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  1. Book ; Online: Digital Peripheries

    Szczepanik, Petr / Zahrádka, Pavel / Macek, Jakub / Stepan, Paul

    The Online Circulation of Audiovisual Content from the Small Market Perspective

    (Springer Series in Media Industries)

    2020  

    Author's details edited by Petr Szczepanik, Pavel Zahrádka, Jakub Macek, Paul Stepan
    Series title Springer Series in Media Industries
    Keywords Industrial management ; Mass media ; Communication ; European Union ; Law ; Motion pictures—European influences
    Subject code 658
    Language English
    Size 1 Online-Ressource (XI, 302 p. 16 illus., 13 illus. in color)
    Edition 1st ed. 2020
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT020468683
    ISBN 978-3-030-44850-9 ; 9783030448493 ; 9783030448516 ; 9783030448523 ; 3-030-44850-9 ; 3030448495 ; 3030448517 ; 3030448525
    DOI 10.1007/978-3-030-44850-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Digital Peripheries

    Szczepanik, Petr / Zahrádka, Pavel / Macek, Jakub / Stepan, Paul

    2020  

    Abstract: This is an open access book. Media industry research and EU policymaking are predominantly tailored to large (and, in the latter case, Western) European markets. This open access book addresses the specific qualities of smaller media markets, ... ...

    Abstract This is an open access book. Media industry research and EU policymaking are predominantly tailored to large (and, in the latter case, Western) European markets. This open access book addresses the specific qualities of smaller media markets, highlighting their vulnerability to global digital competition and outlining survival strategies for them. New online distribution models and new trends in the consumption of audiovisual content are limited by, and pose new challenges for, existing audiovisual business models and their legal framework in the EU. The European Commission's Digital Single Market (DSM) strategy, which was intended e.g. to remove obstacles to the cross-border distribution of audiovisual content, has triggered a heated debate on the transformation of the existing ecosystem for European screen industries. While most current discussions focus on the United States, Western Europe, and the multinational giants, this book approaches these industry trends and policy questions from the perspective of relatively small and peripheral (in terms of their population, language, cross-border cultural flows, and financial and/or symbolic capital) media markets
    Keywords Communication. Mass media ; Sociology (General) ; Political institutions and public administration (General) ; Law in general. Comparative and uniform law. Jurisprudence
    Size 1 electronic resource (302 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020589705
    ISBN 9783030448509 ; 3030448509
    DOI 10.1007/978-3-030-44850-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: A revision of the millipede family Paracortinidae (Diplopoda, Callipodida).

    Akkari, Nesrine / Macek, Oliver / Stoev, Pavel

    ZooKeys

    2023  Volume 1187, Page(s) 341–399

    Abstract: The taxonomy of the family Paracortinidae Wang & Zhang, 1993 is revised based on literature, old and recently collected material. A new ... ...

    Abstract The taxonomy of the family Paracortinidae Wang & Zhang, 1993 is revised based on literature, old and recently collected material. A new genus
    Language English
    Publishing date 2023-12-28
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.1187.113473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The asymmetric Henry reaction as synthetic tool for the preparation of the drugs linezolid and rivaroxaban.

    Vrbický, Martin / Macek, Karel / Pochobradský, Jaroslav / Svoboda, Jan / Sedlák, Miloš / Drabina, Pavel

    Beilstein journal of organic chemistry

    2022  Volume 18, Page(s) 438–445

    Abstract: The human drugs - the antibiotic linezolid ( ...

    Abstract The human drugs - the antibiotic linezolid (
    Language English
    Publishing date 2022-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.18.46
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Precision medicine in cystic fibrosis: predictive role of forskolin-induced swelling assay.

