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  1. Article: Paclitaxel in early breast cancer: a viewpoint by Aman U. Buzdar.

    Buzdar, Aman U

    Drugs

    2004  Volume 64, Issue 16, Page(s) 1848–1849

    MeSH term(s) Antineoplastic Agents, Phytogenic/therapeutic use ; Breast Neoplasms/drug therapy ; Drug Therapy, Combination ; Female ; Humans ; Paclitaxel/therapeutic use
    Chemical Substances Antineoplastic Agents, Phytogenic ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2004-07-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.2165/00003495-200464160-00009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 762: Show issues Location:
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  2. Book: Endocrine therapies in breast cancer

    Buzdar, Aman U.

    (OOL Oxford oncology library)

    2007  

    Author's details ed. by Aman U. Buzdar
    Series title OOL Oxford oncology library
    Keywords Breast Neoplasms / drug therapy ; Antineoplastic Agents, Hormonal / therapeutic use
    Language English
    Size VIII, 120 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015605291
    ISBN 978-0-1992-1814-1 ; 978-0-19-921814-1 ; 0-19-921814-5 ; 0-1992-1814-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 4229 order for loan Magazin

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  3. Book ; Conference proceedings: History and advancement of Anastrozole in the treatment of breast cancer

    Buzdar, Aman U.

    [proceedings from the ATAC Investigators' Meetings]

    2003  

    Author's details ed. by A. Buzdar
    Language English
    Size IX 110 S. : Ill., graph. Darst.
    Publisher Royal Society of Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT014156416
    ISBN 1-85315-557-8 ; 978-1-85315-557-4
    Database Catalogue ZB MED Medicine, Health

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    2004 A 4618 order for loan Magazin

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  4. Book ; Conference proceedings: Proceedings of the First International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer

    Buzdar, Aman U.

    Cambridge, Massachusetts, June 21 - 23, 2001

    (Clinical cancer research ; 7,12, Suppl.)

    2001  

    Event/congress International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer (1, 2001, CambridgeMass.)
    Series title Clinical cancer research ; 7,12, Suppl.
    Collection
    Language English
    Size I S., S. 4335s - 4442s : graph. Darst.
    Publisher American Assoc. for Cancer Research
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013252470
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4223 -7,12,Suppl.- not available for loan Zeitschriften-Lesesaal

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  5. Book: Emerging strategies in the management of breast cancer

    Boccardo, Francesco / Buzdar, Aman U.

    (Clinical breast cancer ; 5, Suppl. 1)

    2004  

    Author's details suppl. ed.: Aman U. Buzdar. Contributors Francesco Boccardo
    Series title Clinical breast cancer ; 5, Suppl. 1
    Collection
    Language English
    Size S30 S. : graph. Darst.
    Publisher Cancer Information Group
    Publishing place Dallas, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT014127829
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5800 -5,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: Deciphering the differential expression patterns of yield-related negative regulators in hexaploid wheat cultivars and hybrids at different growth stages.

    Awan, Muhammad Jawad Akbar / Farooq, Muhammad Awais / Naqvi, Rubab Zahra / Karamat, Umer / Bukhari, Sayyad Ali Raza / Waqas, Muhammad Abu Bakar / Mahmood, Muhammad Arslan / Buzdar, Muhammad Ismail / Rasheed, Awais / Amin, Imran / Saeed, Nasir A / Mansoor, Shahid

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 537

    Abstract: Background: Hexaploid bread wheat underwent a series of polyploidization events through interspecific hybridizations that conferred adaptive plasticity and resulted in duplication and neofunctionalization of major agronomic genes. The genetic ... ...

    Abstract Background: Hexaploid bread wheat underwent a series of polyploidization events through interspecific hybridizations that conferred adaptive plasticity and resulted in duplication and neofunctionalization of major agronomic genes. The genetic architecture of polyploid wheat not only confers adaptive plasticity but also offers huge genetic diversity. However, the contribution of different gene copies (homeologs) encoded from different subgenomes (A, B, D) at different growth stages remained unexplored.
    Methods: In this study, hybrid of elite cultivars of wheat were developed via reciprocal crosses (cytoplasm swapping) and phenotypically evaluated. We assessed differential expression profiles of yield-related negative regulators in these cultivars and their F1 hybrids and identified various cis-regulatory signatures by employing bioinformatics tools. Furthermore, the preferential expression patterns of the syntenic triads encoded from A, B, and D subgenomes were assessed to decipher their functional redundancy at six different growth stages.
    Results: Hybrid progenies showed better heterosis such as up to 17% increase in the average number of grains and up to 50% increase in average thousand grains weight as compared to mid-parents. Based on the expression profiling, our results indicated significant dynamic transcriptional expression patterns, portraying the different homeolog-dominance at the same stage in the different cultivars and their hybrids. Albeit belonging to same syntenic triads, a dynamic trend was observed in the regulatory signatures of these genes that might be influencing their expression profiles.
    Conclusion: These findings can substantially contribute and provide insights for the selective introduction of better cultivars into traditional and hybrid breeding programs which can be harnessed for the improvement of future wheat.
    MeSH term(s) Triticum/genetics ; Plant Breeding ; Hybridization, Genetic ; Hybrid Vigor/genetics
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09454-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1140: Show issues Location:
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  7. Article ; Online: Role of biologic therapy and chemotherapy in hormone receptor- and HER2-positive breast cancer.

