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  1. Book ; Online ; E-Book: Glucose Sensor Use in Children and Adolescents

    Cherubini, Valentino / Elleri, Daniela / Zucchini, Stefano

    A Practical Guide

    2020  

    Abstract: This practical book focuses on the use of glucose sensors in children with type 1 diabetes. It is an evidence-based, simple, illustrated tool written by expert physicians in the field, experienced with patients living in Italy and in the UK. The ... ...

    Author's details edited by Valentino Cherubini, Daniela Elleri, Stefano Zucchini
    Abstract This practical book focuses on the use of glucose sensors in children with type 1 diabetes. It is an evidence-based, simple, illustrated tool written by expert physicians in the field, experienced with patients living in Italy and in the UK. The introductory chapters offer a quick and well-documented update on technology use in the child with diabetes, while the chapter on clinical studies provides a comprehensive overview of the scientific basis and benefits on glucose sensor use. The practical use of sensors in all age groups, including toddlers, and any related psychological issues are also discussed. This volume allows health care professionals, pediatric trainees and medical students caring for children with type 1 diabetes to increase their understanding of sensor use, making this technology easier and more reliable to use.
    Keywords Diabetes ; Pediatrics ; Nursing
    Subject code 616.462
    Language English
    Size 1 online resource (viii, 97 pages)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-42806-0 ; 3-030-42805-2 ; 978-3-030-42806-8 ; 978-3-030-42805-1
    DOI 10.1007/978-3-030-42806-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Autoantibody test for type 1 diabetes in children: are there reasons to implement a screening program in the general population? A statement endorsed by the Italian Society for Paediatric Endocrinology and Diabetes (SIEDP-ISPED) and the Italian Society of Paediatrics (SIP).

    Cherubini, Valentino / Chiarelli, Francesco

    Italian journal of pediatrics

    2023  Volume 49, Issue 1, Page(s) 87

    Abstract: In recent years screening of type 1 diabetes (T1D) in both at risk children and general population has been widely discussed with the aim of increasing awareness of the importance to early detect (and possibly treat) at-risk children in early stages of ... ...

    Abstract In recent years screening of type 1 diabetes (T1D) in both at risk children and general population has been widely discussed with the aim of increasing awareness of the importance to early detect (and possibly treat) at-risk children in early stages of the chronic autoimmune progression to T1D.In fact, it is well known that first-degree relatives have the highest risk of T1D, but up to 90% of children who develop T1D do not have a family history and belong to the general population.The reasons for screening children well before the clinical onset of T1D include prevention of DKA (still up to 60% children are diagnosed with DKA) and related morbidities and mortality, reducing the need for hospitalisation, time to provide emotional support and education to ensure a smooth transition to insulin treatment, and opportunities for new treatments to prevent or delay progression.There are pros and cons of screening of T1D in children, but recent evidences suggest that it is now time to consider possible a screening for T1D in children.Recently, the European Society for Paediatric Endocrinology (ESPE) has endorsed a Position Statement, discussing the pros and cons of screening for T1D in the general population; ESPE supports national Societies for Paediatric Endocrinology to spread information on this important issue in various countries throughout Europe; the Italian Society for Paediatric Endocrinology and Diabetes (SIEDP-ISPED) and the Italian Society of Paediatrics (SIP) endorse this document with the specific aim of increasing awareness on screening for paediatric T1D in the general population.
    MeSH term(s) Child ; Humans ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Morbidity ; Italy/epidemiology ; Pediatrics ; Autoantibodies
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-023-01438-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Which Treatment Modalities Are Being Used by Italian Children and Adolescents with Type 1 Diabetes?

    Cherubini, Valentino / Zucchini, Stefano / Bonfanti, Riccardo / Rabbone, Ivana / Scaramuzza, Andrea

    Diabetes technology & therapeutics

    2024  Volume 26, Issue 4, Page(s) 283–285

    MeSH term(s) Child ; Humans ; Adolescent ; Diabetes Mellitus, Type 1/drug therapy ; Italy
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1452816-2
    ISSN 1557-8593 ; 1520-9156
    ISSN (online) 1557-8593
    ISSN 1520-9156
    DOI 10.1089/dia.2023.0510
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  4. Article: Editorial: Modern Management and Monitoring of Childhood Diabetes.

