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  1. Book ; Online: Techniques for Authenticating Quantile Digests

    Scala, Alessandro

    2024  

    Abstract: We investigate two possible techniques to authenticate the q-digest data structure, along with a worst-case study of the computational complexity both in time and space of the proposed solutions, and considerations on the feasibility of the presented ... ...

    Abstract We investigate two possible techniques to authenticate the q-digest data structure, along with a worst-case study of the computational complexity both in time and space of the proposed solutions, and considerations on the feasibility of the presented approaches in real-world scenarios. We conclude the discussion by presenting some considerations on the information complexity of the queries in the two proposed approaches, and by presenting some interesting ideas that could be the subject of future studies on the topic.
    Keywords Computer Science - Data Structures and Algorithms ; Computer Science - Distributed ; Parallel ; and Cluster Computing ; E.1
    Publishing date 2024-01-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Lean Six Sigma Approach to Improve the Management of Patients Undergoing Laparoscopic Cholecystectomy.

    Scala, Arianna / Improta, Giovanni

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 3

    Abstract: Laparoscopic cholecystectomy (LC) is the gold standard technique for gallbladder diseases in both emergency and elective surgery. The incidence of the disease related to an increasingly elderly population coupled with the efficacy and safety of LC ... ...

    Abstract Laparoscopic cholecystectomy (LC) is the gold standard technique for gallbladder diseases in both emergency and elective surgery. The incidence of the disease related to an increasingly elderly population coupled with the efficacy and safety of LC treatment resulted in an increase in the frequency of interventions without an increase in surgical mortality. For these reasons, managers implement strategies by which to standardize the process of patients undergoing LC. Specifically, the goal is to ensure, in accordance with the guidelines of the Italian Ministry of Health, a reduction in post-operative length of stay (LOS). In this study, a Lean Six Sigma (LSS) methodological approach was implemented to identify and subsequently investigate, through statistical analysis, the effect that corrective actions have had on the post-operative hospitalization for LC interventions performed in a University Hospital. The analysis of the process, which involved a sample of 478 patients, with an approach guided by the Define, Measure, Analyze, Improve, and Control (DMAIC) cycle, made it possible to reduce the post-operative LOS from an average of 6.67 to 4.44 days. The most significant reduction was obtained for the 60-69 age group, for whom the probability of using LC is higher than for younger people. The LSS offers a methodological rigor that has allowed us, as already known, to make significant improvements to the process, standardizing the result by limiting the variability and obtaining a total reduction of post-operative LOS of 67%.
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12030292
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  3. Article ; Online: The mathematics of multiple lockdowns.

    Scala, Antonio

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 8078

    Abstract: While vaccination is the optimal response to an epidemic, recent events have obliged us to explore new strategies for containing worldwide epidemics, like lockdown strategies, where the contacts among the population are strongly reduced in order to slow ... ...

    Abstract While vaccination is the optimal response to an epidemic, recent events have obliged us to explore new strategies for containing worldwide epidemics, like lockdown strategies, where the contacts among the population are strongly reduced in order to slow down the propagation of the infection. By analyzing a classical epidemic model, we explore the impact of lockdown strategies on the evolution of an epidemic. We show that repeated lockdowns have a beneficial effect, reducing the final size of the infection, and that they represent a possible support strategy to vaccination policies.
    MeSH term(s) COVID-19 ; Epidemics ; Humans
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-87556-6
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  4. Article ; Online: On the Fidelity Robustness of CHSH-Bell Inequality via Filtered Random States.

    Mandarino, Antonio / Scala, Giovanni

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 1

    Abstract: The theorem developed by John Bell constituted the starting point of a revolution that translated a philosophical question about the nature of reality into the broad and intense field of research of the quantum information technologies. We focus on a ... ...

    Abstract The theorem developed by John Bell constituted the starting point of a revolution that translated a philosophical question about the nature of reality into the broad and intense field of research of the quantum information technologies. We focus on a system of two qubits prepared in a random, mixed state, and we study the typical behavior of their nonlocality via the CHSH-Bell inequality. Afterward, motivated by the necessity of accounting for inefficiency in the state preparation, we address to what extent states close enough to one with a high degree of nonclassicality can violate local realism with a previously chosen experimental setup.
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25010094
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  5. Article: Editorial: Updates on hidradenitis suppurativa - Pathogenesis, diagnosis and treatment.

    Scala, Emanuele / Zink, Alexander

    Frontiers in medicine

    2023  Volume 10, Page(s) 1209545

    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1209545
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  6. Article ; Online: Measuring the efficacy of a vaccine during an epidemic.

