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Article ; Online: Arthroscopy-Assisted Surgery for Trapeziometacarpal Osteoarthritis.

Fujimura, Shigekazu / Omokawa, Shohei / Hasegawa, Hideo / Kawamura, Kenji / Nakanishi, Yasuaki / Tanaka, Yasuhito

The journal of hand surgery Asian-Pacific volume

2024 Volume 29, Issue 1, Page(s) 12–16

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Female ; Humans ; Arthroscopy ; Activities of Daily Living ; Carpometacarpal Joints/surgery ; Osteoarthritis/surgery ; Pain
Language	English
Publishing date	2024-02-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2848651-1
ISSN	2424-8363 ; 2424-8355
ISSN (online)	2424-8363
ISSN	2424-8355
DOI	10.1142/S2424835524500024
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Zs.A 5911: Show issues

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Article ; Online: Clinical outcomes of reposition flap transfer for fingertip amputation.

Nakanishi, Akito / Kawamura, Kenji / Omokawa, Shohei / Hasegawa, Hideo / Tanaka, Yasuhito

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

2024 Volume 34, Issue 3, Page(s) 1627–1634

Abstract: Purpose: This study aimed to describe the reposition flap for reconstructing fingertip amputation when replantation is not possible.: Methods: This study retrospectively reviewed the records of patients with reposition flap transfers and investigated ...

Abstract	Purpose: This study aimed to describe the reposition flap for reconstructing fingertip amputation when replantation is not possible. Methods: This study retrospectively reviewed the records of patients with reposition flap transfers and investigated postoperative clinical outcomes and patient satisfaction. Sixteen patients with fingertip amputations treated with a reposition flap from 2016 to 2020. The mean age at injury was 46 years (range, 26-70 years). Ten cases were treated with oblique triangular advancement flaps, 3 with retrograde-flow digital artery flaps, and 3 with thumb palmar advancement flaps. Postoperative outcomes, including wound healing period and the IP/PIP extension angle, and the presence of grafted bone absorption and patient satisfaction were evaluated as of 3 years after surgery. Results: The average reduction in passive extension angle of the IP/PIP joint was 19°. The average time for complete wound healing was 28 days (range, 18-41 days). The reduction in passive extension angle of the IP/PIP joint was significantly correlated with the wound healing period (r = 0.66, p = 0.01). The absorption of the grafted bone was observed in 3 cases. In these cases, the distal tip of the flap became thin due to flap retraction and an insufficient flap volume. All patients were highly or fairly satisfied with the results of surgery. Conclusion: Our findings show that IP/PIP flexion contracture can occur due to delayed wound healing after reposition flap transfer, but the patient satisfaction level was generally high. Therefore, reconstruction using a reposition flap gives acceptable clinical outcomes and high patient satisfaction as a result of medium to long-term.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Amputation, Traumatic/surgery ; Retrospective Studies ; Finger Injuries/surgery ; Surgical Flaps ; Amputation, Surgical ; Treatment Outcome
Language	English
Publishing date	2024-02-17
Publishing country	France
Document type	Journal Article
ZDB-ID	1231084-0
ISSN	1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
ISSN (online)	1432-1068
ISSN	1633-8065 ; 0948-4817 ; 0940-3264
DOI	10.1007/s00590-024-03854-5
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Zs.A 3479: Show issues

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Article: Unique Action of Interleukin-18 on T Cells and Other Immune Cells.

Nakanishi, Kenji

Frontiers in immunology

2018 Volume 9, Page(s) 763

Abstract: Interleukin (IL)-18 was originally discovered as a factor that enhances interferon (IFN)-γ production by anti-CD3-stimulated Th1 cells, particularly in association with IL-12. IL-12 is a cytokine that induces development of Th1 cells. IL-18 cannot induce ...

