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Article ; Online: Effects of elevated ozone on bacterial communities inhabiting the phyllo- and endo-spheres of rice plants.

Wang, Qi / Liu, Yuanyuan / Su, Yi / Cheng, Cheng / Shang, Bo / Agathokleous, Evgenios / Feng, Zhaozhong

2022 Volume 830, Page(s) 154705

Abstract: To explore the effects of elevated ozone ( ... ...

Abstract	To explore the effects of elevated ozone (O
MeSH term(s)	Bacteria ; Microbiota ; Oryza/microbiology ; Ozone ; Phosphorus ; Plant Leaves/microbiology
Chemical Substances	Phosphorus (27YLU75U4W) ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2022-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.154705
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Article ; Online: Replantation of lamina spinous process ligament complex and miniature titanium plate shaping internal fixation in the treatment of tumors in the spinal canal.

Dai, Guohua / Zhang, Min / Su, Weiliang / Zhao, Jiaqing / Yu, Xiankai / Sun, Zhaozhong / Dou, Yongfeng / Geng, Xiaopeng

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 873

Abstract: Objective: Purpose This study aims to explore the clinical efficacy of laminospinous process ligament complex reimplantation combined with mini-titanium plate fixation in the treatment of thoracolumbar intraspinal tumors.: Methods: A retrospective ... ...

Abstract	Objective: Purpose This study aims to explore the clinical efficacy of laminospinous process ligament complex reimplantation combined with mini-titanium plate fixation in the treatment of thoracolumbar intraspinal tumors. Methods: A retrospective analysis was performed on 43 cases of intraspinal tumors treated with thoracolumbar intraspinal tumor resection from August 2018 to March 2021, and 27 cases underwent laminospinous process ligament complex reimplantation combined with micro titanium plate shaping. Fixation (laminar replantation group), and 16 patients underwent laminectomy combined with pedicle screw internal fixation (laminectomy group). The operation time, blood loss, drainage tube removal time, cerebrospinal fluid leakage, spinal instability, and the incidence of secondary spinal stenosis were compared between the two groups. The pain VAS score, ODI score, and modified Macnab at the last follow-up were compared between the two groups. And the laminar fusion rate of the laminoplasty group was measured. Results: Both groups successfully completed the surgery and obtained complete follow-up. The incidence of cerebrospinal fluid leakage and secondary spinal canal stenosis in the laminectomy group was lower than that in the laminectomy group, and the difference was statistically significant (P < 0.05). There was no statistically significant difference in the incidence of spinal instability between the two groups (P > 0.05). The operation time and intraoperative blood loss in the laminectomy group were less than those in the laminectomy group, and the drainage tube removal time was earlier than that in the laminectomy group. The difference was statistically significant (P < 0.05). At the final follow-up, there was no statistically significant difference in the pain VAS score, ODI score, and modified Macnab between the two groups (P > 0.05), but they were all significantly improved compared with preoperative ones. Fusion evaluation was conducted on the laminoplasty group. Two years after surgery, the fusion rate was 97.56% (40/41). Conclusions: The application of laminospinous process ligament complex reimplantation combined with mini titanium plate fixation during thoracolumbar intraspinal tumor resection can effectively reconstruct the spinal canal and posterior column structure, reduce the incidence of cerebrospinal fluid leakage and secondary spinal stenosis. The laminar fusion rate is high.
MeSH term(s)	Humans ; Spinal Stenosis/diagnostic imaging ; Spinal Stenosis/surgery ; Titanium ; Retrospective Studies ; Spinal Canal/surgery ; Laminectomy/adverse effects ; Treatment Outcome ; Replantation ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/surgery ; Ligaments/surgery ; Cerebrospinal Fluid Leak/surgery ; Pain/surgery ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery
Chemical Substances	Titanium (D1JT611TNE)
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06984-9
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Article: Effects of elevated ozone on bacterial communities inhabiting the phyllo- and endo-spheres of rice plants

Wang, Qi / Liu, Yuanyuan / Su, Yi / Cheng, Cheng / Shang, Bo / Agathokleous, Evgenios / Feng, Zhaozhong

Science of the total environment. 2022 July 15, v. 830

2022

Abstract: To explore the effects of elevated ozone (O₃) on microbial communities inhabiting phyllo- and endo-spheres of Japonica rice leaves, cultivars Nangeng 5055 (NG5055) and Wuyujing 27 (WYJ27) were grown in either charcoal-filtered air (CF) or elevated O₃ ( ... ...

