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  1. Article ; Online: The positioning of ceftobiprole in the treatment of Staphylococcus aureus bacteremia.

    Minter, Daniel J / Appa, Ayesha / Chambers, Henry F / Doernberg, Sarah B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Can I Safely Discharge a Patient with a Substance Use Disorder Home with a Peripherally Inserted Central Catheter?

    Appa, Ayesha / Barocas, Joshua A

    NEJM evidence

    2022  Volume 1, Issue 2, Page(s) EVIDccon2100012

    Abstract: Discharging Patients Who Use Drugs Home with PICCAmid the U.S. overdose crisis, serious injection-related infections are rising. Determining where a patient goes after hospitalization can be a challenge due to the need for prolonged parenteral ... ...

    Abstract Discharging Patients Who Use Drugs Home with PICCAmid the U.S. overdose crisis, serious injection-related infections are rising. Determining where a patient goes after hospitalization can be a challenge due to the need for prolonged parenteral antibiotics, prompting a common clinical question: Can I safely discharge a patient with a substance use disorder home with a peripherally inserted central catheter?
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDccon2100012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Executive Summary: State-of-The-Art Review: Contemporary Management of Staphylococcus aureus Bacteremia: Controversies in Clinical Practice.

    Minter, Daniel J / Appa, Ayesha / Chambers, Henry F / Doernberg, Sarah B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 11, Page(s) 1489–1491

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Contemporary Management of Staphylococcus aureus Bacteremia-Controversies in Clinical Practice.

    Minter, Daniel J / Appa, Ayesha / Chambers, Henry F / Doernberg, Sarah B

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 11, Page(s) e57–e68

    Abstract: Staphylococcus aureus bacteremia (SAB) carries a high risk for excess morbidity and mortality. Despite its prevalence, significant practice variation continues to permeate clinical management of this syndrome. Since the publication of the 2011 Infectious ...

    Abstract Staphylococcus aureus bacteremia (SAB) carries a high risk for excess morbidity and mortality. Despite its prevalence, significant practice variation continues to permeate clinical management of this syndrome. Since the publication of the 2011 Infectious Diseases Society of America (IDSA) guidelines on management of methicillin-resistant Staphylococcus aureus infections, the field of SAB has evolved with the emergence of newer diagnostic strategies and therapeutic options. In this review, we seek to provide a comprehensive overview of the evaluation and management of SAB, with special focus on areas where the highest level of evidence is lacking to inform best practices.
    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stimulant use and opioid-related harm in patients on long-term opioids for chronic pain.

    Appa, Ayesha / McMahan, Vanessa M / Long, Kyna / Shade, Starley B / Coffin, Phillip O

    Drug and alcohol dependence

    2023  Volume 256, Page(s) 111065

    Abstract: Background: There is lack of clarity regarding the impact of and optimal clinical response to stimulant use among people prescribed long-term opioid therapy (LTOT) for pain.: Objective: To determine if a positive urine drug test (UDT) for stimulants ... ...

    Abstract Background: There is lack of clarity regarding the impact of and optimal clinical response to stimulant use among people prescribed long-term opioid therapy (LTOT) for pain.
    Objective: To determine if a positive urine drug test (UDT) for stimulants was associated with subsequent opioid-related harm or discontinuation of LTOT.
    Design: Retrospective cohort study.
    Patients: People living with and without HIV living in a major metropolitan area with public insurance, prescribed LTOT for chronic, non-cancer pain (n=600).
    Main measures: UDT results from January 2012 to June 2019 were evaluated against 1) opioid-related emergency department (ED) visits (oversedation, constipation, infections associated with injecting opioids, and opioid seeking) or death in each 90-day period following a UDT, using logistic regression, and 2) LTOT discontinuation.
    Results: There were no opioid overdose deaths within 90 days following a stimulant-positive UDT. A stimulant-positive UDT was not statistically significantly associated with opioid-related ED visits within 90 days (adjusted odds ratio [aOR] 1.39; 95% CI=0.88-2.21). Stimulant-positive UDT was independently associated with subsequent discontinuation of LTOT within 90 days (aOR 2.96; 95% CI=2.13 - 4.12). Living with HIV was independently associated with decreased odds of LTOT discontinuation (aOR 0.65; 95% CI 0.43 - 0.99).
    Conclusions: Despite no association between a stimulant-positive UDT and subsequent opioid-related harm, there was an association with subsequent LTOT discontinuation, with heterogeneity across clinical groups. Detection of stimulant use should result in a discussion of substance use and risk, rather than reflex LTOT discontinuation.
    MeSH term(s) Humans ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/urine ; Retrospective Studies ; Chronic Pain/drug therapy ; Substance Abuse Detection ; HIV Infections/drug therapy
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-12-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2023.111065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The IMPACT (Infection Management Plus Addiction Care Together) Pilot: A Case Series of Combined Contingency Management for Substance Use Disorders and Antibiotic Adherence in the Hospital Setting.

    Appa, Ayesha / Baral, Stefan / Stein, Brianna / Knight, Kelly / Gandhi, Monica / Coffin, Phillip / Martin, Marlene

    Journal of addiction medicine

    2023  Volume 18, Issue 2, Page(s) 138–143

    Abstract: Objectives: Psychostimulant-related mortality is rising alongside increasing substance use-related hospitalizations, which are commonly complicated by patient-directed (or "against medical advice") discharges. Contingency management (CM) is an underused ...

