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  1. Article ; Online: Rendezvous therapy with endoscopic and endovascular treatments for rectal arteriovenous malformation: A case report.

    Matsuda, Takashi / Ishikawa, Tsuyoshi / Oono, Takashi / Sasaki, Ryo / Hidaka, Isao / Okada, Munemasa / Sakaida, Isao

    Endoscopy

    2021  Volume 54, Issue 3, Page(s) E77–E78

    MeSH term(s) Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/surgery ; Embolization, Therapeutic ; Endoscopy ; Humans
    Language English
    Publishing date 2021-03-15
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1388-6021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Rendezvous therapy with endoscopic and endovascular treatments for rectal arteriovenous malformation: A case report

    Matsuda, Takashi / Ishikawa, Tsuyoshi / Oono, Takashi / Sasaki, Ryo / Hidaka, Isao / Okada, Munemasa / Sakaida, Isao

    Endoscopy

    2021  Volume 54, Issue 03, Page(s) E77–E78

    Language English
    Publishing date 2021-03-15
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1388-6021
    Database Thieme publisher's database

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  3. Article ; Online: Unique skin manifestations of COVID-19: Is drug eruption specific to COVID-19?

    Sakaida, Takashi / Tanimoto, Isao / Matsubara, Akihiro / Nakamura, Motoki / Morita, Akimichi

    Journal of dermatological science

    2020  Volume 99, Issue 1, Page(s) 62–64

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Betacoronavirus ; COVID-19 ; Cephalosporins/adverse effects ; Coronavirus Infections/complications ; Drug Eruptions/virology ; Female ; Humans ; Middle Aged ; Pandemics ; Phenylpropionates/adverse effects ; Pneumonia, Viral/complications ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Cephalosporins ; Phenylpropionates ; loxoprofen (3583H0GZAP) ; cefcapene pivoxil hydrochloride (5J77167P9E)
    Keywords covid19
    Language English
    Publishing date 2020-05-16
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2020.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differential clinical impact of letermovir prophylaxis according to graft sources: a KSGCT multicenter retrospective analysis.

    Toya, Takashi / Mizuno, Kota / Sakurai, Masatoshi / Kato, Jun / Mori, Takehiko / Doki, Noriko / Masuda, Shinichi / Aotsuka, Nobuyuki / Tsukamoto, Shokichi / Sakaida, Emiko / Nakajima, Yuki / Fujisawa, Shin / Machida, Shinichiro / Aoyama, Yasuyuki / Yokoyama, Hiroki / Shono, Katsuhiro / Hatta, Yoshihiro / Usuki, Kensuke / Kataoka, Keisuke /
    Kanda, Yoshinobu

    Blood advances

    2024  Volume 8, Issue 5, Page(s) 1084–1093

    Abstract: Abstract: Clinically significant cytomegalovirus infection (csCMVi) is frequently observed after allogeneic hematopoietic stem cell transplantation (HSCT) and prophylaxis with letermovir is commonly adopted. However, the clinical benefit of letermovir ... ...

    Abstract Abstract: Clinically significant cytomegalovirus infection (csCMVi) is frequently observed after allogeneic hematopoietic stem cell transplantation (HSCT) and prophylaxis with letermovir is commonly adopted. However, the clinical benefit of letermovir prophylaxis according to graft sources has not been sufficiently elucidated. We retrospectively analyzed 2194 recipients of HSCT who were CMV-seropositive (236 with letermovir prophylaxis and 1958 without prophylaxis against CMV). csCMVi was significantly less frequent in patients with letermovir prophylaxis than in those without (23.7% vs 58.7% at 100 days after HSCT, P < .001) and the same trend was seen when recipients of bone marrow (BM), peripheral blood stem cell (PBSC), or cord blood (CB) transplantation were separately analyzed. In recipients of BM, nonrelapse mortality (NRM) was significantly lower in the letermovir group at 6 months after HSCT (5.0% vs 14.9%, P = .018), and the same trend was observed in recipients of PBSCs (14.7% vs 24.8%, P = .062); however, there was no statistical significance at 1 year (BM, 21.1% vs 30.4%, P = .67; PBSCs, 21.2% vs 30.4%, P = .096). In contrast, NRM was comparable between recipients of CB with and without letermovir prophylaxis throughout the clinical course (6 months, 23.6% vs 24.3%, P =.92; 1 year, 29.3% vs 31.0%, P = .77), which was confirmed by multivariate analyses. In conclusion, the impact of letermovir prophylaxis on NRM and csCMVi should be separately considered according to graft sources.
    MeSH term(s) Humans ; Retrospective Studies ; Antiviral Agents/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects ; Cytomegalovirus Infections/prevention & control ; Acetates ; Quinazolines
    Chemical Substances letermovir (1H09Y5WO1F) ; Antiviral Agents ; Acetates ; Quinazolines
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Unique skin manifestations of COVID-19: Is drug eruption specific to COVID-19?

