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  1. Book ; Thesis: Beitrag systematischer Übersichtsarbeiten zu klinischen Entscheidungsprozessen am Beispiel der pädiatrischen Onkologie und Hämatologie

    Peinemann, Frank

    = Impact of systematic reviews of health care interventions on medical decision making in pediatric oncology and hematology

    2015  

    Title variant Impact of systematic reviews of health care interventions on medical decision making in pediatric oncology and hematology
    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Dr. Dr. med. Frank Peinemann, M.Sc. ; aus der Klinik und Poliklinik für Kinder- und Jugendmedizin der Universität zu Köln
    Language German ; English
    Size 54 Seiten, 102 verschieden gezählte Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universität zu Köln, 2017
    Note Enthält Sonderabdrucke aus verschiedenen Zeitschriften in englischer Sprache ; Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT019505515
    Database Catalogue ZB MED Medicine, Health

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    2017 E 1749 order for loan Magazin

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  2. Book ; Online ; Thesis: Beitrag systematischer Übersichtsarbeiten zu klinischen Entscheidungsprozessen am Beispiel der pädiatrischen Onkologie und Hämatologie

    Peinemann, Frank

    = Impact of systematic reviews of health care interventions on medical decision making in pediatric oncology and hematology

    2015  

    Title variant Impact of systematic reviews of health care interventions on medical decision making in pediatric oncology and hematology
    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Dr. Dr. med. Frank Peinemann, M.Sc. ; aus der Klinik und Poliklinik für Kinder- und Jugendmedizin der Universität zu Köln
    Language German ; English
    Size 1 Online-Ressource (54 Seiten, 102 verschieden gezählte Seiten), Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universität zu Köln, 2017
    Note Enthält Sonderabdrucke aus verschiedenen Zeitschriften in englischer Sprache ; Zusammenfassung in deutscher und englischer Sprache ; Open Access
    HBZ-ID HT019427198
    DOI 10.4126/FRL01-006404089
    Database Repository for Life Sciences

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  3. Book ; Thesis: Klinische Wirksamkeit von Platelet-Rich Plasma (PRP) gegen androgenetischen Haarausfall

    Dervishi, Gezim / Peinemann, Frank / Moinzadeh, Pia

    eine systematische Übersichtsarbeit und Metaanalyse

    2021  

    Institution Klinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Gezim Dervishi ; 1. Gutachter: Privatdozent Dr. med. F. Peinemann, 2. Gutachterin: Professorin Dr. med. P. Moinzadeh ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln
    Subject code 610
    Language German ; English
    Size 111 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT021182862
    Database Catalogue ZB MED Medicine, Health

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    2021 D 709 order for loan Magazin

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  4. Article ; Online: Vakuumversiegelungstherapie von Wunden: randomisierte Studien von 2000 bis 2015.

    Peinemann, Frank

    Zentralblatt fur Chirurgie

    2017  Volume 142, Issue 3, Page(s) 267–274

    Abstract: ... ...

    Title translation Negative Pressure Wound Therapy: Randomised Controlled Trials from 2000 to 2015.
    Abstract Background
    MeSH term(s) Evidence-Based Medicine ; Humans ; Negative-Pressure Wound Therapy/methods ; Randomized Controlled Trials as Topic ; Research Design ; Wound Healing/physiology
    Language German
    Publishing date 2017-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/s-0043-104697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quality issues identified in systematic reviews on early laser intervention to reduce scar formation in wound healing.

    Peinemann, Frank / Behrouz-Pirnia, Armin

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2020  Volume 73, Issue 7, Page(s) 1357–1404

    MeSH term(s) Cicatrix ; Humans ; Lasers ; Wound Healing
    Language English
    Publishing date 2020-03-14
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2020.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Extracorporeal photopheresis for systemic sclerosis: A meta-analysis of randomized clinical trials.