    Abstract Objectives: Psychostimulant-related mortality is rising alongside increasing substance use-related hospitalizations, which are commonly complicated by patient-directed (or "against medical advice") discharges. Contingency management (CM) is an underused evidence-based treatment for substance use disorders with proven efficacy to support medication adherence. Our objective was to describe feasibility and preliminary effectiveness of a novel CM intervention incentivizing both drug use reduction and antibiotic adherence in the hospital setting.
    Methods: We conducted a pilot intervention of twice weekly CM for stimulant and/or opioid use disorder and antibiotic adherence conducted on inpatient wards and/or an embedded skilled nursing facility in an urban public hospital. Based on point-of-care urine drug test results and objective antibiotic adherence review, participants earned increasing opportunities to receive incentives. We measured feasibility via number of visits attempted and cost of gift cards dispensed. We evaluated effectiveness via antibiotic completion, discharge type, and participant perception of intervention effectiveness collected via structured survey.
    Results: Of 13 participants enrolled, most had opioid use disorder (fentanyl in 10/13) and stimulant use disorder (methamphetamine in 7/13). Almost all were receiving treatment for osteomyelitis and/or endocarditis (12/13). Feasibility challenges included competing demands of acute care with variable range of completed visits per participant (1-12 visits). Despite this, antibiotic completion was high (92%, 12/13 participants) with only two patient-directed discharges. Participants described CM as very effective in aiding infection treatment but had greater variability in beliefs regarding CM facilitation of reduced drug use.
    Conclusions: Providing CM in the hospital setting may represent an effective approach to improving health outcomes by increasing antibiotic adherence and addressing substance use.
    MeSH term(s) Humans ; Behavior Therapy/methods ; Methamphetamine ; Central Nervous System Stimulants ; Opioid-Related Disorders ; Hospitals
    Chemical Substances Methamphetamine (44RAL3456C) ; Central Nervous System Stimulants
    Language English
    Publishing date 2023-12-17
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000001254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frame Shift: Focusing on Harm Reduction and Shared Decision Making for People Who Use Drugs Hospitalized With Infections.

    Thakarar, Kinna / Appa, Ayesha / Abdul Mutakabbir, Jacinda C / Goff, Amelia / Brown, Jessica / Tuell, Chasity / Fairfield, Kathleen / Wurcel, Alysse

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 78, Issue 2, Page(s) e12–e26

    MeSH term(s) Humans ; Harm Reduction ; Decision Making, Shared ; Decision Making
    Language English
    Publishing date 2023-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Executive Summary: State-of-the-Art Review: Frame Shift-Focusing on Harm Reduction and Shared Decision Making for People Who Use Drugs Hospitalized With Infections.

    Thakarar, Kinna / Appa, Ayesha / Abdul Mutakabbir, Jacinda C / Goff, Amelia / Brown, Jessica / Tuell, Chasity / Fairfield, Kathleen / Wurcel, Alysse

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 78, Issue 2, Page(s) 233–235

    MeSH term(s) Humans ; Decision Making, Shared ; Harm Reduction ; HIV Infections ; Decision Making
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Home-Based Outpatient Parenteral Antibiotic Therapy at an Urban Safety Net Hospital: Comparing Outcomes in Persons With and Without Noninjection Drug Use.

    Appa, Ayesha / Marquez, Carina / Jain, Vivek

    Open forum infectious diseases

    2020  Volume 7, Issue 5, Page(s) ofaa162

    Abstract: As stimulant use and infections among persons using drugs rise nationally, evidence remains limited on how best to deliver outpatient parenteral antimicrobial therapy (OPAT) to persons using noninjection drugs. In an urban safety net population including ...

    Abstract As stimulant use and infections among persons using drugs rise nationally, evidence remains limited on how best to deliver outpatient parenteral antimicrobial therapy (OPAT) to persons using noninjection drugs. In an urban safety net population including persons using noninjection drugs, home-based OPAT completion rates were similarly high as those of non-drug-using individuals.
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Qualitative Exploration of Intimate Partner Violence Among HIV/TB Coinfected Persons With Problematic Alcohol Use Participating in an Incentive-Based Alcohol/Medication Adherence Intervention in Uganda During COVID-19.

    Miller, Amanda P / Appa, Ayesha / Muyindike, Winnie / Fatch, Robin / Kekibiina, Allen / Beesiga, Brian / Adong, Julian / Emenyonu, Nneka / Marson, Kara / Getahun, Monica / Kamya, Moses / Chamie, Gabriel / Camlin, Carol S / Hahn, Judith A

    Violence against women

    2024  , Page(s) 10778012231225229

    Abstract: In Uganda, four in ten women report experiencing intimate partner violence (IPV) in the past year. Salient drivers of IPV in sub-Saharan Africa include stress related to household finances, alcohol use, and partner infidelity. We conducted 42 interviews ... ...

    Abstract In Uganda, four in ten women report experiencing intimate partner violence (IPV) in the past year. Salient drivers of IPV in sub-Saharan Africa include stress related to household finances, alcohol use, and partner infidelity. We conducted 42 interviews with participants (
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2031375-5
    ISSN 1552-8448 ; 1077-8012
    ISSN (online) 1552-8448
    ISSN 1077-8012
    DOI 10.1177/10778012231225229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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