    Furstova, Eva / Drevinek, Pavel / Novotna, Stepanka / Libik, Malgorzata / Benesova, Klara / Borek-Dohalska, Lucie / Sakmarova, Kristina / Modrak, Martin / Macek, Milan / Dousova, Tereza

    The European respiratory journal

    2024  Volume 63, Issue 4

    MeSH term(s) Humans ; Cystic Fibrosis ; Colforsin/pharmacology ; Precision Medicine ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Intestinal Mucosa ; Mutation
    Chemical Substances Colforsin (1F7A44V6OU) ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00156-2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  6. Book ; Online: Deuteration of proteins boosted by cell lysates

    Napoli, Federico / Guan, Jia-Ying / Arnaud, Charles-Adrien / Macek, Pavel / Fraga, Hugo / Breyton, Cécile / Schanda, Paul

    eISSN: 2699-0016

    high-resolution amide and Hα MAS NMR without re-protonation bottleneck

    2024  

    Abstract: Amide-proton detected magic-angle spinning NMR of deuterated proteins has become a main technique in NMR-based structural biology. In standard deuteration protocols that rely on D 2 O-based culture media, non-exchangeable amide sites remain deuterated, ... ...

    Abstract Amide-proton detected magic-angle spinning NMR of deuterated proteins has become a main technique in NMR-based structural biology. In standard deuteration protocols that rely on D 2 O-based culture media, non-exchangeable amide sites remain deuterated, making these sites unobservable. Here we demonstrate that proteins produced with H 2 O-based culture medium doped with deuterated cell lysate allow to overcome this "reprotonation bottleneck", while retaining a high level of deuteration (ca. 80 %) and narrow line widths. We quantified coherence life times of several proteins prepared with this labelling pattern over a range of MAS frequencies (40–100 kHz). We demonstrate that under commonly used conditions (50–60 kHz MAS), amide 1 H line widths with our labelling approach are comparable to those of perdeuterated proteins and better than those of protonated samples at 100 kHz. For three proteins in the 33–50 kDa size range many previously unobserved amides become visible. We report how to prepare the deuterated cell lysate for our approach from fractions of perdeuterated cultures which are usually discarded, and show that such media can be used identically to commercial media. The residual protonation of Hα sites allows for well-resolved Hα-detected spectra and Hα resonance assignment, exemplified by the de novo assignment of 168 Hα sites in a 39 kDa protein. The approach based on this H 2 O/cell-lysate deuteration and MAS frequencies compatible with 1.3 or 1.9 mm rotors presents a strong sensitivity benefit over 0.7 mm/100 kHz MAS experiments.
    Subject code 333
    Language English
    Publishing date 2024-01-17
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: The asymmetric Henry reaction as synthetic tool for the preparation of the drugs linezolid and rivaroxaban

    Martin Vrbický / Karel Macek / Jaroslav Pochobradský / Jan Svoboda / Miloš Sedlák / Pavel Drabina

    Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 438-

    2022  Volume 445

    Abstract: The human drugs – the antibiotic linezolid (1) and the anticoagulant rivaroxaban (2) – belong among modern pharmaceutics, which contain an oxazolidine-2-one moiety bearing a stereogenic center. The chirality of these drugs is a fundamental attribute for ... ...

    Abstract The human drugs – the antibiotic linezolid (1) and the anticoagulant rivaroxaban (2) – belong among modern pharmaceutics, which contain an oxazolidine-2-one moiety bearing a stereogenic center. The chirality of these drugs is a fundamental attribute for their biological activity. Herein, one of the efficient asymmetric syntheses of these drugs was studied in detail. Highly enantioselective catalysts were tested in the key step of the synthetic procedure, i.e., the asymmetric Henry reaction, under different reaction conditions, using several starting aldehydes. The corresponding nitroaldols as chiral intermediates in the syntheses of these drugs were obtained in high yields and enantiomeric excesses of up to 91% ee.
    Keywords asymmetric henry reaction ; enantioselective catalysis ; linezolid ; oxazolidine-2-one derivatives ; rivaroxaban ; Science ; Q ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Beilstein-Institut
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Contrasting biomass allocations explain adaptations to cold and drought in the world's highest-growing angiosperms.

