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Article ; Online: Mental Health Treatment Should Be an Integrative Part of Caring for Cancer Patients, Caregivers and Families in Japan.

Igarashi, Takashi

2021 Volume 1, Issue 1, Page(s) 75–76

Language	English
Publishing date	2021-03-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2018-0008
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Article ; Online: Integrating mitochondrial and nuclear genomic data to decipher the evolutionary history of Eubranchipus species in Japan.

Kitano, Takashi / Tabata, Mitsutoshi / Takahashi, Norihito / Hirasawa, Kei / Igarashi, Seiki / Hatanaka, Yushi / Ooyagi, Akira / Igarashi, Keiji / Umetsu, Kazuo

Molecular phylogenetics and evolution

2024 Volume 194, Page(s) 108041

Abstract: Understanding the genetic diversity and evolutionary history of species is crucial for their conservation and management. In this study, we investigated the genetic diversity and phylogenetic relationships among Eubranchipus species occurring in Japan. ... ...

Abstract	Understanding the genetic diversity and evolutionary history of species is crucial for their conservation and management. In this study, we investigated the genetic diversity and phylogenetic relationships among Eubranchipus species occurring in Japan. Phylogenetic analyses revealed that nuclear and mitochondrial data yield incompatible results. In E. uchidai, nuclear data support the monophyly of the Shimokita area, while mitochondrial data indicate a clustering of Higashidori2 individuals with Hokkaido (Ishikari and Wakkanai) E. uchidai. Similar incongruences were observed in E. hatanakai, where nuclear data favor the monophyly of the Chokai area, while mitochondrial data cluster some Chokai pool 3 individuals with Aizu individuals. These incompatibilities might be caused by mitochondrial gene flow. The findings emphasize the importance of considering both nuclear and mitochondrial data during phylogenetic studies and provide valuable insights into the complex dynamics of migration and genetic exchange in Eubranchipus species.
MeSH term(s)	Humans ; Phylogeny ; Japan ; DNA, Mitochondrial/genetics ; Sequence Analysis, DNA ; Genomics
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	33610-5
ISSN	1095-9513 ; 1055-7903
ISSN (online)	1095-9513
ISSN	1055-7903
DOI	10.1016/j.ympev.2024.108041
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Zs.A 3644: Show issues

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Article ; Online: Performance of a large language model on Japanese emergency medicine board certification examinations.

Igarashi, Yutaka / Nakahara, Kyoichi / Norii, Tatsuya / Miyake, Nodoka / Tagami, Takashi / Yokobori, Shoji

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2024

Abstract: Background Emergency physicians need a broad range of knowledge and skills to address critical medical, traumatic, and environmental conditions. Artificial intelligence (AI), including large language models (LLMs), has potential applications in ... ...

Abstract	Background Emergency physicians need a broad range of knowledge and skills to address critical medical, traumatic, and environmental conditions. Artificial intelligence (AI), including large language models (LLMs), has potential applications in healthcare settings; however, the performance of LLMs in emergency medicine remains unclear.Methods To evaluate the reliability of information provided by ChatGPT, an LLM was given the questions set by the Japanese Association of Acute Medicine in its board certification examinations over a period of 5 years (2018-2022) and programmed to answer them twice. Statistical analysis was used to assess agreement of the two responses.Results The LLM successfully answered 465 of the 475 text-based questions, achieving an overall correct response rate of 62.3%. For questions without images, the rate of correct answers was 65.9%. For questions with images that were not explained to the LLM, the rate of correct answers was only 52.0%. The annual rates of correct answers to questions without images ranged from 56.3% to 78.8%. Accuracy was better for scenario-based questions (69.1%) than for stand-alone questions (62.1%). Agreement between the two responses was substantial (kappa = 0.70). Factual error accounted for 82% of the incorrectly answered questions.Conclusion An LLM performed satisfactorily on an emergency medicine board certification examination in Japanese and without images. However, factual errors in the responses highlight the need for physician oversight when using LLMs.
Language	English
Publishing date	2024-03-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.JNMS.2024_91-205
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Article ; Online: Skeletal Transformation Triggered by C-F Bond Activation after Photochemical Rearrangement of Fluorinated [7]Helicenes.

