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  1. Article ; Online: Cardiovascular magnetic resonance in the guidelines of the European Society of Cardiology: a comprehensive summary and update.

    von Knobelsdorff-Brenkenhoff, Florian / Schulz-Menger, Jeanette

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

    2023  Volume 25, Issue 1, Page(s) 42

    Abstract: Background: Cardiovascular magnetic resonance (CMR) has been established as a valuable tool in clinical and scientific cardiology. This study summarizes the current evidence and role of CMR in the guidelines of the European Society of Cardiology (ESC) ... ...

    Abstract Background: Cardiovascular magnetic resonance (CMR) has been established as a valuable tool in clinical and scientific cardiology. This study summarizes the current evidence and role of CMR in the guidelines of the European Society of Cardiology (ESC) and is an update of a former guideline analysis.
    Methods: Since the last guideline analysis performed in 2015, 28 new ESC guideline documents have been published. Twenty-seven ESC practice guidelines are currently in use. They were screened regarding CMR in the text, tables and figures. The main CMR-related sentences and recommendations were extracted.
    Results: Nineteen of the 27 guidelines (70.4%) contain relevant text passages regarding CMR in the text and include 92 specific recommendations regarding the use of CMR. Seven guidelines (25.9%) mention CMR in the text, and 1 (3.7%, dyslipidemia) does not mention CMR. The 19 guidelines with recommendations regarding the use of CMR contain 40 class-I recommendations (43.5%), 28 class-IIa recommendations (30.4%), 19 class-IIb recommendations (20.7%) and 5 class-III recommendations (5.4%). Most of the recommendations have evidence level C (56/92; 60.9%), followed by level B (34/92; 37.0%) and level A (2/92; 2.2%). Twenty-one recommendations refer to the field of cardiomyopathies, 21 recommendations to stress perfusion imaging, 20 recommendations to vascular assessment, 12 to myocardial tissue characterization in general, 8 to left and right ventricular function assessment, 5 to the pericardium and 5 to myocarditis.
    Conclusions: CMR is integral part of the majority of the ESC guidelines. Its representation in the guidelines has increased since the last analysis from 2015, now comprising 92 instead of formerly 63 specific recommendations. To enable patient management in accordance to the ESC guidelines, CMR must become more widely available.
    MeSH term(s) Humans ; Predictive Value of Tests ; Cardiology ; Magnetic Resonance Imaging/methods ; Heart ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1458034-2
    ISSN 1532-429X ; 1097-6647
    ISSN (online) 1532-429X
    ISSN 1097-6647
    DOI 10.1186/s12968-023-00950-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: Myokardiale Strain-Analyse mittels kardialer Magnetresonanztomographie

    Schunke, Tobias [Verfasser] / Knobelsdorff-Brenkenhoff, Florian von [Akademischer Betreuer]

    Einfluss von Signalintensität und räumlicher Auflösung

    2022  

    Author's details Tobias Schunke ; Betreuer: Florian von Knobelsdorff-Brenkenhoff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Advanced Assessment of Aortic Stenosis Reflecting the Complex Interplay of Valve, Ventricle, Vessel, and Flow.

    von Knobelsdorff-Brenkenhoff, Florian

    Circulation. Cardiovascular imaging

    2017  Volume 10, Issue 6

    MeSH term(s) Aortic Valve Stenosis ; Echocardiography ; Heart Ventricles ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2017-06-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.117.006594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Der Einfluss der räumlichen Auflösung und der Kontrastmitteldosis auf die kardiale T 1-Relaxationszeit bei der kardialen Magnetresonanztomographie

    Wanke, Felix [Verfasser] / Knobelsdorff, Florian von [Akademischer Betreuer]

    2020  

    Author's details Felix Wanke ; Betreuer: Florian von Knobelsdorff
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article: Changes of aortic hemodynamics after aortic valve replacement-A four dimensional flow cardiovascular magnetic resonance follow up study.

    Wiesemann, Stephanie / Trauzeddel, Ralf Felix / Musa, Ahmed / Hickstein, Richard / Mayr, Thomas / von Knobelsdorff-Brenkenhoff, Florian / Bollache, Emilie / Markl, Michael / Schulz-Menger, Jeanette

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1071643

    Abstract: Objectives: Non-invasive assessment of aortic hemodynamics using four dimensional (4D) flow magnetic resonance imaging (MRI) provides new information on blood flow patterns and wall shear stress (WSS). Aortic valve stenosis (AS) and/or bicuspid aortic ... ...

