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  1. Book ; Online: Bioinformatics of Genome Regulation and Systems Biology

    Orlov, Yuriy L. / Baranova, Ancha

    2020  

    Keywords Science: general issues ; Medical genetics ; genomics ; bioinformactics ; systems biology ; plant science ; gene expression ; special issue
    Size 1 electronic resource (258 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230913
    ISBN 9782889660148 ; 2889660141
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Response to Comment on Baranova et al. Causal Associations Between Basal Metabolic Rate and COVID-19. Diabetes 2023;72:149-154.

    Zhang, Fuquan / Baranova, Ancha

    Diabetes

    2023  Volume 72, Issue 8, Page(s) e8

    MeSH term(s) Humans ; Basal Metabolism ; COVID-19/complications ; Diabetes Mellitus, Type 2/etiology
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi23-0009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Smoking quantitatively increases risk for COVID-19.

    Zhang, Fuquan / Baranova, Ancha

    The European respiratory journal

    2022  Volume 60, Issue 6

    MeSH term(s) Humans ; COVID-19 ; Smoking/adverse effects ; Smoking/epidemiology ; Risk Factors
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01273-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exploring the influences of education, intelligence and income on mental disorders.

    Baranova, Ancha / Cao, Hongbao / Zhang, Fuquan

    General psychiatry

    2024  Volume 37, Issue 1, Page(s) e101080

    Abstract: Background: Previous studies have shown that educational attainment (EA), intelligence and income are key factors associated with mental disorders. However, the direct effects of each factor on major mental disorders are unclear.: Aims: We aimed to ... ...

    Abstract Background: Previous studies have shown that educational attainment (EA), intelligence and income are key factors associated with mental disorders. However, the direct effects of each factor on major mental disorders are unclear.
    Aims: We aimed to evaluate the overall and independent causal effects of the three psychosocial factors on common mental disorders.
    Methods: Using genome-wide association study summary datasets, we performed Mendelian randomisation (MR) and multivariable MR (MVMR) analyses to assess potential associations between the 3 factors (EA, N=766 345; household income, N=392 422; intelligence, N=146 808) and 13 common mental disorders, with sample sizes ranging from 9907 to 807 553. Inverse-variance weighting was employed as the main method in the MR analysis.
    Results: Our MR analysis showed that (1) higher EA was a protective factor for eight mental disorders but contributed to anorexia nervosa, obsessive-compulsive disorder (OCD), bipolar disorder (BD) and autism spectrum disorder (ASD); (2) higher intelligence was a protective factor for five mental disorders but a risk factor for OCD and ASD; (3) higher household income protected against 10 mental disorders but confers risk for anorexia nervosa. Our MVMR analysis showed that (1) higher EA was a direct protective factor for attention-deficit/hyperactivity disorder (ADHD) and insomnia but a direct risk factor for schizophrenia, BD and ASD; (2) higher intelligence was a direct protective factor for schizophrenia but a direct risk factor for major depressive disorder (MDD) and ASD; (3) higher income was a direct protective factor for seven mental disorders, including schizophrenia, BD, MDD, ASD, post-traumatic stress disorder, ADHD and anxiety disorder.
    Conclusions: Our study reveals that education, intelligence and income intertwine with each other. For each factor, its independent effects on mental disorders present a more complex picture than its overall effects.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2941976-1
    ISSN 2517-729X ; 2517-729X ; 2096-5923
    ISSN (online) 2517-729X
    ISSN 2517-729X ; 2096-5923
    DOI 10.1136/gpsych-2023-101080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bidirectional associations between mental disorders, antidepressants and cardiovascular disease.

    Cao, Hongbao / Baranova, Ancha / Zhao, Qian / Zhang, Fuquan

    BMJ mental health

    2024  Volume 27, Issue 1

    Abstract: Background: Mental disorders have a high comorbidity with cardiovascular disease (CVD), but the causality between them has not been fully appreciated.: Objective: This study aimed to systematically explore the bidirectional causality between the two ... ...