Abstract	Interleukin (IL)-18 was originally discovered as a factor that enhances interferon (IFN)-γ production by anti-CD3-stimulated Th1 cells, particularly in association with IL-12. IL-12 is a cytokine that induces development of Th1 cells. IL-18 cannot induce Th1 cell development, but has the capacity to activate established Th1 cells to produce IFN-γ in the presence of IL-12. Thus, IL-18 is regarded as a proinflammatory cytokine that facilitates type 1 responses. However, in the absence of IL-12 but presence of IL-2, IL-18 stimulates natural killer cells, NKT cells, and even established Th1 cells to produce IL-3, IL-9, and IL-13. Thus, IL-18 also facilitates type 2 responses. This unique function of IL-18 contributes to infection-associated allergic diseases. Together with IL-3, IL-18 stimulates mast cells and basophils to produce IL-4, IL-13, and chemical mediators such as histamine. Thus, IL-18 also induces innate-type allergic inflammation. IL-18 belongs to the IL-1 family of cytokines, which share similar molecular structures, receptors structures, and signal transduction pathways. Nevertheless, IL-18 shows a unique function by binding to a specific receptor expressed on distinct types of cells. In this review article, I will focus on the unique features of IL-18 in lymphocytes, basophils, and mast cells, particularly in comparison with IL-33.
MeSH term(s)	Animals ; Basophils/immunology ; Humans ; Interleukin-18/immunology ; Interleukin-33/immunology ; Lymphocytes/immunology ; Mast Cells/immunology
Chemical Substances	Interleukin-18 ; Interleukin-33
Language	English
Publishing date	2018-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.00763
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Article ; Online: Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water.

Nishiwaki, Keiji / Nakatani, Shiori / Nakamura, Shinya / Yoshioka, Kenji / Nakagawa, Eri / Tsuyuguchi, Masato / Kinoshita, Takayoshi / Nakanishi, Isao

RSC medicinal chemistry

2024 Volume 15, Issue 4, Page(s) 1274–1282

Abstract: We recently reported novel purine-based CK2α inhibitors using the solvent ordering-based method as virtual screening. Among these, the X-ray crystal structure of a complex with CK2α was determined. The results showed that the crystalline water molecules ... ...

Abstract	We recently reported novel purine-based CK2α inhibitors using the solvent ordering-based method as virtual screening. Among these, the X-ray crystal structure of a complex with CK2α was determined. The results showed that the crystalline water molecules observed in many previously reported complex structures of CK2α and its inhibitors had been eliminated. We then proposed a structure-based drug design. Since the removal of water molecules would be detrimental to inhibitor binding, new groups of compounds were designed by changing the position of the carboxy group located at the point where a water molecule would be present so as not to eliminate it. Compounds with (
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d3md00755c
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Article: Use of a Lateral Orbital Flap for Lateral Canthal Reconstruction: A Case Report.

Nakanishi, Yuta / Kakudo, Natsuko / Kusumoto, Kenji

Eplasty

2020 Volume 20, Page(s) ic10

Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2412803-X
ISSN	1937-5719
ISSN	1937-5719
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Article ; Online: Does student evaluation of on-demand video lectures vary with student characteristics? A questionnaire survey of medical students at Tokushima University.

Yamaguchi, Harutaka / Kagoshima, Seito / Okura, Yoshihiro / Nakanishi, Yoshinori / Kawahito, Keisuke / Tani, Kenji

The journal of medical investigation : JMI

2023 Volume 70, Issue 3.4, Page(s) 483–493

Abstract: The popularity of online classes in university education has grown rapidly since the COVID-19 outbreak. This study aims to examine the association between the detailed characteristics/various contexts of students and the evaluation of online classes. An ... ...

Abstract	The popularity of online classes in university education has grown rapidly since the COVID-19 outbreak. This study aims to examine the association between the detailed characteristics/various contexts of students and the evaluation of online classes. An online questionnaire survey administered to third- and fourth-grade medical students of Tokushima University in September 2021-with 101 (42.8%) valid responses-showed the respondents' general impressions, comprehension, convenience, and desire for online classes even after the pandemic ends were significantly higher for the on-demand lectures than for simultaneous online classes. Notably, students who did not do other things while watching video lectures (10.9%) rated on-demand lectures as facilitating significantly higher impression, comprehension, and convenience than those who did other things (89.1%). A multivariate analysis revealed that students who did not do anything else while watching, whose waking time changed slightly, who commuted to school for shorter periods, who were not good at morning lectures, and who watched at high speed rated the video lectures highly. Thus, video lectures are appreciated by students who are committed to learning, which is a positive result for the future of on-demand education. J. Med. Invest. 70 : 483-493, August, 2023.
MeSH term(s)	Humans ; Students, Medical ; Universities ; Surveys and Questionnaires ; Learning
Language	English
Publishing date	2023-09-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1435233-3
ISSN	1349-6867 ; 1343-1420
ISSN (online)	1349-6867
ISSN	1343-1420
DOI	10.2152/jmi.70.483
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Zs.A 264: Show issues

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Article ; Online: Feelings toward medicine in remote areas among medical students aiming to become generalists : A comparison with other specialists.

