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  1. Article ; Online: Community adoption of protective behaviours: before and during the COVID-19 pandemic.

    Chow, Angela / Guo, Huiling

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 5, Page(s) 663–664

    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19/epidemiology ; Pandemics/prevention & control ; SARS-CoV-2 ; Hand Hygiene
    Language English
    Publishing date 2023-02-04
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SG-APSIC1093

    Evonne Tay / Angela Chow

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol 3, Pp s1-s

    Engaging inpatients in antibiotic stewardship efforts: The need to enhance knowledge and increase involvement in their antibiotic therapy

    2023  Volume 1

    Abstract: Objectives: In tertiary-care settings, up to 50% of patients are prescribed at least 1 antibiotic. However, patients are often not proactively provided with information nor involved in shared decisions regarding their antibiotic therapies. Understanding ... ...

    Abstract Objectives: In tertiary-care settings, up to 50% of patients are prescribed at least 1 antibiotic. However, patients are often not proactively provided with information nor involved in shared decisions regarding their antibiotic therapies. Understanding inpatients’ knowledge and the extent of their involvement in antibiotic therapy help reduce inappropriate or unnecessary antibiotic use. Methods: A cross-sectional survey was conducted from March to December 2021 in a 1,600-bed, adult, acute-care, tertiary-care hospital. Patients prescribed antibiotics for the past 1 week during their hospital stay were surveyed. Ten questions assessing patients’ knowledge of their antibiotic therapy and 3 questions adapted from the NHS Care Quality Commission Inpatient survey (2013) were included in the survey questionnaire. Results: Among the 323 patients surveyed, 88% knew that they had been given antibiotics, and 80% felt that it was important to be informed of the reason, 76% felt that it was important to be informed of side effects, 74% felt that it was important to be informed of duration, and 72% felt that it was important to be informed of dosing frequency. However, only 71% knew the dosing frequency, 54% knew the side effects, 37% knew the duration, and 13% knew the name of the antibiotic agent administered. Of those unaware of the antibiotic name, 59% had indicated their desire to know. Among those aware of their antibiotic therapy, 85% had trust in their doctors but only 42% felt that they always received answers to their questions on antibiotics in an understandable manner from their doctors. Furthermore, 41% felt that they were often or always not given enough time to question their doctors. To raise their awareness on antibiotic use, 73% of respondents felt that having protected time with the doctors to understand more about their antibiotic therapy would be effective. Conclusions: Most inpatients lacked knowledge of details of their antibiotic therapy, and fewer than half were involved in it. Allocation of ...
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Differences in antibiotic exposures and antibiotic exposure risks for methicillin-resistant Staphylococcus aureus between patients in an acute-care hospital and residents in its closely affiliated intermediate- and long-term care facilities.

    Zhang, Wei / Kanagasabai, Kala / Koh, Jocelyn / Ang, Brenda / Chow, Angela

    Journal of global antimicrobial resistance

    2024  Volume 36, Page(s) 237–239

    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Long-Term Care ; Staphylococcus aureus/genetics ; Hospitals
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2023.12.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Complementary and alternative medicine (CAM) use and its association with antibiotic usage practices: A nationally representative population study.

    Tan, Shannon / Guo, Huiling / Chow, Angela

    International journal of antimicrobial agents

    2023  Volume 61, Issue 6, Page(s) 106796

    Abstract: Background: Inappropriate antibiotic use drives antimicrobial resistance (AMR). Complementary and alternative medicine (CAM) is often used alongside Western medicine in multi-cultural Singapore. This study aimed to assess the influence of CAM use on ... ...

