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Article: Determination of gamma rays induced mutagenic sensitivity of guava (Psidium guajava L.) cv. ‘Lalit' and ‘Shweta’

Maan, Sukhjinder Singh / Gill, Manav Indra Singh / Arora, Naresh Kumar / Sohi, Harjot Singh

Agricultural research journal. 2021 June, v. 58, no. 3

2021

Abstract: In the present investigation, seeds of guava cv. ‘Lalit' and ‘Shweta' were irradiated ... of irradiated seedlings using probit curve analysis, was 57.81 Gy and 57.42 Gy for ‘Lalit' and ‘Shweta' ...

Abstract	In the present investigation, seeds of guava cv. ‘Lalit' and ‘Shweta' were irradiated with different dosages of gamma rays ranging from 25 to 150 Gy using the ⁶⁰Co source to examine its effects on morphological and physiological traits. The LD₅₀ value calculated on the basis of germination percentage of irradiated seedlings using probit curve analysis, was 57.81 Gy and 57.42 Gy for ‘Lalit' and ‘Shweta', respectively. Seed germination and growth parameters viz., plant height, internode number, internodal length and leaf dimensions had negative correlation with gamma irradiation., while the parameters, number of leaves and branches experienced the hormetics radiostimulant effect at lower dosage (up to 50 Gy), but a marginal reduction was observed at higher dosages (125–150 Gy). Reduction in stomatal number with increased stomatal size were observed in the mutant populations. With ascending irradiation doses, a marginal signifcant reduction was observed in leaf chlorophyll content. The results of this study will allow implementation of mutagenesis-based genetic improvement programmes in guava and, serve as a morphological and physiological marker to identify some desirable mutants at early stage.
Keywords	Psidium guajava ; agricultural research ; gamma radiation ; genetic improvement ; guavas ; irradiation ; leaf chlorophyll content ; leaves ; mutagens ; mutants ; plant height ; seed germination
Language	English
Dates of publication	2021-06
Size	p. 474-481.
Publishing place	Punjab Agricultural University, Ludhiana
Document type	Article
ZDB-ID	2970301-3
ISSN	2395-146X ; 2395-1435
ISSN (online)	2395-146X
ISSN	2395-1435
DOI	10.5958/2395-146X.2021.00068.5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adropin may enhance life span and function of corpus luteum by improving antioxidant potential in adult mouse.

Maurya, Shweta / Tripathi, Shashank / Arora, Taruna / Singh, Ajit

The Journal of steroid biochemistry and molecular biology

2024 , Page(s) 106524

Abstract: The corpus luteum (CL) is a temporary endocrine gland that synthesizes progesterone. The luteal progesterone plays a central role in the regulation of the estrous cycle as well as the implantation and maintenance of pregnancy. Our previous study showed ... ...

Abstract	The corpus luteum (CL) is a temporary endocrine gland that synthesizes progesterone. The luteal progesterone plays a central role in the regulation of the estrous cycle as well as the implantation and maintenance of pregnancy. Our previous study showed the expression of adropin and its receptor, GPR19, in the luteal cells and its significant role in luteinization. The aim of the present study was to investigate the in vitro effect of adropin on hCG-induced ovarian functions in adult mice. We also evaluated the effect of exogenous treatment with adropin on ovarian steroidogenesis and anti-oxidant parameters, with special emphasis on CL function. Our results demonstrated that adropin acts synergistically with hCG to promote ovarian steroidogenesis and survival by increasing the expression of StAR, 3β-HSD, and aromatase proteins and decreasing the BAX/BCL2 ratio. Exogenous adropin treatment increased progesterone production by increasing the expression of StAR and 3β-HSD enzymes in the mouse ovary. Also, adropin, via GPR19, inhibited the luteal oxidative stress by increasing nuclear translocation of NRF-2 in CL, which resulted in increased HO-1 expression and SOD, catalase activity. Decreased oxidative stress might inhibit the translocation of NF-κB into the nucleus of luteal cells, resulting into increased survival and decreased apoptosis, as evident by decreased lipid peroxidation, BAX/BCL2 ratio, caspase 3, active caspase 3 expression, and TUNEL-positive cells in adropin treated mice. Our findings suggest that adropin can be a promising candidate that could increase the lifespan of CL and might serve as a potential therapeutic option for treating luteal insufficiency.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2024.106524
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Article: MDR tuberculosis in elderly.

