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Article ; Online: Cineclubismo

Jean Carllo de Souza SILVA / Samuel PONSONI / Bruno de Moura SETTE / Luigy Gabriel Resende MARTINS

Elo, Vol

a experiência do Cineclube Eduardo Coutinho

2023 Volume 12

Abstract: O objetivo deste relato de experiência é discutir a relevância pedagógica, mas, sobretudo, social, do cineclubismo para a formação de estudantes do campo da Comunicação Social. Para tanto, se discute, em específico, a proposta de cineclube praticada pelo ...

Abstract	O objetivo deste relato de experiência é discutir a relevância pedagógica, mas, sobretudo, social, do cineclubismo para a formação de estudantes do campo da Comunicação Social. Para tanto, se discute, em específico, a proposta de cineclube praticada pelo “Cineclube Eduardo Coutinho”, ação extensionista voltada especialmente para exibição de cinema documentário nacional. O projeto, realizado entre julho e dezembro de 2022 em uma universidade localizada em uma cidade do interior de Minas Gerais, exibiu oito documentários de longa-metragem em sessões abertas seguidas de discussões acerca das temáticas e da linguagem cinematográfica adotadas por cada um deles. Com isso, acredita-se que o público participante das sessões teve contato com temas candentes de nossa época e da realidade social brasileira e, sobremaneira, atentou para as múltiplas possibilidades de representá-la em audiovisual.
Keywords	cineclube ; filme ; documentário ; Social Sciences ; H ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Universidade Federal de Viçosa
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unknown/enigmatic functions of extracellular ASC.

de Souza, Jean Gabriel / Starobinas, Nancy / Ibañez, Olga Celia Martinez

Immunology

2021 Volume 163, Issue 4, Page(s) 377–388

Abstract: Apoptosis-associated speck-like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small molecule, which aggregates into ASC specks during inflammasome activation. ASC protein is an adaptor protein present in several ... ...

Abstract	Apoptosis-associated speck-like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small molecule, which aggregates into ASC specks during inflammasome activation. ASC protein is an adaptor protein present in several inflammasome complexes that performs several intra- and extracellular functions, in monomeric form or as ASC specks, during physiological and pathological processes related to inflammation and adaptive immunity. Extracellular ASC specks (eASC specks) released during cell death by pyroptosis can contribute as a danger signal to the propagation of inflammation via phagocytosis and activation of surrounding cells. ASC specks are found in the circulation of patients with chronic inflammatory diseases and have been considered as relevant blood biomarkers of inflammation. eASC amplifies the inflammatory signal, may induce the production of autoantibodies, transports molecules that bind to this complex, contributing to the generation of antibodies, and can induce the maturation of cytokines promoting the modelling of the adaptive immunity. Although several advances have been registered in the last 21 years, there are numerous unknown or enigmatic gaps in the understanding of the role of eASC specks in the organism. Here, we provide an overview about the ASC protein focusing on the probable roles of eASC specks in several diseases, up to the most recent studies concerning COVID-19.
MeSH term(s)	Adaptive Immunity ; Alarmins/metabolism ; Animals ; CARD Signaling Adaptor Proteins/metabolism ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Phagocytosis ; Pyroptosis ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Signal Transduction
Chemical Substances	Alarmins ; CARD Signaling Adaptor Proteins ; Inflammasomes ; Inflammation Mediators ; PYCARD protein, human
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13375
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Article ; Online: Historical determinants of neurosurgical inequities in Africa and the African diaspora: A review and analysis of coloniality.

Barthélemy, Ernest J / Diouf, Sylviane A / Silva, Ana Cristina Veiga / Abu-Bonsrah, Nancy / de Souza, Isabella Assunção Santos / Kanmounye, Ulrick Sidney / Gabriel, Phabinly / Sarpong, Kwadwo / Nduom, Edjah K / Lartigue, Jean Wilguens / Esene, Ignatius / Karekezi, Claire

PLOS global public health

2023 Volume 3, Issue 2, Page(s) e0001550

Abstract: The movement to decolonize global health challenges clinicians and researchers of sub-disciplines, like global neurosurgery, to redefine their field. As an era of racial reckoning recentres the colonial roots of modern health disparities, reviewing the ... ...