Abstract	To explore the effects of elevated ozone (O₃) on microbial communities inhabiting phyllo- and endo-spheres of Japonica rice leaves, cultivars Nangeng 5055 (NG5055) and Wuyujing 27 (WYJ27) were grown in either charcoal-filtered air (CF) or elevated O₃ (ambient O₃ + 40 ppb, E-O₃) in field open-top chambers (OTCs) during a growing season. E-O₃ increased the values of the Shannon (43–80%) and Simpson (34–51%) indexes of the phyllo-and endo-spheric bacterial communities in NG5055. E-O₃ also increased the values of the phyllosphere Simpson index by 58% and the endosphere Shannon index by 54% in WYJ27. Both diversity indexes positively correlated with the contents of nitrogen, phosphorus, magnesium, and soluble sugar, and negatively correlated with the contents of starch and condensed tannins. The leaf-associated bacterial community composition significantly changed in both rice cultivars under E-O₃. Moreover, the leaf-associated bacterial communities in NG5055 were more sensitive to E-O₃ than those in WYJ27. The chemical properties explained 70% and 98% of variations in the phyllosphere and endosphere bacterial communities, respectively, suggesting a predominant role of chemical status for the endospheric bacterial community. Most variation (57.3%) in the endosphere bacterial community assembly was explained by phosphorus. Gammaproteobacteria and Pantoea were found to be the most abundant class (63–76%) and genus (38–48%) in the phyllosphere and endosphere, respectively. E-O₃ significantly increased the relative abundance of Bacteroidetes in the phyllosphere bacterial community and decreased the relative abundance of Gammaproteobacteria in the endophytic community. In conclusion, elevated O₃ increased the diversity of bacterial communities of leaf phyllosphere and endosphere, and leaf chemical properties had a more pronounced effect on the endosphere bacterial community.
Keywords	Bacteroidetes ; Pantoea ; air ; bacterial communities ; community structure ; cultivars ; endophytes ; environment ; leaves ; magnesium ; nitrogen ; ozone ; phosphorus ; phyllosphere ; rice ; starch ; sugars
Language	English
Dates of publication	2022-0715
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.154705
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plasma Levels of Proresolving and Prophlogistic Lipid Mediators: Association With Severity of Respiratory Failure and Mortality in Acute Respiratory Distress Syndrome.

Tejera, Paula / Abdulnour, Raja-Elie E / Zhu, Zhaozhong / Su, Li / Levy, Bruce D / Christiani, David C

Critical care explorations

2020 Volume 2, Issue 10, Page(s) e0241

Abstract: Objectives: Acute respiratory distress syndrome is characterized by an overly exuberant inflammatory state in the lung. Specialized proresolving mediators are endogenous agonists for the resolution of lung inflammation and injury in health, yet their ... ...

Abstract	Objectives: Acute respiratory distress syndrome is characterized by an overly exuberant inflammatory state in the lung. Specialized proresolving mediators are endogenous agonists for the resolution of lung inflammation and injury in health, yet their association with acute respiratory distress syndrome severity and outcomes remains to be defined. In the current study, we investigate associations between plasma levels of specialized proresolving mediators and acute respiratory distress syndrome severity and mortality. Design: Translational pilot study nested within a large prospective cohort of patients with risk factors for acute respiratory distress syndrome. Setting: ICU from a large medical center. Patients: Twenty-six Caucasian patients with acute respiratory distress syndrome and available plasma from early in critical illness. Interventions: None. Measurements and main results: Here, in samples from 26 acute respiratory distress syndrome patients, we examined plasma levels of select specialized proresolving mediators that promote lung injury resolution in preclinical systems, namely lipoxin A Conclusions: Lower specialized proresolving mediator levels in acute respiratory distress syndrome patients may disrupt timely resolution of lung inflammation and/or injury and contribute to clinical severity and mortality.
Keywords	covid19
Language	English
Publishing date	2020-10-12
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000241
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Article ; Online: Enzymatic synthesis of PEGylated lactide-diester-diol copolyesters for highly efficient targeted anticancer drug delivery.