    Sakaida, Takashi / Tanimoto, Isao / Matsubara, Akihiro / Nakamura, Motoki / Morita, Akimichi

    J Dermatol Sci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #276300
    Database COVID19

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  6. Article ; Online: Unique skin manifestations of COVID-19

    Sakaida, Takashi / Tanimoto, Isao / Matsubara, Akihiro / Nakamura, Motoki / Morita, Akimichi

    Journal of Dermatological Science

    Is drug eruption specific to COVID-19?

    2020  Volume 99, Issue 1, Page(s) 62–64

    Keywords Biochemistry ; Molecular Biology ; Dermatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1024446-3
    ISSN 0923-1811
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2020.05.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Bone marrow-derived humoral factors suppress oxidative phosphorylation, upregulate TSG-6, and improve therapeutic effects on liver injury of mesenchymal stem cells.

    Miyaji, Takashi / Takami, Taro / Fujisawa, Koichi / Matsumoto, Toshihiko / Yamamoto, Naoki / Sakaida, Isao

    Journal of clinical biochemistry and nutrition

    2020  Volume 66, Issue 3, Page(s) 213–223

    Abstract: Mesenchymal stem cells, which have the potential to be used in regenerative medicine, require improvements in quality for patient use. To maintain stemness of cultured bone marrow-derived mesenchymal stem cells, we focused on the bone marrow ... ...

    Abstract Mesenchymal stem cells, which have the potential to be used in regenerative medicine, require improvements in quality for patient use. To maintain stemness of cultured bone marrow-derived mesenchymal stem cells, we focused on the bone marrow microenvironment, generated a conditioned medium of whole bone marrow cells (BMC-CM), and assessed its effects on bone marrow-derived mesenchymal stem cells. BMC-CM suppressed morphological deterioration and proliferative decline in cultured bone marrow-derived mesenchymal stem cells, suppressed mitochondrial oxidative phosphorylation activity, a stemness indicator, and upregulated suppressors of oxidative phosphorylation such as hypoxia-inducible factor-1 alpha, Sirtuin 3, 4, and 5. Furthermore, BMC-CM upregulated TNF-stimulated gene 6 and ameliorated the therapeutic effects of cells on liver injury in carbon tetrachloride-administered rats. Since the elimination of 20-220-nm particles attenuated the effects of BMC-CM, we further analyzed exosomal microRNAs produced by whole bone marrow cells. Among the 49 microRNAs observed to be upregulated during the preparation of BMC-CM, several were identified that were associated with suppression of oxidative phosphorylation, upregulation of TNF-stimulated gene 6, and the pathogenesis of liver diseases. Thus, bone marrow-derived humoral factors including exosomal microRNAs may help to improve the therapeutic quality of bone marrow-derived mesenchymal stem cells for liver regenerative therapy.
    Language English
    Publishing date 2020-03-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 632945-7
    ISSN 1880-5086 ; 0912-0009
    ISSN (online) 1880-5086
    ISSN 0912-0009
    DOI 10.3164/jcbn.19-125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Successful Management With Dual Therapy of Lenvatinib and Macitentan for HCC With Portopulmonary Hypertension.

    Ishikawa, Tsuyoshi / Sasaki, Ryo / Matsuda, Takashi / Saeki, Issei / Takami, Taro / Wada, Yasuaki / Yano, Masafumi / Sakaida, Isao

    Hepatology (Baltimore, Md.)

    2021  Volume 74, Issue 4, Page(s) 2300–2303

    MeSH term(s) Aged ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Cardiac Catheterization/methods ; Endothelin Receptor Antagonists/administration & dosage ; Hepatitis B, Chronic/complications ; Humans ; Hypertension, Portal/diagnosis ; Hypertension, Portal/etiology ; Hypertension, Portal/physiopathology ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Male ; Medication Therapy Management ; Phenylurea Compounds/administration & dosage ; Phenylurea Compounds/adverse effects ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pulmonary Arterial Hypertension/diagnosis ; Pulmonary Arterial Hypertension/etiology ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Arterial Hypertension/therapy ; Pyrimidines/administration & dosage ; Quinolines/administration & dosage ; Quinolines/adverse effects ; Sulfonamides/administration & dosage ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Endothelin Receptor Antagonists ; Phenylurea Compounds ; Protein Kinase Inhibitors ; Pyrimidines ; Quinolines ; Sulfonamides ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; lenvatinib (EE083865G2) ; macitentan (Z9K9Y9WMVL)
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Splenic non-infarction volume determines a clinically significant hepatic venous pressure gradient response to partial splenic embolization in patients with cirrhosis and hypersplenism.

    Ishikawa, Tsuyoshi / Sasaki, Ryo / Nishimura, Tatsuro / Matsuda, Takashi / Iwamoto, Takuya / Saeki, Issei / Hidaka, Isao / Takami, Taro / Sakaida, Isao

    Journal of gastroenterology

    2021  Volume 56, Issue 4, Page(s) 382–394

    Abstract: Background: This study aimed to investigate changes in the hepatic venous pressure gradient (HVPG) by partial splenic embolization (PSE) and to identify the determinants of a clinically meaningful postoperative HVPG reduction.: Methods: Sixty-eight ... ...