Abstract	The movement to decolonize global health challenges clinicians and researchers of sub-disciplines, like global neurosurgery, to redefine their field. As an era of racial reckoning recentres the colonial roots of modern health disparities, reviewing the historical determinants of these disparities can constructively inform decolonization. This article presents a review and analysis of the historical determinants of neurosurgical inequities as understood by a group of scholars who share Sub-Saharan African descent. Vignettes profiling the colonial histories of Cape Verde, Rwanda, Cameroon, Ghana, Brazil, and Haiti illustrate the role of the colonial legacy in the currently unmet need for neurosurgical care in each of these nations. Following this review, a bibliographic lexical analysis of relevant terms then introduces a discussion of converging historical themes, and practical suggestions for transforming global neurosurgery through the decolonial humanism promulgated by anti-racist practices and the dialogic frameworks of conscientization.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0001550
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Article ; Online: Comparative Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by Destabilization of Medial Meniscus.

Dias de Oliveira, Felipe Bruno / Antonioli, Eliane / Dias, Olívia Furiama Metropolo / de Souza, Jean Gabriel / Agarwal, Sudha / Chudzinski-Tavassi, Ana Marisa / Ferretti, Mario

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Transplanted mesenchymal stromal cells (MSCs) exhibit a robust anti-inflammatory and homing capacity in response to high inflammatory signals, as observed in studies focused on rheumatic diseases that target articular cartilage (AC) health. However, AC ... ...

Abstract	Transplanted mesenchymal stromal cells (MSCs) exhibit a robust anti-inflammatory and homing capacity in response to high inflammatory signals, as observed in studies focused on rheumatic diseases that target articular cartilage (AC) health. However, AC degradation in osteoarthritis (OA) does not necessarily coincide with a highly inflammatory joint profile. Often, by the time patients seek medical attention, they already have damaged AC. In this study, we examined the therapeutic potential of a single bone marrow MSC transplant (2 × 10
MeSH term(s)	Humans ; Rats ; Female ; Animals ; Menisci, Tibial/metabolism ; Osteoarthritis/metabolism ; Cartilage, Articular/metabolism ; Anti-Inflammatory Agents/pharmacology ; Injections, Intra-Articular ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cell Transplantation/methods
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115543
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Article ; Online: Patients´ satisfaction concerning direct anterior dental restoration.

Freitas, Bruna Neves de / Silva, Paulo Oliveira da / Pintado-Palomino, Karen / Almeida, Cecília Vilela Vasconcelos Barros de / Souza-Gabriel, Aline Evangelista / Corona, Silmara Aparecida Milori / Geraldeli, Saulo / Grosgogeat, Brigitte / Roulet, Jean-François / Tirapelli, Camila

Brazilian dental journal

2023 Volume 34, Issue 3, Page(s) 82–93

Abstract: The objective of this study was to observe patients' satisfaction with their in-service direct anterior dental restorations and to compare it with clinical evaluation using FDI (Federation Dental International) criteria. Patients scored their own ... ...

Abstract	The objective of this study was to observe patients' satisfaction with their in-service direct anterior dental restorations and to compare it with clinical evaluation using FDI (Federation Dental International) criteria. Patients scored their own anterior dental restorations regarding satisfaction (satisfactory /dissatisfactory). If dissatisfaction was mentioned, then, they would be interviewed about the complaint. In the same session, the dental restorations were clinically evaluated by two dentists using FDI criteria (1-5 score) concerning esthetic, functional, and biological domains. Descriptive statistics were used for frequencies of scores attributed by patients and clinicians. In order to compare patients' to clinicians' frequencies, the Chi-square test was applied (p ≤ 0.05). A total of 106 restorations were evaluated by patients and clinicians. Patients reported 52.8% of restorations satisfactory and 47.8% dissatisfactory. Overall, clinicians reported the same restorations as 82,3% satisfactory and 17,6% dissatisfactory. Patients' most frequent complaints referred to color, followed by anatomical form, fracture of material and retention, and approximal anatomical form. Comparing patients' satisfaction and dissatisfaction rates to clinicians' evaluation per criteria, there was no difference regarding esthetics. The frequency of dissatisfactory restorations by clinicians was significantly lower when functional and biological properties were compared with patients' opinions. Direct anterior dental restorations were more frequently reported as satisfactory by patients and clinicians, being the main complaints related to esthetic issues. When clinicians and patients' evaluations were compared, it was observed that the frequencies of satisfactory restoration by patients and clinicians were similar regarding esthetic properties, and significantly different regarding functional and biological properties.
MeSH term(s)	Humans ; Patient Satisfaction ; Esthetics, Dental ; Dental Restoration, Permanent ; Dental Restoration Failure ; Composite Resins
Chemical Substances	Composite Resins
Language	English
Publishing date	2023-07-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1089484-6
ISSN	1806-4760 ; 0103-6440
ISSN (online)	1806-4760
ISSN	0103-6440
DOI	10.1590/0103-6440202305260
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Article ; Online: Microencapsulation of Yarrowia lipolytica: cell viability and application in vitro ruminant diets.

