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Article ; Online: "Advanced" Parkinson's disease: A review.

Aslam, Sana / Manfredsson, Fredric / Stokes, Ashley / Shill, Holly

2024 , Page(s) 106065

Abstract: There is no consensus driven definition of "advanced" Parkinson's disease (APD) currently. APD has been described in terms of emergence of specific clinical features and clinical milestones of the disease e.g., motor fluctuations, time to increasing ... ...

Abstract	There is no consensus driven definition of "advanced" Parkinson's disease (APD) currently. APD has been described in terms of emergence of specific clinical features and clinical milestones of the disease e.g., motor fluctuations, time to increasing falls, emergence of cognitive decline, etc. The pathological burden of disease has been used to characterize various stages of the disease. Imaging markers have been associated with various motor and nonmotor symptoms of advancing disease. In this review, we present an overview of clinical, pathologic, and imaging markers of APD. We also propose a model of disease definition involving longitudinal assessments of these markers as well as quality of life metrics to better understand and predict disease progression in those with Parkinson's disease.
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2024.106065
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Article ; Online: Lack of significant Lewy pathology in 237 essential tremor brains.

Shill, Holly A / Adler, Charles H / Tremblay, Cécilia / Beach, Thomas G

Journal of neuropathology and experimental neurology

2023 Volume 82, Issue 5, Page(s) 452–453

MeSH term(s)	Humans ; Essential Tremor/pathology ; Brain/pathology ; Lewy Body Disease/pathology
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Letter ; Comment
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1093/jnen/nlad022
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Ui II Zs.194: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: α-synuclein seed amplification in Parkinson's disease.

Beach, Thomas G / Adler, Charles H / Shill, Holly A / Serrano, Geidy E / Zhang, Nan

The Lancet. Neurology

2023 Volume 22, Issue 11, Page(s) 985

MeSH term(s)	Humans ; alpha-Synuclein/genetics ; Parkinson Disease/genetics
Chemical Substances	alpha-Synuclein
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2081241-3
ISSN	1474-4465 ; 1474-4422
ISSN (online)	1474-4465
ISSN	1474-4422
DOI	10.1016/S1474-4422(23)00373-3
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Zs.A 5955: Show issues

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Article ; Online: Essential tremor and cognitive decline.

Shill, Holly A / Mehta, Shyamal / Adler, Charles H

Parkinsonism & related disorders

2021 Volume 83, Page(s) 125

MeSH term(s)	Cognitive Dysfunction/etiology ; Dementia ; Essential Tremor ; Humans ; Longitudinal Studies ; Neuropsychological Tests ; Prospective Studies
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2020.12.012
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Article ; Online: Accuracy of the Early Diagnosis of Parkinson's Disease.

Beach, Thomas G / Adler, Charles H / Shill, Holly A / Zhang, Nan / Driver-Dunckley, Erika D / Mehta, Shyamal H / Serrano, Geidy E

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 8, Page(s) 1573–1574

MeSH term(s)	Humans ; Parkinson Disease/diagnosis ; Early Diagnosis ; Autopsy
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Letter ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29556
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 238: Show issues

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Article ; Online: Symmetry of synuclein density in autopsied Parkinson's disease submandibular glands.

Adler, Charles H / Serrano, Geidy E / Shill, Holly A / Driver-Dunckley, Erika / Mehta, Shyamal H / Zhang, Nan / Glass, Michael / Sue, Lucia I / Intorcia, Anthony / Beach, Thomas G

Neuroscience letters

2024 Volume 825, Page(s) 137702

Abstract: Background: Peripheral tissue biopsy in Parkinson's disease (PD) may be valuable for clinical care, biomarker validation, and as research enrollment criteria.: Objective: Determine whether submandibular gland pathologic alpha-synuclein (aSyn) density ...

