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  1. Article ; Online: What hath DNA wrought? CRISPR-CAS gene silencing and engineering from bacteria to humans: comment on "Diversity, evolution, and therapeutic applications of small RNAs in prokaryotic and eukaryotic immune systems" by Edwin L. Cooper and Nicola Overstreet.

    Wanner, Barry L / Teramoto, Jun / Mori, Hirotada

    Physics of life reviews

    2014  Volume 11, Issue 1, Page(s) 144–5; discussion 149–51

    MeSH term(s) Animals ; Archaea/immunology ; Bacteria/immunology ; Eukaryota/immunology ; Evolution, Molecular ; Genetic Variation ; Humans ; RNA, Small Untranslated/genetics
    Chemical Substances RNA, Small Untranslated
    Language English
    Publishing date 2014-03
    Publishing country Netherlands
    Document type Comment ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2013.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gone but not forgotten: resolution of childhood kidney disease and the risk of end-stage kidney disease in adults.

    Wyatt, Christina M / Wanner, Nicola

    Kidney international

    2018  Volume 93, Issue 6, Page(s) 1260–1262

    MeSH term(s) Adult ; Child ; Humans ; Kidney Diseases ; Kidney Failure, Chronic ; Nephrology
    Language English
    Publishing date 2018-05-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Nanobodies: new avenue to treat kidney disease.

    Wanner, Nicola / Eden, Thomas / Liaukouskaya, Nastassia / Koch-Nolte, Friedrich

    Cell and tissue research

    2021  Volume 385, Issue 2, Page(s) 445–456

    Abstract: Current therapeutic options for renal diseases are limited, and the search for disease-specific treatments is ongoing. Nanobodies, single-domain antibodies with many advantages over conventional antibodies, provide flexible, easy-to-format biologicals ... ...

    Abstract Current therapeutic options for renal diseases are limited, and the search for disease-specific treatments is ongoing. Nanobodies, single-domain antibodies with many advantages over conventional antibodies, provide flexible, easy-to-format biologicals with many possible applications. Here, we discuss the potential use of nanobodies for renal diseases.
    MeSH term(s) Animals ; Humans ; Kidney Diseases/therapy ; Single-Domain Antibodies/therapeutic use
    Chemical Substances Single-Domain Antibodies
    Language English
    Publishing date 2021-06-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-021-03479-8
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  4. Article ; Online: Epigenetics of kidney disease.

    Wanner, Nicola / Bechtel-Walz, Wibke

    Cell and tissue research

    2017  Volume 369, Issue 1, Page(s) 75–92

    Abstract: DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and ... ...

    Abstract DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.
    Language English
    Publishing date 2017-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-017-2588-x
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  5. Book ; Online ; Thesis: Ex Vivo Modelling of Prenatally Induced Oligonephronia

    Fuhrmann, Lars Verfasser] / [Huber, Tobias [Akademischer Betreuer] / Wanner, Nicola [Akademischer Betreuer]

    2021  

    Author's details Lars Fuhrmann ; Tobias B. Huber, Nicola Wanner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Nanobodies: new avenue to treat kidney disease

    Wanner, Nicola / Eden, Thomas / Liaukouskaya, Nastassia / Koch-Nolte, Friedrich

    Cell and tissue research. 2021 Aug., v. 385, no. 2

    2021  

    Abstract: Current therapeutic options for renal diseases are limited, and the search for disease-specific treatments is ongoing. Nanobodies, single-domain antibodies with many advantages over conventional antibodies, provide flexible, easy-to-format biologicals ... ...

    Abstract Current therapeutic options for renal diseases are limited, and the search for disease-specific treatments is ongoing. Nanobodies, single-domain antibodies with many advantages over conventional antibodies, provide flexible, easy-to-format biologicals with many possible applications. Here, we discuss the potential use of nanobodies for renal diseases.
    Keywords kidney diseases ; research ; therapeutics
    Language English
    Dates of publication 2021-08
    Size p. 445-456.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-021-03479-8
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    In stock of ZB MED Bonn / Germany

    Z 46/352: Show issues

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  7. Article: Epigenetics of kidney disease

    Wanner, Nicola / Wibke Bechtel-Walz

    Cell and tissue research. 2017 July, v. 369, no. 1

    2017  

    Abstract: DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and ... ...

    Abstract DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.
    Keywords DNA methylation ; biomarkers ; diabetic nephropathy ; disease course ; early development ; epigenetics ; fibrosis ; histones ; pathophysiology ; therapeutics ; translation (genetics)
    Language English
    Dates of publication 2017-07
    Size p. 75-92.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-017-2588-x
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 46/352: Show issues

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  8. Article ; Online: Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.

    Kylies, Dominik / Zimmermann, Marina / Haas, Fabian / Schwerk, Maria / Kuehl, Malte / Brehler, Michael / Czogalla, Jan / Hernandez, Lola C / Konczalla, Leonie / Okabayashi, Yusuke / Menzel, Julia / Edenhofer, Ilka / Mezher, Sam / Aypek, Hande / Dumoulin, Bernhard / Wu, Hui / Hofmann, Smilla / Kretz, Oliver / Wanner, Nicola /
    Tomas, Nicola M / Krasemann, Susanne / Glatzel, Markus / Kuppe, Christoph / Kramann, Rafael / Banjanin, Bella / Schneider, Rebekka K / Urbschat, Christopher / Arck, Petra / Gagliani, Nicola / van Zandvoort, Marc / Wiech, Thorsten / Grahammer, Florian / Sáez, Pablo J / Wong, Milagros N / Bonn, Stefan / Huber, Tobias B / Puelles, Victor G

    Nature nanotechnology

    2023  Volume 18, Issue 4, Page(s) 336–342

    Abstract: Expansion microscopy physically enlarges biological specimens to achieve nanoscale resolution using diffraction-limited microscopy ... ...