Bansal, Avdhesh / Arora, Shweta

The Indian journal of tuberculosis

2022 Volume 69 Suppl 2, Page(s) S267–S271

Abstract: Tuberculosis is very common in young population, but it has emerged in a significant number in geriatric/elderly population (>60 Yrs. of age) as the population is ageing. Most cases of TB in the elderly are linked to the reactivation of lesions that have ...

Abstract	Tuberculosis is very common in young population, but it has emerged in a significant number in geriatric/elderly population (>60 Yrs. of age) as the population is ageing. Most cases of TB in the elderly are linked to the reactivation of lesions that have remained dormant. The awakening of these lesions is attributable to changes in the immune system related to senescence. Mortality rate from tuberculosis remains higher in elderly patients. Diagnosis is difficult as symptoms of active TB are nonspecific and less pronounced in the elderly. MDR TB is known to occur in poorly compliant patients (non-adherence) and this can be a major issue in elderly due to loss of independence and frailty resulting in treatment failure. Multidisciplinary management, involving geriatricians and infectious disease specialists is essential throughout care to optimize a favourable outcome in these vulnerable patients.
MeSH term(s)	Aged ; Humans ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis/diagnosis ; Aging
Language	English
Publishing date	2022-10-30
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	603129-8
ISSN	0019-5707 ; 0019-5705
ISSN	0019-5707 ; 0019-5705
DOI	10.1016/j.ijtb.2022.10.018
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Article ; Online: Self-inflicted bilateral ocular injury with scissors in a psychiatric patient.

Sahu, Jigyasa / Arora, Ritu / Vishwanath, Shweta

GMS ophthalmology cases

2023 Volume 13, Page(s) Doc11

Abstract: A young male was brought to the ophthalmic emergency by his family with severe bleeding from both eyes after self-inflicted injury with scissors in a fit of mania. He had a history of schizophrenia and has been on irregular treatment for the past 10 ... ...

Abstract	A young male was brought to the ophthalmic emergency by his family with severe bleeding from both eyes after self-inflicted injury with scissors in a fit of mania. He had a history of schizophrenia and has been on irregular treatment for the past 10 years. Both eyes were severely damaged with avulsion of all extraocular muscles in one eye and a large corneoscleral laceration in the other. We report this unique case of oedipism or self-enucleation where a sharp instrument was used. Self-inflicted injury to the eyes is a rather uncommon phenomenon described in psychiatric patients. It can range from minor abrasions to severe ocular mutilation and loss of sight. The strict observation of these patients while admitted to the hospital and a multidisciplinary approach to ensure their future safety are imperative.
Language	English
Publishing date	2023-05-23
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2628607-5
ISSN	2193-1496 ; 2193-1496
ISSN (online)	2193-1496
ISSN	2193-1496
DOI	10.3205/oc000219
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of Normal Saline versus PlasmaLyte on Coagulation and Metabolic Status in Patients Undergoing Neurosurgical Procedures.

Arora, Vandna / Khatri, Akanksha / Bala, Renu / Kumar, Vibhuti / Arora, Rashmi / Jindal, Shweta

Asian journal of neurosurgery

2023 Volume 18, Issue 2, Page(s) 301–305

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-06-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2621446-5
ISSN	2248-9614 ; 1793-5482
ISSN (online)	2248-9614
ISSN	1793-5482
DOI	10.1055/s-0043-1768598
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Article ; Online: Adropin may regulate corpus luteum formation and its function in adult mouse ovary.

Maurya, Shweta / Tripathi, Shashank / Arora, Taruna / Singh, Ajit

Hormones (Athens, Greece)

2023 Volume 22, Issue 4, Page(s) 725–739

Abstract: Background: Adropin, a unique peptide hormone, has been associated with the regulation of several physiological processes, including glucose homeostasis, fatty acid metabolism, and neovascularization. However, its possible role in ovarian function is ... ...

