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  1. Article ; Online: α-synuclein seed amplification in Parkinson's disease - Authors' reply.

    Siderowf, Andrew / Concha-Marambio, Luis / Marek, Kenneth / Soto, Claudio

    The Lancet. Neurology

    2023  Volume 22, Issue 11, Page(s) 985–986

    MeSH term(s) Humans ; alpha-Synuclein/genetics ; Parkinson Disease/genetics
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00371-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Challenges in the study of individuals at risk for Parkinson disease.

    Marras, Connie / Alcalay, Roy N / Siderowf, Andrew / Postuma, Ronald B

    Handbook of clinical neurology

    2023  Volume 192, Page(s) 219–229

    Abstract: Identifying individuals at high risk for developing neurodegenerative disease opens the possibility of conducting clinical trials that intervene at an earlier stage of neurodegeneration than has been possible to date, and in doing so hopefully improves ... ...

    Abstract Identifying individuals at high risk for developing neurodegenerative disease opens the possibility of conducting clinical trials that intervene at an earlier stage of neurodegeneration than has been possible to date, and in doing so hopefully improves the odds of efficacy for interventions aimed at slowing or stopping the disease process. The long prodromal phase of Parkinson disease presents opportunities and challenges to establishing cohorts of at-risk individuals. Recruiting people with genetic variants conferring increased risk and people with REM sleep behavior disorder currently constitutes the most promising strategies, but multistage screening of the general population may also be feasible capitalizing on known risk factors and prodromal features. This chapter discusses the challenges involved in identifying, recruiting, and retaining these individuals, and provides insights into possible solutions using examples from studies to date.
    MeSH term(s) Humans ; Parkinson Disease/epidemiology ; Parkinson Disease/genetics ; Parkinson Disease/diagnosis ; Neurodegenerative Diseases/complications ; REM Sleep Behavior Disorder/diagnosis ; REM Sleep Behavior Disorder/epidemiology ; REM Sleep Behavior Disorder/etiology ; Risk Factors
    Language English
    Publishing date 2023-01-29
    Publishing country Netherlands
    Document type Review ; Journal Article
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-323-85538-9.00014-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Outcome Assessment in Parkinson Disease Prevention Trials: Utility of Clinical and Digital Measures.

    Mirelman, Anat / Siderowf, Andrew / Chahine, Lana

    Neurology

    2022  Volume 99, Issue 7 Suppl 1, Page(s) 52–60

    Abstract: Background and objectives: The prodromal phase of Parkinson disease (PD) is accompanied by subtle clinical signs that are not sufficient for diagnosis but could potentially be measured in the context of clinical trials of therapies intended to delay or ... ...

    Abstract Background and objectives: The prodromal phase of Parkinson disease (PD) is accompanied by subtle clinical signs that are not sufficient for diagnosis but could potentially be measured in the context of clinical trials of therapies intended to delay or prevent more definitive clinical features. The objective of this study was to review the available literature on the presence and time course of subtle motor features in prodromal PD in the context of planning for possible clinical trials.
    Methods: We reviewed the available literature based on expert opinion. We considered a range of outcomes including measurement of clinical features, patient-reported outcomes, digital markers, and clinical diagnosis.
    Results: We considered these features and measures in the context of patient stratification, intermediate outcomes, and clinically relevant end points, including phenoconversion.
    Discussion: Substantial progress has been made in understanding how motor features evolve in the period immediately before a PD diagnosis. Digital measures hold substantial progress for measurement precision and may be additionally relevant because they can be used in naturalistic environments outside the clinic. Future studies should focus on advancing digital sensor technology and analysis and developing methods to implement available methods, particularly determination of a clinical diagnosis of PD, in a clinical trial context.
    MeSH term(s) Biomarkers ; Humans ; Outcome Assessment, Health Care/methods ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/therapy ; Research Design
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 374: Show issues

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  4. Article ; Online: Bridging the credibility gap in cost effectiveness analysis.

    Siderowf, Andrew

    Movement disorders : official journal of the Movement Disorder Society

    2014  Volume 29, Issue 2, Page(s) 164–165

    MeSH term(s) Cost of Illness ; Cost-Benefit Analysis/economics ; Humans ; Parkinson Disease/economics
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.25758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  5. Article ; Online: Biomarkers for atypical Parkinsonism: Some progress, but much work remains.