    Abstract Expansion microscopy physically enlarges biological specimens to achieve nanoscale resolution using diffraction-limited microscopy systems
    MeSH term(s) Animals ; Humans ; Mice ; Microscopy, Fluorescence/methods ; Microscopy, Confocal/methods ; Kidney ; Image Enhancement
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-023-01328-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dichotomous Responses to Chronic Fetal Hypoxia Lead to a Predetermined Aging Phenotype.

    Rudloff, Stefan / Bileck, Andrea / Janker, Lukas / Wanner, Nicola / Liaukouskaya, Nastassia / Lundby, Carsten / Huber, Tobias B / Gerner, Christopher / Huynh-Do, Uyen

    Molecular & cellular proteomics : MCP

    2021  Volume 21, Issue 2, Page(s) 100190

    Abstract: Hypoxia-induced intrauterine growth restriction increases the risk for cardiovascular, renal, and other chronic diseases in adults, representing thus a major public health problem. Still, not much is known about the fetal mechanisms that predispose these ...

    Abstract Hypoxia-induced intrauterine growth restriction increases the risk for cardiovascular, renal, and other chronic diseases in adults, representing thus a major public health problem. Still, not much is known about the fetal mechanisms that predispose these individuals to disease. Using a previously validated mouse model of fetal hypoxia and bottom-up proteomics, we characterize the response of the fetal kidney to chronic hypoxic stress. Fetal kidneys exhibit a dichotomous response to chronic hypoxia, comprising on the one hand cellular adaptations that promote survival (glycolysis, autophagy, and reduced DNA and protein synthesis), but on the other processes that induce a senescence-like phenotype (infiltration of inflammatory cells, DNA damage, and reduced proliferation). Importantly, chronic hypoxia also reduces the expression of the antiaging proteins klotho and Sirt6, a mechanism that is evolutionary conserved between mice and humans. Taken together, we uncover that predetermined aging during fetal development is a key event in chronic hypoxia, establishing a solid foundation for Barker's hypothesis of fetal programming of adult diseases. This phenotype is associated with a characteristic biomarker profile in tissue and serum samples, exploitable for detecting and targeting accelerated aging in chronic hypoxic human diseases.
    MeSH term(s) Aging ; Animals ; Fetal Development ; Fetal Hypoxia ; Hypoxia ; Mice ; Phenotype ; Sirtuins
    Chemical Substances Sirt6 protein, mouse (EC 2.4.2.31) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075924-1
    ISSN 1535-9484 ; 1535-9476
    ISSN (online) 1535-9484
    ISSN 1535-9476
    DOI 10.1016/j.mcpro.2021.100190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: BET Proteins Regulate Expression of Osr1 in Early Kidney Development.

    Schreiber, Janina / Liaukouskaya, Nastassia / Fuhrmann, Lars / Hauser, Alexander-Thomas / Jung, Manfred / Huber, Tobias B / Wanner, Nicola

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: In utero renal development is subject to maternal metabolic and environmental influences affecting long-term renal function and the risk of developing chronic kidney failure and cardiovascular disease. Epigenetic processes have been implicated in the ... ...

    Abstract In utero renal development is subject to maternal metabolic and environmental influences affecting long-term renal function and the risk of developing chronic kidney failure and cardiovascular disease. Epigenetic processes have been implicated in the orchestration of renal development and prenatal programming of nephron number. However, the role of many epigenetic modifiers for kidney development is still unclear. Bromodomain and extra-terminal domain (BET) proteins act as histone acetylation reader molecules and promote gene transcription. BET family members Brd2, Brd3 and Brd4 are expressed in the nephrogenic zone during kidney development. Here, the effect of the BET inhibitor JQ1 on renal development is evaluated. Inhibition of BET proteins via JQ1 leads to reduced growth of metanephric kidney cultures, loss of the nephron progenitor cell population, and premature and disturbed nephron differentiation. Gene expression of key nephron progenitor transcription factor Osr1 is downregulated after 24 h BET inhibition, while Lhx1 and Pax8 expression is increased. Mining of BRD4 ChIP-seq and gene expression data identify Osr1 as a key factor regulated by BRD4-controlled gene activation. Inhibition of BRD4 by BET inhibitor JQ1 leads to downregulation of Osr1, thereby causing a disturbance in the balance of nephron progenitor cell self-renewal and premature differentiation of the nephron, which ultimately leads to kidney hypoplasia and disturbed nephron development. This raises questions about the potential teratogenic effects of BET inhibitors for embryonic development. In summary, our work highlights the role of BET proteins for prenatal programming of nephrogenesis and identifies Osr1 as a potential target of BET proteins.
    Language English
    Publishing date 2021-12-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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