Su, Meifei / Xie, Jianhua / Zeng, Qiang / Shu, Man / Liu, Jie / Jiang, Zhaozhong

Materials science & engineering. C, Materials for biological applications

2020 Volume 115, Page(s) 111125

Abstract: PEGylated lactide-diester-diol copolymers were successfully synthesized via lipase-catalyzed copolymerization, the resultant amphiphilic PEG-poly(L-lactate-co-hexamethylene-co-adipate) (PEG-PLLHA) and PEG-poly(D,L-lactate-co-hexamethylene-co-adipate) ( ... ...

Abstract	PEGylated lactide-diester-diol copolymers were successfully synthesized via lipase-catalyzed copolymerization, the resultant amphiphilic PEG-poly(L-lactate-co-hexamethylene-co-adipate) (PEG-PLLHA) and PEG-poly(D,L-lactate-co-hexamethylene-co-adipate) (PEG-PDLLHA) block copolymers readily undergo self-assembly processes to form nanosized micelles in aqueous medium, which are stable under physiological conditions in the presence of serum proteins. By conjugating folic acid (FA) to enzymatic synthesized poly(hexamethylene adipate-co-hexamethylene 2,3-epoxy succinate), we could formulate FA-bearing PEG-polyester micelles for docetaxel (DTX) targeting delivery. FA-PEG-PLLHA and FA-PEG-PDLLHA micelles possess efficient cell-targeting capability toward FA receptor-positive cancer cells (e.g., CT-26), which significantly enhances their cellular uptake rates and efficacy of drug-loaded formulations toward such cells. During in vivo anticancer treatments, the FA-bearing micelles are highly capable of targeting and accumulating preferentially in tumor tissues by both active cell-targeting mechanism and passive targeting via the EPR effect. All these desirable properties enable the FA-bearing micelles to deliver DTX with 97% tumor-inhibiting efficiency through systemic delivery, which is favorable in comparison to the values of various DTX nanoparticle formulations reported in literature. Importantly, biosafety assays reveal that all DTX-loaded micelles are biocompatible and safe for in vivo antitumor treatment applications. Thus, FA-PEG-PLLHA and FA-PEG-PDLLHA micelles represent new types of promising anticancer drug nanocarriers for targeted chemotherapy.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/metabolism ; Dioxanes/chemistry ; Docetaxel/administration & dosage ; Docetaxel/chemistry ; Docetaxel/pharmacology ; Drug Carriers ; Drug Compounding ; Female ; Folic Acid/administration & dosage ; Folic Acid/chemistry ; Folic Acid/pharmacology ; Mice ; Nanoparticles ; Particle Size ; Polyesters/chemistry ; Polyethylene Glycols/chemistry ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Dioxanes ; Drug Carriers ; Polyesters ; Docetaxel (15H5577CQD) ; Polyethylene Glycols (3WJQ0SDW1A) ; Folic Acid (935E97BOY8) ; dilactide (95-96-5)
Language	English
Publishing date	2020-05-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2020.111125
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Article ; Online: Epigenome-wide association study for 28-day survival of acute respiratory distress syndrome.

Guo, Yichen / Zhang, Ruyang / Zhu, Zhaozhong / Shen, Sipeng / Su, Li / Christiani, David C

Intensive care medicine

2018 Volume 44, Issue 7, Page(s) 1182–1184

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Epigenomics ; Female ; Humans ; Male ; Middle Aged ; Respiration, Artificial ; Respiratory Distress Syndrome, Adult/genetics ; Respiratory Distress Syndrome, Adult/mortality ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2018-03-06
Publishing country	United States
Document type	Letter
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-018-5100-5
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Article ; Online: Enzymatic multifunctional biodegradable polymers for pH- and ROS-responsive anticancer drug delivery.

Su, Meifei / Xiao, Shuting / Shu, Man / Lu, Yao / Zeng, Qiang / Xie, Jianhua / Jiang, Zhaozhong / Liu, Jie

Colloids and surfaces. B, Biointerfaces

2020 Volume 193, Page(s) 111067

Abstract: A new family of multifunctional biodegradable block copolymers, PEG-poly(ω-pentadecalactone-co-N-methyldiethyleneamine sebacate-co-2,2'-thiodiethylene sebacate) (PEG-PMT), were synthesized via lipase-catalyzed copolymerization procedures. Amphiphilic PEG- ...

