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Article ; Online: Prevalence of anemia among Saudi patients with solid cancers at diagnosis in King Faisal Hospital, Taif Province, Kingdom of Saudi Arabia.

Almehmadi, Mazen / Salih, Magdi / Elmissbah, Tariq E / Alsharif, Abdulaziz / Alsiwiehri, Naif / Alzahrani, Khalid / Shafie, Alaa / Dahlawi, Haytham

PloS one

2021 Volume 16, Issue 1, Page(s) e0246202

Abstract: ... diagnosed with solid malignancies at King Faisal Hospital in Taif Province, Kingdom of Saudi Arabia ...

Abstract	Objectives: The aim of this study was to estimate the prevalence of anemia among patients newly diagnosed with solid malignancies at King Faisal Hospital in Taif Province, Kingdom of Saudi Arabia. Methods: A descriptive, cross-sectional, hospital-based study was conducted from December 2017 to March 2020. A total of 320 patients newly diagnosed with solid malignancy were examined to assess anemia prevalence. Results: Of 320 patients with solid cancers, 245 (76.6%) were female and 75 (23.4%) were male. The median (interquartile range) age of 57 (45 ─ 66) years, range between 16 and 108 years. The types of cancer included were breast (29.1%), female genital tract (20.0%), colorectal (25.3%), head and neck (10.3%), urinary bladder (4.7%), prostate (5.0%), lung (2.5%), liver (2.2%) and lymphoma (0.9%). The prevalence of anemia at diagnosis of cancer was 44.1% across all cancer types. A higher anemia prevalence was noted in colorectal (n = 46/81, 56.8%) (p = 0.047). Conclusion: Patients with colorectal or female genital tract cancers had a higher anemia prevalence (56.8% and 43.8%, respectively) than did patients with other cancers.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anemia/diagnosis ; Anemia/epidemiology ; Female ; Hospitals ; Humans ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Prevalence ; Saudi Arabia/epidemiology
Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0246202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prevalence of anemia among Saudi patients with solid cancers at diagnosis in King Faisal Hospital, Taif Province, Kingdom of Saudi Arabia.

Mazen Almehmadi / Magdi Salih / Tariq E Elmissbah / Abdulaziz Alsharif / Naif Alsiwiehri / Khalid Alzahrani / Alaa Shafie / Haytham Dahlawi

PLoS ONE, Vol 16, Iss 1, p e

2021 Volume 0246202

Abstract: ... diagnosed with solid malignancies at King Faisal Hospital in Taif Province, Kingdom of Saudi Arabia. Methods ...

Abstract	Objectives The aim of this study was to estimate the prevalence of anemia among patients newly diagnosed with solid malignancies at King Faisal Hospital in Taif Province, Kingdom of Saudi Arabia. Methods A descriptive, cross-sectional, hospital-based study was conducted from December 2017 to March 2020. A total of 320 patients newly diagnosed with solid malignancy were examined to assess anemia prevalence. Results Of 320 patients with solid cancers, 245 (76.6%) were female and 75 (23.4%) were male. The median (interquartile range) age of 57 (45 ─ 66) years, range between 16 and 108 years. The types of cancer included were breast (29.1%), female genital tract (20.0%), colorectal (25.3%), head and neck (10.3%), urinary bladder (4.7%), prostate (5.0%), lung (2.5%), liver (2.2%) and lymphoma (0.9%). The prevalence of anemia at diagnosis of cancer was 44.1% across all cancer types. A higher anemia prevalence was noted in colorectal (n = 46/81, 56.8%) (p = 0.047). Conclusion Patients with colorectal or female genital tract cancers had a higher anemia prevalence (56.8% and 43.8%, respectively) than did patients with other cancers.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online ; E-Book: Role of exosomes in biological communication systems

Alzahrani, Faisal A. / Saadeldin, Islam M.

2021

Abstract: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ ... ...