Abstract	Background: Adropin, a unique peptide hormone, has been associated with the regulation of several physiological processes, including glucose homeostasis, fatty acid metabolism, and neovascularization. However, its possible role in ovarian function is not understood. Our objective was to examine the expression of adropin and its putative receptor, GPR19, in the ovaries of mice at various phases of the estrous cycle. Methods: Immunohistochemistry and western blot analysis were performed to explore the localization and changes in expression of adropin and GPR19 in the ovaries during different phases of the estrous cycle in mice. Hormonal assays were performed with ELISA. An in vitro study was performed to examine the direct effect of adropin (10, 100 ng/ml) on ovarian function. Results: A western blot study showed that adropin and GPR19 proteins were maximum during the estrus phase of the estrous cycle. Interestingly, adropin and GPR19 displayed intense immunoreactivity in granulosa cells of large antral follicles and corpus luteum. This suggested the possible involvement of adropin in corpus luteum formation. Adropin treatment stimulated progesterone synthesis by increasing GPR19, StAR, CYP11A1, and 3β-HSD expressions, while it decreased estrogen synthesis by inhibiting 17β-HSD and aromatase protein expressions. Moreover, adropin treatment upregulated the cell cycle arrest-CDK inhibitor 1B (p27 Conclusions: Adropin GPR19 signaling promotes the synthesis of progesterone and upregulates the expression of p27
MeSH term(s)	Female ; Mice ; Animals ; Ovary/metabolism ; Progesterone/pharmacology ; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived/metabolism ; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived/pharmacology ; Corpus Luteum/metabolism ; Estrous Cycle
Chemical Substances	Progesterone (4G7DS2Q64Y) ; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
Language	English
Publishing date	2023-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2075912-5
ISSN	2520-8721 ; 1109-3099
ISSN (online)	2520-8721
ISSN	1109-3099
DOI	10.1007/s42000-023-00476-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison between presepsin, procalcitonin, and CRP as biomarkers to diagnose sepsis in critically ill patients.

Juneja, Deven / Jain, Navin / Singh, Omender / Goel, Amit / Arora, Shweta

Journal of anaesthesiology, clinical pharmacology

2023 Volume 39, Issue 3, Page(s) 458–462

Abstract: Background and aims: Mortality associated with sepsis continues to remain high. Early diagnosis and aggressive management may improve outcomes. Biomarkers may help in early diagnosis, but the search for an ideal biomarker continues. Presepsin has been ... ...

Abstract	Background and aims: Mortality associated with sepsis continues to remain high. Early diagnosis and aggressive management may improve outcomes. Biomarkers may help in early diagnosis, but the search for an ideal biomarker continues. Presepsin has been introduced as a new biomarker, however, it still needs validation before its use becomes routine. In this study, we aimed to compare the efficacy of various biomarkers in patients with suspected sepsis. Material and methods: A retrospective analysis of 100 patients with suspected infection, admitted in the medical intensive care unit (ICU) was conducted. Diagnosis of sepsis was made on the basis of the current surviving sepsis guidelines criteria. Results: Out of 100 patients, 70 were diagnosed to have sepsis, and overall ICU mortality was 22%. Overall, C-reactive protein (CRP) was positive in 98, procalcitonin in 75, and presepsin in 64 patients. For diagnosis of sepsis the sensitivity, specificity, and AUC, respectively, for CRP was 98.6%, 3.3%, and 0.725. For procalcitonin (>0.5 ng/ml) it was 87.1%, 53.3%, and 0.776, and for procalcitonin (>1 ng/ml) 70%, 70%, and 0.816, respectively. For presepsin sensitivity, specificity, and AUC, respectively, for diagnosis of sepsis was 77.1%, 66.7%, and 0.734. For ICU mortality, sensitivity and specificity for CRP was 95.5% and 1.3%, for procalcitonin (>0.5) 72.7% and 24.4.%, for procalcitonin (>1) 59.1% and 42.3%, and for presepsin 61.5% and 27.3%, respectively. Conclusion: Inflammatory markers may be raised in a large proportion of ICU patients, even in those without sepsis. Procalcitnonin and presepsin had similar efficacy in diagnosing sepsis. However, none of the three biomarkers studied were accurate in predicting ICU mortality.
Language	English
Publishing date	2023-05-29
Publishing country	India
Document type	Journal Article
ZDB-ID	1401760-x
ISSN	0970-9185
ISSN	0970-9185
DOI	10.4103/joacp.joacp_560_21
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Article: Tuberculosis burden in India and its control from 1990 to 2019: Evidence from global burden of disease study 2019.

