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Article ; Online: The Fast and the Furious: Chasing a Clinical Niche for COVID-19 Convalescent Plasma.

Baker, Jason V / Lane, H Clifford

2022 Volume 175, Issue 9, Page(s) 1332–1334

MeSH term(s)	COVID-19/therapy ; Humans ; Immunization, Passive ; SARS-CoV-2 ; Treatment Outcome
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M22-2329
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Ua VI Zs.178/2: Show issues

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Article ; Online: Sexual Racism on Geosocial Networking Applications and Identity Outness Among Sexual Minority Men in the US.

Ma, Junye / Paltin, Dafna / Miller-Perusse, Michael / Black, Ashley / Baker, Jason V / Horvath, Keith J

Journal of homosexuality

2024 , Page(s) 1–17

Abstract: Although the use ... ...

Abstract	Although the use of
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	193138-6
ISSN	1540-3602 ; 0091-8369
ISSN (online)	1540-3602
ISSN	0091-8369
DOI	10.1080/00918369.2024.2319621
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Zs.A 1141: Show issues

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Article ; Online: Cardiovascular Disease Among Persons Living With HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context.

Ntsekhe, Mpiko / Baker, Jason V

Circulation

2022 Volume 147, Issue 1, Page(s) 83–100

Abstract: Widespread use of contemporary antiretroviral therapy globally has transformed HIV disease into a chronic illness associated with excess risk for disorders of the heart and circulatory system. Current clinical care and research has focused on improving ... ...

Abstract	Widespread use of contemporary antiretroviral therapy globally has transformed HIV disease into a chronic illness associated with excess risk for disorders of the heart and circulatory system. Current clinical care and research has focused on improving HIV-related cardiovascular disease outcomes, survival, and quality of life. In high-income countries, emphasis on prevention of atherosclerotic coronary artery disease over the past decade, including aggressive management of traditional risk factors and earlier initiation of antiretroviral therapy, has reduced risk for myocardial infarction among persons living with human immunodeficiency virus-1 infection. Still, across the globe, persons living with human immunodeficiency virus-1 infection on effective antiretroviral therapy treatment remain at increased risk for ischemic outcomes such as myocardial infarction and stroke relative to the persons without HIV. Unique features of HIV-related cardiovascular disease, in part, include the pathogenesis of coronary disease characterized by remodeling ectasia and unusual plaque morphology, the relative high proportion of type 2 myocardial infarction events, abnormalities of the aorta such as aneurysms and diffuse aortic inflammation, and HIV cerebrovasculopathy as a contributor to stroke risk. Literature over the past decade has also reflected a shift in the profile and prevalence of HIV-associated heart failure, with a reduced but persistent risk of heart failure with reduced ejection fraction and a growing risk of heart failure with preserved ejection fraction. Cardiac magnetic resonance imaging and autopsy data have emphasized the central importance of intramyocardial fibrosis for the pathogenesis of both heart failure with preserved ejection fraction and the increase in risk of sudden cardiac death. Still, more research is needed to better characterize the underlying mechanisms and clinical phenotype of HIV-associated myocardial disease in the current era. Across the different cardiovascular disease manifestations, a common pathogenic feature is that HIV-associated inflammation working through different mechanisms may amplify underlying pathology because of traditional risk and other host factors. The prevalence and phenotype of individual cardiovascular disease manifestations is ultimately influenced by the degree of injury from HIV disease combined with the profile of underlying cardiometabolic factors, both of which may differ substantially by region globally.
MeSH term(s)	Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Quality of Life ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Risk Factors ; Heart Failure/pathology ; Myocardial Infarction/complications ; Coronary Artery Disease/complications ; Myocardium/pathology ; Stroke/complications ; Inflammation/complications
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.122.057443
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Ui IV Zs.60: Show issues

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Article ; Online: Opportunities for Re-Engaging Persons with HIV in Care at a Health Care System in Minneapolis, Minnesota.

Shearer, Riley D / Lundberg, William J / Baker, Jason V / Vickery, Katherine Diaz

AIDS patient care and STDs

2022 Volume 36, Issue 3, Page(s) 83–85

MeSH term(s)	Delivery of Health Care ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Minnesota/epidemiology
Language	English
Publishing date	2022-02-17
Publishing country	United States
Document type	Letter
ZDB-ID	1326868-5
ISSN	1557-7449 ; 0893-5068 ; 1087-2914
ISSN (online)	1557-7449
ISSN	0893-5068 ; 1087-2914
DOI	10.1089/apc.2021.0211
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Zs.A 2328: Show issues

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Article ; Online: Prospective association of screen time with binge-eating disorder among adolescents in the United States: The mediating role of depression.