Dos Santos Wanderley, Liliane Alves / Aguiar, Gean Pablo Silva / Calisto, Jean Felipe Fossá / Magro, Jacir Dal / Rossato, Gabriel / Zotti, Claiton André / de Souza Hassemer, Guilherme / Puton, Bruna Maria Saorin / Cansian, Rogério Luis / Dallago, Rogério Marcos / Junges, Alexander

World journal of microbiology & biotechnology

2023 Volume 39, Issue 4, Page(s) 88

Abstract: Microencapsulation is an alternative to increase the survival capacity of microorganisms, including Yarrowia lipolytica, a widely studied yeast that produces high-value metabolites, such as lipids, aromatic compounds, biomass, lipases, and organic acids. ...

Abstract	Microencapsulation is an alternative to increase the survival capacity of microorganisms, including Yarrowia lipolytica, a widely studied yeast that produces high-value metabolites, such as lipids, aromatic compounds, biomass, lipases, and organic acids. Thus, the present study sought to investigate the effectiveness of different wall materials and the influence of the addition of salts on the microencapsulation of Y. lipolytica, evaluating yield, relationship with cell stability, ability to survive during storage, and in vitro application of ruminant diets. The spray drying process was performed via atomization, testing 11 different compositions using maltodextrin (MD), modified starch (MS) and whey protein concentrate (WPC), Y. lipolytica (Y. lipo) cells, tripolyphosphate (TPP), and sodium erythorbate (SE). The data show a reduction in the water activity value in all treatments. The highest encapsulation yield was found in treatments using MD + TPP + Y. lipo (84.0%) and WPC + TPP + Y. lipo (81.6%). Microencapsulated particles showed a survival rate ranging from 71.61 to 99.83% after 24 h. The treatments WPC + Y. lipo, WPC + SE + Y. lipo, WPC + TPP + Y. lipo, and MD + SE + Y. lipo remained stable for up to 105 days under storage conditions. The treatment WPC + SE + Y. lipo (microencapsulated yeast) was applied in the diet of ruminants due to the greater stability of cell survival. The comparison between the WPC + SE + Y. lipo treatment, wall materials, and the non-microencapsulated yeast showed that the microencapsulated yeast obtained a higher soluble fraction, degradability potential, and release of nutrients.
MeSH term(s)	Animals ; Yarrowia/metabolism ; Cell Survival ; Ruminants ; Diet
Language	English
Publishing date	2023-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-023-03534-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

2021 Volume 13, Issue 7

Abstract: Envenomation caused by contact ... ...

Abstract	Envenomation caused by contact with
MeSH term(s)	Animals ; Antigens, CD/metabolism ; Arthropod Venoms/toxicity ; B7-1 Antigen/metabolism ; Cell Survival/drug effects ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Immunoglobulins/metabolism ; Larva ; Lepidoptera ; Macrophages/drug effects ; Macrophages/metabolism ; Membrane Glycoproteins/metabolism ; NF-kappa B/metabolism ; THP-1 Cells ; CD83 Antigen
Chemical Substances	Antigens, CD ; Arthropod Venoms ; B7-1 Antigen ; Cytokines ; Immunoglobulins ; Membrane Glycoproteins ; NF-kappa B
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins13070462
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Article ; Online: Comparative Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by Destabilization of Medial Meniscus

Felipe Bruno Dias de Oliveira / Eliane Antonioli / Olívia Furiama Metropolo Dias / Jean Gabriel de Souza / Sudha Agarwal / Ana Marisa Chudzinski-Tavassi / Mario Ferretti