Author's details	Faisal A. Alzahrani, Islam M. Saadeldin, editors
Abstract	This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
Keywords	Biochemical markers
Subject code	610.28
Language	English
Size	1 online resource (XII, 373 p. 34 illus., 30 illus. in color.)
Edition	1st ed. 2021.
Publisher	Springer
Publishing place	Gateway East, Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-6599-6 ; 981-15-6598-8 ; 978-981-15-6599-1 ; 978-981-15-6598-4
DOI	10.1007/978-981-15-6599-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Exploring the attitudes and practices of female doctors towards cervical cancer screening in primary health care centers.

Aldarmahi, Ahmed / Alzahrani, Hanan / Alqutub, Sulafah / Alzahrani, Faisal

Journal of medicine and life

2023 Volume 16, Issue 5, Page(s) 773–781

Abstract: Cervical cancer is a significant cause of female mortality worldwide, and early detection through regular screening is crucial for reducing mortality rates. However, in developing countries, the uptake of Pap smear tests (PST) is low, mostly due to ... ...

Abstract	Cervical cancer is a significant cause of female mortality worldwide, and early detection through regular screening is crucial for reducing mortality rates. However, in developing countries, the uptake of Pap smear tests (PST) is low, mostly due to cultural and social factors and a lack of knowledge. This cross-sectional study assessed knowledge, attitude, and practice of cervical cancer screening among practitioners working at primary healthcare centers in Saudi Arabia. Furthermore, the study aimed to identify the potential barriers that prevent female physicians from performing cervical cancer screening tests. A self-administrated, well-structured questionnaire was used to survey 95 female physicians, including residents, specialists, and consultants in several primary health care centers (PHCCs) in Jeddah managed by the Ministry of Health during September 2019. The results showed that 80% of participants knew about cervical cancer, and 97.8% were aware that PST is a screening tool. However, only 47% advised female patients to get tested for cervical cancer. The factors identified as barriers to test uptake included asymptomatic females (34%), lack of time on the part of the practitioner (24%), and a lack of evidence for risk factors (23%). Additionally, only 42.2% of the participating physicians had undergone a Pap smear test themselves. The study highlights the need for further research to assess HPV status in the population and explore the correlation between circumcision and cervical cancer, as well as polygamy and cervical cancer. The findings suggest that while a good level of knowledge about cervical cancer exists, there is a need to improve compliance with cervical cancer screening guidelines among female physicians in Saudi Arabia.
Language	English
Publishing date	2023-07-27
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3117 ; 1844-3109
ISSN (online)	1844-3117
ISSN	1844-3117 ; 1844-3109
DOI	10.25122/jml-2022-0344
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes against renal ischemia-reperfusion injury in rats.

Alzahrani, Faisal A

American journal of translational research

2019 Volume 11, Issue 5, Page(s) 2887–2907

Abstract: Renal ischemia-reperfusion injury (RIRI) is one of the main causes for acute kidney injury (AKI). Many previous attempts failed to adopt a suitable treatment regimen for AKI. Recently, combined melatonin (Mel) and mesenchymal stem cell (MSC)-derived ... ...

Abstract	Renal ischemia-reperfusion injury (RIRI) is one of the main causes for acute kidney injury (AKI). Many previous attempts failed to adopt a suitable treatment regimen for AKI. Recently, combined melatonin (Mel) and mesenchymal stem cell (MSC)-derived exosomes (Exo) therapy gave a promising therapeutic option for acute liver ischemic injury, however this treatment approach has not been tested against RIRI yet. This study tested the hypothesis that administration of exosomes derived from MSCs preconditioned with Mel gave best protection against RIRI as compared to therapy by MSCs or exosomes derived from non-preconditioned MSCs. Female adult rats (n = 60) equally divided into control group, sham group, RIRI group (induced by bilateral renal arteries clamping), RIRI + MSCs group (1 × 10
Language	English
Publishing date	2019-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synergistic effect of basic fibroblast growth factor (bFGF) and epidermal growth factor on derivation of camel (

Alzahrani, Faisal A

Zygote (Cambridge, England)

2019 Volume 27, Issue 4, Page(s) 255–258

Abstract: This study aimed to optimize the derivation of trophectoderm from in vitro-produced camel embryos under feeder-free culture conditions using the basement membrane matrix Matrigel. Trophoblastic vesicles were obtained through mechanical microdissection of ...