    Abstract Background: Mental disorders have a high comorbidity with cardiovascular disease (CVD), but the causality between them has not been fully appreciated.
    Objective: This study aimed to systematically explore the bidirectional causality between the two broad categories of diseases.
    Methods: We conducted Mendelian randomisation (MR) and multivariable MR (MVMR) analyses to evaluate potential causal links between 10 mental disorders, the use of antidepressants and 7 CVDs.
    Findings: We discovered that major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD) and insomnia exhibit connections with elevated risks of two or more CVDs. Moreover, the use of antidepressants is linked to heightened risks of each CVD. Each distinct CVD is correlated with a greater probability of taking antidepressants. Our MVMR analysis demonstrated that the use of antidepressants is correlated with the elevation of respective risks across all cardiovascular conditions. This includes arrhythmias (OR: 1.28), atrial fibrillation (OR: 1.44), coronary artery disease (OR: 1.16), hypertension (OR: 1.16), heart failure (OR: 1.16), stroke (OR: 1.44) and entire CVD group (OR: 1.35). However, MDD itself was not linked to a heightened risk of any CVD.
    Conclusions: The findings of our study indicate that MDD, insomnia and ADHD may increase the risk of CVD. Our findings highlight the utilisation of antidepressants as an independent risk factor for CVD, thus explaining the influence of MDD on CVD through the mediating effects of antidepressants.
    Clinical implications: When treating patients with antidepressants, it is necessary to take into consideration the potential beneficial and detrimental effects of antidepressants.
    MeSH term(s) Humans ; Depressive Disorder, Major/drug therapy ; Sleep Initiation and Maintenance Disorders/complications ; Cardiovascular Diseases/epidemiology ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Antidepressive Agents/adverse effects
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2755-9734
    ISSN (online) 2755-9734
    DOI 10.1136/bmjment-2023-300975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Causal influences of neuropsychiatric disorders on Alzheimer's disease.

    Baranova, Ancha / Zhao, Qian / Cao, Hongbao / Chandhoke, Vikas / Zhang, Fuquan

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 114

    Abstract: Previous studies have observed a significant comorbidity between Alzheimer's disease (AD) and some other neuropsychiatric disorders. However, the mechanistic connections between neuropsychiatric disorders and AD are not well understood. We conducted a ... ...

    Abstract Previous studies have observed a significant comorbidity between Alzheimer's disease (AD) and some other neuropsychiatric disorders. However, the mechanistic connections between neuropsychiatric disorders and AD are not well understood. We conducted a Mendelian randomization analysis to appraise the potential influences of 18 neurodegenerative and neuropsychiatric disorders on AD. We found that four disorders are causally associated with increased risk for AD, including bipolar disorder (BD) (OR: 1.09), migraine (OR: 1.09), schizophrenia (OR: 1.05), and Parkinson's disease (PD) (OR: 1.07), while attention-deficit/hyperactivity disorder (ADHD) was associated with a decreased risk for AD (OR: 0.80). In case of amyotrophic lateral sclerosis (OR: 1.04) and Tourette's syndrome (OR: 1.05), there was suggestive evidence of their causal effects of on AD. Our study shows that genetic components predisposing to BD, migraine, schizophrenia, and PD may promote the development of AD, while ADHD may be associated with a reduced risk of AD. The treatments aimed at alleviating neuropsychiatric diseases with earlier onset may also influence the risk of AD-related cognitive decline, which is typically observed later in life.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Schizophrenia/epidemiology ; Schizophrenia/genetics ; Parkinson Disease/genetics ; Attention Deficit Disorder with Hyperactivity/genetics ; Migraine Disorders/genetics ; Genome-Wide Association Study
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02822-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluating the effects of circulating inflammatory proteins as drivers and therapeutic targets for severe COVID-19.

    Baranova, Ancha / Luo, Jing / Fu, Li / Yao, Guanqun / Zhang, Fuquan

    Frontiers in immunology

    2024  Volume 15, Page(s) 1352583

    Abstract: Objective: The relationships between circulating inflammatory proteins and COVID-19 have been observed in previous cohorts. However, it is not unclear which circulating inflammatory proteins may boost the risk of or protect against COVID-19.: Methods!# ...