    Scala, Antonio / Cavallo, Pierpaolo

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0290652

    Abstract: The urgency to develop vaccines during the COVID-19 pandemic has resulted in the acceleration of clinical trials. Specifically, a broad spectrum of efficacy levels has been reported for various vaccines based on phase III cohort studies. Our study ... ...

    Abstract The urgency to develop vaccines during the COVID-19 pandemic has resulted in the acceleration of clinical trials. Specifically, a broad spectrum of efficacy levels has been reported for various vaccines based on phase III cohort studies. Our study demonstrates that conducting large cohort phase III clinical trials during the peak of an epidemic leads to a significant underestimation of vaccine efficacy, even in the absence of confounding factors. Furthermore, we find that this underestimation increases with the proportion of infectious individuals in the population during the experiment and the severity of the epidemic, as measured by its basic reproduction number.
    MeSH term(s) Humans ; Pandemics/prevention & control ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccines ; Acceleration ; Basic Reproduction Number
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290652
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  7. Article ; Online: The explosive value of the networks.

    Scala, Antonio / Delmastro, Marco

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1037

    Abstract: Networks have always played a special role for human beings in shaping social relations, forming public opinion, and driving economic equilibria. Nowadays, online networked platforms dominate digital markets and capitalization leader-boards, while social ...

    Abstract Networks have always played a special role for human beings in shaping social relations, forming public opinion, and driving economic equilibria. Nowadays, online networked platforms dominate digital markets and capitalization leader-boards, while social networks drive public discussion. Despite the importance of networks in many economic and social domains (economics, sociology, anthropology, psychology, etc.), the knowledge about the laws that dominate their dynamics is still scarce and fragmented. Here, we analyse a wide set of online networks (those financed by advertising) by investigating their value dynamics from several perspectives: the type of law they follow, their geographic scope, and the relationship between economic value and financial value. The results show that the networks are dominated by strongly nonlinear dynamics. The existence of non-linearity is often underestimated in social sciences because it involves contexts that are difficult to deal with, such as the presence of multiple equilibria-some of which are unstable. Yet, these dynamics must be fully understood and addressed if we aim to understand the recent evolution in the economic, political and social milieus, which are precisely characterised by corner equilibria (e.g., polarisation, winner-take-all solutions, increasing inequality) and nonlinear patterns.
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26961-x
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  8. Article ; Online: Late-onset endobronchial metastasis of oncocytic cell thyroid carcinoma.

    Ielo, S / Campione, A / Scala, R

    Pulmonology

    2024  

    Language English
    Publishing date 2024-02-23
    Publishing country Spain
    Document type Letter
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2024.02.005
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  9. Article ; Online: Special Issue "Materials for Photobiology".

    Scala, Angela / Caruso, Enrico / Mazzaglia, Antonino

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Photobiology is a challenging research area that aims to explore the interactions between light and living organisms and their biological consequences, with applications in the fields of photomedicine, photo(nano)technology, photosynthesis, and ... ...

    Abstract Photobiology is a challenging research area that aims to explore the interactions between light and living organisms and their biological consequences, with applications in the fields of photomedicine, photo(nano)technology, photosynthesis, and photosensory biology [...].
    MeSH term(s) Photobiology ; Photosynthesis ; Light
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063209
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  10. Article ; Online: Sesamoid Avascular Necrosis and Stress Fracture Treated with Core Decompression and Biologic Augmentation.

    Scala, Victoria A / Kikuchi, Christian K

    Hawai'i journal of health & social welfare

    2022  Volume 81, Issue 3 Suppl 1, Page(s) 16–18

    Abstract: Sesamoid bone disorders are disabling conditions with limited treatment options. This case report describes a 17-year-old football player with avascular necrosis (AVN) in both the tibial and fibular hallux sesamoids with a concomitant non-displaced ... ...

    Abstract Sesamoid bone disorders are disabling conditions with limited treatment options. This case report describes a 17-year-old football player with avascular necrosis (AVN) in both the tibial and fibular hallux sesamoids with a concomitant non-displaced stress fracture of the tibial hallux sesamoid. After a short period of conservative management, the patient underwent open sesamoid core decompression with an application of concentrated bone marrow aspirate and amnion matrix. After postoperative physical therapy, the patient achieved a painless range of motion of the first metatarsophalangeal joint. He returned to full athletic activities by 6 months postoperatively. Core decompression with biologic augmentation is a viable treatment option for sesamoid AVN. Earlier surgical intervention for sesamoid AVN can also be considered, particularly in younger active patients.
    MeSH term(s) Adolescent ; Biological Products ; Decompression ; Fractures, Stress/complications ; Fractures, Stress/surgery ; Humans ; Male ; Necrosis ; Sesamoid Bones
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2983566-5
    ISSN 2641-5224 ; 2641-5216
    ISSN (online) 2641-5224
    ISSN 2641-5216
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