    Feigin, Andrew / Siderowf, Andrew

    Parkinsonism & related disorders

    2018  Volume 48, Page(s) 1–2

    MeSH term(s) Biomarkers/metabolism ; Humans ; Parkinsonian Disorders/diagnosis ; Parkinsonian Disorders/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-03-02
    Publishing country England
    Document type Editorial
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2018.02.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 420: Show issues

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  6. Article: Predictive value of abbreviated olfactory tests in prodromal Parkinson disease.

    Vaswani, Pavan A / Morley, James F / Jennings, Danna / Siderowf, Andrew / Marek, Kenneth

    NPJ Parkinson's disease

    2023  Volume 9, Issue 1, Page(s) 103

    Abstract: There is disagreement in the literature whether olfaction may show specific impairments in Parkinson Disease (PD) and if olfactory tests comprised of selected odors could be more specific for diagnosis. We sought to validate previously proposed subsets ... ...

    Abstract There is disagreement in the literature whether olfaction may show specific impairments in Parkinson Disease (PD) and if olfactory tests comprised of selected odors could be more specific for diagnosis. We sought to validate previously proposed subsets of the University of Pennsylvania Smell Identification Test (UPSIT) odors for predicting conversion to PD in an independent, prodromal cohort. Conversion to PD was assessed in 229 participants in the Parkinson At Risk Study who completed baseline olfactory testing with the UPSIT and up to 12 years of clinical and imaging evaluations. No commercially available or proposed subset performed better than the full 40-item UPSIT. The proposed "PD-specific" subsets also did not perform better than expected by chance. We did not find evidence for selective olfactory impairment in Parkinson disease. Shorter odor identification tests, including commercially available 10-12 item tests, may have utility for ease of use and cost, but not for superior predictive value.
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-023-00530-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Treatment strategies and quality of care indicators for patients with Parkinson's disease

    Chen, Jack J. / Lew, Mark F. / Siderowf, Andrew

    (Journal of managed care pharmacy ; 15,3, Suppl.)

    2009  

    Title variant Treatment strategies and quality-of-care indicators for patients with Parkinson's disease
    Author's details Jack J. Chen ; Mark F. Lew ; Andrew Siderowf
    Series title Journal of managed care pharmacy ; 15,3, Suppl.
    Collection
    Language English
    Size S21 S. : graph. Darst.
    Publisher Acad. of Managed Care Pharmacy
    Publishing place Alexandria, VA
    Publishing country United States
    Document type Book
    HBZ-ID HT017765220
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 5450 -15,3,Suppl.- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Serial olfactory testing for the diagnosis of prodromal Parkinson's disease in the PARS study.

    Vaswani, Pavan A / Morley, James F / Jennings, Danna / Siderowf, Andrew / Marek, Kenneth

    Parkinsonism & related disorders

    2022  Volume 104, Page(s) 15–20

    Abstract: Background: The Parkinson Associated Risk Syndrome (PARS) study was designed to evaluate whether screening with olfactory testing and dopamine transporter (DAT) imaging could identify participants at risk for developing Parkinson's disease (PD).: ... ...

    Abstract Background: The Parkinson Associated Risk Syndrome (PARS) study was designed to evaluate whether screening with olfactory testing and dopamine transporter (DAT) imaging could identify participants at risk for developing Parkinson's disease (PD).
    Objective: Hyposmia on a single test has been associated with increased risk of PD, but, taken alone, lacks specificity. We evaluated whether repeating olfactory testing improves the diagnostic characteristics of this screening approach.
    Methods: Participants completed up to 10 years of clinical and imaging evaluations in the PARS cohort. Olfaction was assessed with the University of Pennsylvania Smell Identification Test at baseline and on average 1.4 years later. Multiple logistic regression and Cox proportional hazards regression were used to estimate the hazard of development of clinical PD or abnormal DAT imaging.
    Results: Of 186 participants who were initially hyposmic, 28% reverted to normosmia on repeat testing (reverters). No initially normosmic subjects and only 2% of reverters developed DAT imaging progression or clinical PD, compared to 29% of subjects with persistent hyposmia who developed abnormal DAT and 20% who developed clinical PD. The relative risk of clinical conversion to PD was 8.3 (95% CI:0.92-75.2, p = 0.06) and of abnormal DAT scan was 12.5 (2.4-156.2, p = 0.005) for persistent hyposmia, compared to reversion.
    Conclusions: Persistent hyposmia on serial olfactory testing significantly increases the risk of developing clinical PD and abnormal DAT imaging, compared to hyposmia on a single test. Repeat olfactory testing may be an efficient and cost-effective strategy to improve identification of at-risk patients for early diagnosis and disease modification studies.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/diagnostic imaging ; Smell ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Anosmia ; Cohort Studies
    Language English
    Publishing date 2022-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2022.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 420: Show issues

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  9. Article ; Online: Proposal for a Biologic Staging System of Parkinson's Disease.