Abstract	A new family of multifunctional biodegradable block copolymers, PEG-poly(ω-pentadecalactone-co-N-methyldiethyleneamine sebacate-co-2,2'-thiodiethylene sebacate) (PEG-PMT), were synthesized via lipase-catalyzed copolymerization procedures. Amphiphilic PEG-PMT copolymers can be readily transformed into stable micellar nanoparticles through self-assembling processes in aqueous medium. The particle sizes increase dramatically after exposure of the particles to the acidic pH and high reactive oxygen species (ROS) conditions in tumor microenvironments, due to protonation of thioether groups and oxidation of amino groups in the PMT micelle cores, respectively. For example, docetaxel (DTX)-loaded PEG-PM-19 % TS micelles were triggered synergistically by acidic pH and ROS stimuli to release over 85 % of the anti-cancer drug. In particular, DTX/PEG-PMT-19 % TS and DTX/PEG-PMT-48 % TS micelles performed better than commercial Duopafei formulation in prohibiting growth of CT-26 tumors xenografed in vivo (70 % of tumor-inhibiting efficiency). Biosafety analysis revealed that DTX-loaded PEG-PMT nanoparticles possessed minimal toxicity towards normal organs, such as liver and kidney. These experimental data demonstrated that the pH- and ROS-responsive PEG-PMT micelles are promising vectors for both delivery of anti-tumor drugs and their controlled release at tumor intracellular sites.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Docetaxel/chemistry ; Docetaxel/pharmacology ; Drug Carriers/chemical synthesis ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Delivery Systems ; Drug Screening Assays, Antitumor ; Female ; Hydrogen-Ion Concentration ; Lipase/chemistry ; Lipase/metabolism ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Particle Size ; Polymers/chemical synthesis ; Polymers/chemistry ; Polymers/metabolism ; Reactive Oxygen Species/metabolism ; Surface Properties ; Tumor Microenvironment/drug effects
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; Polymers ; Reactive Oxygen Species ; Docetaxel (15H5577CQD) ; Lipase (EC 3.1.1.3)
Language	English
Publishing date	2020-04-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2020.111067
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Article: Effect of Perillaldehyde on Prophylaxis and Treatment of Vaginal Candidiasis in a Murine Model.

Qu, Su / Chen, Lei / Tian, Hui / Wang, Zhen / Wang, Fei / Wang, Liqin / Li, Jinting / Ji, Hui / Xi, Liurong / Feng, Zhaojun / Tian, Jun / Feng, Zhaozhong

Frontiers in microbiology

2019 Volume 10, Page(s) 1466

Abstract: Vulvovaginal candidiasis is a common fungal infection afflicting women which is primarily caused by the ... ...

Abstract	Vulvovaginal candidiasis is a common fungal infection afflicting women which is primarily caused by the yeast
Language	English
Publishing date	2019-07-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.01466
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Article ; Online: Association of Serum Mannose With Acute Respiratory Distress Syndrome Risk and Survival.

Wei, Yongyue / Huang, Hui / Zhang, Ruyang / Zhu, Zhaozhong / Zhu, Ying / Lin, Lijuan / Dong, Xuesi / Wei, Liangmin / Chen, Xin / Liu, Zhonghua / Zhao, Yang / Su, Li / Chen, Feng / Christiani, David C

JAMA network open

2021 Volume 4, Issue 1, Page(s) e2034569

Abstract: Importance: Acute respiratory distress syndrome (ARDS) confers high mortality risk among critically ill patients. Identification of biomarkers associated with ARDS risk may guide clinical diagnosis and prognosis.: Objective: To systematically ... ...

