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  1. Article ; Online: Antirheumatic biologics in pregnant patients: a call for studies to address the knowledge gap.

    Østensen, Monika

    Expert review of clinical immunology

    2018  Volume 14, Issue 2, Page(s) 95–97

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Autoimmune Diseases/therapy ; Biological Products/therapeutic use ; Biosimilar Pharmaceuticals/therapeutic use ; Clinical Trials as Topic ; Female ; Humans ; Immunity ; Male ; Maternal Exposure ; Paternal Exposure ; Pregnancy ; Prenatal Exposure Delayed Effects ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances Antirheumatic Agents ; Biological Products ; Biosimilar Pharmaceuticals ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2018-01-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2018.1423963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6661: Show issues Location:
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  2. Article ; Online: The use of biologics in pregnant patients with rheumatic disease.

    Østensen, Monika

    Expert review of clinical pharmacology

    2017  Volume 10, Issue 6, Page(s) 661–669

    Abstract: Introduction: An increasing number of female patients with autoimmune diseases are treated with biologic drugs. Concerns in regard to safety of biologics during pregnancy arise in patients who have not completed their families. Areas covered: A review ... ...

    Abstract Introduction: An increasing number of female patients with autoimmune diseases are treated with biologic drugs. Concerns in regard to safety of biologics during pregnancy arise in patients who have not completed their families. Areas covered: A review of the literature dealing with child outcomes of pregnancies exposed to biologics shows that TNF inhibitors (TNFi) are the best studied in regard to human pregnancy. In studies comparing exposed pregnancies to disease-matched controls no increased risk of spontaneous abortion, low birth weight, prematurity or congenital malformations has been observed. For rituximab, tocilizumab, anakinra, belimumab and ustekinumab no prospective, controlled studies are available, and firm conclusions about their safety during pregnancy cannot be drawn. Expert commentary: TNFi appear fairly safe when given in early pregnancy. For biologics other than TNFi prospective, controlled studies on outcomes after early and late pregnancy exposure are urgently needed. Possible effects of TNFi and all other biologics on children's immune function, infection rate and vaccination responses are either limited or absent and need to be extended. Development of laboratory tests to measure concentrations of biologics routinely in children exposed in utero would facilitate decisions in regard to the time point of vaccination with live vaccines.
    MeSH term(s) Animals ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Female ; Humans ; Immunologic Factors/adverse effects ; Immunologic Factors/therapeutic use ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Complications/physiopathology ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/physiopathology ; Time Factors ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
    Chemical Substances Antirheumatic Agents ; Immunologic Factors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2017.1305268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Preconception Counseling.

    Østensen, Monika

    Rheumatic diseases clinics of North America

    2017  Volume 43, Issue 2, Page(s) 189–199

    Abstract: Chronic rheumatic disease may interfere with procreation in women of childbearing age. Female patients should have counseling in regard to family planning and parenting. Preconception counseling requires risk assessment of possible maternal or fetal ... ...

    Abstract Chronic rheumatic disease may interfere with procreation in women of childbearing age. Female patients should have counseling in regard to family planning and parenting. Preconception counseling requires risk assessment of possible maternal or fetal risks, screening for biomarkers with predictive value for adverse pregnancy outcomes, adjustment of therapy, and a schedule for monitoring and follow-up during pregnancy. Delivering comprehensive information and addressing all patient concerns are both essential for enabling patients to engage actively in decision making.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Counseling ; Female ; Humans ; Preconception Care/methods ; Pregnancy ; Pregnancy Complications/drug therapy ; Rheumatic Diseases/drug therapy
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2016.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sexual and reproductive health in rheumatic disease.

    Østensen, Monika

    Nature reviews. Rheumatology

    2017  Volume 13, Issue 8, Page(s) 485–493

    Abstract: Family size is reduced among patients with rheumatic diseases. The causes for the low number of children are multifactorial and include impaired sexual function, decreased gonadal function, pregnancy loss, therapy and personal choices. Sexuality ... ...

    Abstract Family size is reduced among patients with rheumatic diseases. The causes for the low number of children are multifactorial and include impaired sexual function, decreased gonadal function, pregnancy loss, therapy and personal choices. Sexuality contributes to quality of life in patients with rheumatic disease, but is often ignored by health professionals. Both disease-related factors and psychological responses to chronic disease can impair sexual functioning. Toxic effects of anti-inflammatory and immunosuppressive drugs can induce transient or permanent gonadal failure in women and men. Furthermore, permanent infertility can be a consequence of treatment with cyclophosphamide, whereas transient infertility can be caused by NSAIDs in women and sulfasalazine in men. These adverse effects must be communicated to the patients, and measures to preserve fertility should be initiated before the start of gonadotoxic therapy. Management of patients of both genders should include regular family planning, effective treatment of high disease activity, sexual counselling, and, if necessary, infertility treatment.
    MeSH term(s) Anti-Inflammatory Agents/adverse effects ; Family Planning Services ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Infertility/etiology ; Infertility/psychology ; Male ; Quality of Life ; Reproductive Health ; Rheumatic Diseases/complications ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/psychology ; Sexual Dysfunction, Physiological/etiology ; Sexual Dysfunction, Physiological/psychology ; Sexuality/psychology
    Chemical Substances Anti-Inflammatory Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2017.102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6338: Show issues Location:
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  5. Article ; Online: Biologics and small molecules in the management of psoriatic arthritis: Reproduction related issues in female and male patients.

