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  1. Article: Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path.

    Iessi, Elisabetta / Vona, Rosa / Cittadini, Camilla / Matarrese, Paola

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: In cancer cells, metabolic adaptations are often observed in terms of nutrient absorption, biosynthesis of macromolecules, and production of energy necessary to meet the needs of the tumor cell such as uncontrolled proliferation, dissemination, and ... ...

    Abstract In cancer cells, metabolic adaptations are often observed in terms of nutrient absorption, biosynthesis of macromolecules, and production of energy necessary to meet the needs of the tumor cell such as uncontrolled proliferation, dissemination, and acquisition of resistance to death processes induced by both unfavorable environmental conditions and therapeutic drugs. Many oncogenes and tumor suppressor genes have a significant effect on cellular metabolism, as there is a close relationship between the pathways activated by these genes and the various metabolic options. The metabolic adaptations observed in cancer cells not only promote their proliferation and invasion, but also their survival by inducing intrinsic and acquired resistance to various anticancer agents and to various forms of cell death, such as apoptosis, necroptosis, autophagy, and ferroptosis. In this review we analyze the main metabolic differences between cancer and non-cancer cells and how these can affect the various cell death pathways, effectively determining the susceptibility of cancer cells to therapy-induced death. Targeting the metabolic peculiarities of cancer could represent in the near future an innovative therapeutic strategy for the treatment of those tumors whose metabolic characteristics are known.
    Language English
    Publishing date 2021-12-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path

    Elisabetta Iessi / Rosa Vona / Camilla Cittadini / Paola Matarrese

    Biomedicines, Vol 9, Iss 1942, p

    2021  Volume 1942

    Abstract: In cancer cells, metabolic adaptations are often observed in terms of nutrient absorption, biosynthesis of macromolecules, and production of energy necessary to meet the needs of the tumor cell such as uncontrolled proliferation, dissemination, and ... ...

    Abstract In cancer cells, metabolic adaptations are often observed in terms of nutrient absorption, biosynthesis of macromolecules, and production of energy necessary to meet the needs of the tumor cell such as uncontrolled proliferation, dissemination, and acquisition of resistance to death processes induced by both unfavorable environmental conditions and therapeutic drugs. Many oncogenes and tumor suppressor genes have a significant effect on cellular metabolism, as there is a close relationship between the pathways activated by these genes and the various metabolic options. The metabolic adaptations observed in cancer cells not only promote their proliferation and invasion, but also their survival by inducing intrinsic and acquired resistance to various anticancer agents and to various forms of cell death, such as apoptosis, necroptosis, autophagy, and ferroptosis. In this review we analyze the main metabolic differences between cancer and non-cancer cells and how these can affect the various cell death pathways, effectively determining the susceptibility of cancer cells to therapy-induced death. Targeting the metabolic peculiarities of cancer could represent in the near future an innovative therapeutic strategy for the treatment of those tumors whose metabolic characteristics are known.
    Keywords cancer cell metabolism ; cell death ; anticancer therapy ; chemoresistance ; glucose ; glycolysis ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Sex differences in antiviral immunity in SARS-CoV-2 infection: Mitochondria and mitomiR come into view.

    Iessi, Elisabetta / Cittadini, Camilla / Anticoli, Simona / Fecchi, Katia / Matarrese, Paola / Ruggieri, Anna

    Acta physiologica (Oxford, England)

    2020  Volume 231, Issue 2, Page(s) e13571

    MeSH term(s) Animals ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; COVID-19/genetics ; COVID-19/immunology ; Female ; Immunity, Innate ; Male ; MicroRNAs/genetics ; Mitochondria/genetics ; Mitochondria/immunology ; Oxidative Stress ; SARS-CoV-2/immunology ; Sex Characteristics
    Chemical Substances Antibodies, Viral ; MicroRNAs
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Editorial
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13571
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  4. Article ; Online: The impact of the COVID-19 pandemic on eating disorders risk and symptoms: a retrospective study.

    Straface, Elisabetta / Jacobis, Isabella Tarissi De / Capriati, Teresa / Pretelli, Italo / Grandin, Annalisa / Mascolo, Cristina / Vona, Rosa / Gambardella, Lucrezia / Cittadini, Camilla / Villani, Alberto / Marchili, Maria Rosaria

    Italian journal of pediatrics

    2023  Volume 49, Issue 1, Page(s) 50

    Abstract: Background: Social distancing and quarantine imposed by the authority during the COVID-19 pandemic caused restrictions, which had a negative impact on eating behavior, especially among adolescents. We proposed a retrospective study aimed to evaluate the ...