    Abstract Background: Inappropriate antibiotic use drives antimicrobial resistance (AMR). Complementary and alternative medicine (CAM) is often used alongside Western medicine in multi-cultural Singapore. This study aimed to assess the influence of CAM use on antibiotic usage practices.
    Methods: A nationally representative cross-sectional population survey was conducted in Singapore from November 2020 to January 2021. CAM use was defined as the use of traditional Chinese medicine, acupuncture, Jamu, Ayurvedic medicine or herbal remedies. Multi-variable logistic regression analysis was conducted to assess the association between CAM use and good antibiotic usage practices, as defined by six proxy statements adapted from guidance from the US Centers for Disease Control and Prevention. Sociodemographic characteristics, motivations for CAM use, and knowledge of antibiotic use and AMR were analysed.
    Results: Thirty-four percent of 2004 respondents used CAM. The majority of CAM users were female (CAM users 57% vs non-CAM users 50%; P=0.004), Chinese (82% vs 66%; P<0.001), had a higher level of education (68% vs 64%; P=0.036), lived in the highest tier of public housing apartments or private housing (45% vs 36%; P<0.001), and had good knowledge of antibiotic use (63% vs 58%; P=0.036). After adjusting for potential confounding, CAM use (adjusted odds ratio 1.23, 95% confidence interval 1.00-1.52; P=0.048) was associated with 23% increased odds of good antibiotic usage practices. The top reasons for CAM use included recommendations from family and friends (65%), and concern about the side effects of Western medicine (44%).
    Conclusion: CAM use is positively associated with good antibiotic usage practices. Further studies assessing educational interventions utilizing social networks and highlighting the side effects of antibiotics may be useful in improving antibiotic usage practices in communities.
    MeSH term(s) Humans ; Male ; Female ; Cross-Sectional Studies ; Surveys and Questionnaires ; Complementary Therapies ; Medicine, Chinese Traditional ; Asian People ; Drug-Related Side Effects and Adverse Reactions
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.106796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Practical challenges in lung cancer pathology: bedside care to treatment decisions.

    Takano, Angela Maria / Chow, Chun Yuen / Lim, Kiat Hon

    Current opinion in pulmonary medicine

    2023  Volume 30, Issue 1, Page(s) 48–57

    Abstract: Purpose of review: Lung cancer is one of the most common malignancies in the whole world, and the pulmonologist is generally the first medical professional to meet the patient and decide what method of tumour sampling is preferable in each specific case. ...

    Abstract Purpose of review: Lung cancer is one of the most common malignancies in the whole world, and the pulmonologist is generally the first medical professional to meet the patient and decide what method of tumour sampling is preferable in each specific case. It is imperative for pulmonary physicians to be aware of the intricacies of the diagnostic process, and understand the multiple challenges that are encountered, from the moment the tissue specimen leaves their offices and is sent to the pathology laboratory, until the diagnosis reaches the patient and treating physician.
    Recent findings: The new 2021 WHO classification of thoracic tumours recommended a minimum immunohistochemical (IHC) diagnostic panel for nonsmall cell lung cancer (NSCLC), and following publications of different institutional and country-based guidelines, advocated basic molecular testing for epithelial growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) and programmed cell death ligand 1 (PD-L1) to be initiated by the diagnosing pathologist in all cases of biopsy or resection specimens. In general, sequential testing for molecular biomarkers was not recommended due to tissue wastage, instead next generation sequencing (NGS) diagnostic panel was supported.
    Summary: The lung cancer specimen has to undergo histologic diagnosis through a panel of IHC studies, and -preferably, a reflex molecular study by NGS including several targetable genes. Adequate communication and clinical information preclude the pathologist from "overusing" the tissue for additional studies, while focusing on preservation of material for molecular testing.
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/drug therapy ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Biomarkers ; Biopsy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Influence of Marriage and Cohabitation on Physical Activity Among Middle-Aged and Older People.

    Yuan, Shuhan / Elam, Kit K / Johnston, Jeanne D / Chow, Angela

    Journal of applied gerontology : the official journal of the Southern Gerontological Society

    2023  Volume 43, Issue 2, Page(s) 139–148

    Abstract: Using data from a nationally representative longitudinal study, Midlife in the United States (waves 1-3; ...