    Abstract Background: This study aimed to investigate changes in the hepatic venous pressure gradient (HVPG) by partial splenic embolization (PSE) and to identify the determinants of a clinically meaningful postoperative HVPG reduction.
    Methods: Sixty-eight patients with cirrhosis and hypersplenism who underwent PSE at our department between September 2007 and June 2020 were included. The HVPG was evaluated pre- and immediately post-PSE. The patients were divided into three groups according to their preprocedural HVPG: low-HVPG (< 10 mmHg, n = 22), intermediate-HVPG (10 mmHg ≤ HVPG < 16 mmHg, n = 33), and high-HVPG (≥ 16 mmHg, n = 13).
    Results: Overall, PSE significantly reduced HVPG from 12.2 ± 4.0 to 9.4 ± 3.6 mmHg (p < 0.01) with a relative decrease of 22.2 ± 20.4%. In addition, HVPG reductions were 19.4 ± 28.7%, 24.0 ± 15.9%, and 22.5 ± 13.3% in the low-, intermediate-, and high-HVPG groups, respectively, indicating no significant difference in HVPG reduction between the groups. An HVPG decrease of ≥ 20% from the baseline, defined in this study as a clinically significant HVPG response to PSE, was achieved in 55.9% of all patients. Multivariate logistic regression and receiver operating characteristic curve analyses identified splenic non-infarction volume as an independent determinant of a 20% decrease in HVPG (p < 0.05), with a cut-off of 139.2 cm
    Conclusions: The splenic non-infarction volume, namely the residual functional spleen volume, independently determines a clinically significant HVPG response to PSE in patients with cirrhosis and hypersplenism.
    MeSH term(s) Adult ; Embolization, Therapeutic/methods ; Embolization, Therapeutic/standards ; Embolization, Therapeutic/statistics & numerical data ; Female ; Fibrosis/drug therapy ; Fibrosis/physiopathology ; Humans ; Hypersplenism/drug therapy ; Hypersplenism/physiopathology ; Liver/physiology ; Liver/physiopathology ; Male ; Middle Aged ; Portal Pressure/physiology ; Spleen/injuries ; Spleen/physiopathology ; Statistics, Nonparametric ; Venous Pressure/physiology
    Language English
    Publishing date 2021-02-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-021-01762-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A prospective, multicenter, open-label phase III study of emicizumab prophylaxis in patients with acquired hemophilia A.

    Shima, Midori / Amano, Kagehiro / Ogawa, Yoshiyuki / Yoneyama, Koichiro / Ozaki, Ryoto / Kobayashi, Ryota / Sakaida, Emiko / Saito, Makoto / Okamura, Takashi / Ito, Toshihiro / Hattori, Norimichi / Higasa, Satoshi / Suzuki, Nobuaki / Seki, Yoshinobu / Nogami, Keiji

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 21, Issue 3, Page(s) 534–545

    Abstract: Background: Emicizumab is a bispecific antibody that mimics the cofactor function of activated factor (F) VIII. It prevents bleeds in patients with congenital hemophilia A regardless of the inhibitor status; however, no prospective clinical studies have ...

    Abstract Background: Emicizumab is a bispecific antibody that mimics the cofactor function of activated factor (F) VIII. It prevents bleeds in patients with congenital hemophilia A regardless of the inhibitor status; however, no prospective clinical studies have been conducted for emicizumab in patients with acquired hemophilia A (PwAHA).
    Objectives: To describe the primary analysis results from a prospective, multicenter, open-label phase III study evaluating the efficacy, safety, and pharmacokinetics of emicizumab in PwAHA (AGEHA; JapicCTI-205151).
    Methods: Emicizumab was administered subcutaneously at 6 mg/kg on day 1 and 3 mg/kg on day 2, followed by 1.5 mg/kg once weekly from day 8 onward. Predefined criteria for the completion of dosing included FVIII activity of >50 IU/dL.
    Results: By the cutoff date (April 23, 2021), 12 patients on immunosuppressive therapy were enrolled, and 11 of them (91.7%) completed emicizumab treatment. The mean trough plasma emicizumab concentration rapidly reached a steady state (1 week), achieving the efficacious level that was established in patients with congenital hemophilia A (>30 μg/mL). Before first emicizumab administration, 7 patients (58.3%) experienced 77 major bleeds. During emicizumab treatment, no major bleeds occurred in any patient. Neither death due to bleeding or infection nor any study treatment-related serious adverse event was reported. One asymptomatic, nonserious deep vein thrombosis was discovered with no laboratory findings indicating any trend toward hypercoagulation.
    Conclusion: These results suggest that emicizumab prophylaxis with the tested dosing regimen and completion criteria may have a favorable benefit-risk profile in PwAHA.
    MeSH term(s) Humans ; Hemophilia A/drug therapy ; Factor VIII ; Hemorrhage/chemically induced ; Antibodies, Bispecific/therapeutic use
    Chemical Substances Factor VIII (9001-27-8) ; emicizumab (7NL2E3F6K3) ; Antibodies, Bispecific
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Clinical Trial, Phase III ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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