Abstract	This study aimed to optimize the derivation of trophectoderm from in vitro-produced camel embryos under feeder-free culture conditions using the basement membrane matrix Matrigel. Trophoblastic vesicles were obtained through mechanical microdissection of in vitro-produced camel (Camelus dromedarius) embryos. Supplementing the culture medium with 10 ng/ml of epidermal growth factor and 10 ng/ml fibroblast growth factor improved the attachment and subsequent outgrowths of cultured trophoblastic vesicles when compared with the control group and the groups supplemented individually with each growth factor. The expression levels of pluripotency genes octamer-binding transcription factor 4 (Oct4), sex determining region Y-box 2 (Sox2), myelocytomatosis proto-oncogene (c-Myc) and anti-apoptotic gene B-cell lymphoma 2 (Bcl2) were increased in trophoblastic vesicles supplemented with both growth factors when compared with the control group. Conversely, both growth factors decreased the expression of apoptotic genes tumour protein p53 (p53) and Bcl-2-associated X protein (Bax). To the best of our knowledge, this may be the first report describing the derivation of trophoblast stem cells from in vitro-produced camel embryos.
MeSH term(s)	Animals ; Camelus ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cells, Cultured ; Drug Synergism ; Embryo, Mammalian/cytology ; Embryo, Mammalian/drug effects ; Embryo, Mammalian/metabolism ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/drug effects ; Embryonic Stem Cells/metabolism ; Epidermal Growth Factor/pharmacology ; Female ; Fibroblast Growth Factor 2/pharmacology ; Gene Expression Regulation, Developmental/drug effects ; Octamer Transcription Factor-3/genetics ; Proto-Oncogene Proteins c-myb/genetics ; SOXB1 Transcription Factors/genetics ; Trophoblasts/cytology ; Trophoblasts/drug effects ; Trophoblasts/metabolism
Chemical Substances	Octamer Transcription Factor-3 ; Proto-Oncogene Proteins c-myb ; SOXB1 Transcription Factors ; Fibroblast Growth Factor 2 (103107-01-3) ; Epidermal Growth Factor (62229-50-9)
Language	English
Publishing date	2019-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1166294-3
ISSN	1469-8730 ; 0967-1994
ISSN (online)	1469-8730
ISSN	0967-1994
DOI	10.1017/S0967199419000169
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hyperintense Perilesional Edema on T1-Weighted Imaging in Cavernoma: A Case Report.

Alturki, Ibrahim A / Alluhidan, Tareq A / Alturki, Abdulrahman A / Alzahrani, Faisal S / Alluwaymi, Nawaf A

Cureus

2024 Volume 16, Issue 1, Page(s) e51454

Abstract: Cavernoma, also called a cavernous malformation, is a vascular malformation that happens during development. It tends to look like a berry-shaped lesion. In cerebral hemorrhagic cavernous malformations (cavernoma), T1-weighted imaging that shows ... ...

Abstract	Cavernoma, also called a cavernous malformation, is a vascular malformation that happens during development. It tends to look like a berry-shaped lesion. In cerebral hemorrhagic cavernous malformations (cavernoma), T1-weighted imaging that shows hyperintense perilesional edema in brain masses is an unusual radiological finding. This sign's association with cavernoma is gaining prominence. We present the case of a 35-year-old female patient without significant medical history who reported a seven-day history of left-side weakness that began in the upper limb, progressed to the lower limb, and was associated with nausea. The non-contrast T1- T1-weighted images displayed a gradient of hyperintense content of the lesion with surrounding relatively hyperintense perilesional edema. The patient consequently underwent surgery to evacuate the hematoma and excise the lesion, which went uneventfully.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recognition of Differentially Expressed Molecular Signatures and Pathways Associated with COVID-19 Poor Prognosis in Glioblastoma Patients.