    Delbrück, Claudia / Gambichler, Thilo / Susok, Laura / Peinemann, Frank

    Dermatologic therapy

    2022  Volume 35, Issue 7, Page(s) e15530

    Abstract: Systemic sclerosis (scleroderma) (SSc) is a rare autoimmune disorder characterized by excessive production of collagen. Extracorporeal photopheresis (photochemotherapy, phototherapy) (ECP) involves repeated exposure of peripheral blood lymphocytes to ... ...

    Abstract Systemic sclerosis (scleroderma) (SSc) is a rare autoimmune disorder characterized by excessive production of collagen. Extracorporeal photopheresis (photochemotherapy, phototherapy) (ECP) involves repeated exposure of peripheral blood lymphocytes to ultraviolet A (UVA) radiation. The rationale for treating patients with SSc by ECP lies in its presumed immunomodulatory effects, though, rigorous data on the specific effects of ECP are limited, particularly in patients with SSc. The objective was to evaluate the effects of extracorporeal photopheresis as a treatment modality for patients with SSc. We searched the databases CENTRAL and MEDLINE on 13 March 2022 and included randomized clinical trials (RCTs) on patients diagnosed with SSc and treated with ECP. Primary outcome was the change of skin scores. We applied independent extraction and judgment by multiple observers. We conducted a meta-analysis applying the inverse variance method and the random effects model; the main outcome measure was standard mean difference of skin scores. We identified three relevant RCTs including 162 randomized (132 analyzed) people who received ECP in a simple parallel design. Pooled data of the three studies were indifferent. We estimated a standard mean difference from baseline of -0.11 (95% confidence interval -0.45 to 0.23), p = 0.54, I
    MeSH term(s) Humans ; Photopheresis/adverse effects ; Photopheresis/methods ; Randomized Controlled Trials as Topic ; Scleroderma, Systemic/therapy ; Skin
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Vakuumversiegelungstherapie von Wunden: randomisierte Studien von 2000 bis 2015

    Peinemann, Frank

    Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie

    2017  Volume 142, Issue 03, Page(s) 267–274

    Abstract: Hintergrund: Die Vakuumversiegelungstherapie von Wunden (englisch: negative pressure wound therapy, NPWT) soll den Heilungsprozess der Wunde fördern. In randomisierten Studien (englisch: randomized controlled trials, RCT) werden hierzu widersprüchliche ... ...

    Abstract Hintergrund: Die Vakuumversiegelungstherapie von Wunden (englisch: negative pressure wound therapy, NPWT) soll den Heilungsprozess der Wunde fördern. In randomisierten Studien (englisch: randomized controlled trials, RCT) werden hierzu widersprüchliche Ergebnisse berichtet. Systematische Reviews berichten über eine unklare Evidenz auch aufgrund methodischer Schwächen der RCTs und fordern weitere und bessere RCTs.
    Methoden: Ein Ziel der Arbeit war, die Anzahl der RCTs und der systematischen Reviews randomisierter Studien zu ermitteln, die im Zeitraum von 2000 bis 2015 publiziert wurden. Als Literaturquelle dienten PubMed, die Cochrane Library, Google, Literaturverzeichnisse identifizierter Artikel und Herausgeber von Evidenzberichten. Ein weiteres Ziel war die Bewertung der Qualität der RCTs. Es wurde evaluiert, ob die Randomisierung nachvollziehbar beschrieben wurde und ob die Schlussfolgerung von akzeptablen Endpunkten abgeleitet wurde.
    Ergebnisse: Die Literaturrecherche ergab 456 verschiedene Referenzen, in denen 49 randomisierte Studien und 81 systematische Reviews identifiziert wurden. Die Randomisierung wurde in 37% (18 von 49 RCTs) und ihre Verdeckung in 10% (5 von 49 RCTs) nachvollziehbar berichtet. Die Schlussfolgerungen wurden in 55% (27 von 49 RCTs) von akzeptablen Endpunkten abgeleitet. In 65% (32 von 49 RCTs) wurde eine Überlegenheit der NPWT berichtet. Dieser Anteil betrug 16% (8 von 49 RCTs), wenn lediglich Studien mit akzeptablen Endpunkten berücksichtigt wurden. In den systematischen Reviews wurden wiederholt identische Studiendaten eingeschlossen.
    Schlussfolgerung: Im Verlauf von über 16 Jahren wurden mehr systematische Reviews mit Sekundärdaten aus RCTs publiziert als die eigentlichen RCTs, in denen die klinischen Primärdaten berichtet wurden. Die Qualität vieler RCTs erscheint gering und die Aussagekraft der Schlussfolgerungen wird dadurch erheblich eingeschränkt. Die Fortsetzung wenig glaubwürdiger RCTs und redundanter systematischer Reviews scheint dringende Fragen in der klinischen Praxis nicht überzeugend beantworten zu können. Eine Strategieänderung mit Fokussierung auf individuelle Eigenschaften der jeweiligen Person und spezifische Wunden sollte in Erwägung gezogen werden.
    Keywords Vakuumversiegelungstherapie von Wunden ; randomisierte Studien ; systematische Reviews ; evidenzbasierte Medizin ; systematic reviews ; evidence-based medicine ; randomised trials ; negative pressure wound therapy
    Language German
    Publishing date 2017-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/s-0043-104697
    Database Thieme publisher's database

