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  1. Book ; Online ; E-Book: Breast cancer, from bench to personalized medicine

    Malik, Saima Shakil / Masood, Nosheen

    2022  

    Author's details edited by Saima Shakil Malik and Nosheen Masood
    Keywords Breast/Cancer/Treatment ; Breast/Cancer ; Càncer de mama ; Terapèutica
    Subject code 616.9449
    Language English
    Size 1 online resource (534 pages)
    Publisher Springer
    Publishing place Gateway East, Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-0197-X ; 9789811901966 ; 978-981-19-0197-3 ; 9811901961
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

    Masood, Nosheen / Shakil Malik, Saima

    2020  

    Abstract: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical ... ...

    Author's details edited by Nosheen Masood, Saima Shakil Malik
    Abstract This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
    Keywords Cancer research ; Oncology   ; Human genetics ; Bioinformatics ; Nanotechnology ; Genètica humana ; Càncer ; Oncologia ; Bioinformàtica ; Nanotecnologia ; Cancer Research ; Oncology ; Human Genetics ; Nanotechnology and Microengineering
    Subject code 616.994042
    Language English
    Size 1 online resource (XVIII, 499 p. 59 illus., 50 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-1067-9 ; 981-15-1066-0 ; 978-981-15-1067-0 ; 978-981-15-1066-3
    DOI 10.1007/978-981-15-1067-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Editorial: An era of personalized medicine in breast cancer: integrating artificial intelligence into practice.

    Masood, Nosheen / Wu, San-Gang

    Frontiers in oncology

    2023  Volume 13, Page(s) 1164808

    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1164808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial

    Nosheen Masood / San-Gang Wu

    Frontiers in Oncology, Vol

    An era of personalized medicine in breast cancer: integrating artificial intelligence into practice

    2023  Volume 13

    Keywords artificial intelligence ; personalized medicine ; clinical tumor prediction ; precision medicine ; breast cancer ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Correlation of ERCC5 polymorphisms and linkage disequilibrium associated with overall survival and clinical outcome to chemotherapy in breast cancer.

    Khan, Iqra / Masood, Nosheen / Yasmin, Azra

    Frontiers in oncology

    2023  Volume 12, Page(s) 1091514

    Abstract: Purpose: ERCC5 is a DNA endonuclease and nucleotide excision repair gene; its mutations lead to a lack of activity by this enzyme, causing oxidative DNA damage. This study aimed to assess the role of four selected single nucleotide polymorphisms (SNPs) ... ...

    Abstract Purpose: ERCC5 is a DNA endonuclease and nucleotide excision repair gene; its mutations lead to a lack of activity by this enzyme, causing oxidative DNA damage. This study aimed to assess the role of four selected single nucleotide polymorphisms (SNPs) in ERCC5 and their linkage disequilibrium associated with survival analysis and clinical outcomes in breast cancer.
    Patients and methods: Four SNPs (rs751402, rs17655, rs2094258, and rs873601) of the ERCC5 gene were analyzed using the PCR-RFLP technique, followed by sequencing in 430 breast cancer (BC) cases and 430 cancer-free individuals. Statistical analysis was performed using MedCalc 17 and SPSS version 24, while bioinformatic analysis of linkage disequilibrium was performed using Haploview software 4.2.
    Results: Multivariate analysis showed that the rs751402 and rs2094258 polymorphisms were significantly associated with an elevated risk of BC (P < 0.001), while the other two SNPs, rs17655 and rs873601, did not show any association (P > 0.001). Survival analysis revealed that rs751402 and rs2094258 had longer overall survival periods (P <0.001) than rs17655 and rs873601. Moreover, rs751402 and rs2094258 also had significantly longer overall survival (log-rank test, P < 0.005) for all three survival functions (positive family history, ER+PR status, and use of contraceptives), while rs17655 and rs873601 did not show any significant association. Only rs873601 showed a strong negative correlation with all the chemotherapeutic groups.
    Conclusion: The current results suggest that variations in ERCC5 may contribute to BC development and that their genetic anomalies may be associated with cancer risk and may be used as a biomarker of clinical outcome.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1091514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A meta-analysis and experimental data for multidrug resistance genes in breast cancer.

