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  1. Article ; Online: Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine-Reply.

    White, C Michael / Hernandez, Adrian V

    JAMA

    2021  Volume 326, Issue 20, Page(s) 2077–2078

    MeSH term(s) Dimethylnitrosamine ; Ranitidine/adverse effects ; Water Pollutants, Chemical/analysis
    Chemical Substances Water Pollutants, Chemical ; Ranitidine (884KT10YB7) ; Dimethylnitrosamine (M43H21IO8R)
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.16264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation.

    White, C Michael / Hernandez, Adrian V

    JAMA

    2021  Volume 326, Issue 3, Page(s) 225–227

    MeSH term(s) Dimethylnitrosamine ; Ranitidine/adverse effects ; Water Pollutants, Chemical/analysis
    Chemical Substances Water Pollutants, Chemical ; Ranitidine (884KT10YB7) ; Dimethylnitrosamine (M43H21IO8R)
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.10043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The impact of psychedelics on patients with alcohol use disorder: a systematic review with meta-analysis.

    Sicignano, Dakota / Hernandez, Adrian V / Schiff, Benjamin / Elmahy, Nawal / White, C Michael

    Current medical research and opinion

    2024  Volume 40, Issue 2, Page(s) 293–302

    Abstract: Objectives: Critique the available systematic review and de novo assessment of the role of psychedelics in the treatment of alcohol use disorder.: Methods: A systematic literature search of PubMed was completed from 1960 to 9/9/2023. We pooled ... ...

    Abstract Objectives: Critique the available systematic review and de novo assessment of the role of psychedelics in the treatment of alcohol use disorder.
    Methods: A systematic literature search of PubMed was completed from 1960 to 9/9/2023. We pooled randomized controlled trials comparing psychedelics to control therapy for the treatment of alcohol use disorder.
    Results: At the first recorded follow-up, LSD [
    Conclusions: The use of psychedelics to treat alcohol use disorder is promising, but the weaknesses in the literature base preclude making definitive statements about its value. Future trials with greater methodological rigor are needed.
    MeSH term(s) Humans ; Hallucinogens/therapeutic use ; Alcoholism ; Alcohol Drinking ; Ethanol ; Randomized Controlled Trials as Topic
    Chemical Substances Hallucinogens ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2023.2296968
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  4. Article: Efficacy of Tunnel Technique (TUN) versus Coronally Advanced Flap (CAF) in the Management of Multiple Gingival Recession Defects: A Meta-Analysis.

    Mayta-Tovalino, Frank / Barboza, Joshuan J / Pasupuleti, Vinay / Hernandez, Adrian V

    International journal of dentistry

    2023  Volume 2023, Page(s) 8671484

    Abstract: Objective: We systematically assessed the efficacy of tunnel technique (TUN) vs. coronally advanced flap (CAF) in the management of multiple gingival recession defects in adults.: Methods: Five databases were searched until September 2021 for ... ...

    Abstract Objective: We systematically assessed the efficacy of tunnel technique (TUN) vs. coronally advanced flap (CAF) in the management of multiple gingival recession defects in adults.
    Methods: Five databases were searched until September 2021 for randomized controlled trials (RCTs) assessing TUN vs. CAF; grafts of interest were acellular dermal matrix (ADM) and connective tissue graft (CTG). Primary outcomes were root coverage (RC) and complete root coverage (CRC). Secondary outcomes were clinical attachment level (CAL), keratinized tissue width (KTW), probing depth (PD), and recession coverage (REC). Effect measures were risk ratio (RR) or mean difference (MD) with their confidence intervals (95% CI). Inverse variance methods and random-effects model meta-analyses were used. Subgroup analyses by the type of graft were performed. Quality of evidence was assessed using GRADE methodology.
    Results: Five RCTs (
    Conclusions: In adults with gingival recessions, TUN had similar primary and secondary outcomes in comparison with CAF. Subgroup analyses by the type of graft did not affect main conclusions. More RCTs with better design are needed to further characterize the effects of TUN vs. CAF in the treatment of multiple gingival recession defects.
    Language English
    Publishing date 2023-04-06
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2546524-7
    ISSN 1687-8736 ; 1687-8728
    ISSN (online) 1687-8736
    ISSN 1687-8728
    DOI 10.1155/2023/8671484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Impact of Psychedelic Drugs on Anxiety and Depression in Advanced Cancer or other Life-threatening Disease: A Systematic Review With Meta-analysis.

