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Article ; Online: Cryptogenic organizing pneumonia after withdrawal of systemic corticosteroids for chronic eosinophilic pneumonia and severe asthma under benralizumab treatment.

Morikawa, Keisuke / Toyoshima, Mikio / Koda, Keigo / Kamiya, Yosuke / Suda, Takafumi

2024 Volume 62, Issue 2, Page(s) 231–233

Abstract: A 79-year-old woman with severe asthma developed chronic eosinophilic pneumonia (CEP). After CEP resolved with oral prednisolone at 30 mg/day, prednisolone was tapered and discontinued under introduction of benralizumab for her severe asthma. However, 8 ... ...

Abstract	A 79-year-old woman with severe asthma developed chronic eosinophilic pneumonia (CEP). After CEP resolved with oral prednisolone at 30 mg/day, prednisolone was tapered and discontinued under introduction of benralizumab for her severe asthma. However, 8 weeks later, symptoms and bilateral patchy infiltrates on chest radiography appeared. Lymphocytosis without eosinophilia was seen in bronchoalveolar lavage fluids, and transbronchial biopsy indicated organizing pneumonia. Cryptogenic organizing pneumonia (COP) was diagnosed and resolved with prednisolone at 30 mg/day. Prednisolone was tapered to 3 mg/day without relapse of CEP or COP. This case suggests the overlap and similar pathogenesis of CEP and COP.
MeSH term(s)	Female ; Humans ; Aged ; Pulmonary Eosinophilia/chemically induced ; Pulmonary Eosinophilia/drug therapy ; Cryptogenic Organizing Pneumonia/chemically induced ; Cryptogenic Organizing Pneumonia/drug therapy ; Cryptogenic Organizing Pneumonia/pathology ; Asthma/drug therapy ; Adrenal Cortex Hormones ; Prednisolone/adverse effects ; Antibodies, Monoclonal, Humanized
Chemical Substances	benralizumab (71492GE1FX) ; Adrenal Cortex Hormones ; Prednisolone (9PHQ9Y1OLM) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-14
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2023.12.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Idiopathic Fibrotic Nonspecific Interstitial Pneumonia with Cicatricial Organizing Pneumonia and Intraluminal Pulmonary Ossification Containing Bone Marrow.

Morikawa, Keisuke / Toyoshima, Mikio / Koda, Keigo / Suda, Takafumi

Internal medicine (Tokyo, Japan)

2023

Abstract: A 72-year-old man presented with bilateral ground-glass opacities in the lower lung fields on chest radiography. Computed chest tomography showed ground-glass opacities and micronodules in both lower lungs. A video-assisted thoracoscopic biopsy of the ... ...

Abstract	A 72-year-old man presented with bilateral ground-glass opacities in the lower lung fields on chest radiography. Computed chest tomography showed ground-glass opacities and micronodules in both lower lungs. A video-assisted thoracoscopic biopsy of the right lower lung showed homogeneous thickening of the alveolar septa with fibrosis and inflammatory cell infiltration consistent with fibrotic non-specific interstitial pneumonia (fNSIP). Cicatricial organizing pneumonia and intraluminal pulmonary ossification containing bone marrow that was considered to represent dendriform pulmonary ossification. Idiopathic fNSIP was diagnosed. The patient remains stable under antifibrotic treatment.
Language	English
Publishing date	2023-11-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2834-23
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Article ; Online: Mediastinal Emphysema with Electrocardiogram Abnormality.

Tsuchiya, Kazuo / Sagisaka, Shinya / Suda, Takafumi

Internal medicine (Tokyo, Japan)

2020 Volume 59, Issue 14, Page(s) 1783–1784

Language	English
Publishing date	2020-04-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.4460-20
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Article ; Online: Varus placement of the tibial component reduces the potential risk of fracture with adequate bony coverage in the Oxford unicompartmental knee arthroplasty.

Kamenaga, Tomoyuki / Hiranaka, Takafumi / Suda, Yoshihito / Fujishiro, Takaaki / Okamoto, Koji / Kuroda, Ryosuke / Matsumoto, Tomoyuki

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1274

Abstract: A short keel-cortex distance (KCD), especially to the posterior cortex, is a potential risk factor for tibial plateau fracture after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to evaluate the effect of tibial ... ...