    Cherubini, Valentino / Tiberi, Valentina / Chiarelli, Francesco

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 900278

    MeSH term(s) Diabetes Mellitus, Type 1 ; Diabetic Ketoacidosis ; Humans
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.900278
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  5. Article ; Online: Open-Source Automated Insulin Delivery in Type 1 Diabetes.

    Scaramuzza, Andrea E / Cherubini, Valentino / Rabbone, Ivana

    The New England journal of medicine

    2022  Volume 387, Issue 21, Page(s) 2006–2007

    MeSH term(s) Humans ; Insulin/therapeutic use ; Diabetes Mellitus, Type 1/drug therapy ; Insulin Infusion Systems ; Pancreas, Artificial
    Chemical Substances Insulin
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2213228
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  6. Article ; Online: Differences in Plasma 25-Hydroxyvitamin D Levels at Diagnosis of Celiac Disease and Type 1 Diabetes.

    Marino, Monica / Galeazzi, Tiziana / Gesuita, Rosaria / Ricci, Salima / Catassi, Carlo / Cherubini, Valentino / Lionetti, Elena

    Nutrients

    2024  Volume 16, Issue 5

    Abstract: Aim: The aim of this work is to assess the vitamin D levels, evaluated as plasma 25-hydroxyvitamin D of children with a new diagnosis of celiac disease (CD), of children with a new onset of type 1 diabetes (T1D) and in children with CD at diagnosis of ... ...

    Abstract Aim: The aim of this work is to assess the vitamin D levels, evaluated as plasma 25-hydroxyvitamin D of children with a new diagnosis of celiac disease (CD), of children with a new onset of type 1 diabetes (T1D) and in children with CD at diagnosis of T1D (T1D&CD).
    Methods: In this single-center observational study, we collected data for four groups of children and adolescents: T1D, CD, T1D&CD, and a control group (CG). The CG included schoolchildren who had negative results during a mass screening campaign for CD and were not diagnosed for T1D, according to RIDI Marche registry data, were considered for the purposes of this study. Plasma 25-hydroxyvitamin D, 25(OH)D
    Results: The number of children enrolled for the present study was 393: 131 in the CG, 131 CD, 109 T1D, and 22 T1D&CD. Significantly lower levels of vitamin D were displayed for children with CD, T1D, or both the diseases. Interestingly, severe vitamin D deficiency was detected in no children with CD, 1.5% of children in the CG, in 24.4% with T1D, and 31.8% with T1D&CD (
    Conclusions: Our results showed low levels of vitamin D diagnosis of T1D, CD, and T1D&CD; however, severe deficiency was only reported in children with T1D and T1D&CD. More studies are needed to better understand the role of this deficiency in children newly diagnosed with CD and T1D.
    MeSH term(s) Child ; Adolescent ; Humans ; Diabetes Mellitus, Type 1 ; Celiac Disease/complications ; Vitamin D/analogs & derivatives ; Vitamin D Deficiency ; Vitamins ; Calcifediol
    Chemical Substances 25-hydroxyvitamin D (A288AR3C9H) ; Vitamin D (1406-16-2) ; Vitamins ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Observational Study ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16050743
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  7. Article ; Online: Adjustment of octreotide dose given via insulin pump based on continuous glucose monitoring (CGM) in a child with congenital hyperinsulinism.

    Tiberi, Valentina / Cherubini, Valentino / Iannilli, Antonio / Gasparini, Francesco / Marino, Monica

    Journal of pediatric endocrinology & metabolism : JPEM

    2023  Volume 36, Issue 8, Page(s) 803–807

    Abstract: Objectives: CHI is a relevant cause of persistent and severe hypoglycemia and the ABCC8 gene mutation is one of most common cause of the disease. Two main types of CHI have been described, diffuse and focal form. Octreotide is a medication utilized in ... ...