    Abstract Using data from a nationally representative longitudinal study, Midlife in the United States (waves 1-3;
    MeSH term(s) Aged ; Humans ; Middle Aged ; Aging ; Exercise ; Family Characteristics ; Longitudinal Studies ; Marriage ; United States
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 155897-3
    ISSN 1552-4523 ; 0733-4648
    ISSN (online) 1552-4523
    ISSN 0733-4648
    DOI 10.1177/07334648231203124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Octenidine exposure was not associated with reduced Octenidine susceptibility of meticillin-resistant Staphylococcus aureus (MRSA) in an extended-care facility in Singapore.

    Tang, Ying Wei / Hon, Pei Yun / Tan, Joanna / Poh, Bee Fong / Ang, Brenda / Chow, Angela

    The Journal of hospital infection

    2024  

    Abstract: Objectives: Antiseptics such as chlorhexidine gluconate (CHG) and octenidine dihydrochloride (OCT) are frequently used in hospitals to prevent and control meticillin-resistant Staphylococcus aureus (MRSA) transmission. With increasing prevalence of ... ...

    Abstract Objectives: Antiseptics such as chlorhexidine gluconate (CHG) and octenidine dihydrochloride (OCT) are frequently used in hospitals to prevent and control meticillin-resistant Staphylococcus aureus (MRSA) transmission. With increasing prevalence of reduced CHG susceptibility of MRSA, concerns are raised about the possibility of reduced OCT susceptibility. Hence, we evaluated the prevalence of reduced CHG and OCT susceptibility over 3 years and assessed the association between exposure to OCT and MRSA reduced susceptibility to OCT.
    Methods: MRSA isolates from inpatients who acquired MRSA in an extended-care facility from 2019 to 2021, were included for antiseptic susceptibility testing. Inpatients were exposed to universal daily CHG bathing from January to September 2019, and universal daily OCT bathing after October 2019. The minimum inhibitory concentrations (MICs) were determined by broth microdilution method. Multivariable logistic regression was used to assess if exposure to OCT bathing was independently associated with reduced OCT susceptibility.
    Results: Of 186 isolates, 179 (96%) had reduced CHG susceptibility (MIC ≥4 mg/L) whilst 46 (25%) had reduced OCT susceptibility (MIC ≥2 mg/L). OCT reduced susceptibility rates were 26.9%, 13.8% and 14.3% in 2019, 2020 and 2021, respectively. CHG reduced susceptibility rates were 95.4%, 100% and 95.9% in 2019, 2020 and 2021, respectively. OCT exposure was not associated with reduced OCT susceptibility (adjusted odds ratio [aOR] 0.23, 95% confidence interval [CI] 0.08 - 0.75, p 0.014), after adjusting for age, gender, race, sample collection year, days-at-risk in facility, past hospitalisation and previous MRSA in the preceding year.
    Conclusion: The prevalence of reduced OCT susceptibility has remained low, despite universal OCT bathing for extended inpatient care. However, CHG reduced susceptibility rates were high. OCT exposure was not associated with reduced OCT susceptibility in MRSA.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2024.02.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Does taking charge help or harm employees' promotability and visibility? An investigation from supervisors' status perspective.

    Xu, Angela J / Loi, Raymond / Chow, Cheris W C

    The Journal of applied psychology

    2022  

    Abstract: Taking charge is an important form of proactive behavior that sustains organizational survival and success. Despite considerable research on how to encourage employees to take charge, little is known about whether and when supervisors will evaluate those ...

    Abstract Taking charge is an important form of proactive behavior that sustains organizational survival and success. Despite considerable research on how to encourage employees to take charge, little is known about whether and when supervisors will evaluate those who take charge as more or less promotable and visible. Building on and extending the theoretical notion of dyadic complementary fit, we propose that, compared with lower status-goal-striving supervisors, higher status-goal-striving supervisors regard those who take charge as helping enhance their status in the organization more (i.e., a dyadic fit condition) and subsequently evaluate these employees as more promotable and visible. In a vignette-based experiment using 175 U.S.-based supervisors (Study 1), a two-wave field survey among 143 supervisor-subordinate dyads in a hotel (Study 2), and a three-wave survey among 294 supervisor-subordinate dyads in various organizations and industries in China (Study 3), we find support for our predictions. The findings have important implications for proactivity theory and practice. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219157-x
    ISSN 1939-1854 ; 0021-9010
    ISSN (online) 1939-1854
    ISSN 0021-9010
    DOI 10.1037/apl0000752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Health Information Orientation Profiles and Their Association with Knowledge of Antibiotic Use in a Population with Good Internet Access: A Cross-Sectional Study.