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  8. Article ; Online: Thin-catheter Surfactant Application for Respiratory Distress Syndrome in Spontaneously Breathing Preterm Infants: A Meta-analysis of Randomized Clinical Trials.

    Kesler, Hanan / Lohmeier, Klaus / Hoehn, Thomas / Kribs, Angela / Peinemann, Frank

    Current pediatric reviews

    2022  Volume 18, Issue 4, Page(s) 286–300

    Abstract: Background: Surfactant application by a thin catheter represented by the term less invasive surfactant administration (LISA) for respiratory distress syndrome in spontaneously breathing preterm infants was developed as an alternative to endotracheal ... ...

    Abstract Background: Surfactant application by a thin catheter represented by the term less invasive surfactant administration (LISA) for respiratory distress syndrome in spontaneously breathing preterm infants was developed as an alternative to endotracheal intubation.
    Methods: We conducted a meta-analysis to assess the effects of LISA when compared to the socalled intubation-surfactant-extubation (INSURE) and the standard endotracheal intubation and mechanical ventilation (MV). The primary outcome was the composite incidence of death or bronchopulmonary dysplasia at a postmenstrual age of 36 weeks. The secondary outcome was the composite incidence of seven other severe adverse events. On 06 October 2021, we searched randomized clinical trials (RCTs) in PubMed, the Cochrane Library, ClinicalTrials.gov, and the ICTRP Registry.
    Results: We included 18 RCTs. The pooled data on the primary outcome favored LISA when compared to either INSURE (risk ratio 0.67; 95% CI, 0.51 to 0.88) or MV (risk ratio 0.78; 95% CI, 0.61 to 0.99). The pooled data on the second outcome also favored LISA when compared to INSURE (risk ratio 0.75; 95% CI, 0.60 to 0.94) and MV (risk ratio 0.73; 95% CI, 0.55 to 0.96).
    Conclusion: The findings showed that surfactant application by non-intubation respiratory support and the use of a thin catheter may decrease the composite risk of death or bronchopulmonary dysplasia. The included data support the view that LISA should be considered the preferred treatment option in eligible infants.
    MeSH term(s) Bronchopulmonary Dysplasia ; Catheters ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Pulmonary Surfactants ; Randomized Controlled Trials as Topic ; Respiratory Distress Syndrome, Newborn ; Surface-Active Agents
    Chemical Substances Pulmonary Surfactants ; Surface-Active Agents
    Language English
    Publishing date 2022-04-04
    Publishing country United Arab Emirates
    Document type Meta-Analysis
    ISSN 1875-6336
    ISSN (online) 1875-6336
    DOI 10.2174/1573396318666220404194857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quality issues identified in systematic reviews on platelet-rich plasma therapy for pattern hair loss-A method study.