    Buzdar, A U

    Annals of oncology : official journal of the European Society for Medical Oncology

    2009  Volume 20, Issue 6, Page(s) 993–999

    Abstract: Background: To review the efficacy of chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted therapy when used in addition to hormonal therapy for the optimal management of estrogen receptor-positive (ER+)/human epidermal growth ... ...

    Abstract Background: To review the efficacy of chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted therapy when used in addition to hormonal therapy for the optimal management of estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-positive (HER2+) breast cancer.
    Design: Literature published from January 2003 to March 2008 was reviewed to assess the use of chemotherapy and biologic therapy in addition to hormonal agents.
    Results: Aromatase inhibitors (AIs) demonstrated greater effectiveness in the adjuvant setting than tamoxifen for the management of ER+ and HER2+ breast cancer. Evidence of cross talk between HER2- and ER-signaling pathways suggests that combined treatment with HER2 blockade and hormonal therapy may offer clinical advantages beyond those provided by hormonal therapy alone in ER+/HER2+ disease. Combined therapy with trastuzumab plus an aromatase AI significantly improves progression-free survival, response rates, and clinical benefits when compared with AI monotherapy in postmenopausal women. Several large studies demonstrated that trastuzumab significantly improves disease-free and overall survival when given in combination with, or following, chemotherapy, regardless of hormone receptor status.
    Conclusions: HER2-targeted therapy maybe combined with AIs for the treatment of ER+/HER2+ metastatic breast cancer in postmenopausal women. HER2-targeted therapy in combination with AIs for treatment of ER+/HER2+ early breast cancer needs to be prospectively evaluated.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Biological Therapy ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Drug Resistance, Neoplasm ; Female ; Humans ; Receptor, ErbB-2/biosynthesis ; Receptors, Estrogen/biosynthesis ; Receptors, Progesterone/biosynthesis ; Signal Transduction
    Chemical Substances Antineoplastic Agents ; Receptors, Estrogen ; Receptors, Progesterone ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2009-01-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdn739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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  8. Article ; Online: Meta-analysis: selective estrogen-receptor modulators reduce breast cancer incidence.

    Buzdar, Aman U

    Annals of internal medicine

    2013  Volume 159, Issue 6, Page(s) JC9

    MeSH term(s) Anticarcinogenic Agents/therapeutic use ; Breast Neoplasms/prevention & control ; Female ; Humans ; Selective Estrogen Receptor Modulators/therapeutic use
    Chemical Substances Anticarcinogenic Agents ; Selective Estrogen Receptor Modulators
    Language English
    Publishing date 2013-09-17
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-159-6-201309170-02009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.178/2: Show issues Location:
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  9. Article ; Online: Combination endocrine treatments unproven in breast cancer.

    Buzdar, Aman U

    The Lancet. Oncology

    2013  Volume 14, Issue 10, Page(s) 917–918

    MeSH term(s) Anastrozole ; Androstadienes/therapeutic use ; Antineoplastic Agents/therapeutic use ; Aromatase Inhibitors/administration & dosage ; Breast Neoplasms/drug therapy ; Estradiol/administration & dosage ; Estradiol/analogs & derivatives ; Estrogen Antagonists/administration & dosage ; Female ; Fulvestrant ; Humans ; Nitriles/administration & dosage ; Triazoles/administration & dosage
    Chemical Substances Androstadienes ; Antineoplastic Agents ; Aromatase Inhibitors ; Estrogen Antagonists ; Nitriles ; Triazoles ; Fulvestrant (22X328QOC4) ; Anastrozole (2Z07MYW1AZ) ; Estradiol (4TI98Z838E) ; exemestane (NY22HMQ4BX)
    Language English
    Publishing date 2013-07-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(13)70364-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  10. Article: St Gallen guidelines: aromatase inhibitors recommended by name for adjuvant therapy.

    Buzdar, A U

    Annals of oncology : official journal of the European Society for Medical Oncology

    2006  Volume 17, Issue 5, Page(s) 878–879

    MeSH term(s) Aromatase Inhibitors/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Patient Care Management
    Chemical Substances Aromatase Inhibitors
    Language English
    Publishing date 2006-04-20
    Publishing country England
    Document type Comment ; Letter ; Practice Guideline
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdj093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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