Abstract	Background: Peripheral tissue biopsy in Parkinson's disease (PD) may be valuable for clinical care, biomarker validation, and as research enrollment criteria. Objective: Determine whether submandibular gland pathologic alpha-synuclein (aSyn) density is symmetrical and whether previous needle biopsy caused tissue damage. Methods: Thirty autopsy-confirmed PD cases having fixed submandibular gland tissue from one side and frozen submandibular gland tissue from the contralateral side were studied. Tissue was stained for phosphorylated aSyn and density (0-4 semiquantitative scale) was determined. Three previously biopsied cases were also assessed for tissue damage at subsequent autopsy. Results: Mean (SD) age was 80.9 (5.5) years and disease duration 12.5 (9.3). Submandibular gland aSyn staining had a mean score of 2.13 for both the initially fixed and the initially frozen submandibular glands. The correlation between aSyn density of the two sides was r = 0.63. Correlation of aSyn density, in the originally fixed submandibular gland, with disease duration was good (r = 0.49, p =.006). No permanent tissue damage was found in the three previously biopsied cases. Conclusions: This study found good correlation between aSyn density in both submandibular glands of patients with PD and found no evidence of significant tissue damage in previously biopsied subjects.
MeSH term(s)	Humans ; Aged, 80 and over ; Parkinson Disease/pathology ; Submandibular Gland/pathology ; alpha-Synuclein ; Biopsy ; Biomarkers ; Autopsy
Chemical Substances	alpha-Synuclein ; Biomarkers
Language	English
Publishing date	2024-02-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2024.137702
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Article ; Online: Conjugal Synucleinopathies: A Clinicopathologic Study.

Adler, Charles H / Halverson, Matthew / Zhang, Nan / Shill, Holly A / Driver-Dunckley, Erika / Mehta, Shyamal H / Atri, Alireza / Caviness, John N / Serrano, Geidy E / Shprecher, David R / Belden, Christine M / Sabbagh, Marwan N / Long, Kathy / Beach, Thomas G

Movement disorders : official journal of the Movement Disorder Society

2024

Abstract: Background: While preclinical studies have shown that alpha-synuclein can spread through cell-to-cell transmission whether it can be transmitted between humans is unknown.: Objectives: The aim was to assess the presence of a synucleinopathy in ... ...

Abstract	Background: While preclinical studies have shown that alpha-synuclein can spread through cell-to-cell transmission whether it can be transmitted between humans is unknown. Objectives: The aim was to assess the presence of a synucleinopathy in autopsied conjugal couples. Methods: Neuropathological findings in conjugal couples were categorized as Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease with Lewy bodies (ADLB), incidental Lewy body disease (ILBD), or no Lewy bodies. Results: Ninety conjugal couples were included; the mean age of death was 88.3 years; 32 couples had no Lewy bodies; 42 couples had 1 spouse with a synucleinopathy: 10 PD, 3 DLB, 13 ADLB, and 16 ILBD; 16 couples had both spouses with a synucleinopathy: in 4 couples both spouses had PD, 1 couple had PD and DLB, 4 couples had PD and ADLB, 2 couples had PD and ILBD, 1 couple had DLB and ADLB, in 3 couples both had ADLB, and 1 couple had ADLB and ILBD. No couples had both spouses with ILBD. Conclusions: This large series of 90 autopsied conjugal couples found 16 conjugal couples with synucleinopathies, suggesting transmission of synucleinopathy between spouses is unlikely. © 2024 International Parkinson and Movement Disorder Society.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29783
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 238: Show issues

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Article ; Online: The Relationship Between Social Anxiety Disorder and Motor Symptoms of Parkinson Disease: A Pilot Study.

Moguel-Cobos, Guillermo / Saldivar, Christina / Goslar, Pamela W / Shill, Holly A

Psychosomatics

2020 Volume 61, Issue 4, Page(s) 321–326

Abstract: Background: In patients with Parkinson disease (PD), motor symptoms coexist with several nonmotor neuropsychiatric symptoms. Various anxiety subtypes (generalized anxiety disorder, panic disorder, and social anxiety disorder [SAD]) are more prevalent in ...