    Guo, Huiling / Lim, Huai Yang / Chow, Angela

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: Background: Poor knowledge of antibiotic use drives poor antibiotic practices, but little is known about the influence of health information orientation (HIO) on knowledge of antibiotic use in the general public. Methods: We conducted a nationally- ... ...

    Abstract Background: Poor knowledge of antibiotic use drives poor antibiotic practices, but little is known about the influence of health information orientation (HIO) on knowledge of antibiotic use in the general public. Methods: We conducted a nationally-representative population-wide cross-sectional study (November 2020−January 2021), on a proportionately stratified random sample of 2004 Singapore residents aged ≥21 years. Multivariable logistic regression analysis was performed to assess the association between HIO and knowledge of antibiotic use. Results: Forty percent of respondents had low-levels of HIO (LL-HIO); they tended to be younger, not currently married, and did not have family/friends working in the healthcare sector. Respondents with LL-HIO (aOR 1.82, 95% CI 1.32−2.51, p < 0.001) were 82% more likely to have poor knowledge of antibiotic use. In particular, older adults aged ≥50 years with LL-HIO (aOR 1.81, 95% CI [1.32−2.51], p < 0.001) were much more likely to have poor knowledge than their HL-HIO counterparts. They were also less likely to use the Internet to seek health information and had poor eHealth efficacy. Conclusion: LL-HIO is independently associated with poor knowledge of antibiotic use. Educational strategies on antibiotic use should disseminate a consistent message through both online and offline platforms, involving traditional and non-traditional healthcare and non-healthcare influencers.
    Language English
    Publishing date 2022-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11060769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: "Antibiotics are for everyone, our past and our future generations, right? If antibiotics are dead, we will be in big trouble": Building on community values for public engagement on appropriate use of antibiotics in Singapore.

    Guo, Huiling / Hildon, Zoe Jane-Lara / Chow, Angela

    Frontiers in public health

    2022  Volume 10, Page(s) 1001282

    Abstract: Introduction: Shared decision-making (SDM) and trust building through continuity of care are known to play a pivotal role in improving appropriate antibiotic prescribing and use.: Problem: However, less is known about : Methods: We addressed this ... ...

    Abstract Introduction: Shared decision-making (SDM) and trust building through continuity of care are known to play a pivotal role in improving appropriate antibiotic prescribing and use.
    Problem: However, less is known about
    Methods: We addressed this question using a convergent parallel mixed-methods design. Focus group discussions (
    Findings: Poor knowledge and misbeliefs on appropriate antibiotic use and antimicrobial resistance (AMR) were identified. For example, only 9% of the surveyed population understood that AMR occurs when the bacteria, not the human body, become resistant to antibiotics. Qualitative data corroborated the survey findings and suggested a shared value was placed on public education to avoid the fallout from resistant bacterial strains on current and future generations. This study also identified the opportunity to harness community trust in primary care doctors, who were described as highly valued educators for antibiotic use and AMR. Those who had trust in doctors were 75% more likely to prefer SDM (aOR 1.75, 95% CI 1.10-2.77,
    Conclusion: This study highlights the long-term value-add of building on cultural capital pertaining to appropriate antibiotic use and AMR, by leveraging on the role of trust in doctors, desire for SDM and anchoring these in continuity of care when possible.
    Recommendations: Using focused messaging and exploring alternative channels of communications such as annual check-ins or tele-consultations with a regular doctor, and emphasizing continuity of care across all age groups would help bridge the identified gaps.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Humans ; Singapore ; Social Responsibility ; Surveys and Questionnaires
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1001282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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