    Abstract Objectives: Non-invasive assessment of aortic hemodynamics using four dimensional (4D) flow magnetic resonance imaging (MRI) provides new information on blood flow patterns and wall shear stress (WSS). Aortic valve stenosis (AS) and/or bicuspid aortic valves (BAV) are associated with altered aortic flow patterns and elevated WSS. Aim of this study was to investigate changes in aortic hemodynamics over time in patients with AS and/or BAV with or without aortic valve replacement.
    Methods: We rescheduled 20 patients for a second 4D flow MRI examination, whose first examination was at least 3 years prior. A total of 7 patients received an aortic valve replacement between baseline and follow up examination (=operated group = OP group). Aortic flow patterns (helicity/vorticity) were assessed using a semi-quantitative grading approach from 0 to 3, flow volumes were evaluated in 9 planes, WSS in 18 and peak velocity in 3 areas.
    Results: While most patients had vortical and/or helical flow formations within the aorta, there was no significant change over time. Ascending aortic forward flow volumes were significantly lower in the OP group than in the NOP group at baseline (NOP 69.3 mL ± 14.2 mL vs. OP 55.3 mL ± 1.9 mL
    Conclusion: Aortic valve replacement influences aortic hemodynamics. The parameters improve after surgery.
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1071643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multi-site comparison of parametric T1 and T2 mapping: healthy travelling volunteers in the Berlin research network for cardiovascular magnetic resonance (BER-CMR).

    Gröschel, Jan / Trauzeddel, Ralf-Felix / Müller, Maximilian / von Knobelsdorff-Brenkenhoff, Florian / Viezzer, Darian / Hadler, Thomas / Blaszczyk, Edyta / Daud, Elias / Schulz-Menger, Jeanette

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

    2023  Volume 25, Issue 1, Page(s) 47

    Abstract: Background: Parametric mapping sequences in cardiovascular magnetic resonance (CMR) allow for non-invasive myocardial tissue characterization. However quantitative myocardial mapping is still limited by the need for local reference values. Confounders, ... ...

    Abstract Background: Parametric mapping sequences in cardiovascular magnetic resonance (CMR) allow for non-invasive myocardial tissue characterization. However quantitative myocardial mapping is still limited by the need for local reference values. Confounders, such as field strength, vendors and sequences, make intersite comparisons challenging. This exploratory study aims to assess whether multi-site studies that control confounding factors provide first insights whether parametric mapping values are within pre-defined tolerance ranges across scanners and sites.
    Methods: A cohort of 20 healthy travelling volunteers was prospectively scanned at three sites with a 3 T scanner from the same vendor using the same scanning protocol and acquisition scheme. A Modified Look-Locker inversion recovery sequence (MOLLI) for T1 and a fast low-angle shot sequence (FLASH) for T2 were used. At one site a scan-rescan was performed to assess the intra-scanner reproducibility. All acquired T1- and T2-mappings were analyzed in a core laboratory using the same post-processing approach and software.
    Results: After exclusion of one volunteer due to an accidentally diagnosed cardiac disease, T1- and T2-maps of 19 volunteers showed no significant differences between the 3 T sites (mean ± SD [95% confidence interval] for global T1 in ms: site I: 1207 ± 32 [1192-1222]; site II: 1207 ± 40 [1184-1225]; site III: 1219 ± 26 [1207-1232]; p = 0.067; for global T2 in ms: site I: 40 ± 2 [39-41]; site II: 40 ± 1 [39-41]; site III 39 ± 2 [39-41]; p = 0.543).
    Conclusion: Parametric mapping results displayed initial hints at a sufficient similarity between sites when confounders, such as field strength, vendor diversity, acquisition schemes and post-processing analysis are harmonized. This finding needs to be confirmed in a powered clinical trial. Trial registration ISRCTN14627679 (retrospectively registered).
    MeSH term(s) Humans ; Berlin ; Reproducibility of Results ; Predictive Value of Tests ; Magnetic Resonance Imaging ; Healthy Volunteers ; Volunteers ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1458034-2
    ISSN 1532-429X ; 1097-6647
    ISSN (online) 1532-429X
    ISSN 1097-6647
    DOI 10.1186/s12968-023-00954-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Influence of contrast agent and spatial resolution on myocardial strain results using feature tracking MRI.