Kawahito, Keisuke / Yamaguchi, Harutaka / Nakanishi, Yoshinori / Kawaminami, Shingo / Tabata, Ryo / Okura, Yoshihiro / Tani, Kenji

The journal of medical investigation : JMI

2023 Volume 70, Issue 1.2, Page(s) 129–134

Abstract: Geographic maldistribution of physicians is a serious problem in Japan, resulting in a few physicians in remote areas. We distributed questionnaires to 396 medical students at Tokushima University from 2013 to 2016. We examined the intensity of medical ... ...

Abstract	Geographic maldistribution of physicians is a serious problem in Japan, resulting in a few physicians in remote areas. We distributed questionnaires to 396 medical students at Tokushima University from 2013 to 2016. We examined the intensity of medical students toward medicine in remote areas by using a visual analog scale and investigated what medical specialty they chose after two years of clinical training. The intensity of interest in medicine and the intensity of willingness to contribute to it in remote areas were statistically higher among medical students who intended to choose general medicine. After graduation, only five participants chose to specialize in general medicine. Of the 14 medical students who originally chose general medicine, six chose internal medicine, three chose general medicine, and the others chose surgery, neurosurgery, anesthesiology, orthopedics, or emergency medicine. This study demonstrated that medical students who intend to choose general medicine have a higher intensity of willingness to contribute to medicine in remote areas, indicating that the support program for these students to become general practitioners after graduation increases the number of physicians in remote areas. J. Med. Invest. 70 : 129-134, February, 2023.
MeSH term(s)	Humans ; Students, Medical ; Career Choice ; Medicine ; Emotions ; Japan ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1435233-3
ISSN	1349-6867 ; 1343-1420
ISSN (online)	1349-6867
ISSN	1343-1420
DOI	10.2152/jmi.70.129
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Zs.A 264: Show issues

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Article ; Online: Association of the Controlling Nutritional Status Score with the Development of Postoperative Paralytic Ileus After Radical Cystectomy: Retrospective Cohort Study.

Tanabe, Kenji / Nakanishi, Yasukazu / Okubo, Noya / Umino, Yousuke / Kataoka, Madoka / Yajima, Shugo / Masuda, Hitoshi

Urology research & practice

2023 Volume 49, Issue 3, Page(s) 184–190

Abstract: Objective: Postoperative paralytic ileus is a major adverse event of radical cystectomy, causing prolonged hospitalization. The controlling nutritional status score, consisting of serum albumin, total lymphocyte count, and total cholesterol, indicates ... ...

Abstract	Objective: Postoperative paralytic ileus is a major adverse event of radical cystectomy, causing prolonged hospitalization. The controlling nutritional status score, consisting of serum albumin, total lymphocyte count, and total cholesterol, indicates the nutritional status and may evaluate gastrointestinal status. This study aimed to clarify the association between the controlling nutritional status score and the development of postoperative paralytic ileus in patients who underwent radical cystectomy with ileal conduit or ileal neobladder. Materials and methods: We retrospectively analyzed the clinical features of patients who underwent open radical cystectomy or robotic assisted laparoscopic radical cystectomy with ileal conduit or ileal neobladder for bladder cancer between April 2011 and May 2021. The association between clinical variables, including the controlling nutritional status score and the development of postoperative paralytic ileus, was examined. Results: Out of 133 patients, 34 (26%) developed postoperative paralytic ileus. The patients who developed postoperative paralytic ileus were likely to have a higher controlling nutritional status score (P = .055) compared to those who did not develop postoperative paralytic ileus. Multivariate analysis revealed that a preoperative controlling nutritional status score of ≥1 (odds ratio: 2.90, 95% CI: 1.08-7.80, P = .034) and longer operating time (odds ratio: 3.02, 95% CI: 1.13-8.11, P = .027) were significant independent factors for postoperative paralytic ileus development. Conclusion: A high controlling nutritional status score and long operating time may be risk factors for developing postoperative paralytic ileus in patients who underwent radical cystectomy with ileal conduit or ileal neobladder for bladder cancer. Preoperative controlling nutritional status may be able to predict postoperative paralytic ileus development.
Language	English
Publishing date	2023-10-25
Publishing country	Turkey
Document type	Journal Article
ISSN	2980-1478
ISSN (online)	2980-1478
DOI	10.5152/tud.2023.22232
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Article: The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons.