Matsuda, Chikako / Igarashi, Ryo / Katagiri, Hiroshi / Murase, Takashi

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 19, Page(s) e202200132

Abstract: Tri- and tetra-fluorinated [7]helicenes are photolabile and undergo a double fluorine atom transfer. Herein, we show that the transferred product further undergoes a skeletal transformation on silica gel. The transformation begins with activation of the ... ...

Abstract	Tri- and tetra-fluorinated [7]helicenes are photolabile and undergo a double fluorine atom transfer. Herein, we show that the transferred product further undergoes a skeletal transformation on silica gel. The transformation begins with activation of the allylic C-F bond on the silanol surface. Then, the resulting carbocation readily undergoes a regioselective nucleophilic aromatic substitution with water, depending on the position of the fluorine substituents. Hexafluoro-2-propanol also activated the allylic C-F bond and acted as a nucleophile. These findings support the generation of a highly reactive cationic electrophilic intermediate in the successive transformations involving fluorine atoms.
Language	English
Publishing date	2022-03-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202200132
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Article ; Online: Distal sacral nerve roots severed by a fragility fracture of the sacrum: a case report.

Igarashi, Shun / Kobayashi, Takashi / Kijima, Hiroaki / Miyakoshi, Naohisa

Journal of medical case reports

2022 Volume 16, Issue 1, Page(s) 315

Abstract: Background: Owing to the aging population, fragility fractures of the pelvis are occurring more frequently. Fixation of the fracture and stabilization of the pelvic ring usually provide good clinical results. A case of distal sacral nerve roots severed ... ...

Abstract	Background: Owing to the aging population, fragility fractures of the pelvis are occurring more frequently. Fixation of the fracture and stabilization of the pelvic ring usually provide good clinical results. A case of distal sacral nerve roots severed by a fragility fracture of the sacrum is presented. Case presentation: A 62-year-old Japanese woman with schizophrenia with low back pain, gait disorder, dysuria, and fecal incontinence presented to an emergency department, and plain X-rays showed no findings. She also complained of dysuria, and neurogenic bladder and cystitis were diagnosed. One month later, she was admitted to a psychiatric hospital for exacerbation of schizophrenia. In hospital, she had a urethral catheter inserted and spent 3 months in bed. She was referred to our orthopedic department because a gait disorder was discovered after her mental condition improved and she was permitted to walk. On examination, she could not walk and had decreased sensation from the buttocks to both posterior thighs and around the anus and perineum. Manual muscle testing of her lower limbs showed mild weakness of about 4 in bilateral flexor hallucis longus and gastrocnemius, and bilateral Achilles tendon reflexes were lost. Her anal sphincter did not contract, and urinary retention continued after urethral catheter removal. Imaging examinations showed an H-shaped sacral fracture consisting of a transverse fracture with displacement of the third sacral vertebra and vertical fractures of the bilateral sacral wings, with severe stenosis of the spinal canal at the site of the transverse fracture. The patient was diagnosed as having bladder and rectal dysfunction due to a displaced, unstable sacral fracture. First to third sacral laminectomy and alar-iliac fixation using percutaneous pedicle screws and sacral alar-iliac screws were then performed. The bilateral distal sacral nerve roots (S3, S4, S5) were completely severed at the second to third sacral levels, but bilateral second sacral nerve roots were not compressed from the bifurcation to the sacral foramen. Postoperatively, bladder and rectal dysfunction remained, but the low back pain was alleviated. Two weeks postoperatively, she could walk with a walker and was discharged. Three months after the operation, bone fusion of the fracture was observed. Conclusions: In cases of bladder-rectal dysfunction with low back pain, the possibility of sacral fracture should be considered, and computed tomography, magnetic resonance imaging, and X-ray examinations should be performed. Even sacral fractures without displacement require attention because they can cause serious injury in the event of a nerve root being severed if not diagnosed early and given appropriate treatment.
MeSH term(s)	Aged ; Dysuria ; Female ; Fracture Fixation, Internal/adverse effects ; Fractures, Bone/complications ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Humans ; Low Back Pain ; Middle Aged ; Pelvis/injuries ; Sacrum/diagnostic imaging ; Sacrum/injuries ; Sacrum/surgery ; Spinal Fractures/complications ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery
Language	English
Publishing date	2022-08-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-022-03551-z
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Article ; Online: Retinal folds and tracheomalacia in a boy with otopalatodigital syndrome type 2.

