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  1. Article ; Online: Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

    Cheng, Tong / Petraglia, Anthony L / Li, Zhang / Thiyagarajan, Meenakshisundaram / Zhong, Zhihui / Wu, Zhenhua / Liu, Dong / Maggirwar, Sanjay B / Deane, Rashid / Fernández, José A / LaRue, Barbra / Griffin, John H / Chopp, Michael / Zlokovic, Berislav V

    Nature medicine

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Expression of Concern
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02911-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4212: Show issues Location:
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  2. Article ; Online: Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb

    Mödinger, Yvonne / Knaub, Katharina / Dharsono, Tanita / Wacker, Roland / Meyrat, Remo / Land, M Hunter / Petraglia, Anthony L / Schön, Christiane

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 9

    Abstract: β-Caryophyllene (BCP), a common constituent of many spice and food plants, is gaining increased attention due to recent research identifying numerous potential health benefits. Due to limited oral bioavailability observed in preclinical models, the ... ...

    Abstract β-Caryophyllene (BCP), a common constituent of many spice and food plants, is gaining increased attention due to recent research identifying numerous potential health benefits. Due to limited oral bioavailability observed in preclinical models, the described benefits of BCP may be maximized by using a suitable delivery system. Additionally, human pharmacokinetics (PK) remain unknown. This study evaluates the relative oral bioavailability of BCP formulated in a self-emulsifying drug delivery system (SEDDS) based on VESIsorb
    MeSH term(s) Administration, Oral ; Biological Availability ; Drug Delivery Systems/methods ; Emulsions/pharmacokinetics ; Female ; Healthy Volunteers ; Humans ; Male ; Polycyclic Sesquiterpenes ; Solubility ; Technology
    Chemical Substances Emulsions ; Polycyclic Sesquiterpenes ; caryophyllene (BHW853AU9H)
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  3. Article ; Online: Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb ® Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS)

    Yvonne Mödinger / Katharina Knaub / Tanita Dharsono / Roland Wacker / Remo Meyrat / M. Hunter Land / Anthony L. Petraglia / Christiane Schön

    Molecules, Vol 27, Iss 2860, p

    2022  Volume 2860

    Abstract: β-Caryophyllene (BCP), a common constituent of many spice and food plants, is gaining increased attention due to recent research identifying numerous potential health benefits. Due to limited oral bioavailability observed in preclinical models, the ... ...

    Abstract β-Caryophyllene (BCP), a common constituent of many spice and food plants, is gaining increased attention due to recent research identifying numerous potential health benefits. Due to limited oral bioavailability observed in preclinical models, the described benefits of BCP may be maximized by using a suitable delivery system. Additionally, human pharmacokinetics (PK) remain unknown. This study evaluates the relative oral bioavailability of BCP formulated in a self-emulsifying drug delivery system (SEDDS) based on VESIsorb ® formulation technology (BCP-SEDDS) compared to BCP neat oil. Hence, a randomized, double-blind, cross-over design, single oral dose study (100 mg BCP) in 24 healthy subjects (12 men/12 women) was performed under fasting conditions. Pharmacokinetic parameters were analyzed from individual concentration-time curves. The data show that BCP-SEDDS resulted in a 2.2/2.0-fold increase in AUC 0–12h /AUC 0–24h and a 3.6-fold increase in C max compared to BCP neat oil. Moreover, BCP was absorbed faster from BCP-SEDDS (T max : 1.43 h) compared to BCP neat oil (T max : 3.07 h). Gender analysis revealed that there is no significant difference between men and women for both the investigated formulations and all investigated PK endpoints. In conclusion, BCP-SEDDS offers a well-tolerated and effective oral delivery system to significantly enhance the oral bioavailability of BCP in humans.
    Keywords beta-caryophyllene (BCP) ; bioavailability ; hemp ; Cannabis sativa L ; human ; oral drug delivery system ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Journal Club: brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure.

