    Language English
    Publishing date 2018-10-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.09.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Cytotoxicity of Luffa cylindrica (L.) M.Roem. extract against circulating cancer stem cells in hepatocellular carcinoma

    Abdel-Salam, Ibrahim M / Nihal El-Sayed Awadein / Mohamed Ashour

    Journal of ethnopharmacology. 2019 Jan. 30, v. 229

    2019  

    Abstract: Luffa cylindrica (L.) M.Roem. has been recognized as traditional medicine for the treatment ...

    Abstract Luffa cylindrica (L.) M.Roem. has been recognized as traditional medicine for the treatment of various diseases like inflammatory diseases, diarrhea and viral infections. The usual parts used include fruit, seeds and leaves.To evaluate the anticancer activity of the hot water extract of the whole plant of Luffa cylindrica using circulating tumor cells and cancer stem cells isolated from the peripheral blood of hepatocellular carcinoma patients in vitro.Seventy five adult patients who reported as stage II and III Hepatocellular carcinoma were selected. Blood samples were withdrawn and the circulating tumor cells were isolated from the whole blood. Tumor cells and cancer stem cells were detected and isolated by flow cytometric techniques. The isolated cell types were cultured and propagated in the tissue culture facility, the extract was tested on the isolated cells.Luffa cylindrica hot water extract has shown cytotoxic activity against circulating tumor cells of hepatocellular carcinoma especially the cells sub-population CD133+/CD44+ with little effect among CD133+/CD44- sub-population.Hot water extract of Luffa cylindrica whole plant could decrease the ratio of cancer stem cells in blood of HCC patients and may be used to minimize recurrence and metastasis in hepatocellular carcinoma patients.
    Keywords Luffa aegyptiaca ; adults ; antineoplastic activity ; blood ; blood sampling ; cytotoxicity ; diarrhea ; flow cytometry ; fruits ; hepatoma ; metastasis ; neoplasm cells ; patients ; seeds ; stem cells ; tissue culture ; traditional medicine
    Language English
    Dates of publication 2019-0130
    Size p. 89-96.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.09.034
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  7. Article: The Effect of Melatonin Supplement on High Arterial Blood Pressure: An Overview from Clinicaltrials.gov.

    Ashour, Ahmed M

    Journal of multidisciplinary healthcare

    2024  Volume 17, Page(s) 517–520

    Abstract: Background: Melatonin is a hormone produced by the pineal gland primarily at night. It has been suggested that melatonin may possess various cardiovascular benefits, including the potential to lower blood pressure. For this reason, we sought to identify ...

    Abstract Background: Melatonin is a hormone produced by the pineal gland primarily at night. It has been suggested that melatonin may possess various cardiovascular benefits, including the potential to lower blood pressure. For this reason, we sought to identify and provide evidence of the effectiveness of melatonin on high arterial blood pressure in clinical trials.
    Methods: Using the search term "melatonin and hypertension", a search of the ClinicalTrials.gov database was performed on October 10
    Results: Of the 13 clinical trials identified, only three focused on examining the effects of melatonin. The study titles, enrollment numbers, conditions, statuses, interventions, and outcome measures have been explained in depth. Information gathered from these clinical trials will assist us in identifying the possible risks and benefits of melatonin with respect to high arterial blood pressure.
    Conclusion: Melatonin has been shown to be an effective treatment for lowering blood pressure. More research is required to fully establish the potential benefits and risks and highlight the mechanisms through which melatonin may influence blood pressure regulation.
    Language English
    Publishing date 2024-02-02
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S446521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 3-M syndrome: a report of three Egyptian cases with review of the literature.

    Temtamy, Samia A / Aglan, Mona S / Ashour, Adel M / Ramzy, Magda I / Hosny, Laila A / Mostafa, Mostafa I

    Clinical dysmorphology

    2006  Volume 15, Issue 2, Page(s) 55–64

    Abstract: The 3-M syndrome is a rare autosomal recessive disorder. It is characterized by prenatal and ... radiological findings of the 3-M syndrome. The main features in our cases were low birth weight, short stature ... in some cases of 3-M syndrome will aid diagnosis. ...

    Abstract The 3-M syndrome is a rare autosomal recessive disorder. It is characterized by prenatal and postnatal growth retardation associated with characteristic features. In this study, we report on three patients from two unrelated families, including two male sibs, with the characteristic features and radiological findings of the 3-M syndrome. The main features in our cases were low birth weight, short stature, malar hypoplasia, anteverted nostrils with a fleshy nasal tip, long philtrum, pointed full chin, short broad neck, broad chest with transverse grooves of anterior thorax and hyperlordosis. An orodental examination revealed characteristic findings, some of which were not reported before. Prominent premaxilla, hypoplastic maxilla, thick patulous lips, high-arched palate, median fissured tongue, delayed eruption of teeth with enamel hypocalcification and malocclusion were present in our three studied cases. Radiographic studies showed slender long bones and ribs, a narrow pelvis and foreshortened vertebral bodies. Our reported cases are the offspring of healthy consanguineous parents, confirming the autosomal recessive pattern of inheritance in the syndrome. Cases were reported from different countries all over the world. To our knowledge, these are the first reported Egyptian patients with this rare disorder. This syndrome may be underreported because of the phenotypic overlap with other low birth dwarfism syndromes. Recent identification of a gene mutated in some cases of 3-M syndrome will aid diagnosis.
    MeSH term(s) Abnormalities, Multiple/diagnosis ; Abnormalities, Multiple/diagnostic imaging ; Abnormalities, Multiple/pathology ; Adolescent ; Adult ; Asian Continental Ancestry Group ; Child ; Diagnosis, Differential ; Egypt ; Family ; Female ; Hand Deformities, Congenital/diagnostic imaging ; Humans ; Male ; Pedigree ; Radiography ; Spine/diagnostic imaging ; Syndrome ; Tooth Abnormalities/diagnostic imaging
    Language English
    Publishing date 2006-04
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1121482-x
    ISSN 1473-5717 ; 0962-8827
    ISSN (online) 1473-5717
    ISSN 0962-8827
    DOI 10.1097/01.mcd.0000198926.01706.33
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Efficacy and safety of ondansetron for morning sickness in pregnancy: a systematic review of clinical trials.

    Ashour, Ahmed M

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1291235

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1291235
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  10. Article: The preventive effects of ondansetron on chemotherapy-induced nausea and vomiting in adult cancer patients: systematic review from ClinicalTrials.gov.

    Ashour, Ahmed M

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1310455

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1310455
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