    von Knobelsdorff-Brenkenhoff, Florian / Schunke, Tobias / Reiter, Stephanie / Scheck, Roland / Höfling, Berthold / Pilz, Günter

    European radiology

    2020  Volume 30, Issue 11, Page(s) 6099–6108

    Abstract: Objectives: Feature tracking for assessing myocardial strain from cardiac magnetic resonance (CMR) cine images detects myocardial deformation abnormalities with prognostic implication, e.g., in myocardial infarction and cardiomyopathy. Standards for ... ...

    Abstract Objectives: Feature tracking for assessing myocardial strain from cardiac magnetic resonance (CMR) cine images detects myocardial deformation abnormalities with prognostic implication, e.g., in myocardial infarction and cardiomyopathy. Standards for image acquisition and processing are not yet available. Study aim was analyzing the influence of spatial resolution and contrast agent on myocardial strain results.
    Methods: Seventy-five patients underwent CMR for analyzing peak systolic circumferential, longitudinal, and radial strain. Group A included n = 50 with normal left ventricular ejection fraction, no wall motion abnormality, and no fibrosis on late enhancement imaging. Group B included n = 25 with chronic myocardial infarct. For feature tracking, steady-state free precession cine images were acquired repeatedly. (1) Native standard cine (spatial resolution 1.4 × 1.4 × 8 mm
    Results: Lower spatial resolution was associated with elevated longitudinal strain (- 21.7% vs. - 19.8%; p < 0.001) in viable myocardium in group A, and with elevated longitudinal (- 17.0% vs. - 14.3%; p = 0.001), circumferential (- 18.6% vs. - 14.6%; p = 0.002), and radial strain (36.8% vs. 31.0%; p = 0.013) in infarcted myocardium in group B. Gadolinium administration was associated with reduced circumferential (- 21.4% vs. - 22.3%; p = 0.001) and radial strain (44.4% vs. 46.9%; p = 0.016) in group A, whereas strain results of the infarcted tissue in group B did not change after contrast agent administration.
    Conclusions: Variations in spatial resolution and the administration of contrast agent may influence myocardial strain results in viable and partly in infarcted myocardium. Standardized image acquisition seems important for CMR feature tracking.
    Key points: • Feature tracking is used for calculating myocardial strain from cardiac magnetic resonance (CMR) cine images. • This prospective study demonstrated that CMR strain results may be influenced by spatial resolution and by the administration of gadolinium-based contrast agent. • The results underline the need for standardized image acquisition for CMR strain analysis, with constant imaging parameters and without contrast agent.
    MeSH term(s) Aged ; Cardiomyopathies/diagnosis ; Cardiomyopathies/physiopathology ; Contrast Media/pharmacology ; Female ; Fibrosis/diagnosis ; Fibrosis/physiopathology ; Humans ; Magnetic Resonance Imaging, Cine/methods ; Male ; Middle Aged ; Myocardium/pathology ; Prospective Studies ; Ventricular Function, Left/physiology
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-05-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-06971-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction to: Subclinical myocardial injury in patients with Facioscapulohumeral muscular dystrophy 1 and preserved ejection fraction - assessment by cardiovascular magnetic resonance.

    Blaszczyk, Edyta / Grieben, Ulrike / von Knobelsdorff-Brenkenhoff, Florian / Kellman, Peter / Schmacht, Luisa / Funk, Stephanie / Spuler, Simone / Schulz-Menger, Jeanette

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

    2019  Volume 21, Issue 1, Page(s) 32

    Abstract: In the original version of this article [1], published on 29 April 2019, there is 1 error in the 'Method' section of the article. ...

    Abstract In the original version of this article [1], published on 29 April 2019, there is 1 error in the 'Method' section of the article.
    Language English
    Publishing date 2019-06-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1458034-2
    ISSN 1532-429X ; 1097-6647
    ISSN (online) 1532-429X
    ISSN 1097-6647
    DOI 10.1186/s12968-019-0541-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quantification of myocardial strain assessed by cardiovascular magnetic resonance feature tracking in healthy subjects-influence of segmentation and analysis software.