Abstract	A short keel-cortex distance (KCD), especially to the posterior cortex, is a potential risk factor for tibial plateau fracture after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to evaluate the effect of tibial component alignment in the coronal plane and tibial proximal morphology on the KCD. Included in this study were 51 patients scheduled for primary Oxford medial unicompartmental knee arthroplasty (UKA). The anterior and posterior KCD were preoperatively assessed using 3D simulation software with the component set perpendicular to the tibial mechanical axis (neutral), 3° valgus, 3° varus, and 6° varus, relative to neutral alignment. We evaluated the existence of overhanging medial tibial condyle where the medial eminence line, the line including the medial tibial eminence parallel to the tibial axis, passes outside of the tibial shaft. In all component alignments, patients with a medial overhanging condyle had significantly shorter posterior KCD than those without. In patients with a medial overhanging condyle, the posterior KCD significantly increased when the tibial component was placed in 3° varus (4.6 ± 1.5 mm, P = 0.003 vs neutral, P < 0.001 vs 3° valgus) and 6° varus (5.0 ± 1.4 mm, P < 0.001 vs neutral, P < 0.001 vs 3° valgus) compared with in neutral (3.5 ± 1.9 mm) or 3° valgus (2.8 ± 1.8 mm). In OUKA, varus implantation increased the KCD. This could potentially decrease the risk of fracture, even in knees with the overhanging medial condyle. Conversely, valgus implantation of the tibial component shortened the KCD, and should therefore be avoided.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Knee Prosthesis/adverse effects ; Tibia/surgery ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Tibial Fractures/etiology ; Risk Factors ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/complications ; Retrospective Studies
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48659-4
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Article ; Online: Varus placement of the tibial component reduces the potential risk of fracture with adequate bony coverage in the Oxford unicompartmental knee arthroplasty

Tomoyuki Kamenaga / Takafumi Hiranaka / Yoshihito Suda / Takaaki Fujishiro / Koji Okamoto / Ryosuke Kuroda / Tomoyuki Matsumoto

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 9

Abstract: Abstract A short keel-cortex distance (KCD), especially to the posterior cortex, is a potential risk factor for tibial plateau fracture after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to evaluate the effect of ... ...

Abstract	Abstract A short keel-cortex distance (KCD), especially to the posterior cortex, is a potential risk factor for tibial plateau fracture after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to evaluate the effect of tibial component alignment in the coronal plane and tibial proximal morphology on the KCD. Included in this study were 51 patients scheduled for primary Oxford medial unicompartmental knee arthroplasty (UKA). The anterior and posterior KCD were preoperatively assessed using 3D simulation software with the component set perpendicular to the tibial mechanical axis (neutral), 3° valgus, 3° varus, and 6° varus, relative to neutral alignment. We evaluated the existence of overhanging medial tibial condyle where the medial eminence line, the line including the medial tibial eminence parallel to the tibial axis, passes outside of the tibial shaft. In all component alignments, patients with a medial overhanging condyle had significantly shorter posterior KCD than those without. In patients with a medial overhanging condyle, the posterior KCD significantly increased when the tibial component was placed in 3° varus (4.6 ± 1.5 mm, P = 0.003 vs neutral, P < 0.001 vs 3° valgus) and 6° varus (5.0 ± 1.4 mm, P < 0.001 vs neutral, P < 0.001 vs 3° valgus) compared with in neutral (3.5 ± 1.9 mm) or 3° valgus (2.8 ± 1.8 mm). In OUKA, varus implantation increased the KCD. This could potentially decrease the risk of fracture, even in knees with the overhanging medial condyle. Conversely, valgus implantation of the tibial component shortened the KCD, and should therefore be avoided.
Keywords	Medicine ; R ; Science ; Q
Subject code	600
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Up-to-Date Information on Rheumatoid Arthritis-Associated Interstitial Lung Disease

Takafumi Suda

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol 2015, Iss Suppl. 1, Pp 155-

2016 Volume 162

Keywords	Internal medicine ; RC31-1245 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Diseases of the respiratory system ; RC705-779
Language	English
Publishing date	2016-05-01T00:00:00Z
Publisher	Libertas Academica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nationwide survey of adult patients with pulmonary alveolar proteinosis using the National Database of designated intractable diseases of Japan.

Miyashita, Koichi / Hozumi, Hironao / Inoue, Yoshikazu / Suzuki, Takuji / Suda, Takafumi

Respiratory investigation

2023 Volume 61, Issue 3, Page(s) 364–370

Abstract: Background: Autoimmune pulmonary alveolar proteinosis (APAP) and congenital/hereditary PAP were labeled intractable diseases in Japan in 2015. Since then, patients registered in the National Database of Designated Incurable Diseases (NDDID) who met ... ...

Abstract	Background: Autoimmune pulmonary alveolar proteinosis (APAP) and congenital/hereditary PAP were labeled intractable diseases in Japan in 2015. Since then, patients registered in the National Database of Designated Incurable Diseases (NDDID) who met certain requirements became eligible for medical subsidies. Epidemiological studies using recent data are needed for the development of management protocols for patients with PAP. Methods: We conducted the first nationwide study describing the epidemiology and characteristics of PAP using data for patients registered in the Japanese NDDID between 2015 and 2020. We focused on patient demographics, diagnosis, disease severity score (DSS), symptoms, test results, and treatment. Results: We identified 110 patients with PAP, among whom 96.4% had APAP/idiopathic PAP (IPAP). The median age was 58 years, with a slight male predominance. Most patients had a DSS ≥3 (64.5%) and reported symptoms (e.g., dyspnea on exertion). High-resolution computed tomography typically revealed ground glass opacity and crazy paving appearances. Pulmonary function was relatively preserved, except for carbon monoxide diffusing capacity. Only 27.4% of patients underwent therapeutic whole-lung lavage and/or bronchoalveolar lavage, while 25% required long-term oxygen therapy. Serum Krebs von den Lungen-6, surfactant protein D, and lactate dehydrogenase levels significantly and positively correlated with the DSS. Conclusions: Most patients registered in the NDDID have APAP/IPAP with a DSS ≥3, and about one-quarter require long-term oxygen therapy and infrequent lavages. Our results provide important details of the current prevalence and clinical practice related to APAP/IPAP with a DSS ≥3 in Japan.
MeSH term(s)	Humans ; Adult ; Male ; Middle Aged ; Female ; Pulmonary Alveolar Proteinosis/epidemiology ; Pulmonary Alveolar Proteinosis/therapy ; Japan/epidemiology ; Lung ; Autoimmune Diseases/therapy ; Bronchoalveolar Lavage ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2023.02.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Up-to-Date Information on Rheumatoid Arthritis-Associated Interstitial Lung Disease.