    Kimmell, Kristopher T / Petraglia, Anthony L

    Neurosurgery

    2012  Volume 71, Issue 5, Page(s) E1059–61

    Language English
    Publishing date 2012-11
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0b013e31826d2b94
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Conservative management of a cervical ligamentum flavum hematoma: Case report.

    Algattas, Hanna / Kimmell, Kristopher T / Petraglia, Anthony L / Maurer, Paul K

    Surgical neurology international

    2016  Volume 7, Issue Suppl 3, Page(s) S61–3

    Abstract: Background: Spontaneous epidural hematoma arising from the ligamentum flavum is a rare cause of acute spinal cord compression. There are only four reports in the cervical spine literature, and all were managed with surgery. Here, we describe an acute ... ...

    Abstract Background: Spontaneous epidural hematoma arising from the ligamentum flavum is a rare cause of acute spinal cord compression. There are only four reports in the cervical spine literature, and all were managed with surgery. Here, we describe an acute case of a spontaneous epidural hematoma arising from the ligamentum flavum in the cervical spine successfully managed without surgery.
    Case description: A 69-year-old woman with a cervical spine epidural hematoma contained within the ligamentum flavum presented with paroxysmal neck pain and stiffness without a history of trauma. The magnetic resonance imaging (MRI) revealed a posterolateral epidural hematoma contained within the ligamentum flavum. As the patient was intact, she was managed conservatively with cervical orthosis. Three months later, she was symptom-free, and the hematoma resolved on the follow-up MRI study.
    Conclusion: Spontaneous epidural hematoma arising from ligamentum flavum is a rare cause of spinal cord compression. Previous reports have described success with surgical decompression. However, initial observation and conservative management may be successful as illustrated in this case.
    Language English
    Publishing date 2016-01-25
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.4103/2152-7806.174887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Handbook of neurological sports medicine

    Petraglia, Anthony L / Bailes, Julian E / Day, Arthur L

    concussion and other nervous system injuries in the athlete

    2015  

    Author's details Anthony L. Petraglia, Julian Bailes, Arthur L. Day
    MeSH term(s) Athletic Injuries ; Brain Injuries ; Trauma, Nervous System
    Language English
    Size xiii, 401 pages :, illustrations
    Document type Book
    ISBN 9781450441810 ; 1450441815
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Handbook of neurological sports medicine

    Petraglia, Anthony L. / Bailes, Julian E. / Day, Arthur L.

    concussion and other nervous system injuries in the athlete

    2015  

    Author's details Anthony L. Petraglia; Julian E. Bailes; Arthur L. Day
    Size XIII, 401 Seiten: Illustrationen
    Publisher Human Kinetics; Champaign, Ill. [u.a.]
    Document type Book
    HBZ-ID HT018434593
    ISBN 978-1-4504-41810 ; 1-4504-4181-5
    Database Central Library of Sport Science of the German Sport University Cologne

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  8. Article ; Online: Cumulative effects of repetitive mild traumatic brain injury.

    Bailes, Julian E / Dashnaw, Matthew L / Petraglia, Anthony L / Turner, Ryan C

    Progress in neurological surgery

    2014  Volume 28, Page(s) 50–62

    Abstract: The majority of traumatic brain injuries (TBI) in the USA are mild in severity. Sports, particularly American football, and military experience are especially associated with repetitive, mild TBI (mTBI). The consequences of repetitive brain injury have ... ...

    Abstract The majority of traumatic brain injuries (TBI) in the USA are mild in severity. Sports, particularly American football, and military experience are especially associated with repetitive, mild TBI (mTBI). The consequences of repetitive brain injury have garnered increasing scientific and public attention following reports of altered mood and behavior, as well as progressive neurological dysfunction many years after injury. This report provides an up-to-date review of the clinical, pathological, and pathophysiological changes associated with repetitive mTBI, and their potential for cumulative effects in certain individuals.
    MeSH term(s) Animals ; Athletic Injuries ; Brain/pathology ; Brain Concussion/diagnosis ; Brain Concussion/pathology ; Brain Concussion/physiopathology ; Brain Injuries/diagnosis ; Brain Injuries/etiology ; Brain Injuries/pathology ; Humans ; Sleep/physiology ; Sports
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-3924 ; 0079-6492
    ISSN (online) 1662-3924
    ISSN 0079-6492
    DOI 10.1159/000358765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An overview of the basic science of concussion and subconcussion: where we are and where we are going.