    Lim, Carolin / Blaszczyk, Edyta / Riazy, Leili / Wiesemann, Stephanie / Schüler, Johannes / von Knobelsdorff-Brenkenhoff, Florian / Schulz-Menger, Jeanette

    European radiology

    2020  Volume 31, Issue 6, Page(s) 3962–3972

    Abstract: Objectives: Quantification of myocardial deformation by feature tracking is of growing interest in cardiovascular magnetic resonance. It allows the assessment of regional myocardial function based on cine images. However, image acquisition, post- ... ...

    Abstract Objectives: Quantification of myocardial deformation by feature tracking is of growing interest in cardiovascular magnetic resonance. It allows the assessment of regional myocardial function based on cine images. However, image acquisition, post-processing, and interpretation are not standardized. We aimed to assess the influence of segmentation procedure such as slice selection and different types of analysis software on values and quantification of myocardial strain in healthy adults.
    Methods: Healthy volunteers were retrospectively analyzed. Post-processing was performed using CVI
    Results: We screened healthy volunteers studied at 1.5 or 3.0 T and included 67 (age 44.3 ± 16.3 years, 31 females). Circumferential and radial
    Conclusions: Myocardial deformation assessed by feature tracking depends on segmentation procedure and type of analysis software. Circumferential
    MeSH term(s) Adult ; Female ; Healthy Volunteers ; Humans ; Magnetic Resonance Imaging, Cine ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Software ; Ventricular Function, Left
    Language English
    Publishing date 2020-12-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-07539-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Role of cardiovascular magnetic resonance in the guidelines of the European Society of Cardiology.

    von Knobelsdorff-Brenkenhoff, Florian / Schulz-Menger, Jeanette

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

    2016  Volume 18, Page(s) 6

    Abstract: Background: Despite common enthusiasm for cardiovascular magnetic resonance (CMR), its application in Europe is quite diverse. Restrictions are attributed to a number of factors, like limited access, deficits in training, and incomplete reimbursement. ... ...

    Abstract Background: Despite common enthusiasm for cardiovascular magnetic resonance (CMR), its application in Europe is quite diverse. Restrictions are attributed to a number of factors, like limited access, deficits in training, and incomplete reimbursement. Aim of this study is to perform a systematic summary of the representation of CMR in the guidelines of the European Society of Cardiology (ESC).
    Methods: Twenty-nine ESC guidelines were screened for the terms "magnetic", "MRI", "CMR", "MR" and "imaging". As 3 topics were published twice (endocarditis, pulmonary hypertension, NSTEMI), 26 guidelines were finally included. MRI in the context of non-cardiovascular examinations was not recognized. The main CMR-related conclusions and, if available, the level of evidence and the class of recommendation were extracted.
    Results: Fourteen of the 26 guidelines (53.8%) contain specific recommendations regarding the use of CMR. Nine guidelines (34.6%) mention CMR in the text, and 3 (11.5%) do not mention CMR. The 14 guidelines with recommendations regarding the use of CMR contain 39 class-I recommendations, 12 class-IIa recommendations, 10 class-IIb recommendations and 2 class-III recommendations. Most of the recommendations have evidence level C (41/63; 65.1%), followed by level B (16/63; 25.4%) and level A (6/63; 9.5%). The four guidelines, which absolutely contained most recommendations for CMR, were stable coronary artery disease (n = 14), aortic diseases (n = 9), HCM (n = 7) and myocardial revascularization (n = 7).
    Conclusions: CMR is represented in the majority of the ESC guidelines. They contain many recommendations in favour of the use of CMR in specific scenarios. Issues regarding access, training and reimbursement have to be solved to offer CMR to patients in accordance with the ESC guidelines.
    MeSH term(s) Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/physiopathology ; Consensus ; Europe ; Evidence-Based Medicine/standards ; Humans ; Magnetic Resonance Imaging/standards ; Practice Guidelines as Topic/standards ; Predictive Value of Tests ; Societies, Medical/standards
    Language English
    Publishing date 2016-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1458034-2
    ISSN 1532-429X ; 1097-6647
    ISSN (online) 1532-429X
    ISSN 1097-6647
    DOI 10.1186/s12968-016-0225-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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