    Sicignano, Dakota / Snow-Caroti, Kimberly / Hernandez, Adrian V / White, C Michael

    American journal of clinical oncology

    2023  Volume 46, Issue 6, Page(s) 236–245

    Abstract: Objectives: Life-threatening cancer or other diseases can induce anxiety and depressive symptoms. We performed a systematic review with meta-analyses of randomized controlled trials assessing patients with cancer or other life-threatening diseases using ...

    Abstract Objectives: Life-threatening cancer or other diseases can induce anxiety and depressive symptoms. We performed a systematic review with meta-analyses of randomized controlled trials assessing patients with cancer or other life-threatening diseases using validated anxiety and depression scales.
    Methods: PubMed was searched up to November 15, 2022 and citations were applied to prespecified inclusion criteria. Disease rating scales for anxiety or depression included the State-Trait Anxiety Inventory (STAI) (STAI Trait [STAI-T], STAI-State [STAI-S]), Beck Depression Inventory (BDI), Hospital Anxiety and Depression Scale (HADS) (HADS-Anxiety [HADS-A]; HADS-Depression [HADS-D]), Profile of Mood States (POMS), and the Hamilton Rating Scale for Depression (HAM-D or GRID-HAM-D-17). Safety outcomes included assessments of blood pressure and heart rate.
    Results: Five trials, predominantly in cancer patients, had data assessing anxiety and depressive symptoms. These trials found promising results for psychedelics versus placebo in several anxiety and depression scales but increases in blood pressure and heart rate also occurred. There were some concerns of risk of bias because it is difficult to truly randomize a psychedelic trial and there was a high percentage of patients in the trials who had used psychedelics in the past. There was high heterogeneity for all analyses that we could not explain.
    Conclusions: Although the results are promising, future trials are needed to assess the optimal psychedelic, dose, number of sessions required, and how psychedelic naïve patients would respond both psychologically and hemodynamically before this therapy can be considered for widescale clinical use.
    MeSH term(s) Humans ; Hallucinogens/therapeutic use ; Depression ; Anxiety/drug therapy ; Anxiety Disorders/diagnosis ; Anxiety Disorders/drug therapy ; Neoplasms
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604536-4
    ISSN 1537-453X ; 0277-3732
    ISSN (online) 1537-453X
    ISSN 0277-3732
    DOI 10.1097/COC.0000000000000998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1557: Show issues Location:
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  6. Article ; Online: Why Your Patients' Believing Hydroxychloroquine and Chloroquine Are 90% Effective for COVID-19 Is 100% Dangerous.

    White, C Michael / Hernandez, Adrian V

    Journal of clinical pharmacology

    2020  Volume 60, Issue 8, Page(s) 949–953

    MeSH term(s) Antimalarials/adverse effects ; Antimalarials/therapeutic use ; COVID-19 ; Chloroquine/adverse effects ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Coronavirus Infections/mortality ; Culture ; Endpoint Determination ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Pandemics ; Patient Education as Topic ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/mortality ; Randomized Controlled Trials as Topic
    Chemical Substances Antimalarials ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.1687
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  7. Article: Efficacy and safety of sacubitril/valsartan in heart failure compared to renin-angiotensin-aldosterone system inhibitors: a systematic review and meta-analysis of randomised controlled trials.

    Hernandez, Adrian V / Pasupuleti, Vinay / Scarpelli, Nancy / Malespini, Jack / Banach, Maciej / Bielecka-Dabrowa, Agata M

    Archives of medical science : AMS

    2023  Volume 19, Issue 3, Page(s) 565–576

    Abstract: ... the world. Aim of the study was to assess the benefits and harms of sacubitril/valsartan (S/V) compared ... We systematically searched for randomised controlled trials (RCTs) evaluating S/V vs. ACEI or ARB in acute or ...

    Abstract Introduction: Heart failure (HF) is still a major cause of morbidity and mortality all over the world. Aim of the study was to assess the benefits and harms of sacubitril/valsartan (S/V) compared to angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) in patients with HF.
    Material and methods: We systematically searched for randomised controlled trials (RCTs) evaluating S/V vs. ACEI or ARB in acute or chronic HF in August 2021. Primary outcomes were HF hospitalisations and cardiovascular (CV) mortality; secondary outcomes included all-cause mortality, biomarkers, and renal function.
    Results: We selected 11 RCTs (
    Conclusions: Sacubitril/valsartan had better clinical, intermediate, and renal outcomes in HF in comparison to ACEI or ARB. There was no difference in angioedema and hyperkalaemia events, but there were more hypotension events.
    Language English
    Publishing date 2023-05-14
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms/159113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Microdosing Sprint Distribution as an Alternative to Achieve Better Sprint Performance in Field Hockey Players.