    Zaib, Shumaila / Tahir, Sammia / Masood, Nosheen / Hameed, Abdul / Azra, Yasmin

    African health sciences

    2022  Volume 22, Issue 4, Page(s) 1–9

    Abstract: Background: Increasing trend of breast cancer incidence worldwide is a known fact. This curable disease may become fatal if drug resistance is developed leading to metastatic cancerous tissue.: Objective: This is a two parts study; a meta-analysis ... ...

    Abstract Background: Increasing trend of breast cancer incidence worldwide is a known fact. This curable disease may become fatal if drug resistance is developed leading to metastatic cancerous tissue.
    Objective: This is a two parts study; a meta-analysis exploring association of drug resistance (mdr1 and ABCG2) genes with breast cancer and mutational association with molecular subtypes of cancer. Methods: PCR-SSCP for genomic polymorphisms and RT-PCR for expression analysis were performed.
    Results: C3435T polymorphism of mdr1 gene was most commonly studied mutation with contradictory results. Association of ABCG2 gene mutations with untreated breast cancer was reported only by one study so far. Regarding current genomic analysis of mdr1 gene, three novel mutations were found in exon 12 and 2 mutations were found in exon 26. In ABCG2 gene, addition of C and T were found in intron 8 at the intron-exon junction. A positive correlation was observed between these mutations and tumor grade. Levels of mRNA expression revealed that they were over expressed in cancerous tissues compared with controls.
    Conclusion: These findings suggest that these genes are associated with breast cancer.
    MeSH term(s) Humans ; Female ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/therapeutic use ; Genes, MDR ; Genotype ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1
    Language English
    Publishing date 2022-04-18
    Publishing country Uganda
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v22i4.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Clinical manifestations and outcome of patients with primary amoebic meningoencephalitis in Pakistan. A single-center experience

    Shakeel Ur Rehman / Salman Farooq / Muhammad Bilal Tariq / Nosheen Nasir / Mohammad Wasay / Sobia Masood / Musa Karim

    PLoS ONE, Vol 18, Iss

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Imaging spectrum of acquired uterine vascular abnormalities with angiographic correlates, a pictorial review

    Laiba Masood / Atif I. Rana / Zahid A. Khan / Saman Nosheen / Haider Ali / Jamshed Anwar

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: Abstract Background Acquired uterine arterial anomalies, including uterine artery pseudoaneurysms (UAP), arteriovenous malformations (AVMs) and arteriovenous fistulae (AFVs), are rare presenting causes of abnormal uterine bleeding. Timely diagnosis is ... ...

    Abstract Abstract Background Acquired uterine arterial anomalies, including uterine artery pseudoaneurysms (UAP), arteriovenous malformations (AVMs) and arteriovenous fistulae (AFVs), are rare presenting causes of abnormal uterine bleeding. Timely diagnosis is essential for safe and effective treatment, avoiding life-threatening haemorrhage resulting from erroneous uterine curettage due to misdiagnosing these as other more common differentials. Main text This pictorial review discusses the ultrasound (USG), CT and MRI features of various acquired uterine vascular abnormalities with angiographic correlates. Conclusion Acquired uterine arteriovenous injuries are a fundamental cause of dysfunctional intractable bleeding recalcitrant to traditional conservative management. Endovascular transcatheter uterine artery embolisation is an increasingly popular and safe mode of treatment, especially in young patients desiring to have the option of future pregnancies, with lesser morbidity and in-hospital stay duration.
    Keywords Arteriovenous malformation ; Ultrasound ; Magnetic resonance imaging ; Computed tomography angiography ; Uterine artery embolisation ; Uterus ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Clinical manifestations and outcome of patients with primary amoebic meningoencephalitis in Pakistan. A single-center experience.

    Rehman, Shakeel Ur / Farooq, Salman / Tariq, Muhammad Bilal / Nasir, Nosheen / Wasay, Mohammad / Masood, Sobia / Karim, Musa

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0290394

    Abstract: Primary amoebic meningoencephalitis (PAM) is a rapidly progressing central nervous system (CNS) infection caused by Naegleria fowleri, a free-living amoeba found in warm freshwater. The disease progression is very rapid, and the outcome is nearly always ... ...

