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  1. Book: Cardiovascular issues in endocrinology

    Granata, Riccarda

    (Frontiers of hormone research ; 43)

    2014  

    Author's details ed. Riccarda Granata
    Series title Frontiers of hormone research ; 43
    Collection
    Keywords Endokrinopathie ; Kardiovaskuläre Krankheit ; Stoffwechselkrankheit
    Subject Stoffwechsel ; Stoffwechselerkrankung ; Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten ; Endokrine Krankheit ; Endokrine Drüse ; Endokrine Regulationsstörung ; Hormonstörung ; Hormonelle Störung
    Language English
    Size X, 163 S. : zahlr. Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018307667
    ISBN 978-3-318-02673-3 ; 3-318-02673-5 ; 9783318026740 ; 3318026743
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2549 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: Neuroendocrine Control of Feeding Behavior

    Luquet, Serge H. / Granata, Riccarda / Vaudry, Hubert

    2019  

    Keywords Science: general issues ; Neurosciences ; energy homeostasis ; Appetite ; satiety ; nutrient sensing ; Orexigenic and anorexigenic neuropeptides ; Hypothalamus
    Size 1 electronic resource (397 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230311
    ISBN 9782889632022 ; 2889632024
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Editorial: Pathophysiological Interrelationship Between Obesity, Metabolic Diseases, and Cancer.

    Gahete, Manuel D / Granata, Riccarda / Luque, Raúl M

    Frontiers in oncology

    2021  Volume 11, Page(s) 755735

    Language English
    Publishing date 2021-09-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.755735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Neuroendocrine Control of Feeding Behavior.

    Luquet, Serge H / Vaudry, Hubert / Granata, Riccarda

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 399

    Language English
    Publishing date 2019-06-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Cardiovascular issues in endocrinology

    Granata, Riccarda / Isgaard, Jørgen

    (Frontiers of hormone research, ; vol.43)

    2014  

    Author's details volume editors, Riccarda Granata, Jørgen Isgaard
    Series title Frontiers of hormone research, ; vol.43
    MeSH term(s) Endocrine System Diseases/complications ; Metabolic Diseases/complications ; Cardiovascular Diseases/etiology
    Language English
    Size x, 163 pages :, illustrations.
    Document type Book
    ISBN 9783318026733 ; 9783318026740 ; 3318026735 ; 3318026743
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.

    Boido, Marina / Gesmundo, Iacopo / Caretto, Anna / Pedrolli, Francesca / Schellino, Roberta / Leone, Sheila / Cai, Renzhi / Sha, Wei / Ghigo, Ezio / Schally, Andrew V / Vercelli, Alessandro / Granata, Riccarda

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 2, Page(s) e2216814120

    Abstract: Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene ( ...

    Abstract Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene (
    MeSH term(s) Animals ; Mice ; Atrophy/metabolism ; Disease Models, Animal ; Growth Hormone-Releasing Hormone/agonists ; Motor Neurons/metabolism ; Muscular Atrophy, Spinal/drug therapy ; Muscular Atrophy, Spinal/genetics ; Muscular Atrophy, Spinal/metabolism ; Spinal Cord/metabolism ; Survival of Motor Neuron 1 Protein/genetics ; Survival of Motor Neuron 1 Protein/metabolism
    Chemical Substances Growth Hormone-Releasing Hormone (9034-39-3) ; Survival of Motor Neuron 1 Protein
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2216814120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Thermomagnetic Resonance Effect of the Extremely Low Frequency Electromagnetic Field on Three-Dimensional Cancer Models.

    Bergandi, Loredana / Lucia, Umberto / Grisolia, Giulia / Salaroglio, Iris Chiara / Gesmundo, Iacopo / Granata, Riccarda / Borchiellini, Romano / Ponzetto, Antonio / Silvagno, Francesca

    International journal of molecular sciences

    2022  Volume 23, Issue 14

    Abstract: In our recent studies, we have developed a thermodynamic biochemical model able to select the resonant frequency of an extremely low frequency electromagnetic field (ELF-EMF) specifically affecting different types of cancer, and we have demonstrated its ... ...

    Abstract In our recent studies, we have developed a thermodynamic biochemical model able to select the resonant frequency of an extremely low frequency electromagnetic field (ELF-EMF) specifically affecting different types of cancer, and we have demonstrated its effects in vitro. In this work, we investigate the cellular response to the ELF electromagnetic wave in three-dimensional (3D) culture models, which mimic the features of tumors in vivo. Cell membrane was modelled as a resistor-capacitor circuit and the specific thermal resonant frequency was calculated and tested on two-dimensional (2D) and three-dimensional (3D) cell cultures of human pancreatic cancer, glioblastoma and breast cancer. Cell proliferation and the transcription of respiratory chain and adenosine triphosphate synthase subunits, as well as uncoupling proteins, were assessed. For the first time, we demonstrate that an ELF-EMF hampers growth and potentiates both the coupled and uncoupled respiration of all analyzed models. Interestingly, the metabolic shift was evident even in the 3D aggregates, making this approach particularly valuable and promising for future application in vivo, in aggressive cancer tissues characterized by resistance to treatments.
    MeSH term(s) Cell Proliferation ; Electromagnetic Fields ; Electromagnetic Radiation ; Glioblastoma ; Humans
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23147955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Cardiovascular issues in endocrinology

    Granata, Riccarda / Isgaard, Jørgen

    (Frontiers of hormone research ; 43)

    2014  

    Abstract: Most endocrine diseases, if not treated or controlled, have cardiovascular manifestations. Both GH deficiency and GH excess impair cardiovascular functions, e.g. in patients with acromegaly, who have a shortened life expectancy and increased mortality ... ...