Al-Shoaibi, Abubakr A A / Shao, Iris Yuefan / Ganson, Kyle T / Lavender, Jason M / Testa, Alexander / Kiss, Orsolya / He, Jinbo / Glidden, David V / Baker, Fiona C / Nagata, Jason M

The International journal of eating disorders

2024

Abstract: Objective: Screen time has been reported to be associated with binge-eating disorder (BED) among adolescents in the US; however, potential mediators remain unclear. This study aimed to evaluate depression symptoms as a mediator of the prospective ... ...

Abstract	Objective: Screen time has been reported to be associated with binge-eating disorder (BED) among adolescents in the US; however, potential mediators remain unclear. This study aimed to evaluate depression symptoms as a mediator of the prospective association between screen time and BED. Method: We utilized data from 9465 children (aged 9-11 years at baseline) from the Adolescent Brain Cognitive Development (ABCD) study (2016-2021). A generalized structural equation model was used to examine the prospective association between average daily screen time at baseline and BED at year 2, adjusting for baseline BED diagnosis, and other potential covariates (e.g., age, sex, and income). Mediation was examined using bias-corrected (BC) 95% confidence intervals for the indirect effect of baseline screen time on year 2 BED through depression symptoms (change from baseline to year 1). Results: One hundred and one participants (42.7% male, 49.4% racial/ethnic minority) met the criteria for BED in year 2. Participants were 9.9 years of age on average at baseline, 51.3% identified as male, and 43.1% identified as a racial/ethnic minority. Adjusting for covariates, screen time was prospectively associated with BED (OR = 1.09, 95% CI [1.03, 1.14], p = .005). Depression symptoms (B = .19, BC 95% CI [0.10, 0.28]) partially mediated (9.2%) the prospective association between screen time and BED. Discussion: Among US adolescents, higher baseline screen time was prospectively associated with BED diagnosis at year 2, and this relationship was partially mediated by increased depression symptoms. Preventive approaches targeting high screen use may have utility for reducing BED risk among adolescents. Public significance: Among U.S. adolescents, higher screen time was prospectively associated with the incidence of BED. This association was partially mediated by the change in depressive symptoms. Preventive approaches targeting high screen use may have utility for reducing BED risk among adolescents.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	603170-5
ISSN	1098-108X ; 0276-3478
ISSN (online)	1098-108X
ISSN	0276-3478
DOI	10.1002/eat.24169
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Zs.A 1749: Show issues

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Article ; Online: The Use of Daily and On-Demand Oral Pre-Exposure Prophylaxis Dosing Strategies Among Young Adult Gay, Bisexual and Other Men who have Sex with Men Enrolled in an mHealth Adherence Intervention.

Horvath, Keith J / Ma, Junye / Storholm, Erik D / Black, Ashley / Klaphake, Jonathan / Baker, Jason V

AIDS and behavior

2023 Volume 27, Issue 11, Page(s) 3632–3644

Abstract: Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention option for gay, bisexual and other men who have sex with men (GBMSM). However, with newer PrEP options, a greater understanding of whether and why GBMSM switch dosing strategies is ... ...

Abstract	Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention option for gay, bisexual and other men who have sex with men (GBMSM). However, with newer PrEP options, a greater understanding of whether and why GBMSM switch dosing strategies is needed to inform clinical practice and research. We assessed the dosing strategies (daily or on-demand) of GBMSM enrolled in an mHealth PrEP adherence pilot intervention at four timepoints over approximately 10 months. Among GBMSM with complete data (n = 66), a consistent daily dosing strategy was used by most (73%) participants across all time points, while on-demand PrEP was used at least once during the study period by 27% of participants. A higher percentage of on-demand PrEP users self-reported as Asian/Pacific Islander and had less positive attitudes toward PrEP, adjusting for key sociodemographic variables and intervention arm. Daily PrEP users reported high numbers of sexual partners, and the primary reason that they would switch to on-demand PrEP is reduced sexual activity. At the final assessment, 75% of participants were taking daily PrEP, of whom 27% reported that they would like to switch to another option, including on-demand and long-acting injectable PrEP. While findings were largely descriptive, they showed that switches in PrEP dosing strategies are relatively common and PrEP strategy choice may vary across racial and ethnic groups.
MeSH term(s)	Male ; Humans ; Young Adult ; Sexual and Gender Minorities ; Homosexuality, Male ; Pre-Exposure Prophylaxis ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Sexual Behavior
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-023-04077-1
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Zs.A 6451: Show issues

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Article ; Online: Assessing inflammation and its role in comorbidities among persons living with HIV.