    Abstract Objectives: CHI is a relevant cause of persistent and severe hypoglycemia and the ABCC8 gene mutation is one of most common cause of the disease. Two main types of CHI have been described, diffuse and focal form. Octreotide is a medication utilized in case of diazoxide-unresponsive forms of CHI. For those CHI focal forms where is decided either to manage medically or until resolutive surgery is completed, octreotide can be administered as subcutaneous injection or as continuous subcutaneous infusion via insulin pump. However, it is unclear how to adjust the drug's daily basal pattern when a pump is used.
    Case presentation: We present a case of an infant with a diazoxide-unresponsive focal form of CHI, due to ABCC8 mutation ABCC8, treated with octreotide. To better evaluate the glycemic trend, a CGM was placed. In order to achieve a better personalization of the therapy we utilized an insulin pump for octreotide administration.
    Conclusions: The adoption of the CGM and insulin pump, allowed a better personalization of the therapy and a reduction of acute carbohydrate intake, promoting a good auxological growth before resolutive surgery. What is new? Octreotide administered with an insulin pump in patient with CHI allows a wide modulation of the daily therapy. The CGM allows a continuous and a less painful control of the glycemic trend in a patient with CHI. Different basal rates, given via insulin pump may allow a better personalization of the therapy. Prevention of hypoglycemia reduces the acute introduction of carbohydrates, promoting normal growth..
    MeSH term(s) Humans ; Male ; Infant ; Congenital Hyperinsulinism/drug therapy ; Diazoxide/administration & dosage ; Diazoxide/therapeutic use ; Octreotide/administration & dosage ; Octreotide/therapeutic use ; Blood Glucose Self-Monitoring ; Treatment Outcome ; Insulin/therapeutic use
    Chemical Substances Diazoxide (O5CB12L4FN) ; Octreotide (RWM8CCW8GP) ; Insulin
    Language English
    Publishing date 2023-05-31
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1231070-0
    ISSN 2191-0251 ; 0334-018X
    ISSN (online) 2191-0251
    ISSN 0334-018X
    DOI 10.1515/jpem-2022-0643
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    Zs.A 2258: Show issues Location:
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  8. Article ; Online: A nationwide survey of Italian pediatric diabetologists about COVID-19 vaccination in children and adolescents with type 1 diabetes.

    Scaramuzza, Andrea E / Cherubini, Valentino / Schiaffini, Riccardo / Rabbone, Ivana

    Acta diabetologica

    2022  Volume 59, Issue 8, Page(s) 1109–1111

    MeSH term(s) Adolescent ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Diabetes Mellitus, Type 1/epidemiology ; Humans ; Italy/epidemiology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-022-01885-0
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  9. Article: Early diagnosis of focal congenital hyperinsulinism: A fluorine-18-labeled l-dihydroxyphenylalanine positron emission tomography/computed tomography study.

    Burroni, Luca / Palucci, Andrea / Biscontini, Giuseppina / Cherubini, Valentino

    World journal of nuclear medicine

    2021  Volume 20, Issue 4, Page(s) 395–397

    Abstract: Congenital hyperinsulinism (CHI) is responsible for hyperinsulinemic hypoglycemia which needs aggressive treatment in order to prevent neurological damages. Recent advances in genetics have linked CHI to mutations in many different genes that play a key ... ...

    Abstract Congenital hyperinsulinism (CHI) is responsible for hyperinsulinemic hypoglycemia which needs aggressive treatment in order to prevent neurological damages. Recent advances in genetics have linked CHI to mutations in many different genes that play a key role in regulating insulin secretion from pancreatic ß-cells. Furthermore, histopathological lesions, diffuse and focal, have been associated with these different genetic alterations. This short manuscript describes how the advent of fluorine-18-labeled L-dihydroxyphenylalanine-positron emission tomography/computed tomography (
    Language English
    Publishing date 2021-11-01
    Publishing country Austria
    Document type Case Reports
    ZDB-ID 2911903-0
    ISSN 1607-3312 ; 1450-1147
    ISSN (online) 1607-3312
    ISSN 1450-1147
    DOI 10.4103/wjnm.wjnm_159_20
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  10. Article ; Online: Implementing Control-IQ technology after a virtual educational camp in children and adolescents with type 1 diabetes: Does time in range plateau over 1 year?

    Scaramuzza, Andrea E / Marigliano, Marco / Bonfanti, Riccardo / Cherubini, Valentino / Schiaffini, Riccardo / Toni, Sonia / Rabbone, Ivana

    Diabetes, obesity & metabolism

    2023  Volume 26, Issue 2, Page(s) 763–766

    MeSH term(s) Child ; Humans ; Adolescent ; Diabetes Mellitus, Type 1/drug therapy ; Hypoglycemic Agents/therapeutic use ; Blood Glucose ; Technology ; Insulin Infusion Systems ; Insulin/therapeutic use ; Blood Glucose Self-Monitoring
    Chemical Substances Hypoglycemic Agents ; Blood Glucose ; Insulin
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Letter
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15343
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