    Dolezal, Jiri / Chondol, Thinles / Chlumska, Zuzana / Altman, Jan / Capkova, Katerina / Dvorsky, Miroslav / Fibich, Pavel / Korznikov, Kirill A / Ruka, Adam T / Kopecky, Martin / Macek, Martin / Rehakova, Klara

    Annals of botany

    2024  

    Abstract: Background and aims: Understanding biomass allocation among plant organs is crucial for comprehending plant growth optimization, survival and responses to global change drivers. Yet, mechanisms governing mass allocation in vascular plants from extreme ... ...

    Abstract Background and aims: Understanding biomass allocation among plant organs is crucial for comprehending plant growth optimization, survival and responses to global change drivers. Yet, mechanisms governing mass allocation in vascular plants from extreme elevations exposed to cold and drought stresses remain poorly understood.
    Methodology: We analyzed organ mass weights and fractions in 258 Himalayan herbaceous species across diverse habitats (wetland, steppe, alpine), growth forms (annual, perennial taprooted, rhizomatous, cushiony), and climatic gradients (3500-6150 m elevation) to explore whether biomass distribution adhered to fixed allometric or optimal partitioning rules, and how variation in size, phylogeny, and ecological preferences influence their strategies for resource allocation.
    Key findings: Following the optimal partitioning theory, Himalayan plants distribute more biomass to key organs vital for acquiring and preserving limited resources necessary for their growth and survival. Allocation strategies are mainly influenced by plant growth forms and habitat conditions, notably temperature, water availability, and evaporative demands. Alpine plants primarily invest in belowground stem bases for storage and regeneration, reducing aboveground stems while increasing leaf mass fraction to maximize carbon assimilation in their short growing season. Conversely, arid steppe plants prioritize deep roots over leaves to secure water and minimize transpiration. Wetland plants allocate resources to aboveground stems and belowground rhizomes, enabling them to resist competition and grazing in fertile environments.
    Conclusions: Himalayan plants from extreme elevations optimize their allocation strategies to acquire scarce resources under specific conditions, efficiently investing carbon from supportive to acquisitive and protective functions with increasing cold and drought. Intraspecific variation and shared ancestry did not significantly alter Himalayan plants' biomass allocation strategies. Despite diverse evolutionary histories, plants from similar habitats have developed comparable phenotypic structures to adapt to their specific environments. This study offers new insights into plant adaptations in diverse Himalayan environments and underscores the importance of efficient resource allocation for survival and growth in challenging conditions.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcae028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Backbone and methyl resonances assignment of the 87 kDa prefoldin from Pyrococcus horikoshii.

    Törner, Ricarda / Henot, Faustine / Awad, Rida / Macek, Pavel / Gans, Pierre / Boisbouvier, Jerome

    Biomolecular NMR assignments

    2021  Volume 15, Issue 2, Page(s) 351–360

    Abstract: Prefoldin is a heterohexameric protein assembly which acts as a co-chaperonin for the well conserved Hsp60 chaperonin, present in archaebacteria and the eukaryotic cell cytosol. Prefoldin is a holdase, capturing client proteins and subsequently ... ...

    Abstract Prefoldin is a heterohexameric protein assembly which acts as a co-chaperonin for the well conserved Hsp60 chaperonin, present in archaebacteria and the eukaryotic cell cytosol. Prefoldin is a holdase, capturing client proteins and subsequently transferring them to the Hsp60 chamber for refolding. The chaperonin family is implicated in the early stages of protein folding and plays an important role in proteostasis in the cytosol. Here, we report the assignment of
    MeSH term(s) Pyrococcus horikoshii
    Language English
    Publishing date 2021-05-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388861-1
    ISSN 1874-270X ; 1874-2718
    ISSN (online) 1874-270X
    ISSN 1874-2718
    DOI 10.1007/s12104-021-10029-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Publisher Correction: Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR.

    Gauto, Diego F / Macek, Pavel / Malinverni, Duccio / Fraga, Hugo / Paloni, Matteo / Sučec, Iva / Hessel, Audrey / Bustamante, Juan Pablo / Barducci, Alessandro / Schanda, Paul

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3593

    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31243-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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