    Dashnaw, Matthew L / Petraglia, Anthony L / Bailes, Julian E

    Neurosurgical focus

    2012  Volume 33, Issue 6, Page(s) E5: 1–9

    Abstract: There has been a growing interest in the diagnosis and management of mild traumatic brain injury (TBI), or concussion. Repetitive concussion and subconcussion have been linked to a spectrum of neurological sequelae, including postconcussion syndrome, ... ...

    Abstract There has been a growing interest in the diagnosis and management of mild traumatic brain injury (TBI), or concussion. Repetitive concussion and subconcussion have been linked to a spectrum of neurological sequelae, including postconcussion syndrome, chronic traumatic encephalopathy, mild cognitive impairment, and dementia pugilistica. A more common risk than chronic traumatic encephalopathy is the season-ending or career-ending effects of concussion or its mismanagement. To effectively prevent and treat the sequelae of concussion, it will be important to understand the basic processes involved. Reviewed in this paper are the forces behind the primary phase of injury in mild TBI, as well as the immediate and delayed cellular events responsible for the secondary phase of injury leading to neuronal dysfunction and possible cell death. Advanced neuroimaging sequences have recently been developed that have the potential to increase the sensitivity of standard MRI to detect both structural and functional abnormalities associated with concussion, and have provided further insight into the potential underlying pathophysiology. Also discussed are the potential long-term effects of repetitive mild TBI, particularly chronic traumatic encephalopathy. Much of the data regarding this syndrome is limited to postmortem analyses, and at present there is no animal model of chronic traumatic encephalopathy described in the literature. As this arena of TBI research continues to evolve, it will be imperative to appropriately model concussive and even subconcussive injuries in an attempt to understand, prevent, and treat the associated chronic neurodegenerative sequelae.
    MeSH term(s) Animals ; Athletic Injuries/diagnosis ; Athletic Injuries/physiopathology ; Athletic Injuries/therapy ; Biophysics/methods ; Brain Concussion/diagnosis ; Brain Concussion/physiopathology ; Brain Concussion/therapy ; Humans ; Neurology/trends ; Trauma Severity Indices
    Language English
    Publishing date 2012-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2012.10.FOCUS12284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Models of mild traumatic brain injury: translation of physiological and anatomic injury.

    Petraglia, Anthony L / Dashnaw, Matthew L / Turner, Ryan C / Bailes, Julian E

    Neurosurgery

    2014  Volume 75 Suppl 4, Page(s) S34–49

    Abstract: Mild traumatic brain injury (TBI) has become a rising epidemic, affecting millions of people each year. Even though it is the most common type of brain injury, our understanding of the science underlying mild TBI is just in its infancy. There has been an ...

    Abstract Mild traumatic brain injury (TBI) has become a rising epidemic, affecting millions of people each year. Even though it is the most common type of brain injury, our understanding of the science underlying mild TBI is just in its infancy. There has been an explosion of basic science research interest in mild TBI, as emerging clinical evidence is suggestive that concussion and subconcussion may result in detrimental long-term neurological sequelae, particularly when occurring repetitively. Many animal models have been developed to study the different pathological mechanisms implicated in TBI, and more recently there has been a heightened focus on modeling mild TBI in the laboratory as well. The most widely used models of TBI have been adapted for experimental mild TBI research, although more work still remains. The ability to create improved diagnostic measures and treatment approaches for concussion depend on the development and characterization of clinically relevant models of mild TBI. This review aims to provide a broad general overview of the current efforts to model mild TBI in animals and the challenges and limitations that exist in translating this behavioral, physiological, and anatomic knowledge from the bench to the clinical arena.
    MeSH term(s) Animals ; Brain Injuries ; Disease Models, Animal ; Humans
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000000472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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