Okuno, Takashi / Igarashi, Aiko / Sugihara, Yuka / Imoto, Yoshimasa / Ohshima, Yusei

Pediatrics international : official journal of the Japan Pediatric Society

2022 Volume 64, Issue 1, Page(s) e15127

MeSH term(s)	Craniofacial Abnormalities/complications ; Craniofacial Abnormalities/diagnosis ; Hand Deformities, Congenital ; Humans ; Male ; Osteochondrodysplasias/complications ; Osteochondrodysplasias/diagnosis ; Tracheomalacia
Language	English
Publishing date	2022-04-09
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15127
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Article ; Online: Perforation of the membranous atrioventricular septum caused by infective endocarditis in a patient with a unicuspid aortic valve.

Sugawara, Yukiko / Kobayashi, Atsushi / Muto, Yuki / Igarashi, Takashi / Takeishi, Yasuchika

Journal of medical ultrasonics (2001)

2022 Volume 49, Issue 2, Page(s) 311–312

MeSH term(s)	Endocarditis/complications ; Endocarditis/diagnostic imaging ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis, Bacterial/surgery ; Heart Atria ; Heart Valve Diseases/complications ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/surgery ; Humans
Language	English
Publishing date	2022-01-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-021-01180-5
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Zs.B 2695: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.B 2695 -Engl.Ausg.-: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Complete mitochondrial genomes of three fairy shrimps from snowmelt pools in Japan.

Kitano, Takashi / Sato, Hidenori / Takahashi, Norihito / Igarashi, Seiki / Hatanaka, Yushi / Igarashi, Keiji / Umetsu, Kazuo

BMC zoology

2022 Volume 7, Issue 1, Page(s) 11

Abstract: Background: Fairy shrimps belong to order Anostraca, class Branchiopoda, subphylum Crustacea, and phylum Arthropoda. Three fairy shrimp species (Eubranchipus uchidai, E. asanumai, and E. hatanakai) that inhabit snowmelt pools are currently known in ... ...

Abstract	Background: Fairy shrimps belong to order Anostraca, class Branchiopoda, subphylum Crustacea, and phylum Arthropoda. Three fairy shrimp species (Eubranchipus uchidai, E. asanumai, and E. hatanakai) that inhabit snowmelt pools are currently known in Japan. Whole mitochondrial genomes are useful genetic information for conducting phylogenetic analyses. Mitochondrial genome sequences for Branchiopoda members are gradually being collated. Results: Six whole mitochondrial genomes from the three Eubranchipus species are presented here. Eubranchipus species share the anostracan pattern of gene arrangement in their mitochondrial genomes. The mitochondrial genomes of the Eubranchipus species have a higher GC content than those of other anostracans. Accelerated substitution rates in the lineage of Eubranchipus species were observed. Conclusion: This study is the first to obtain whole mitochondrial genomes for Far Eastern Eubranchipus species. We show that the nucleotide sequences of cytochrome oxidase subunit I and the 16S ribosomal RNA of E. asanumai presented in a previous study were nuclear mitochondrial DNA segments. Higher GC contents and accelerated substitution rates are specific characteristics of the mitochondrial genomes of Far Eastern Eubranchipus. The results will be useful for further investigations of the evolution of Anostraca as well as Branchiopoda.
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article
ISSN	2056-3132
ISSN (online)	2056-3132
DOI	10.1186/s40850-022-00111-2
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Article ; Online: Outcomes of 6-mm diameter fully covered self-expandable metal stents for preoperative biliary drainage in pancreatic cancer.