    Fischer-Betz, Rebecca / Østensen, Monika

    Expert review of clinical pharmacology

    2021  Volume 14, Issue 8, Page(s) 979–989

    Abstract: ... ...

    Abstract STRACT
    MeSH term(s) Animals ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; Arthritis, Psoriatic/drug therapy ; Biological Products/administration & dosage ; Biological Products/adverse effects ; Female ; Humans ; Lactation ; Male ; Pregnancy ; Pregnancy Complications/drug therapy ; Reproduction/drug effects
    Chemical Substances Antirheumatic Agents ; Biological Products
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2021.1925536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Contraception and pregnancy counselling in rheumatoid arthritis.

    Østensen, Monika

    Current opinion in rheumatology

    2014  Volume 26, Issue 3, Page(s) 302–307

    Abstract: Purpose of review: The purpose of this study is to encourage discussion of reproduction issues in all patients of fertile age in order to prevent unplanned and ill-timed pregnancies in patients with rheumatoid arthritis (RA).: Recent findings: ... ...

    Abstract Purpose of review: The purpose of this study is to encourage discussion of reproduction issues in all patients of fertile age in order to prevent unplanned and ill-timed pregnancies in patients with rheumatoid arthritis (RA).
    Recent findings: Counselling patients who desire children requires consideration of relevant reproductive health issues, including fertility, interaction of pregnancy and RA, and management during pregnancy and lactation. RA patients have no disease-related restrictions in regard to contraception, but need to be counselled on safe birth control particularly during treatment with potentially teratogenic drugs. In spite of mostly beneficial effects of pregnancy on RA, active disease and aggressive drug treatment can impair pregnancy outcomes. Options for drug therapy, though limited, may help to maintain low disease activity during pregnancy and lactation.
    Summary: Careful preconception counselling and risk assessment is important in RA women, with a particular focus on preventing unplanned pregnancy by information on contraception. Antibody status and all medications need to be reviewed before pregnancy. Maintaining low disease activity before and during pregnancy is crucial for good outcomes. Preconceptional counselling shared with all health professionals engaged in the care of a patient helps to ensure healthy pregnancy outcomes for mother and child.
    MeSH term(s) Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Contraception/methods ; Counseling/methods ; Family Planning Services/methods ; Female ; Humans ; Preconception Care/methods ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Outcome ; Pregnancy, Unplanned
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3028: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online: Basic physics of ultrasonic imaging / by Nimrod M. Tole ; Editor

    Tole, Nimrod M / Ostensen, Harald / World Health Organization. Diagnostic Imaging and Laboratory Technology Team

    Harald Ostensen

    2005  

    Abstract: 95 p. ...

    Abstract 95 p.
    Keywords Ultrasonography ; Medical Technology and Radiation Medicine
    Language English
    Publisher Geneva : World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Basic physics of ultrasonic imaging / by Nimrod M. Tole ; Editor

    Tole, Nimrod M / Ostensen, Harald / World Health Organization. Diagnostic Imaging and Laboratory Technology Team

    Harald Ostensen

    2005  

    Abstract: 95 p. ...

    Abstract 95 p.
    Keywords Ultrasonography ; Medical Technology and Radiation Medicine
    Language English
    Publisher World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Perceived influence of health status on sexual activity in patients with psoriatic arthritis.

    Haugeberg, G / Michelsen, B / Østensen, M / Kavanaugh, A

    Scandinavian journal of rheumatology

    2020  Volume 49, Issue 6, Page(s) 468–475

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Arthritis, Psoriatic/complications ; Arthritis, Psoriatic/psychology ; Fatigue/complications ; Fatigue/psychology ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Quality of Life ; Self Report ; Severity of Illness Index ; Sexual Behavior/physiology ; Sexual Behavior/psychology
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 121265-5
    ISSN 1502-7732 ; 0300-9742
    ISSN (online) 1502-7732
    ISSN 0300-9742
    DOI 10.1080/03009742.2020.1774647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 832: Show issues Location:
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  10. Conference proceedings: Transplacental passage of belimumab during pregnancy and follow-up of a child exposed in utero

    Østensen, Monika / Bitter, Helle / Warren, David / Bolstad, Nils / Noraas, Anne

    2023  , Page(s) VS.09

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh240
    Database German Medical Science

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