    Chahine, Lana M / Merchant, Kalpana / Siderowf, Andrew / Sherer, Todd / Tanner, Caroline / Marek, Kenneth / Simuni, Tanya

    Journal of Parkinson's disease

    2023  Volume 13, Issue 3, Page(s) 297–309

    Abstract: The Parkinson's disease (PD) research field has seen the advent of several promising biomarkers and a deeper understanding of the clinical features of the disease from the earliest stages of pathology to manifest disease. Despite progress, a biologically ...

    Abstract The Parkinson's disease (PD) research field has seen the advent of several promising biomarkers and a deeper understanding of the clinical features of the disease from the earliest stages of pathology to manifest disease. Despite progress, a biologically based PD staging system does not exist. Such staging would be a useful framework within which to model the disease, develop and validate biomarkers, guide therapeutic development, and inform clinical trials design. We propose that the presence of aggregated neuronal α-synuclein, dopaminergic neuron dysfunction/degeneration, and clinical signs and symptoms identifies a group of individuals that have Lewy body pathology, which in early stages manifests with what is now referred to as prodromal non-motor features and later stages with the manifestations of PD and related Lewy body diseases as defined by clinical diagnostic criteria. Based on the state of the field, we herein propose a definition and staging of PD based on biology. We present the biologic basis for such a staging system and review key assumptions and evidence that support the proposed approach. We identify gaps in knowledge and delineate crucial research priorities that will inform the ultimate integrated biologic staging system for PD.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/pathology ; alpha-Synuclein ; Lewy Body Disease/diagnosis ; Lewy Bodies/pathology ; Nerve Degeneration/pathology ; Biomarkers ; Prodromal Symptoms ; Biological Products
    Chemical Substances alpha-Synuclein ; Biomarkers ; Biological Products
    Language English
    Publishing date 2023-04-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-225111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6964: Show issues Location:
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  10. Article: Linked Patient and Provider Impressions of Outpatient Teleneurology Encounters.

    James, Justin G / Park, Jane / Oliver, Alexandria / Xie, Sharon X / Siderowf, Andrew / Spindler, Meredith / Wechsler, Lawrence R / Tropea, Thomas F

    Neurology. Clinical practice

    2023  Volume 13, Issue 3, Page(s) e200159

    Abstract: Background and objectives: Teleneurology is common in clinical practice partly due to the SARS CoV-2 pandemic. Impressions about teleneurology from patients and providers alike are generally favorable; some of the reported benefits include ease of ... ...

    Abstract Background and objectives: Teleneurology is common in clinical practice partly due to the SARS CoV-2 pandemic. Impressions about teleneurology from patients and providers alike are generally favorable; some of the reported benefits include ease of access to specialized health care, savings of time and money, and similar quality of care as an in-person visit. However, comparisons between patient and provider impressions about the same teleneurology encounter have not been described. In this study, we describe patient impressions about a teleneurology encounter and evaluate concordance with provider impressions about the same encounter.
    Methods: Patients and providers at the University of Pennsylvania Hospital Neurology Department were surveyed about their impressions of teleneurology between April 27, 2020, and June 16, 2020. A convenience sample of patients, whose providers completed a questionnaire, were contacted by telephone to solicit their impressions about the same encounter. Unique questionnaires for patients and providers focused on similar themes, such as adequacy of technology, assessment of history obtained, and overall quality of the visit. Summaries of patient responses are reported with the raw percent agreement between patients and providers for similar questions.
    Results: One hundred thirty-seven patients completed the survey; 64 (47%) were male and 73 (53%) were female. Sixty-six (47%) patients had a primary diagnosis of PD, 42 (30%) a non-PD/parkinsonism movement disorder, and 29 (21%) a nonmovement disorder neurologic disease. One hundred one (76%) were established patient visits and 36 (26%) were new patient visits. Provider responses from 8 different physicians were included. Most of the patients responded that the ease of joining their visit, their comfort engaging with their physicians during their visit, understanding their plan of care after their visit, and the quality of care from their teleneurology visit were satisfactory. Patients and providers agreed about their impressions of the quality of the history obtained (87% agreement), patient-provider relationship (88% agreement), and overall quality of their experience (70% agreement).
    Discussion: Patients had favorable impressions about their clinical experience with teleneurology and expressed an interest in incorporating telemedicine visits into their ongoing care. Patients and providers were highly concordant for the history obtained, patient-provider relationship, and overall quality.
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000200159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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