Suda, Takafumi

Clinical medicine insights. Circulatory, respiratory and pulmonary medicine

2016 Volume 9, Issue Suppl 1, Page(s) 155–162

Abstract: Pulmonary involvement is common in rheumatoid arthritis (RA) and affects all the components of the lung. Interstitial lung disease (ILD) is the most predominant pulmonary manifestation and has been identified as the main cause of morbidity and mortality ... ...

Abstract	Pulmonary involvement is common in rheumatoid arthritis (RA) and affects all the components of the lung. Interstitial lung disease (ILD) is the most predominant pulmonary manifestation and has been identified as the main cause of morbidity and mortality in RA. Clinically significant RA-ILD occurs in approximately 10% of RA patients. Several risk factors, such as old age, male gender, and smoking, have been reported to date. Histologically, the proportion of the usual interstitial pneumonia (UIP) pattern is higher in RA-ILD than in ILD associated with other connective tissue diseases, and RA-ILD also shows nonspecific interstitial pneumonia and organizing pneumonia patterns. High-resolution computed tomography scans are highly predictive of the histological UIP pattern with a specificity of 96%-100%. Acute exacerbation, which is the acute deterioration of the respiratory status characterized by newly developed bilateral infiltrates with unknown etiologies, has been reported in RA-ILD. Although acute exacerbation of RA-ILD has high mortality, similar to that of idiopathic pulmonary fibrosis, its incidence is lower in RA-ILD than in idiopathic pulmonary fibrosis. A consensus treatment has not yet been established. Current therapeutic regimens typically include corticosteroids with or without cytotoxic agents. Recent large longitudinal studies reported that the prognosis of RA-ILD was poor with a median survival of 2.6-3.0 years. Furthermore, histological and/or radiological patterns, such as UIP or non-UIP, have significant prognostic implications. RA-ILD patients with histological or radiological UIP patterns have poorer prognoses than those with non-UIP patterns. This review assessed the characteristics of RA-ILD by overviewing recent studies in the field and focused on the clinical significance of histological and/or radiological patterns in RA-ILD.
Language	English
Publishing date	2016-05-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583465-4
ISSN	1179-5484
ISSN	1179-5484
DOI	10.4137/CCRPM.S23289
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Article ; Online: CLEC10A expression defines functionally distinct subsets of conventional type 2 dendritic cells (cDC2) in the mouse lung.

Nihashi, Fumiya / Furuhashi, Kazuki / Horiguchi, Ryo / Kitahara, Yoshihiro / Inoue, Yusuke / Yasui, Hideki / Karayama, Masato / Suzuki, Yuzo / Hozumi, Hironao / Enomoto, Noriyuki / Fujisawa, Tomoyuki / Nakamura, Yutaro / Inui, Naoki / Suda, Takafumi

Allergology international : official journal of the Japanese Society of Allergology

2024

Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Letter
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2024.01.011
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Zs.A 5248: Show issues

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Article ; Online: Pulmonary Hypertension Associated with Diffuse Panbronchiolitis That Improved with Erythromycin and Home Oxygen Therapy.

Kamiya, Chiaki / Odagiri, Keiichi / Inui, Naoki / Suda, Takafumi / Watanabe, Hiroshi

Internal medicine (Tokyo, Japan)

2022 Volume 62, Issue 15, Page(s) 2231–2236

Abstract: Pulmonary hypertension (PH) often complicates chronic lung disease. However, there are few reports of PH associated with diffuse panbronchiolitis, and there is no effective treatment. We herein report a 64-year-old woman diagnosed with PH due to diffuse ... ...

Abstract	Pulmonary hypertension (PH) often complicates chronic lung disease. However, there are few reports of PH associated with diffuse panbronchiolitis, and there is no effective treatment. We herein report a 64-year-old woman diagnosed with PH due to diffuse panbronchiolitis. She received erythromycin, carbocysteine, and home oxygen therapy (1 L O
MeSH term(s)	Female ; Humans ; Middle Aged ; Erythromycin/therapeutic use ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/drug therapy ; Bronchiolitis/complications ; Bronchiolitis/drug therapy ; Oxygen
Chemical Substances	Erythromycin (63937KV33D) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-12-14
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0929-22
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