Peterson, Tess E / Baker, Jason V

Current opinion in infectious diseases

2018 Volume 32, Issue 1, Page(s) 8–15

Abstract: Purpose of review: This article describes the use of biomarkers in expanding our understanding of chronic non-AIDS comorbidities among persons living with HIV (PLWH) receiving antiretroviral therapy (ART).: Recent findings: We review current evidence ...

Abstract	Purpose of review: This article describes the use of biomarkers in expanding our understanding of chronic non-AIDS comorbidities among persons living with HIV (PLWH) receiving antiretroviral therapy (ART). Recent findings: We review current evidence that biomarkers of chronic immune activation and inflammation associate with a broad spectrum of end-organ diseases in PLWH. We discuss how ART may impact inflammation associated with HIV infection and the degree to which inflammation persists despite effective suppression of viral replication in plasma. We then discuss the limitations of the current literature, which lacks evidence of causality and disproportionately involves a few protein biomarkers that are unable to disentangle complex and overlapping biological pathways. Summary: Premature end-organ disease among PLWH has been repeatedly associated with higher levels of blood biomarkers reflecting inflammation and immune activation, which, despite viral suppression and CD4 T-cell increases after ART treatment, remain elevated relative to uninfected persons. There remain important unanswered questions with implications for the development of anti-inflammatory treatment strategies aimed at mitigating excess risk for end-organ comorbidities among PLWH.
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Biomarkers/blood ; Comorbidity ; HIV Infections/blood ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Inflammation/blood ; Inflammation/metabolism ; Viral Load
Chemical Substances	Anti-HIV Agents ; Biomarkers
Language	English
Publishing date	2018-11-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000510
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Zs.A 2462: Show issues

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Article ; Online: Lactic acid levels are associated with morbidity, length of stay, and total treatment costs in urban trauma patients with lower extremity long bone fractures.

Oladipo, Victoria / Portney, Daniel / Haber, Jordan / Baker, Hayden / Strelzow, Jason

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

2024

Abstract: Introduction: Lactic acid is well studied in the trauma population and is frequently used as a laboratory indicator that correlates with resuscitation status and has thus been associated with patient outcomes. There is limited literature that assesses ... ...

Abstract	Introduction: Lactic acid is well studied in the trauma population and is frequently used as a laboratory indicator that correlates with resuscitation status and has thus been associated with patient outcomes. There is limited literature that assesses the association of initial lactic acid with post-operative morbidity and hospitalization costs in the orthopedic literature. The purpose of this study was to assess the association of lactic acid levels and alcohol levels post-operative morbidity, length of stay and admission costs in a cohort of operative lower extremity long bone fractures, and to compare these effects in the ballistic and blunt trauma sub-population. Methods: Patients presenting as trauma activations who underwent tibial and/or femoral fixation at a single institution from May 2018 to August 2020 were divided based on initial lactate level into normal, (< 2.5) intermediate (2.5-4.0), and high (> 4.0). Mechanism of trauma (blunt vs. ballistic) was also stratified for analysis. Data on other injuries, surgical timing, level of care, direct hospitalization costs, length of stay, and discharge disposition were collected from the electronic medical record. The primary outcome assessed was post-operative morbidity defined as in-hospital mortality or unanticipated escalation of care. Secondary outcomes included hospital costs, lengths of stay, and discharge disposition. Data were analyzed using ANOVA and multivariate regression. Results: A total of 401 patients met inclusions criteria. Average age was 34.1 ± 13.0 years old, with patients remaining hospitalized for 8.8 ± 9.5 days, and 35.2% requiring ICU care during their hospitalization. Patients in the ballistic cohort were younger, had fewer other injuries and had higher lactate levels (4.0 ± 2.4) than in the blunt trauma cohort (3.4 ± 1.9) (p = 0.004). On multivariate regression, higher lactate was associated with post-operative morbidity (p = 0.015), as was age (p < 0.001) and BMI (p = 0.033). ISS, ballistic versus blunt injury mechanism, and other included laboratory markers were not. Lactate was also associated with longer lengths of stay, and higher associated direct hospitalization cost (p < 0.001) and lower rates of home disposition (p = 0.008). Conclusion: High initial lactate levels are independently associated with post-operative morbidity as well as higher direct hospitalization costs and longer lengths of stay in orthopedic trauma patients who underwent fixation for fractures of the lower extremity long bones. Ballistic trauma patients had significantly higher lactate levels compared to the blunt cohort, and lactate was not independently associated with increased rates of post-operative morbidity in the ballistic cohort alone. Level of evidence: III.
Language	English
Publishing date	2024-03-14
Publishing country	France
Document type	Journal Article
ZDB-ID	1231084-0
ISSN	1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
ISSN (online)	1432-1068
ISSN	1633-8065 ; 0948-4817 ; 0940-3264
DOI	10.1007/s00590-024-03877-y
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Zs.A 3479: Show issues

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Article ; Online: Attitudes Toward and Beliefs in the Effectiveness of Biomedical HIV Prevention Strategies Among Emerging and Young Adult Sexual Minority Men.