Alzahrani, Faisal A / Khan, Mohd Faheem / Ahmad, Varish

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Glioblastoma (GBM) is a type of brain cancer that is typically very aggressive and difficult to treat. Glioblastoma cases have been reported to have increased during COVID-19. The mechanisms underlying this comorbidity, including genomic interactions, ... ...

Abstract	Glioblastoma (GBM) is a type of brain cancer that is typically very aggressive and difficult to treat. Glioblastoma cases have been reported to have increased during COVID-19. The mechanisms underlying this comorbidity, including genomic interactions, tumor differentiation, immune responses, and host defense, are not completely explained. Therefore, we intended to investigate the differentially expressed shared genes and therapeutic agents which are significant for these conditions by using in silico approaches. Gene expression datasets of GSE68848, GSE169158, and GSE4290 studies were collected and analyzed to identify the DEGs between the diseased and the control samples. Then, the ontology of the genes and the metabolic pathway enrichment analysis were carried out for the classified samples based on expression values. Protein-protein interactions (PPI) map were performed by STRING and fine-tuned by Cytoscape to screen the enriched gene module. In addition, the connectivity map was used for the prediction of potential drugs. As a result, 154 overexpressed and 234 under-expressed genes were identified as common DEGs. These genes were found to be significantly enriched in the pathways involved in viral diseases, NOD-like receptor signaling pathway, the cGMP-PKG signaling pathway, growth hormone synthesis, secretion, and action, the immune system, interferon signaling, and the neuronal system. STAT1, CXCL10, and SAMDL were screened out as the top 03 out of the top 10 most critical genes among the DEGs from the PPI network. AZD-8055, methotrexate, and ruxolitinib were predicted to be the possible agents for the treatment. The current study identified significant key genes, common metabolic signaling networks, and therapeutic agents to improve our perception of the common mechanisms of GBM-COVID-19.
MeSH term(s)	Humans ; Computational Biology ; COVID-19/diagnosis ; COVID-19/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Glioblastoma/complications ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Protein Interaction Maps/genetics ; Prognosis
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043562
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Retraction: Intussusception in Adults: A Rare Etiology of Small Intestinal Obstruction.

Alshahrani, Abdulwahab A / Alotaibi, Naif A / Alzahrani, Fahad K / Alaqidi, Meshal F / Alabbad, Faisal A / Alqarni, Mohammed A / Altwirki, Abdulah A / Alshabri, Meshari I / Al Dakheel, Khalid A / Faqihi, Essa J / Mijlad, Waleed K / Al-Hawaj, Faisal

Cureus

2024 Volume 16, Issue 1, Page(s) r117

Abstract: This retracts the article DOI: 10.7759/cureus.20502.]. ...

Abstract	[This retracts the article DOI: 10.7759/cureus.20502.].
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.r117
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Outcome of the Masquelet Technique for Complex Bilateral Distal Femoral Bone Defects.

Aljaafri, Ziad A / Alzahrani, Abdullah / Alshehri, Ali / AlHussain, Ahmed / Alzahrani, Faisal / Alsheikh, Khalid

Cureus

2023 Volume 15, Issue 5, Page(s) e38503

Abstract: Bone defects are severe conditions caused by various etiologies, including trauma, tumor resection, or chronic osteomyelitis. Different surgical interventions can be utilized to manage such cases, including autologous graft or allograft implantation, ... ...

Abstract	Bone defects are severe conditions caused by various etiologies, including trauma, tumor resection, or chronic osteomyelitis. Different surgical interventions can be utilized to manage such cases, including autologous graft or allograft implantation, distraction osteogenesis, acute shortening, amputation, or the induced membrane technique. Herein, the case of a 39-year-old woman with complex bilateral distal femoral fractures with intra-articular extension is presented. The fractures were accompanied by a significant metaphyseal bone defect, which was managed successfully using the induced membrane Masquelet technique. The patient fully healed despite residual knee joint contractures that did not inhibit her mobility. In conclusion, the Masquelet technique successfully manages complex bone defects and restores functionality even in bilateral simultaneous open bone defects.
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.38503
Database	MEDical Literature Analysis and Retrieval System OnLINE

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