International Journal of Molecular Sciences, Vol 24, Iss 21, p

2023 Volume 15543

Abstract	Transplanted mesenchymal stromal cells (MSCs) exhibit a robust anti-inflammatory and homing capacity in response to high inflammatory signals, as observed in studies focused on rheumatic diseases that target articular cartilage (AC) health. However, AC degradation in osteoarthritis (OA) does not necessarily coincide with a highly inflammatory joint profile. Often, by the time patients seek medical attention, they already have damaged AC. In this study, we examined the therapeutic potential of a single bone marrow MSC transplant (2 × 10 6 cells/kg bw ) through two different routes: intra-articular (MSCs-IAt) and intravenous (MSCs-IVt) in a preclinical model of low-grade inflammatory OA with an established AC degeneration. OA was induced through the destabilization of the medial meniscus (DMM) in female Wistar Kyoto rats. The animals received MSCs 9 weeks after surgery and were euthanized 4 and 12 weeks post-transplant. In vivo and ex vivo tracking of MSCs were analyzed via bioluminescence and imaging flow cytometry, respectively. Cytokine/chemokine modulation in serum and synovial fluid was measured using a multiplex panel. AC degeneration was quantified through histology, and hindlimb muscle balance was assessed with precision weighing. To our knowledge, we are the first group to show the in vivo (8 h) and ex vivo (12 h) homing of cells to the DMM–OA joint following MSCs-IVt. In the case of MSCs-IAt, the detection of cellular bioluminescence at the knee joint persisted for up to 1 week. Intriguingly, intra-articular saline injection (placebo-IAt) resulted in a worse prognosis of OA when compared to a non-invasive control (placebo-IVt) without joint injection. The systemic cytokines/chemokines profile exhibited a time-dependent variation between transplant routes, displaying a transient anti-inflammatory systemic response for both MSCs-IVt and MSCs-IAt. A single injection of MSCs, whether administered via the intra-articular or intravenous route, performed 9 weeks after DMM surgery, did not effectively inhibit AC ...
Keywords	osteoarthritis ; mesenchymal stromal cell ; mesenchymal stem cell ; intra-articular ; intravenous ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Angiotensin II Receptor Blockers (ARBs Antihypertensive Agents) Increase Replication of SARS-CoV-2 in Vero E6 Cells.

Pires de Souza, Gabriel Augusto / Osman, Ikram Omar / Le Bideau, Marion / Baudoin, Jean-Pierre / Jaafar, Rita / Devaux, Christian / La Scola, Bernard

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 639177

Abstract: Several comorbidities, including hypertension, have been associated with an increased risk of developing severe disease during SARS-CoV-2 infection. Angiotensin II receptor blockers (ARBs) are currently some of the most widely-used drugs to control blood ...

Abstract	Several comorbidities, including hypertension, have been associated with an increased risk of developing severe disease during SARS-CoV-2 infection. Angiotensin II receptor blockers (ARBs) are currently some of the most widely-used drugs to control blood pressure by acting on the angiotensin II type 1 receptor (AT1R). ARBs have been reported to trigger the modulation of the angiotensin I converting enzyme 2 (ACE2), the receptor used by the virus to penetrate susceptible cells, raising concern that such treatments may promote virus capture and increase their viral load in patients receiving ARBs therapy. In this
MeSH term(s)	Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Antihypertensive Agents/pharmacology ; COVID-19 ; Humans ; Renin-Angiotensin System ; SARS-CoV-2
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents
Language	English
Publishing date	2021-06-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.639177
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Article ; Online: Control of

Osman, Ikram Omar / Garrec, Clémence / de Souza, Gabriel Augusto Pires / Zarubica, Ana / Belhaouari, Djamal Brahim / Baudoin, Jean-Pierre / Lepidi, Hubert / Mege, Jean-Louis / Malissen, Bernard / Scola, Bernard La / Devaux, Christian Albert

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 798767

Abstract: COVID-19 is the biggest pandemic the world has seen this century. Alongside the respiratory damage observed in patients with severe forms of the disease, gastrointestinal symptoms have been frequently reported. These symptoms (e.g., diarrhoea), sometimes ...

Abstract	COVID-19 is the biggest pandemic the world has seen this century. Alongside the respiratory damage observed in patients with severe forms of the disease, gastrointestinal symptoms have been frequently reported. These symptoms (e.g., diarrhoea), sometimes precede the development of respiratory tract illnesses, as if the digestive tract was a major target during early SARS-CoV-2 dissemination. We hypothesize that in patients carrying intestinal SARS-CoV-2, the virus may trigger epithelial barrier damage through the disruption of E-cadherin (E-cad) adherens junctions, thereby contributing to the overall gastrointestinal symptoms of COVID-19. Here, we use an intestinal Caco-2 cell line of human origin which expresses the viral receptor/co-receptor as well as the membrane anchored cell surface adhesion protein E-cad to investigate the expression of E-cad after exposure to SARS-CoV-2. We found that the expression of
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antigens, CD/genetics ; COVID-19 ; Caco-2 Cells ; Cadherins/genetics ; Gastrointestinal Diseases ; Gene Expression ; Humans ; Mice ; RNA, Messenger ; Receptors, Virus/genetics ; SARS-CoV-2/genetics
Chemical Substances	Antigens, CD ; CDH1 protein, human ; Cadherins ; RNA, Messenger ; Receptors, Virus ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-05-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.798767
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