Nakagawa, Hiroki / Takeda, Tsuyoshi / Okamoto, Takeshi / Mie, Takafumi / Kasuga, Akiyoshi / Sasaki, Takashi / Ozaka, Masato / Matsuda, Takahisa / Igarashi, Yoshinori / Sasahira, Naoki

DEN open

2024 Volume 4, Issue 1, Page(s) e360

Abstract: Background: 10-mm self-expandable metal stents (SEMSs) are commonly used for preoperative biliary drainage in pancreatic cancer. However, smaller diameter SEMSs have attracted attention with the attempt to reduce stent-related adverse events (AEs).: ... ...

Abstract	Background: 10-mm self-expandable metal stents (SEMSs) are commonly used for preoperative biliary drainage in pancreatic cancer. However, smaller diameter SEMSs have attracted attention with the attempt to reduce stent-related adverse events (AEs). Methods: We retrospectively analyzed consecutive borderline resectable pancreatic cancer patients who underwent neoadjuvant therapy and fully covered SEMS (FCSEMS) placement from April 2015 to May 2023. The primary outcome was stent-related non-event rate (NER), which was defined as the rate of completion of surgery without developing any preoperative events (recurrent biliary obstruction [RBO] or stent-related AEs). Secondary outcomes included stent-related AEs, causes of RBO, and cumulative incidence of RBO. Risk factors for pancreatitis, RBO, and stent migration were also examined. Results: A total of 76 patients were included (6-mm group: 23; 10-mm group: 53). Stent-related NER (57% vs. 64%, Conclusions: Stent-related NER was not significantly affected by FCSEMS diameter. Further studies are needed to confirm the usefulness of 6-mm diameter FCSEMS for preoperative biliary drainage in patients with borderline resectable pancreatic cancer.
Language	English
Publishing date	2024-04-09
Publishing country	Australia
Document type	Journal Article
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.360
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Article ; Online: Distal sacral nerve roots severed by a fragility fracture of the sacrum

Shun Igarashi / Takashi Kobayashi / Hiroaki Kijima / Naohisa Miyakoshi

Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-

a case report

2022 Volume 5

Abstract: Abstract Background Owing to the aging population, fragility fractures of the pelvis are occurring more frequently. Fixation of the fracture and stabilization of the pelvic ring usually provide good clinical results. A case of distal sacral nerve roots ... ...

Abstract	Abstract Background Owing to the aging population, fragility fractures of the pelvis are occurring more frequently. Fixation of the fracture and stabilization of the pelvic ring usually provide good clinical results. A case of distal sacral nerve roots severed by a fragility fracture of the sacrum is presented. Case presentation A 62-year-old Japanese woman with schizophrenia with low back pain, gait disorder, dysuria, and fecal incontinence presented to an emergency department, and plain X-rays showed no findings. She also complained of dysuria, and neurogenic bladder and cystitis were diagnosed. One month later, she was admitted to a psychiatric hospital for exacerbation of schizophrenia. In hospital, she had a urethral catheter inserted and spent 3 months in bed. She was referred to our orthopedic department because a gait disorder was discovered after her mental condition improved and she was permitted to walk. On examination, she could not walk and had decreased sensation from the buttocks to both posterior thighs and around the anus and perineum. Manual muscle testing of her lower limbs showed mild weakness of about 4 in bilateral flexor hallucis longus and gastrocnemius, and bilateral Achilles tendon reflexes were lost. Her anal sphincter did not contract, and urinary retention continued after urethral catheter removal. Imaging examinations showed an H-shaped sacral fracture consisting of a transverse fracture with displacement of the third sacral vertebra and vertical fractures of the bilateral sacral wings, with severe stenosis of the spinal canal at the site of the transverse fracture. The patient was diagnosed as having bladder and rectal dysfunction due to a displaced, unstable sacral fracture. First to third sacral laminectomy and alar–iliac fixation using percutaneous pedicle screws and sacral alar–iliac screws were then performed. The bilateral distal sacral nerve roots (S3, S4, S5) were completely severed at the second to third sacral levels, but bilateral second sacral nerve roots were not ...
Keywords	Sacral fracture ; Fragility fracture ; Sacral nerve root ; Gait disorder ; Fecal incontinence ; Sacral laminectomy ; Medicine ; R
Subject code	941 ; 616
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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