    Abstract Primary amoebic meningoencephalitis (PAM) is a rapidly progressing central nervous system (CNS) infection caused by Naegleria fowleri, a free-living amoeba found in warm freshwater. The disease progression is very rapid, and the outcome is nearly always fatal. We aim to describe the disease course in patients admitted with PAM in a tertiary care center in Karachi, Pakistan between the periods of 2010 to 2021. A total of 39 patients were included in the study, 33 males (84.6%). The median age of the patients was 34 years. The most frequent presenting complaint was fever, which was found in 37 patients (94.9%) followed by headache in 28 patients (71.8%), nausea and vomiting in 27 patients (69.2%), and seizures in 10 patients (25.6%). Overall, 39 patients underwent lumbar puncture, 27 patients (69.2%) had a positive motile trophozoites on CSF wet preparation microscopy, 18 patients (46.2%) had a positive culture, and 10 patients had a positive PCR. CSF analysis resembled bacterial meningitis with elevated white blood cell counts with predominantly neutrophils (median, 3000 [range, 1350-7500] cells/μL), low glucose levels median, 14 [range, 1-92] mg/dL), and elevated protein levels (median, 344 [range, 289-405] mg/dL). Imaging results were abnormal in approximately three-fourths of the patients which included cerebral edema (66.7%), hydrocephalus (25.6%), and cerebral infarctions (12.8%). Only one patient survived. PAM is a fatal illness with limited treatment success. Early diagnosis and prompt initiation of treatment can improve the survival of the patients and reduce mortality.
    MeSH term(s) Male ; Humans ; Adult ; Pakistan/epidemiology ; Central Nervous System Protozoal Infections/diagnosis ; Central Nervous System Protozoal Infections/epidemiology ; Central Nervous System Protozoal Infections/drug therapy ; Naegleria fowleri ; Spinal Puncture ; Amebiasis/diagnosis ; Amebiasis/epidemiology ; Meningoencephalitis/diagnosis ; Meningoencephalitis/epidemiology
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical manifestations and outcome of patients with primary amoebic meningoencephalitis in Pakistan. A single-center experience.

    Shakeel Ur Rehman / Salman Farooq / Muhammad Bilal Tariq / Nosheen Nasir / Mohammad Wasay / Sobia Masood / Musa Karim

    PLoS ONE, Vol 18, Iss 11, p e

    2023  Volume 0290394

    Abstract: Primary amoebic meningoencephalitis (PAM) is a rapidly progressing central nervous system (CNS) infection caused by Naegleria fowleri, a free-living amoeba found in warm freshwater. The disease progression is very rapid, and the outcome is nearly always ... ...

    Abstract Primary amoebic meningoencephalitis (PAM) is a rapidly progressing central nervous system (CNS) infection caused by Naegleria fowleri, a free-living amoeba found in warm freshwater. The disease progression is very rapid, and the outcome is nearly always fatal. We aim to describe the disease course in patients admitted with PAM in a tertiary care center in Karachi, Pakistan between the periods of 2010 to 2021. A total of 39 patients were included in the study, 33 males (84.6%). The median age of the patients was 34 years. The most frequent presenting complaint was fever, which was found in 37 patients (94.9%) followed by headache in 28 patients (71.8%), nausea and vomiting in 27 patients (69.2%), and seizures in 10 patients (25.6%). Overall, 39 patients underwent lumbar puncture, 27 patients (69.2%) had a positive motile trophozoites on CSF wet preparation microscopy, 18 patients (46.2%) had a positive culture, and 10 patients had a positive PCR. CSF analysis resembled bacterial meningitis with elevated white blood cell counts with predominantly neutrophils (median, 3000 [range, 1350-7500] cells/μL), low glucose levels median, 14 [range, 1-92] mg/dL), and elevated protein levels (median, 344 [range, 289-405] mg/dL). Imaging results were abnormal in approximately three-fourths of the patients which included cerebral edema (66.7%), hydrocephalus (25.6%), and cerebral infarctions (12.8%). Only one patient survived. PAM is a fatal illness with limited treatment success. Early diagnosis and prompt initiation of treatment can improve the survival of the patients and reduce mortality.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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