    Abstract Background: Social distancing and quarantine imposed by the authority during the COVID-19 pandemic caused restrictions, which had a negative impact on eating behavior, especially among adolescents. We proposed a retrospective study aimed to evaluate the effect of the COVID-19 pandemic on eating disorders risk and symptoms.
    Methods: In this study, a group of 127 pediatric patients (117 females and 10 males) with eating disorders admitted to the Bambino Gesù Children's Hospital of Rome (Italy), in the period between August 2019 and April 2021, was analyzed. All patient data were collected from patients' electronic medical records.
    Results: We found that 80.3% of patients were at the onset of eating disorders and that 26% of patients had familiarity for psychotic disorders. Often these patients had comorbidities and alterations in blood parameters such as leukocytopenia, neutropenia, hypovitaminosis and hormonal problems that could affect their future.
    Conclusions: Our findings could provide a framework for developing clinical and educational interventions to mitigate the short- and long-term negative impact of the pandemic on adolescent future health.
    MeSH term(s) Adolescent ; Female ; Male ; Humans ; Child ; COVID-19/epidemiology ; Retrospective Studies ; Pandemics ; Feeding and Eating Disorders/epidemiology ; Adolescent Health
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-023-01443-6
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  5. Article ; Online: Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases.

    Vona, Rosa / Gambardella, Lucrezia / Cittadini, Camilla / Straface, Elisabetta / Pietraforte, Donatella

    Oxidative medicine and cellular longevity

    2019  Volume 2019, Page(s) 8267234

    Abstract: Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and impaired glucose tolerance. The link between the MS and the associated ... ...

    Abstract Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and impaired glucose tolerance. The link between the MS and the associated diseases is represented by oxidative stress (OS) and by the intracellular redox imbalance, both caused by the persistence of chronic inflammatory conditions that characterize MS. The increase in oxidizing species formation in MS has been accepted as a major underlying mechanism for mitochondrial dysfunction, accumulation of protein and lipid oxidation products, and impairment of the antioxidant systems. These oxidative modifications are recognized as relevant OS biomarkers potentially able to (i) clarify the role of reactive oxygen and nitrogen species in the etiology of the MS, (ii) contribute to the diagnosis/evaluation of the disease's severity, and (iii) evaluate the utility of possible therapeutic strategies based on natural antioxidants. The antioxidant therapies indeed could be able to (i) counteract systemic as well as mitochondrial-derived OS, (ii) enhance the endogenous antioxidant defenses, (iii) alleviate MS symptoms, and (iv) prevent the complications linked to MS-derived cardiovascular diseases. The focus of this review is to summarize the current knowledge about the role of OS in the development of metabolic alterations characterizing MS, with particular regard to the occurrence of OS-correlated biomarkers, as well as to the use of therapeutic strategies based on natural antioxidants.
    MeSH term(s) Animals ; Humans ; Metabolic Syndrome/metabolism ; Oxidation-Reduction ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2019-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2019/8267234
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  6. Article ; Online: Clinical characteristics of children infected with SARS-CoV-2 in Italy.

    De Jacobis, Isabella Tarissi / Vona, Rosa / Cittadini, Camilla / Marchesi, Alessandra / Cursi, Laura / Gambardella, Lucrezia / Villani, Alberto / Straface, Elisabetta

    Italian journal of pediatrics

    2021  Volume 47, Issue 1, Page(s) 90

    Abstract: Background: Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and adolescents are limited. We ... ...

    Abstract Background: Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and adolescents are limited. We propose a retrospective study aimed to evaluate clinical characteristics of children infected with SARS-CoV-2 in Italy.
    Methods: A pediatric population admitted with COVID-19 to Bambino Gesù Children's Hospital of Rome (Italy) in the period from the end of February to July 2020 has been studied. Medical history, comorbidities, symptoms and laboratory findings were obtained from patients' electronic medical records.
    Results: In 66 patients (35 males and 31 females) we found that: i) fever and cough were the dominant symptoms, while vomit and convulsions were rare symptoms; and ii) all ages of childhood were susceptible to COVID-19. Furthermore, we found that, compared to females, males with COVID-19, although not significantly, had higher values of inflammatory markers such as C-reactive protein (CRP) and ESR. Conversely, we found that COVID-19 positive females were older than males and required more days of hospitalization. Both males and females COVID-19 positives had procalcitonin values within the normal range and D-Dimer values slightly higher than the normal range. With regard to this latter marker, the value measured in females, although not significant, was higher than that measured in males. Interestingly, the presence of leukopenia was found in both sexes.
    Conclusions: Compared to the adults we found that COVID-19 infection in children is a non-severe inflammatory disease in both males and females. In any case, many detailed studies should be conducted.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; Child ; Child, Preschool ; Comorbidity ; Female ; Humans ; Infant ; Italy/epidemiology ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-021-01045-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1961: Show issues Location:
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  7. Article: Sex differences in antiviral immunity in SARS-CoV-2 infection: Mitochondria and mitomiR come into view