    Cuadrado-Peñafiel, Víctor / Castaño-Zambudio, Adrián / Martínez-Aranda, Luis Manuel / González-Hernández, Jorge Miguel / Martín-Acero, Rafael / Jiménez-Reyes, Pedro

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 2

    Abstract: ... to influence the full spectrum of the F-V relationship. Results: Conditional demands analysis (matches and ...

    Abstract Introduction: The implementation of optimal sprint training volume is a relevant component of team sport performance. This study aimed to compare the efficiency and effectiveness of two different configurations of within-season training load distribution on sprint performance over 6 weeks. Methods: Twenty male professional FH players participated in the study. Players were conveniently assigned to two groups: the experimental group (MG; n = 11; applying the microdosing training methodology) and the control group (TG; n = 9; traditional training, with players being selected by the national team). Sprint performance was evaluated through 20 m sprint time (T20) m and horizontal force−velocity profile (HFVP) tests before (Pre) and after (Post) intervention. Both measurements were separated by a period of 6 weeks. The specific sprint training program was performed for each group (for vs. two weekly sessions for MG and TG, respectively) attempting to influence the full spectrum of the F-V relationship. Results: Conditional demands analysis (matches and training sessions) showed no significant differences between the groups during the intervention period (p > 0.05). No significant between-group differences were found at Pre or Post for any sprint-related performance (p > 0.05). Nevertheless, intra-group analysis revealed significant differences in F0, Pmax, RFmean at 10 m and every achieved time for distances ranging from 5 to 25 m for MG (p < 0.05). Such changes in mechanical capabilities and sprint performance were characterized by an increase in stride length and a decrease in stride frequency during the maximal velocity phase (p < 0.05). Conclusion: Implementing strategies such as microdosed training load distribution appears to be an effective and efficient alternative for sprint training in team sports such as hockey.
    MeSH term(s) Male ; Humans ; Athletic Performance ; Hockey ; Running ; Team Sports
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23020650
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  9. Article: Efficacy of Enamel Matrix Derivative in Periodontal Regeneration Defects: A Systematic Review and Meta-Analysis.

    Mayta-Tovalino, Frank / Diaz-Arocutipa, Carlos / Barja-Ore, John / Hernandez, Adrian V

    Contemporary clinical dentistry

    2023  Volume 14, Issue 4, Page(s) 249–255

    Abstract: Aim: To evaluate the efficacy of enamel matrix derivative (EMD) on periodontal regeneration defects.: Materials and methods: Four databases were searched until October 2021. Experimental animal studies evaluating the efficacy of EMD were used. The ... ...

    Abstract Aim: To evaluate the efficacy of enamel matrix derivative (EMD) on periodontal regeneration defects.
    Materials and methods: Four databases were searched until October 2021. Experimental animal studies evaluating the efficacy of EMD were used. The primary outcomes were bone formation (BF) and cementum formation (CF). The secondary outcomes were junctional epithelium (JE), gingival recession (GR), and clinical attachment level (CAL). Measures of effect were mean difference (MD) with 95% confidence intervals (CIs). Random-effects model were used for all meta-analyses. The Systematic Review Centre for Laboratory animal Experimentation tool was used to assess the risk of bias.
    Results: Seven experimental animal studies (
    Conclusion: EMD had no effect on BF values while it did not reduce CF. Otherwise, in the secondary outcomes, EMD only significantly reduced JE values and had no effect on GR and CAL.
    Language English
    Publishing date 2023-12-19
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2582352-8
    ISSN 0976-2361 ; 0976-237X
    ISSN (online) 0976-2361
    ISSN 0976-237X
    DOI 10.4103/ccd.ccd_97_23
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  10. Article ; Online: Reply to Banno et al and Padhi et al.

    Hernandez, Adrian V / Roman, Yuani M / Burela, Paula A / Pasupuleti, Vinay / Piscoya, Alejandro / Vidal, Jose E

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 74, Issue 6, Page(s) 1122–1123

    MeSH term(s) COVID-19 ; Humans ; Ivermectin ; Randomized Controlled Trials as Topic
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab693
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