Abstract	Background: In patients with Parkinson disease (PD), motor symptoms coexist with several nonmotor neuropsychiatric symptoms. Various anxiety subtypes (generalized anxiety disorder, panic disorder, and social anxiety disorder [SAD]) are more prevalent in patients with PD than in the general population. Objective: We estimated the prevalence of SAD in early patients with PD and the relationship between severity of SAD and PD symptoms. Methods: The Liebowitz Social Anxiety Scale (LSAS) and Unified Parkinson's Disease Rating Scale (UPDRS) III, which assess function impairment, were used to grade symptom severity among 41 patients with early PD. Ratings were compared and analyzed in relation to UPDRS subdivisions. Results: UPDRS III and LSAS scores were not significantly correlated (r = 0.23, P = 0.14), but LSAS and UPDRS I, which evaluate nonanxiety psychiatric symptoms, were significantly correlated (r = 0.44; P = 0.004) and were stronger in the group not treated for PD (r = 0.82) but were in the group treated for PD (r = 0.28), although this difference did not reach statistical significance (P = 0.07 using the Fisher r-to-z transformation). LSAS also correlated with total UPDRS and UPDRS II (P ≤ 0.04). Conclusions: Results suggest that SAD symptoms in patients with PD correlate with PD symptoms as evaluated by the total UPDRS and UPDRS I and II. In our pilot study, this correlation was higher in levodopa-untreated patients with PD but was not statistically significant. Because the UPDRS III and LSAS were not statistically significantly correlated, a direct motor correlation with SAD symptoms cannot be suggested. Further investigation is needed to clarify the relationship of SAD in patients with PD and potential treatment options.
MeSH term(s)	Aged ; Depression/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/psychology ; Phobia, Social/epidemiology ; Pilot Projects ; Prevalence ; Psychiatric Status Rating Scales ; Quality of Life ; Severity of Illness Index
Language	English
Publishing date	2020-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	209487-3
ISSN	1545-7206 ; 0033-3182
ISSN (online)	1545-7206
ISSN	0033-3182
DOI	10.1016/j.psym.2020.03.006
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Article ; Online: RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction.

Tremblay, Cécilia / Aslam, Sidra / Walker, Jessica E / Lorenzini, Ileana / Intorcia, Anthony J / Arce, Richard A / Choudhury, Parichita / Adler, Charles H / Shill, Holly A / Driver-Dunckley, Erika / Mehta, Shyamal / Piras, Ignazio S / Belden, Christine M / Atri, Alireza / Beach, Thomas G / Serrano, Geidy E

Neurobiology of disease

2024 , Page(s) 106514

Abstract: The olfactory bulb is involved early in the pathophysiology of Parkinson's disease (PD), which is consistent with the early onset of olfactory dysfunction. Identifying the molecular mechanisms through which PD affects the olfactory bulb could lead to a ... ...

Abstract	The olfactory bulb is involved early in the pathophysiology of Parkinson's disease (PD), which is consistent with the early onset of olfactory dysfunction. Identifying the molecular mechanisms through which PD affects the olfactory bulb could lead to a better understanding of the pathophysiology and etiology of olfactory dysfunction in PD. We specifically aimed to assess gene expression changes, affected pathways and co-expression network by whole transcriptomic profiling of the olfactory bulb in subjects with clinicopathologically defined PD. Bulk RNA sequencing was performed on frozen human olfactory bulbs of 20 PD and 20 controls without dementia or any other neurodegenerative disorder, from the Arizona Study of Aging and Neurodegenerative disorders and the Brain and Body Donation Program. Differential expression analysis (19 PD vs 19 controls) revealed 2164 significantly differentially expressed genes (1090 upregulated and 1074 downregulated) in PD. Pathways enriched in downregulated genes included oxidative phosphorylation, olfactory transduction, metabolic pathways, and neurotransmitters synapses while immune and inflammatory responses as well as cellular death related pathways were enriched within upregulated genes. An overrepresentation of microglial and astrocyte-related genes was observed amongst upregulated genes, and excitatory neuron-related genes were overrepresented amongst downregulated genes. Co-expression network analysis revealed significant modules highly correlated with PD and olfactory dysfunction that were found to be involved in the MAPK signaling pathway, cytokine-cytokine receptor interaction, cholinergic synapse, and metabolic pathways. LAIR1 (leukocyte associated immunoglobulin like receptor 1) and PPARA (peroxisome proliferator activated receptor alpha) were identified as hub genes with a high discriminative power between PD and controls reinforcing an important role of neuroinflammation in the olfactory bulb of PD subjects. Olfactory identification test score positively correlated with expression of genes coding for G-coupled protein, glutamatergic, GABAergic, and cholinergic receptor proteins and negatively correlated with genes for proteins expressed in glial olfactory ensheathing cells. In conclusion, this study reveals gene alterations associated with neuroinflammation, neurotransmitter dysfunction, and disruptions of factors involved in the initiation of olfactory transduction signaling that may be involved in PD-related olfactory dysfunction.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2024.106514
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Article ; Online: Chorea in IgLON5-Mediated Autoimmune Encephalitis.

Aslam, Sana / Shill, Holly

Movement disorders clinical practice

2020 Volume 7, Issue Suppl 3, Page(s) S83–S84

Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Case Reports
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.13061
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