    Peinemann, Frank / Dervishi, Gezim

    Journal of cosmetic dermatology

    2019  Volume 19, Issue 8, Page(s) 1918–1920

    Abstract: Background: Systematic reviews of healthcare interventions aim to evaluate the quality of clinical studies, but they might have quality issues in their own right.: Objective: We aimed to evaluate methodological inconsistencies in systematic reviews.!# ...

    Abstract Background: Systematic reviews of healthcare interventions aim to evaluate the quality of clinical studies, but they might have quality issues in their own right.
    Objective: We aimed to evaluate methodological inconsistencies in systematic reviews.
    Methods: We searched the database MEDLINE and included systematic reviews and/or meta-analyses on platelet-rich plasma therapy for pattern hair loss.
    Results: We identified 15 relevant systematic reviews and/or meta-analyses, and we identified various overt methodological inconsistencies in five of those systematic reviews. These inconsistencies concerned including duplicate data, mixing data from various study designs, misclassifying study designs and treatment comparisons, misinterpreting heterogeneity, and mistaking reporting standards.
    Conclusion: The identification of various inconsistencies in previous systematic reviews on platelet-rich plasma therapy for pattern hair loss should prompt future authors to consult the Cochrane Handbook and to implement the PRISMA statement.
    MeSH term(s) Alopecia/therapy ; Humans ; Platelet-Rich Plasma ; Research Design
    Language English
    Publishing date 2019-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13237
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    Zs.A 6539: Show issues Location:
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  10. Article ; Online: Varying results of early benefit assessment of newly approved pharmaceutical drugs in Germany from 2011 to 2017: A study based on federal joint committee data.

    Peinemann, Frank / Labeit, Alexander

    Journal of evidence-based medicine

    2019  Volume 12, Issue 1, Page(s) 9–15

    Abstract: Background: Since January 2011, the Federal Joint Committee (FJC) conducts early benefit assessments (EBA) of newly approved pharmaceutical drugs compared to appropriate standard therapies. The FJC commissions the Institute for Quality and Efficiency in ...

    Abstract Background: Since January 2011, the Federal Joint Committee (FJC) conducts early benefit assessments (EBA) of newly approved pharmaceutical drugs compared to appropriate standard therapies. The FJC commissions the Institute for Quality and Efficiency in Healthcare (IQEH) to prepare preliminary reports. We aimed to evaluate the extent, impact, and reason for different judgments on added benefit of both institutions.
    Methods: We searched EBA data on the FJC website and included completed procedures from 2011 to 2017. We conducted a quantitative analysis of the difference between FJC and IQEH on divergent judgments, a quantitative analysis of the impact of EBA on market withdrawal, and a qualitative analysis to identify potential factors contributing to divergent judgments.
    Results: FJC rated an added benefit in 30% (139 of 457) and IQEH in 22% (101 of 457) matching research questions (P = 0.004). In the aftermath of EBA, 28 pharmaceutical drugs were withdrawn from the German market. We identified three potential factors that might have contributed to the divergent judgments. IQEH used a unique threshold concept to define the rating, FJC conducted additional public hearings, and FJC showed more flexibility with adherence to stringent criteria and interpretation of results.
    Conclusions: FJC and IQEH differed significantly in their early benefit assessment. In response to negative EBA decisions, pharmaceutical companies withdrew a considerable number of medicines from the German market. The present work uncovers the subjectivity and possible variance inherent in benefit assessment, as the two institutions observe the same rules of procedure.
    MeSH term(s) Advisory Committees ; Cost-Benefit Analysis/methods ; Drug Approval ; Drug Costs ; Federal Government ; Germany ; Humans ; Pharmaceutical Preparations/economics ; Product Surveillance, Postmarketing/methods ; Time Factors
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2019-01-30
    Publishing country England
    Document type Journal Article
    ISSN 1756-5391
    ISSN (online) 1756-5391
    DOI 10.1111/jebm.12340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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