    Abstract Objective: The relationships between circulating inflammatory proteins and COVID-19 have been observed in previous cohorts. However, it is not unclear which circulating inflammatory proteins may boost the risk of or protect against COVID-19.
    Methods: We performed Mendelian randomization (MR) analysis using GWAS summary result of 91 circulating inflammation-related proteins (N = 14,824) to assess their causal impact on severe COVID-19. The COVID-19 phenotypes encompassed both hospitalized (N = 2,095,324) and critical COVID-19 (N = 1,086,211). Moreover, sensitivity analyses were conducted to evaluate the robustness and reliability.
    Results: We found that seven circulating inflammatory proteins confer positive causal effects on severe COVID-19. Among them, serum levels of IL-10RB, FGF-19, and CCL-2 positively contributed to both hospitalized and critical COVID-19 conditions (OR: 1.10~1.16), while the other 4 proteins conferred risk on critical COVID-19 only (OR: 1.07~1.16), including EIF4EBP1, IL-7, NTF3, and LIF. Meanwhile, five proteins exert protective effects against hospitalization and progression to critical COVID-19 (OR: 0.85~0.95), including CXCL11, CDCP1, CCL4/MIP, IFNG, and LIFR. Sensitivity analyses did not support the presence of heterogeneity in the majority of MR analyses.
    Conclusions: Our study revealed risk and protective inflammatory proteins for severe COVID-19, which may have vital implications for the treatment of the disease.
    MeSH term(s) Humans ; Reproducibility of Results ; COVID-19 ; Hospitalization ; Inflammation ; Mendelian Randomization Analysis ; Antigens, Neoplasm ; Cell Adhesion Molecules
    Chemical Substances CDCP1 protein, human ; Antigens, Neoplasm ; Cell Adhesion Molecules
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1352583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Causal Associations between Posttraumatic Stress Disorder and COVID-19.

    Baranova, Ancha / Fu, Li / Song, Yuqing / Cao, Hongbao / Zhang, Fuquan

    Journal of integrative neuroscience

    2024  Volume 23, Issue 4, Page(s) 68

    Abstract: Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19.: Methods: We investigated potential causal associations between PTSD and two COVID-19 conditions (COVID-19 hospitalization ... ...

    Abstract Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19.
    Methods: We investigated potential causal associations between PTSD and two COVID-19 conditions (COVID-19 hospitalization and SARS-CoV-2 infection) via Mendelian randomization (MR) analyses. Three genome-wide association study (GWAS) summary datasets were used in the study, including PTSD (N = 174,659), SARS-CoV-2 infection (N = 2,597,856), and COVID-19 hospitalization (N = 2,095,324). We performed a literature-based analysis to uncover molecular pathways connecting PTSD and COVID-19.
    Results: We found that PTSD exerts a causal effect on SARS-CoV-2 infection (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.00-1.21,
    Conclusions: Our study suggests that PTSD was associated with increased risks for COVID-19 susceptibility and severity. Early diagnosis and effective treatment of PTSD in individuals infected with the coronavirus may improve the management of the outcomes of COVID-19.
    MeSH term(s) Stress Disorders, Post-Traumatic/genetics ; Humans ; COVID-19/complications ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Hospitalization ; Causality
    Language English
    Publishing date 2024-04-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2304068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Associations between pulse rate and COVID-19.

    Baranova, Ancha / Xu, Yong / Cao, Hongbao / Zhang, Fuquan

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28194

    MeSH term(s) Humans ; COVID-19 ; Heart Rate ; SARS-CoV-2
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study.

    Fu, Li / Baranova, Ancha / Cao, Hongbao / Zhang, Fuquan

    Frontiers in medicine

    2023  Volume 10, Page(s) 1287043

    Abstract: Objective: Although observational and genetic studies have indicated a correlation between OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed to investigate the potential causal ... ...

    Abstract Objective: Although observational and genetic studies have indicated a correlation between OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed to investigate the potential causal links between the two.
    Methods: In this study, we conducted Mendelian randomization (MR) analysis to investigate whether there is a potential causal connection between OA and COVID-19 outcomes. The analysis utilized publicly available GWAS summary datasets, incorporating data on OA (
    Results: The MR analysis showed causal effects of OA on hospitalized COVID-19 (OR: 1.21, 95% CI: 1.02-1.43,
    Conclusion: Our findings indicate that OA elevates the risk of severe COVID-19. Therefore, larger efforts should be made in the prevention of COVID-19 in OA patients.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1287043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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