    Author's details volume editors, Riccarda Granata, Jørgen Isgaard
    Series title Frontiers of hormone research ; 43
    Abstract Most endocrine diseases, if not treated or controlled, have cardiovascular manifestations. Both GH deficiency and GH excess impair cardiovascular functions, e.g. in patients with acromegaly, who have a shortened life expectancy and increased mortality mostly due to cardiovascular complications in uncontrolled disease. Moreover, Cushing's syndrome and diabetes are well known for metabolic and cardiovascular manifestations, as well as hypo- and hyperthyroidism. Both adipose tissue and the heart have been increasingly recognized as organs with partially endocrine functions, which produce adipokines and brain natriuretic peptide, respectively, and influence a number of cardiovascular parameters. Primary aldosteronism as a cause for secondary hypertension is still a great challenge to detect and diagnose properly; however, new important discoveries have been made regarding the genetics of this probably underestimated cause of hypertension. Written by distinguished researchers in their respective fields, this book will give both researchers and clinicians an excellent update on all these topics, as well as provide insight into the use of hormones as treatment tools in more controversial areas.
    MeSH term(s) Cardiovascular Diseases/etiology ; Endocrine System Diseases/complications ; Metabolic Diseases/complications
    Keywords Endocrinology ; Medizin / Gesundheit Gynäkologie ; Medizin / Gesundheit Innere Medizin ; Medizin / Gesundheit Urologie
    Language English
    Size Online-Ressource (x, 163 pages)
    Publisher Karger
    Publishing place Basel ;New York
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 1306924782 ; 3318026735 ; 3318026743 ; 9781306924788 ; 9783318026733 ; 9783318026740
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Growth hormone-releasing hormone antagonist MIA-602 inhibits inflammation induced by SARS-CoV-2 spike protein and bacterial lipopolysaccharide synergism in macrophages and human peripheral blood mononuclear cells.

    Granato, Giuseppina / Gesmundo, Iacopo / Pedrolli, Francesca / Kasarla, Ramesh / Begani, Laura / Banfi, Dana / Bruno, Stefania / Lopatina, Tatiana / Brizzi, Maria Felice / Cai, Renzhi / Sha, Wei / Ghigo, Ezio / Schally, Andrew V / Granata, Riccarda

    Frontiers in immunology

    2023  Volume 14, Page(s) 1231363

    Abstract: COVID-19 is characterized by an excessive inflammatory response and macrophage hyperactivation, leading, in severe cases, to alveolar epithelial injury and acute respiratory distress syndrome. Recent studies have reported that SARS-CoV-2 spike (S) ... ...

    Abstract COVID-19 is characterized by an excessive inflammatory response and macrophage hyperactivation, leading, in severe cases, to alveolar epithelial injury and acute respiratory distress syndrome. Recent studies have reported that SARS-CoV-2 spike (S) protein interacts with bacterial lipopolysaccharide (LPS) to boost inflammatory responses
    MeSH term(s) Humans ; COVID-19 ; Endothelial Cells ; Growth Hormone-Releasing Hormone/antagonists & inhibitors ; Inflammation/drug therapy ; Leukocytes, Mononuclear ; Lipopolysaccharides ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Tumor Necrosis Factor-alpha
    Chemical Substances GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)- ; Growth Hormone-Releasing Hormone (9034-39-3) ; Lipopolysaccharides ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1231363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Products of the ghrelin gene, the pancreatic β-cell and the adipocyte.

    Granata, Riccarda / Ghigo, Ezio

    Endocrine development

    2013  Volume 25, Page(s) 144–156

    Abstract: The ghrelin system comprises acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin, besides the receptor for AG, the growth hormone (GH) secretagogue receptor type 1a (GHS-R1a), and the enzyme-promoting ghrelin acylation, ghrelin O- ... ...

    Abstract The ghrelin system comprises acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin, besides the receptor for AG, the growth hormone (GH) secretagogue receptor type 1a (GHS-R1a), and the enzyme-promoting ghrelin acylation, ghrelin O-acyltransferase (GOAT). The ghrelin peptides exert a variety of biological actions, including regulation of energy homeostasis and glucose metabolism, as well as survival and proliferative effects in different cell types. Besides the stomach, its main site of production, ghrelin is expressed in pancreatic islets, where it represents an independent islet cell population. AG exerts insulinostatic actions, UAG has been shown to oppose the AG inhibitory effects on insulin secretion, and obestatin has demonstrated insulinotropic activities. Although differences exist in the regulation of glucose homeostasis, all peptides display survival and antiapoptotic actions in pancreatic β-cells, preserving β-cell mass and function both in vitro and in vivo. The ghrelin system is also expressed in adipose tissue, and ghrelin effects have been demonstrated in both white and brown adipocytes. Indeed, AG, UAG and obestatin promote adipogenesis and glucose uptake, and inhibit adipocyte lipolysis. Interestingly, despite similar effects at the cellular level, results from ghrelin, GHS-R and GOAT knockout mice have indicated that AG display diabetogenic effects in vivo. Conversely, UAG and obestatin positively regulate glucose metabolism, and a new role has been recently proposed for obestatin on adipocyte function and insulin sensitivity.
    MeSH term(s) Adipocytes/metabolism ; Animals ; Ghrelin/genetics ; Ghrelin/metabolism ; Humans ; Insulin-Secreting Cells/metabolism ; Mice ; Mice, Knockout ; Peptide Hormones/metabolism ; Peptide Hormones/pharmacology
    Chemical Substances Ghrelin ; Peptide Hormones
    Language English
    Publishing date 2013
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1662-2979 ; 1421-7082
    ISSN (online) 1662-2979
    ISSN 1421-7082
    DOI 10.1159/000346306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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