Dhamnetiya, Deepak / Arora, Shweta / Jha, Ravi Prakash

The Indian journal of tuberculosis

2022 Volume 70, Issue 1, Page(s) 87–98

Abstract: Background: Tuberculosis is still a major public health problem in India. This study aims to assess trends in the burden of tuberculosis from 1990 to 2019 for tracking success of tuberculosis control programme in India.: Methods: In this study, the ... ...

Abstract	Background: Tuberculosis is still a major public health problem in India. This study aims to assess trends in the burden of tuberculosis from 1990 to 2019 for tracking success of tuberculosis control programme in India. Methods: In this study, the 2019 global burden of disease study data were used to measure the incidence, prevalence, mortality, and disability-adjusted life years lost (DALY)rates of Tuberculosis during 1990-2019 for India and its states. Age and gender-specific rates were also analyzed for India. All rates were age-standardized and 95% uncertainty intervals (UIs) were computed. Result: Overall incidence, prevalence, death and DALY of TB decreased in India from 1990 to 2019. Tuberculosis morbidity and mortality was higher in males as compared to females. Incidence of TB was low in children up to 14 years of age. Prevalence of TB was higher in females as compared to males till 29 years of age, whereas higher prevalence was reported in males as compared to females in adults aged 30 years and more. Death rate of TB was low in children and young adults up to 29 years of age. Conclusion: This study shows that overall incidence, prevalence, death and DALY of tuberculosis decreased from 1990 to 2019 in India. The burden of TB was higher among males as compared to females during study period. TB affects all the age groups but deaths were higher in older age groups.
MeSH term(s)	Male ; Child ; Female ; Young Adult ; Humans ; Aged ; Adult ; Global Burden of Disease ; Quality-Adjusted Life Years ; Morbidity ; Prevalence ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Incidence ; India/epidemiology ; Global Health
Language	English
Publishing date	2022-03-15
Publishing country	India
Document type	Journal Article
ZDB-ID	603129-8
ISSN	0019-5707 ; 0019-5705
ISSN	0019-5707 ; 0019-5705
DOI	10.1016/j.ijtb.2022.03.016
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Article ; Online: Self-inflicted bilateral ocular injury with scissors in a psychiatric patient

Sahu, Jigyasa / Arora, Ritu / Vishwanath, Shweta

GMS Ophthalmology Cases - An Open Access Journal

2023 Volume 13, Page(s) 11

Abstract	A young male was brought to the ophthalmic emergency by his family with severe bleeding from both eyes after self-inflicted injury with scissors in a fit of mania. He had a history of schizophrenia and has been on irregular treatment for the past 10 years. Both eyes were severely damaged with avulsion of all extraocular muscles in one eye and a large corneoscleral laceration in the other. We report this unique case of oedipism or self-enucleation where a sharp instrument was used. Self-inflicted injury to the eyes is a rather uncommon phenomenon described in psychiatric patients. It can range from minor abrasions to severe ocular mutilation and loss of sight. The strict observation of these patients while admitted to the hospital and a multidisciplinary approach to ensure their future safety are imperative.
Keywords	Medizin, Gesundheit ; oedipus complex ; deliberate self-harm ; schizophrenia ; self-mutilation ; eye injury
Publishing date	2023-05-23
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Article ; Online
ISSN	2193-1496
ISSN (online)	2193-1496
DOI	10.3205/oc000219
Database	German Medical Science

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Article ; Online: Mn(II) Polypyridyl Complexes: Precursors to High Valent Mn(V)=O Species and Inhibitors of Cancer Cell Proliferation.

Arora, Pragya / Gupta, Sikha / Kumari Vechalapu, Sai / Kumar, Rakesh / Awasthi, Ayushi / Senthil, Sathyapriya / Khanna, Shweta / Allimuthu, Dharmaraja / Draksharapu, Apparao

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 53, Page(s) e202301506

Abstract: The reaction of [(L) ... ...

Abstract	The reaction of [(L)Mn
MeSH term(s)	Manganese/chemistry ; Ligands ; Chlorobenzoates ; Neoplasms
Chemical Substances	3-chloroperbenzoic acid (G203D4H1RB) ; Manganese (42Z2K6ZL8P) ; Ligands ; Chlorobenzoates
Language	English
Publishing date	2023-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301506
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