Okui, Tatsuo / Hiasa, Masahiro / Hata, Kenji / Roodman, G David / Nakanishi, Masako / Yoneda, Toshiyuki

Research square

2023

Abstract: Cancers showing excessive innervation of sensory neurons (SN) in their microenvironments are associated with poor outcomes due to promoted growth, increased tumor recurrence, metastasis, and cancer pain, suggesting SNs play a regulatory role in cancer ... ...

Abstract	Cancers showing excessive innervation of sensory neurons (SN) in their microenvironments are associated with poor outcomes due to promoted growth, increased tumor recurrence, metastasis, and cancer pain, suggesting SNs play a regulatory role in cancer aggressiveness. Using a preclinical model in which mouse 4T1 breast cancer (BC) cells were injected into the bone marrow of tibiae, we found 4T1 BC cells aggressively colonized bone with bone destruction and subsequently spread to the lung. Of note, 4T1 BC colonization induced the acidic tumor microenvironment in bone in which SNs showed increased innervation and excitation with elevated expression of the acid-sensing nociceptor transient receptor potential vanilloid-1 (TRPV1), eliciting bone pain (BP) assessed by mechanical hypersensitivity. Further, these excited SNs produced increased hepatocyte growth factor (HGF). Importantly, the administration of synthetic and natural TRPV1 antagonists and genetic deletion of TRPV1 decreased HGF production in SNs and inhibited 4T1 BC colonization in bone, pulmonary metastasis from bone, and BP induction. Our results suggest the TRPV1 of SNs promotes BC colonization in bone and lung metastasis via up-regulating HGF production in SNs. The SN TRPV1 may be a novel therapeutic target for BC growing in the acidic bone microenvironment and for BP.
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3105966/v1
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Article ; Online: Reliability and Validity Analysis of the Distal Radioulnar Joint Ballottement Test.

Nagashima, Mitsuyuki / Omokawa, Shohei / Hasegawa, Hideo / Nakanishi, Yasuaki / Kawamura, Kenji / Tanaka, Yasuhito

The Journal of hand surgery

2023 Volume 49, Issue 1, Page(s) 15–22

Abstract: Purpose: Triangular fibrocartilage complex injuries can cause distal radioulnar joint (DRUJ) instability, which can be evaluated clinically with the DRUJ ballottement test. However, the reliability and validity of the test are unclear. This study aimed ... ...

Abstract	Purpose: Triangular fibrocartilage complex injuries can cause distal radioulnar joint (DRUJ) instability, which can be evaluated clinically with the DRUJ ballottement test. However, the reliability and validity of the test are unclear. This study aimed to analyze the reliability and validity of the test using a tracking device on healthy participants and patients with triangular fibrocartilage complex injuries. Methods: In this cross-sectional study, three orthopedic hand surgeons performed the DRUJ ballottement test using a technique of holding the carpal bones to the radius on 25 healthy participants (50 hands; 10 men and 15 women; mean age, 33 years; range, 20-51 years) and eight patients with triangular fibrocartilage complex injuries (16 hands; six men and two women; mean age, 43 years; range, 27-59 years). We used a three-dimensional electromagnetic tracking device to quantify the movement of the DRUJ and verify the reliability and validity of the test. Results: The intrarater and interrater intraclass correlation coefficients for DRUJ movement were 0.77 and 0.61, respectively, and the kappa coefficient for grading of DRUJ instability was 0.79. The correlation coefficient between DRUJ movement measured using the tracking device and instability judged clinically was 0.77. A comparison of healthy participants and the patients showed significantly greater DRUJ movement in the patients. Conclusions: The test showed substantial intrarater and interrater reliability for assessing DRUJ movement and instability. The significant positive correlation between DRUJ movement and instability indicates the concurrent validity of the test. Moreover, the test showed discriminative validity in identifying mild or moderate DRUJ instability. Clinical relevance: The DRUJ ballottement test using the holding technique has a relatively high diagnostic accuracy and can be used to assess DRUJ instability.
MeSH term(s)	Male ; Humans ; Female ; Pregnancy ; Adult ; Cross-Sectional Studies ; Reproducibility of Results ; Wrist Joint ; Triangular Fibrocartilage/injuries ; Radius ; Joint Instability/diagnosis ; Joint Instability/surgery
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	605716-0
ISSN	1531-6564 ; 0363-5023
ISSN (online)	1531-6564
ISSN	0363-5023
DOI	10.1016/j.jhsa.2023.10.006
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