Ma, Junye / Chase, Gregory E / Black, Ashley / Klaphake, Jonathan / Garcia-Myers, Kelly / Baker, Jason V / Horvath, Keith J

International journal of behavioral medicine

2023

Abstract: Background: Pre-exposure prophylaxis (PrEP) and HIV treatment as prevention, which underlies the Undetectable = Untransmittable (U = U) campaign, are two effective biomedical approaches for HIV prevention among sexual minority men (SMM). Attitudes ... ...

Abstract	Background: Pre-exposure prophylaxis (PrEP) and HIV treatment as prevention, which underlies the Undetectable = Untransmittable (U = U) campaign, are two effective biomedical approaches for HIV prevention among sexual minority men (SMM). Attitudes toward PrEP and U = U may differ between SMM emerging adults (EA: 18-24 years old) and young adults (YA: 25-29 years old) to drive differences in sexual behavior. However, to date, few studies assessed the degree to which YAs and EAs differ in their beliefs in the effectiveness of PrEP and U = U. Method: A national sample of 80 SMM in the USA (M Results: Compared to EAs, higher proportions of YAs trusted PrEP's effectiveness and considered condom use unnecessary after taking PrEP. More YAs than EAs were willing to engage in sexual behaviors that they felt too risky before learning about U = U and were more comfortable having condomless sex with HIV-positive partners. Conversely, a greater proportion of EAs than YAs preferred to use condoms even when their partners are on anti-HIV medications. Conclusion: Overall, YAs trusted the effectiveness of U = U and PrEP more than EAs, underscoring developmental differences in SMM's perspectives on biomedical HIV prevention tools. Our findings underscore the importance of tailoring messages on biomedical HIV prevention options differently for EAs and YAs to optimize uptake.
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1187972-5
ISSN	1532-7558 ; 1070-5503
ISSN (online)	1532-7558
ISSN	1070-5503
DOI	10.1007/s12529-023-10244-4
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Zs.A 5090: Show issues

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Article ; Online: Predictive Dosimetry and Outcomes of Hepatocellular Carcinoma Treated by Yttrium-90 Resin Microsphere Radioembolization: A Retrospective Analysis Using Technetium-99m Macroaggregated Albumin SPECT/CT and Planning Software.

Doyle, Patrick W / Workman, C Spencer / Grice, Jared V / McGonigle, Trey W / Huang, Shi / Borgmann, Anthony J / Baker, Jennifer C / Duncan, David P / Taylor, Jason E / Brown, Daniel B

Journal of vascular and interventional radiology : JVIR

2024 Volume 35, Issue 5, Page(s) 689–698.e3

Abstract: Purpose: To characterize estimated mean absorbed tumor dose (AD: Materials and methods: In this retrospective, single-center study, multicompartment dosimetry of index tumors receiving : Results: The median follow-up period was 148 days ( ... ...

Abstract	Purpose: To characterize estimated mean absorbed tumor dose (AD Materials and methods: In this retrospective, single-center study, multicompartment dosimetry of index tumors receiving Results: The median follow-up period was 148 days (interquartile range [IQR], 92-273 days). The median AD Conclusions: For HCC treated with resin microspheres, tumors receiving higher AD
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/therapy ; Liver Neoplasms/pathology ; Liver Neoplasms/mortality ; Retrospective Studies ; Yttrium Radioisotopes/administration & dosage ; Yttrium Radioisotopes/adverse effects ; Male ; Female ; Middle Aged ; Radiopharmaceuticals/administration & dosage ; Radiopharmaceuticals/adverse effects ; Aged ; Embolization, Therapeutic/adverse effects ; Technetium Tc 99m Aggregated Albumin/administration & dosage ; Treatment Outcome ; Microspheres ; Single Photon Emission Computed Tomography Computed Tomography ; Predictive Value of Tests ; Time Factors ; Radiotherapy Planning, Computer-Assisted ; Aged, 80 and over ; Software ; Radiotherapy Dosage ; Adult
Chemical Substances	Yttrium Radioisotopes ; Radiopharmaceuticals ; Technetium Tc 99m Aggregated Albumin ; Yttrium-90 (1K8M7UR6O1)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2023.11.026
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Zs.A 3720: Show issues

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