Abstract	Importance: Acute respiratory distress syndrome (ARDS) confers high mortality risk among critically ill patients. Identification of biomarkers associated with ARDS risk may guide clinical diagnosis and prognosis. Objective: To systematically evaluate the association of blood metabolites with ARDS risk and survival. Design, setting, and participants: In this cohort study, data from the Molecular Epidemiology of ARDS (MEARDS) study, a prospective cohort of 403 patients with ARDS and 1227 non-ARDS controls, were analyzed. Patients were recruited in intensive care units (ICUs) at Massachusetts General Hospital and Beth Israel Deaconess Medical Center, both in Boston, Massachusetts, from January 1, 1998, to December 31, 2014. Data analysis was performed from December 9, 2018, to January 4, 2019. Main outcomes and measures: Participants were followed up daily for ARDS development defined by Berlin criteria, requiring fulfillment of chest radiograph and oxygenation criteria on the same calendar day during invasive ventilatory assistance. A 2-stage study design was used to explore novel metabolites associated with ARDS risk and survival. Results: Of the 1630 participants from MEARDS who were admitted to the ICU , 403 (24.7%) were diagnosed with ARDS (mean [SD] age, 63.0 [17.0] years; 251 [62.3%] male) and 1227 (75.3%) were at-risk but did not have ARDS (mean [SD] age, 62.3 [16.9] years; 753 [61.4%] male). Mendelian randomization suggested that genetically regulated serum mannose was associated with ARDS risk (odds ratio [OR], 0.64; 95% CI, 0.53-0.78; P = 7.46 × 10-6) in the discovery stage. In the functional validation stage incorporating 83 participants with ARDS and matched at-risk participants in the control group from the ICU, the protective association of mannose with ARDS risk was validated (OR, 0.67; 95% CI, 0.46-0.97; P = .03). Furthermore, serum mannose was associated with 28-day (OR, 0.25; 95% CI, 0.11-0.56; P = 6.95 × 10-4) and 60-day (OR, 0.36; 95% CI, 0.19-0.71; P = 3.12 × 10-3) mortality and 28-day (hazard ratio, 0.49; 95% CI, 0.32-0.74; P = 6.41 × 10-4) and 60-day (hazard ratio, 0.55; 95% CI, 0.37-0.80; P = 2.11 × 10-3) survival. Conclusions and relevance: In this study, genetically regulated serum mannose appeared to be associated with ARDS risk and outcome, and increased serum mannose at admission was associated with reduced ARDS risk and better survival. These findings could inform prevention and clinical intervention in ARDS cases, which have increased with the expansion of the coronavirus disease 2019 pandemic.
MeSH term(s)	APACHE ; Aged ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Logistic Models ; Male ; Mannose/blood ; Mendelian Randomization Analysis ; Middle Aged ; Patient Admission/statistics & numerical data ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/mortality ; Risk Assessment
Chemical Substances	Mannose (PHA4727WTP)
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2020.34569
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Article ; Online: Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.

Du, Mulong / Garcia, Joe G N / Christie, Jason D / Xin, Junyi / Cai, Guoshuai / Meyer, Nuala J / Zhu, Zhaozhong / Yuan, Qianyu / Zhang, Zhengdong / Su, Li / Shen, Sipeng / Dong, Xuesi / Li, Hui / Hutchinson, John N / Tejera, Paula / Lin, Xihong / Wang, Meilin / Chen, Feng / Christiani, David C

Intensive care medicine

2021 Volume 47, Issue 7, Page(s) 761–771

Abstract: Purpose: Acute respiratory distress syndrome (ARDS) is accompanied by a dysfunctional immune-inflammatory response following lung injury, including during coronavirus disease 2019 (COVID-19). Limited causal biomarkers exist for ARDS development. We ... ...

Abstract	Purpose: Acute respiratory distress syndrome (ARDS) is accompanied by a dysfunctional immune-inflammatory response following lung injury, including during coronavirus disease 2019 (COVID-19). Limited causal biomarkers exist for ARDS development. We sought to identify novel genetic susceptibility targets for ARDS to focus further investigation on their biological mechanism and therapeutic potential. Methods: Meta-analyses of ARDS genome-wide association studies were performed with 1250 cases and 1583 controls in Europeans, and 387 cases and 387 controls in African Americans. The functionality of novel loci was determined in silico using multiple omics approaches. The causality of 114 factors potentially involved in ARDS development was assessed using Mendelian Randomization analysis. Results: There was distinct genetic heterogeneity in ARDS between Europeans and African Americans. rs7967111 at 12p13.2 was functionally associated with ARDS susceptibility in Europeans (odds ratio = 1.38; P = 2.15 × 10 Conclusion: Our findings suggest a novel susceptibility locus in ARDS pathophysiology that implicates BORCS5 and DUSP16 as potentially acting in immune-inflammatory processes. This locus warrants further investigation to inform the development of therapeutic targets and clinical care strategies for ARDS, including those induced by COVID-19.
MeSH term(s)	COVID-19 ; Genome-Wide Association Study ; Humans ; Respiratory Distress Syndrome/genetics ; SARS-CoV-2 ; Whites/genetics
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-021-06410-5
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