    Iessi, Elisabetta / Cittadini, Camilla / Anticoli, Simona / Fecchi, Katia / Matarrese, Paola / Ruggieri, Anna

    Acta Physiol (Oxf)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #884550
    Database COVID19

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  8. Article ; Online: Sex differences in antiviral immunity in SARS‐CoV‐2 infection

    Iessi, Elisabetta / Cittadini, Camilla / Anticoli, Simona / Fecchi, Katia / Matarrese, Paola / Ruggieri, Anna

    Acta Physiologica ; ISSN 1748-1708 1748-1716

    mitochondria and mitomiR come into view

    2020  

    Keywords Physiology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/apha.13571
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Stroke incidence, prevalence and mortality in women worldwide.

    Arnao, Valentina / Acciarresi, Monica / Cittadini, Elisabetta / Caso, Valeria

    International journal of stroke : official journal of the International Stroke Society

    2016  Volume 11, Issue 3, Page(s) 287–301

    Abstract: Background: The study of sex differences on stroke incidence, prevalence and mortality is an emerging field of stroke epidemiology and care.: Aims: This study sought to determine the information available on stroke epidemiology in women worldwide and ...

    Abstract Background: The study of sex differences on stroke incidence, prevalence and mortality is an emerging field of stroke epidemiology and care.
    Aims: This study sought to determine the information available on stroke epidemiology in women worldwide and possible sex differences in stroke epidemiology, and, if so, describe the nature of these differences and whether they are consistent across countries/groups of countries.
    Summary: We searched the available literature in English published between 1 January 2008 and 5 May 2015. Out of 17.789 papers only 56 peer-reviewed papers (29 community-based studies, 17 retrospective studies, 6 reviews, and 4 cross-sectional studies) have been included in the study. This review adopted the epidemiologic transition theory, which classifies countries into four stages according to their levels of industrialization and economy. For the first and second stages, reliable registries and health certification are lacking, and therefore our sought after data were very limited.In the third stage, specifically for Eastern Europe (post-socialist countries), the burden from stroke in women was on the rise, while in the fourth stage, despite an aging population, decreases in stroke incidence, prevalence and mortality have been observed, even in subjects older than 80 years for both sexes. However, regarding studies of US populations, these trends for women were less pronounced for African Americans, and Hispanics as well as Indians. This suggests a "gender-gap" regarding access to treatment and care.In conclusion, identifying the presence of differing global burden between the sexes will allow us to better understand how to prevent, treat, and manage both men and women.
    MeSH term(s) Age Factors ; Ethnic Groups ; Female ; Humans ; Male ; Prevalence ; Sex Factors ; Stroke/epidemiology ; Stroke/mortality ; Survival Analysis
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1177/1747493016632245
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  10. Article ; Online: Headache.

    Cittadini, Elisabetta / Caso, Valeria

    Frontiers of neurology and neuroscience

    2012  Volume 30, Page(s) 9–12

    Abstract: Headache can be a symptom of vast pathologies, and common secondary headache including head or neck trauma, cranial or cervical vascular disorder, non-vascular intracranial disorders headache related to a substance or its withdrawals, infection, ... ...

    Abstract Headache can be a symptom of vast pathologies, and common secondary headache including head or neck trauma, cranial or cervical vascular disorder, non-vascular intracranial disorders headache related to a substance or its withdrawals, infection, disorders of homeostasis, disorders of cranium or facial mouth or cranial disorders, and headache attributable to psychiatric. Stroke-related headache has been reported between 7 and 65% and headache is also the most frequent symptom of cerebral venous thrombosis, which is present in nearly 90% of patients.
    MeSH term(s) Headache/epidemiology ; Headache/etiology ; Humans ; Stroke/complications
    Language English
    Publishing date 2012
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2804 ; 1660-4431
    ISSN (online) 1662-2804
    ISSN 1660-4431
    DOI 10.1159/000333374
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